Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

Nature

Volumn 535, Issue 7610, 2016, Pages 159-163

  Marceau, Caleb D ^a   Puschnik, Andreas S ^a   Majzoub, Karim ^a   Ooi, Yaw Shin ^a   Brewer, Susan M ^a   Fuchs, Gabriele ^a   Swaminathan, Kavya ^a   Mata, Miguel A ^a   Elias, Joshua E ^a   Sarnow, Peter ^a   Carette, Jan E ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOST FACTOR; MULTIENZYME COMPLEX; OLIGOSACCHARYLTRANSFERASE; SIGNAL PEPTIDE; TRANSFERASE; UNCLASSIFIED DRUG; VIRUS RNA; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE - PROTEIN GLYCOTRANSFERASE; FLAVINE ADENINE NUCLEOTIDE; GLYCOSYLTRANSFERASE; MEMBRANE PROTEIN; PROTEIN BINDING; RNA BINDING PROTEIN; VIRAL PROTEIN; VIRUS RECEPTOR;

ANTIMICROBIAL ACTIVITY; CELLS AND CELL COMPONENTS; DENGUE FEVER; DISEASE TREATMENT; GENETIC ANALYSIS; GENOME; HOST-PATHOGEN INTERACTION; IDENTIFICATION METHOD; INFECTIOUS DISEASE; METABOLISM; PATHOGENICITY; PROTEIN; VACCINE;

ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; FLAVIVIRIDAE; GENETIC SCREENING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RNA REPLICATION; RNA TRANSLATION; VIRUS REPLICATION; ZIKA VIRUS; BIOSYNTHESIS; CRISPR CAS SYSTEM; DEFICIENCY; DRUG DEVELOPMENT; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; FLAVIVIRUS INFECTION; GENETICS; GLYCOSYLATION; GROWTH, DEVELOPMENT AND AGING; HEPACIVIRUS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN GENOME; METABOLISM; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY; VIROLOGY;

DENGUE VIRUS; FLAVIVIRIDAE; HEPATITIS C VIRUS; ZIKA VIRUS;

CRISPR-CAS SYSTEMS; DENGUE VIRUS; DRUG DISCOVERY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; FLAVIN-ADENINE DINUCLEOTIDE; FLAVIVIRUS INFECTIONS; GENOME, HUMAN; GLYCOSYLATION; HEPACIVIRUS; HEXOSYLTRANSFERASES; HOST-DERIVED CELLULAR FACTORS; HOST-PATHOGEN INTERACTIONS; HUMANS; MEMBRANE PROTEINS; MOLECULAR TARGETED THERAPY; PROTEIN BINDING; PROTEIN SORTING SIGNALS; RECEPTORS, VIRUS; RNA-BINDING PROTEINS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION; ZIKA VIRUS;

EID: 84977639708     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18631     Document Type: Article

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