Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

Nature Communications

Volumn 7, Issue , 2016, Pages

  Timms, Richard T ^a   Menzies, Sam A ^a   Tchasovnikarova, Iva A ^a   Christensen, Lea C ^b   Williamson, James C ^a   Antrobus, Robin ^a   Dougan, Gordon ^c   Ellgaard, Lars ^b   Lehner, Paul J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOPLASMIC RETICULUM DEGRADATION ENHANCING ALPHA MANNOSIDASE LIKE PROTEIN 2; ENDOPLASMIC RETICULUM DEGRADATION ENHANCING ALPHA MANNOSIDASE LIKE PROTEIN 3; GLUCOSIDASE 2 SUBUNIT ALPHA; GLUCOSIDASE 2 SUBUNIT BETA; GLYCOPROTEIN; HLA A2 ANTIGEN; PEPTIDES AND PROTEINS; PROTEIN DISULFIDE ISOMERASE; THIOREDOXIN DOMAIN CONTAINING PROTEIN 11; THIOREDOXIN DOMAIN CONTAINING PROTEIN 5; UNCLASSIFIED DRUG; ALPHA GLUCOSIDASE; FLUORESCENT DYE; HLA ANTIGEN CLASS 1; PROTEIN BINDING; THIOREDOXIN;

BIODEGRADATION; CELL ORGANELLE; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; MAMMAL; PROTEIN;

ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GENETIC SCREENING; HAPLOIDY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MUTAGENESIS; PROTEIN BINDING; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; CRISPR CAS SYSTEM; GENETICS; HEK293 CELL LINE; HELA CELL LINE; MAMMAL; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN DOMAIN; REPORTER GENE;

BACTERIA (MICROORGANISMS); MAMMALIA;

ALPHA-GLUCOSIDASES; ANIMALS; CRISPR-CAS SYSTEMS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; FLUORESCENT DYES; GENES, REPORTER; GENETIC TESTING; GLYCOPROTEINS; HAPLOIDY; HEK293 CELLS; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MAMMALS; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN DOMAINS; THIOREDOXINS;

EID: 84974603544     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11786     Document Type: Article

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