Programmable RNA recognition and cleavage by CRISPR/Cas9

Nature

Volumn 516, Issue 7530, 2014, Pages 263-266

  O'Connell, Mitchell R ^a   Oakes, Benjamin L ^a   Sternberg, Samuel H ^a   East Seletsky, Alexandra ^a   Kaplan, Matias ^a,c   Doudna, Jennifer A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c University of Florida   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN CAS9; GENOMIC DNA; GUIDE RNA; MESSENGER RNA; NUCLEASE; OLIGONUCLEOTIDE; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; CELL EXTRACT; DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; RNA;

DNA; ENZYME ACTIVITY; GENETIC ANALYSIS; GENOME; GERM CELL; PROKARYOTE; RNA; SUBSTRATE;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA CLEAVAGE; DNA RNA HYBRIDIZATION; DNA SEQUENCE; ENZYME ACTIVATION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENETIC TRANSCRIPTION; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR RECOGNITION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTOSPACER ADJACENT MOTIF; RNA CLEAVAGE; RNA ISOLATION; RNA SEQUENCE; STREPTOCOCCUS PYOGENES; CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; ENZYME SPECIFICITY; GENETIC ENGINEERING; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; NUCLEOTIDE MOTIF; PHYSIOLOGY; PROCEDURES;

EUKARYOTA; PROKARYOTA;

BASE SEQUENCE; CELL EXTRACTS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DNA; GENETIC ENGINEERING; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); HELA CELLS; HUMANS; NUCLEOTIDE MOTIFS; OLIGONUCLEOTIDES; RNA; RNA, GUIDE; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 84913568580     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13769     Document Type: Article

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