Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic

Cell

Volumn 167, Issue 4, 2016, Pages 1088-1098.e6

  Diehl, William E ^a   Lin, Aaron E ^b,c   Grubaugh, Nathan D ^d   Carvalho, Luiz Max ^e   Kim, Kyusik ^a   Kyawe, Pyae Phyo ^a   McCauley, Sean M ^a   Donnard, Elisa ^a   Kucukural, Alper ^a   McDonel, Patrick ^a   Schaffner, Stephen F ^b,c   Garber, Manuel ^a   Rambaut, Andrew ^e   Andersen, Kristian G ^b,d,f   Sabeti, Pardis C ^b,c   Luban, Jeremy ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD UNIVERSITY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE   (United States)

Author keywords

adaptation; Ebola virus; epidemic; Filovirus; glycoprotein; infection; mutation; NPC1; outbreak; RNA virus

Indexed keywords

MUTANT PROTEIN; VIRUS GLYCOPROTEIN; CARRIER PROTEIN; ENVELOPE GLYCOPROTEIN, EBOLA VIRUS; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN; VIRUS ENVELOPE PROTEIN;

ARTICLE; BINDING SITE; DISEASE SEVERITY; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; EPIDEMIC; HUMAN; HUMAN CELL; MORTALITY RATE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS MUTATION; AFRICA; ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL; CALLITHRIX; CHEIROGALEIDAE; CHEMISTRY; CYTOPLASM; GENETICS; HEMORRHAGIC FEVER, EBOLA; METABOLISM; PATHOGENICITY; PHYSIOLOGY; VIRION; VIROLOGY; VIRULENCE;

AFRICA, WESTERN; AMINO ACID SUBSTITUTION; ANIMALS; CALLITHRIX; CARRIER PROTEINS; CHEIROGALEIDAE; CYTOPLASM; EBOLAVIRUS; HEMORRHAGIC FEVER, EBOLA; HUMANS; MEMBRANE GLYCOPROTEINS; PROTEIN CONFORMATION, ALPHA-HELICAL; VIRAL ENVELOPE PROTEINS; VIRION; VIRULENCE;

EID: 84994772159     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.10.014     Document Type: Article

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