Gene essentiality and synthetic lethality in haploid human cells

Science

Volumn 350, Issue 6264, 2015, Pages 1092-1096

  Blomen, Vincent A ^a   Májek, Peter ^b   Jae, Lucas T ^a   Bigenzahn, Johannes W ^b   Nieuwenhuis, Joppe ^a   Staring, Jacqueline ^a   Sacco, Roberto ^b   Van Diemen, Ferdy R ^a   Olk, Nadine ^b   Stukalov, Alexey ^b   Marceau, Caleb ^c   Janssen, Hans ^a   Carette, Jan E ^c   Bennett, Keiryn L ^b   Colinge, Jacques ^b,d   Superti Furga, Giulio ^b,e   Brummelkamp, Thijn R ^a,b,f  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIV MONTPELLIER   (France)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f Cancer Genomics Center (CGCnl)   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; OLIGOSACCHARYLTRANSFERASE COMPLEX; PHOSPHATIDYLINOSITOL KINASE; UNCLASSIFIED DRUG; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE - PROTEIN GLYCOTRANSFERASE; GLYCOSYLTRANSFERASE; MEMBRANE PROTEIN;

CELL ORGANELLE; CELLS AND CELL COMPONENTS; CHROMOSOME; GENE; HOMEOSTASIS; MUTATION; VIRUS; YEAST;

ARTICLE; CELL CULTURE; CELL DEATH; CELLS; CONTROLLED STUDY; CYTOLOGY; ESSENTIAL GENE; GENE INTERACTION; GENETIC CROSS; GOLGI COMPLEX; HAPLOID HUMAN CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; SECRETORY PATHWAY; YEAST; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; HAPLOIDY; LETHAL GENE; REPRODUCTIVE FITNESS; SACCHAROMYCES CEREVISIAE;

GENE REGULATORY NETWORKS; GENES, ESSENTIAL; GENES, LETHAL; GENETIC FITNESS; GOLGI APPARATUS; HAPLOIDY; HEXOSYLTRANSFERASES; HUMANS; MEMBRANE PROTEINS; MUTAGENESIS, INSERTIONAL; MUTATION; SACCHAROMYCES CEREVISIAE;

EID: 84947471998     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac7557     Document Type: Article

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