Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

mBio

Volumn 6, Issue 4, 2015, Pages

  Kleinfelter, Lara M ^a   Jangra, Rohit K ^a   Jae, Lucas T ^b   Herbert, Andrew S ^c   Mittler, Eva ^a   Stiles, Katie M ^a   Wirchnianski, Ariel S ^c   Kielian, Margaret ^a   Brummelkamp, Thijn R ^b   Dye, John M ^c   Chandran, Kartik ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; MATRIX PROTEIN; MEMBRANE BOUND TRANSCRIPTION FACTOR PEPTIDASE; MEMBRANE FUSION PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; CHOLESTEROL;

ALPHAVIRUS; ANDES VIRUS; ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CELL VIABILITY; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; GENE FREQUENCY; GENE FUNCTION; GENETIC SCREENING; HANTAVIRUS; HANTAVIRUS INFECTION; HUMAN; HUMAN CELL; MBTPS1 GENE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RHABDOVIRIDAE; VIRUS ATTACHMENT; VIRUS ENTRY; VIRUS GENE; VIRUS VIRULENCE; ANIMAL; CHLOROCEBUS AETHIOPS; HAPLOIDY; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; VERO CELL LINE;

ANIMALS; CERCOPITHECUS AETHIOPS; CHOLESTEROL; GENETIC TESTING; HANTAVIRUS; HAPLOIDY; HEK293 CELLS; HUMANS; VERO CELLS; VIRUS INTERNALIZATION;

EID: 84940856868     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00801-15     Document Type: Article

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