-
1
-
-
34147137118
-
Seven transmembrane receptors: Something old, something new
-
Lefkowitz RJ. Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf). 2007;190:9-19.
-
(2007)
Acta Physiol (Oxf).
, vol.190
, pp. 9-19
-
-
Lefkowitz, R.J.1
-
3
-
-
0027368165
-
Structure and mechanism of the G protein-coupled receptor kinases
-
Inglese J, Freedman NJ, Koch WJ, et al. Structure and mechanism of the G protein-coupled receptor kinases. J Biol Chem. 1993;268:23735-23738.
-
(1993)
J Biol Chem.
, vol.268
, pp. 23735-23738
-
-
Inglese, J.1
Freedman, N.J.2
Koch, W.J.3
-
8
-
-
77951844975
-
Teaching old receptors new tricks: Biasing seven-transmembrane receptors
-
Rajagopal S, Rajagopal K, Lefkowitz RJ. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov. 2010;9:373-386.
-
(2010)
Nat Rev Drug Discov.
, vol.9
, pp. 373-386
-
-
Rajagopal, S.1
Rajagopal, K.2
Lefkowitz, R.J.3
-
9
-
-
67649856866
-
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
-
Zidar DA, Violin JD, Whalen EJ, et al. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc Natl Acad Sci USA. 2009;106:9649-9654.
-
(2009)
Proc Natl Acad Sci USA.
, vol.106
, pp. 9649-9654
-
-
Zidar, D.A.1
Violin, J.D.2
Whalen, E.J.3
-
11
-
-
84926611120
-
The evolving impact of g protein-coupled receptor kinases in cardiac health and disease
-
Sato PY, Chuprun JK, Schwartz M, et al. The evolving impact of g protein-coupled receptor kinases in cardiac health and disease. Physiol Rev. 2015;95:377-404.
-
(2015)
Physiol Rev.
, vol.95
, pp. 377-404
-
-
Sato, P.Y.1
Chuprun, J.K.2
Schwartz, M.3
-
12
-
-
33947375174
-
Physiological roles of G proteincoupled receptor kinases and arrestins
-
Premont RT, Gainetdinov RR. Physiological roles of G proteincoupled receptor kinases and arrestins. Annu Rev Physiol. 2007;69: 511-534.
-
(2007)
Annu Rev Physiol.
, vol.69
, pp. 511-534
-
-
Premont, R.T.1
Gainetdinov, R.R.2
-
13
-
-
0033391143
-
Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice
-
Gainetdinov RR, Bohn LM, Walker JK, et al. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron. 1999;24:1029-1036.
-
(1999)
Neuron.
, vol.24
, pp. 1029-1036
-
-
Gainetdinov, R.R.1
Bohn, L.M.2
Walker, J.K.3
-
15
-
-
85029713597
-
G protein-coupled receptor kinases: Crucial regulators of blood pressure
-
Yang J, Villar VA, Armando I, et al. G protein-coupled receptor kinases: crucial regulators of blood pressure. J Am Heart Assoc. 2016;5. doi: 10.1161/JAHA.116.003519.e003519. pii: e003519.
-
(2016)
J Am Heart Assoc.
, vol.5
-
-
Yang, J.1
Villar, V.A.2
Armando, I.3
-
16
-
-
84888336227
-
Structural insights into G protein-coupled receptor kinase function
-
Homan KT, Tesmer JJ. Structural insights into G protein-coupled receptor kinase function. Curr Opin Cell Biol. 2014;27:25-31.
-
(2014)
Curr Opin Cell Biol.
, vol.27
, pp. 25-31
-
-
Homan, K.T.1
Tesmer, J.J.2
-
17
-
-
80053355585
-
G protein-coupled receptor kinases in normal and failing myocardium
-
Huang ZM, Gold JI, Koch WJ. G protein-coupled receptor kinases in normal and failing myocardium. Front Biosci (Landmark Ed). 2011;16: 3047-3060.
-
(2011)
Front Biosci (Landmark Ed).
, vol.16
, pp. 3047-3060
-
-
Huang, Z.M.1
Gold, J.I.2
Koch, W.J.3
-
18
-
-
0032513146
-
A novel subtype of G-proteincoupled receptor kinase, GRK7, in teleost cone photoreceptors
-
Hisatomi O, Matsuda S, Satoh T, et al. A novel subtype of G-proteincoupled receptor kinase, GRK7, in teleost cone photoreceptors. FEBS Lett. 1998;424:159-164.
-
(1998)
FEBS Lett.
, vol.424
, pp. 159-164
-
-
Hisatomi, O.1
Matsuda, S.2
Satoh, T.3
-
19
-
-
0026726050
-
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
-
Inglese J, Koch WJ, Caron MG, et al. Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. Nature. 1992;359:147-150.
-
(1992)
Nature.
, vol.359
, pp. 147-150
-
-
Inglese, J.1
Koch, W.J.2
Caron, M.G.3
-
20
-
-
34547781132
-
Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A
-
Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol Biol Cell. 2007;18:2960-2969.
-
(2007)
Mol Biol Cell.
, vol.18
, pp. 2960-2969
-
-
Jiang, X.1
Benovic, J.L.2
Wedegaertner, P.B.3
-
22
-
-
0028030060
-
Palmitoylation of G proteincoupled receptor kinase, GRK6
-
Stoffel RH, Randall RR, Premont RT, et al. Palmitoylation of G proteincoupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. J Biol Chem. 1994;269:27791-27794.
-
(1994)
Lipid Modification Diversity in the GRK Family. J Biol Chem.
, vol.269
, pp. 27791-27794
-
-
Stoffel, R.H.1
Randall, R.R.2
Premont, R.T.3
-
23
-
-
2342446156
-
A predicted amphipathic helix mediates plasma membrane localization of GRK5
-
Thiyagarajan MM, Stracquatanio RP, Pronin AN, et al. A predicted amphipathic helix mediates plasma membrane localization of GRK5. J Biol Chem. 2004;279:17989-17995.
-
(2004)
J Biol Chem.
, vol.279
, pp. 17989-17995
-
-
Thiyagarajan, M.M.1
Stracquatanio, R.P.2
Pronin, A.N.3
-
24
-
-
83555168220
-
G protein-coupled receptor kinases: More than just kinases and not only for GPCRs
-
Gurevich EV, Tesmer JJ, Mushegian A, et al. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther. 2012;133:40-69.
-
(2012)
Pharmacol Ther.
, vol.133
, pp. 40-69
-
-
Gurevich, E.V.1
Tesmer, J.J.2
Mushegian, A.3
-
25
-
-
0025346217
-
G protein gamma subunits contain a 20-carbon isoprenoid
-
Mumby SM, Casey PJ, Gilman AG, et al. G protein gamma subunits contain a 20-carbon isoprenoid. Proc Natl Acad Sci USA. 1990;87: 5873-5877.
-
(1990)
Proc Natl Acad Sci USA.
, vol.87
, pp. 5873-5877
-
-
Mumby, S.M.1
Casey, P.J.2
Gilman, A.G.3
-
26
-
-
0027481032
-
The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase
-
Koch WJ, Inglese J, Stone WC, et al. The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. J Biol Chem. 1993;268:8256-8260.
-
(1993)
J Biol Chem.
, vol.268
, pp. 8256-8260
-
-
Koch, W.J.1
Inglese, J.2
Stone, W.C.3
-
27
-
-
0026803164
-
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors
-
Pitcher JA, Inglese J, Higgins JB, et al. Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science. 1992;257:1264-1267.
-
(1992)
Science.
, vol.257
, pp. 1264-1267
-
-
Pitcher, J.A.1
Inglese, J.2
Higgins, J.B.3
-
28
-
-
0028891875
-
Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase
-
Touhara K, Koch WJ, Hawes BE, et al. Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. J Biol Chem. 1995;270:17000-17005.
-
(1995)
Differential Effects on G Beta Gamma and Phosphatidylinositol 4,5-bisphosphate Binding. J Biol Chem.
, vol.270
, pp. 17000-17005
-
-
Touhara, K.1
Koch, W.J.2
Hawes, B.E.3
-
29
-
-
0029788099
-
G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits
-
DebBurman SK, Ptasienski J, Benovic JL, et al. G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits. J Biol Chem. 1996;271:22552-22562.
-
(1996)
J Biol Chem.
, vol.271
, pp. 22552-22562
-
-
DebBurman, S.K.1
Ptasienski, J.2
Benovic, J.L.3
-
30
-
-
84978043722
-
Effect of lipid composition on the membrane orientation of the G protein-coupled receptor kinase 2-Gbeta1gamma2 complex
-
Yang P, Homan KT, Li Y, et al. Effect of lipid composition on the membrane orientation of the G protein-coupled receptor kinase 2-Gbeta1gamma2 complex. Biochemistry. 2016;55:2841-2848.
-
(2016)
Biochemistry.
, vol.55
, pp. 2841-2848
-
-
Yang, P.1
Homan, K.T.2
Li, Y.3
-
32
-
-
65249153536
-
The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes
-
Dupre DJ, Robitaille M, Rebois RV, et al. The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annu Rev Pharmacol Toxicol. 2009;49:31-56.
-
(2009)
Annu Rev Pharmacol Toxicol.
, vol.49
, pp. 31-56
-
-
Dupre, D.J.1
Robitaille, M.2
Rebois, R.V.3
-
33
-
-
84873912942
-
The expanding roles of Gbetagamma subunits in G protein-coupled receptor signaling and drug action
-
Khan SM, Sleno R, Gora S, et al. The expanding roles of Gbetagamma subunits in G protein-coupled receptor signaling and drug action. Pharmacol Rev. 2013;65:545-577.
-
(2013)
Pharmacol Rev.
, vol.65
, pp. 545-577
-
-
Khan, S.M.1
Sleno, R.2
Gora, S.3
-
34
-
-
79952784761
-
Recognition in the face of diversity: Interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs
-
Huang CC, Tesmer JJ. Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs. J Biol Chem. 2011;286: 7715-7721.
-
(2011)
J Biol Chem.
, vol.286
, pp. 7715-7721
-
-
Huang, C.C.1
Tesmer, J.J.2
-
35
-
-
0035487327
-
Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors
-
Pierce KL, Lefkowitz RJ. Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nat Rev Neurosci. 2001; 2:727-733.
-
(2001)
Nat Rev Neurosci.
, vol.2
, pp. 727-733
-
-
Pierce, K.L.1
Lefkowitz, R.J.2
-
36
-
-
67349181755
-
GRK mythology: G-protein receptor kinases in cardiovascular disease
-
Dorn GW II. GRK mythology: G-protein receptor kinases in cardiovascular disease. J Mol Med (Berl). 2009;87:455-463.
-
(2009)
J Mol Med (Berl).
, vol.87
, pp. 455-463
-
-
Dorn, G.W.I.I.1
-
37
-
-
0027497584
-
Altered expression of betaadrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart
-
Ungerer M, Bohm M, Elce JS, et al. Altered expression of betaadrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation. 1993;87:454-463.
-
(1993)
Circulation.
, vol.87
, pp. 454-463
-
-
Ungerer, M.1
Bohm, M.2
Elce, J.S.3
-
38
-
-
0033529637
-
Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression
-
Cho MC, Rapacciuolo A, Koch WJ, et al. Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. J Biol Chem. 1999;274:22251-22256.
-
(1999)
J Biol Chem.
, vol.274
, pp. 22251-22256
-
-
Cho, M.C.1
Rapacciuolo, A.2
Koch, W.J.3
-
39
-
-
0033002089
-
Molecular beta-adrenergic signaling abnormalities in failing rabbit hearts after infarction
-
Maurice JP, Shah AS, Kypson AP, et al. Molecular beta-adrenergic signaling abnormalities in failing rabbit hearts after infarction. Am J Physiol. 1999;276(6 pt 2):H1853-H1860.
-
(1999)
Am J Physiol.
, vol.276
, Issue.6
, pp. H1853-H1860
-
-
Maurice, J.P.1
Shah, A.S.2
Kypson, A.P.3
-
40
-
-
33751277224
-
Adenylyl cyclase and G protein receptor kinase expression during development of heart failure
-
Ping P, Anzai T, Gao M, et al. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol. 1997;273(2 pt 2):H707-H717.
-
(1997)
Am J Physiol.
, vol.273
, Issue.2
, pp. H707-H717
-
-
Ping, P.1
Anzai, T.2
Gao, M.3
-
41
-
-
0036278332
-
Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats
-
Yi XP, Gerdes AM, Li F. Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats. Hypertension. 2002;39:1058-1063.
-
(2002)
Hypertension.
, vol.39
, pp. 1058-1063
-
-
Yi, X.P.1
Gerdes, A.M.2
Li, F.3
-
42
-
-
84969756546
-
The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development
-
Hullmann J, Traynham CJ, Coleman RC, et al. The expanding GRK interactome: implications in cardiovascular disease and potential for therapeutic development. Pharmacol Res. 2016;110:52-64.
-
(2016)
Pharmacol Res.
, vol.110
, pp. 52-64
-
-
Hullmann, J.1
Traynham, C.J.2
Coleman, R.C.3
-
43
-
-
77952840083
-
The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets
-
Penela P, Murga C, Ribas C, et al. The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol. 2010;160:821-832.
-
(2010)
Br J Pharmacol.
, vol.160
, pp. 821-832
-
-
Penela, P.1
Murga, C.2
Ribas, C.3
-
44
-
-
4344648498
-
Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins
-
Sterne-Marr R, Dhami GK, Tesmer JJ, et al. Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins. Methods Enzymol. 2004;390:310-336.
-
(2004)
Methods Enzymol.
, vol.390
, pp. 310-336
-
-
Sterne-Marr, R.1
Dhami, G.K.2
Tesmer, J.J.3
-
45
-
-
0037044197
-
Phosphorylation-independent desensitization of G protein-coupled receptors?
-
Pao CS, Benovic JL. Phosphorylation-independent desensitization of G protein-coupled receptors? Sci STKE. 2002;2002:pe42.
-
(2002)
Sci STKE.
, vol.2002
, pp. pe42
-
-
Pao, C.S.1
Benovic, J.L.2
-
46
-
-
21444461126
-
Roles of phosphorylationdependent and-independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons
-
Willets JM, Nahorski SR, Challiss RA. Roles of phosphorylationdependent and-independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons. J Biol Chem. 2005;280:18950-18958.
-
(2005)
J Biol Chem.
, vol.280
, pp. 18950-18958
-
-
Willets, J.M.1
Nahorski, S.R.2
Challiss, R.A.3
-
47
-
-
0037067705
-
Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G proteincoupled receptor kinase 2
-
Dhami GK, Anborgh PH, Dale LB, et al. Phosphorylation-independent regulation of metabotropic glutamate receptor signaling by G proteincoupled receptor kinase 2. J Biol Chem. 2002;277:25266-25272.
-
(2002)
J Biol Chem.
, vol.277
, pp. 25266-25272
-
-
Dhami, G.K.1
Anborgh, P.H.2
Dale, L.B.3
-
48
-
-
29144497998
-
Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease
-
Penela P, Murga C, Ribas C, et al. Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc Res. 2006;69:46-56.
-
(2006)
Cardiovasc Res.
, vol.69
, pp. 46-56
-
-
Penela, P.1
Murga, C.2
Ribas, C.3
-
49
-
-
84872066649
-
The interplay between G proteincoupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility
-
Lafarga V, Mayor F Jr, Penela P. The interplay between G proteincoupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility. Cell Adh Migr. 2012;6:495-501.
-
(2012)
Cell Adh Migr.
, vol.6
, pp. 495-501
-
-
Lafarga, V.1
Mayor, F.2
Penela, P.3
-
50
-
-
84887580253
-
Role of G protein-coupled receptor kinases in cell migration
-
Penela P, Nogues L, Mayor F Jr. Role of G protein-coupled receptor kinases in cell migration. Curr Opin Cell Biol. 2014;27:10-17.
-
(2014)
Curr Opin Cell Biol.
, vol.27
, pp. 10-17
-
-
Penela, P.1
Nogues, L.2
Mayor, F.3
-
51
-
-
77957600228
-
G proteincoupled receptor kinase 2 plays a relevant role in insulin resistance and obesity
-
Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, et al. G proteincoupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. Diabetes. 2010;59:2407-2417.
-
(2010)
Diabetes.
, vol.59
, pp. 2407-2417
-
-
Garcia-Guerra, L.1
Nieto-Vazquez, I.2
Vila-Bedmar, R.3
-
52
-
-
27644433164
-
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes
-
Usui I, Imamura T, Babendure JL, et al. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005;19:2760-2768.
-
(2005)
Mol Endocrinol.
, vol.19
, pp. 2760-2768
-
-
Usui, I.1
Imamura, T.2
Babendure, J.L.3
-
53
-
-
79959199413
-
G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance
-
Mayor F Jr, Lucas E, Jurado-Pueyo M, et al. G Protein-coupled receptor kinase 2 (GRK2): a novel modulator of insulin resistance. Arch Physiol Biochem. 2011;117:125-130.
-
(2011)
Arch Physiol Biochem.
, vol.117
, pp. 125-130
-
-
Mayor, F.1
Lucas, E.2
Jurado-Pueyo, M.3
-
54
-
-
84900838933
-
G protein-coupled receptor kinase 2: A link between myocardial contractile function and cardiac metabolism
-
Woodall MC, Ciccarelli M, Woodall BP, et al. G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism. Circ Res. 2014;114:1661-1670.
-
(2014)
Circ Res.
, vol.114
, pp. 1661-1670
-
-
Woodall, M.C.1
Ciccarelli, M.2
Woodall, B.P.3
-
55
-
-
0141629679
-
Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
-
Penela P, Ribas C, Mayor F Jr. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal. 2003;15:973-981.
-
(2003)
Cell Signal.
, vol.15
, pp. 973-981
-
-
Penela, P.1
Ribas, C.2
Mayor, F.3
-
56
-
-
0346874333
-
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
-
Lorenz K, Lohse MJ, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature. 2003;426:574-579.
-
(2003)
Nature.
, vol.426
, pp. 574-579
-
-
Lorenz, K.1
Lohse, M.J.2
Quitterer, U.3
-
57
-
-
30044434455
-
G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits
-
Jimenez-Sainz MC, Murga C, Kavelaars A, et al. G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol Biol Cell. 2006;17:25-31.
-
(2006)
Mol Biol Cell.
, vol.17
, pp. 25-31
-
-
Jimenez-Sainz, M.C.1
Murga, C.2
Kavelaars, A.3
-
58
-
-
24744444714
-
A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
-
Liu S, Premont RT, Kontos CD, et al. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med. 2005;11:952-958.
-
(2005)
Nat Med.
, vol.11
, pp. 952-958
-
-
Liu, S.1
Premont, R.T.2
Kontos, C.D.3
-
59
-
-
33947424008
-
The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling
-
Ribas C, Penela P, Murga C, et al. The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta. 2007;1768:913-922.
-
(2007)
Biochim Biophys Acta.
, vol.1768
, pp. 913-922
-
-
Ribas, C.1
Penela, P.2
Murga, C.3
-
60
-
-
0032564277
-
Beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
-
Premont RT, Claing A, Vitale N, et al. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc Natl Acad Sci USA. 1998;95:14082-14087.
-
(1998)
Proc Natl Acad Sci USA.
, vol.95
, pp. 14082-14087
-
-
Premont, R.T.1
Claing, A.2
Vitale, N.3
-
61
-
-
0035375104
-
Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by betaadrenergic receptor kinase 1
-
Naga Prasad SV, Barak LS, Rapacciuolo A, et al. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by betaadrenergic receptor kinase 1. A role in receptor sequestration. J Biol Chem. 2001;276:18953-18959.
-
(2001)
A Role in Receptor Sequestration. J Biol Chem.
, vol.276
, pp. 18953-18959
-
-
Naga Prasad, S.V.1
Barak, L.S.2
Rapacciuolo, A.3
-
62
-
-
0033605584
-
Regulation of G protein-coupled receptor kinases by caveolin
-
Carman CV, Lisanti MP, Benovic JL. Regulation of G protein-coupled receptor kinases by caveolin. J Biol Chem. 1999;274:8858-8864.
-
(1999)
J Biol Chem.
, vol.274
, pp. 8858-8864
-
-
Carman, C.V.1
Lisanti, M.P.2
Benovic, J.L.3
-
63
-
-
0030800966
-
Regulation of G proteincoupled receptor kinases by calmodulin and localization of the calmodulin binding domain
-
Pronin AN, Satpaev DK, Slepak VZ, et al. Regulation of G proteincoupled receptor kinases by calmodulin and localization of the calmodulin binding domain. J Biol Chem. 1997;272:18273-18280.
-
(1997)
J Biol Chem.
, vol.272
, pp. 18273-18280
-
-
Pronin, A.N.1
Satpaev, D.K.2
Slepak, V.Z.3
-
64
-
-
0035101820
-
Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
-
Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev. 2001;53:1-24.
-
(2001)
Pharmacol Rev.
, vol.53
, pp. 1-24
-
-
Ferguson, S.S.1
-
66
-
-
0033607665
-
The molecular basis for distinct beta-adrenergic receptor subtype actions in cardiomyocytes
-
Steinberg SF. The molecular basis for distinct beta-adrenergic receptor subtype actions in cardiomyocytes. Circ Res. 1999;85:1101-1111.
-
(1999)
Circ Res.
, vol.85
, pp. 1101-1111
-
-
Steinberg, S.F.1
-
67
-
-
0037303007
-
Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts
-
Cohen AW, Park DS, Woodman SE, et al. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol. 2003;284: C457-C474.
-
(2003)
Am J Physiol Cell Physiol.
, vol.284
, pp. C457-C474
-
-
Cohen, A.W.1
Park, D.S.2
Woodman, S.E.3
-
68
-
-
0036080902
-
Caveolin-1/3 doubleknockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype
-
Park DS, Woodman SE, Schubert W, et al. Caveolin-1/3 doubleknockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype. Am J Pathol. 2002;160:2207-2217.
-
(2002)
Am J Pathol.
, vol.160
, pp. 2207-2217
-
-
Park, D.S.1
Woodman, S.E.2
Schubert, W.3
-
69
-
-
0033521109
-
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
-
Pitcher JA, Tesmer JJ, Freeman JL, et al. Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem. 1999;274:34531-34534.
-
(1999)
J Biol Chem.
, vol.274
, pp. 34531-34534
-
-
Pitcher, J.A.1
Tesmer, J.J.2
Freeman, J.L.3
-
70
-
-
0033607326
-
Selective regulation of Galpha (q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2
-
Carman CV, Parent JL, Day PW, et al. Selective regulation of Galpha (q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem. 1999;274:34483-34492.
-
(1999)
J Biol Chem.
, vol.274
, pp. 34483-34492
-
-
Carman, C.V.1
Parent, J.L.2
Day, P.W.3
-
71
-
-
0034111099
-
Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: Direct interaction of kinase N terminus with activated galphaq
-
Sallese M, Mariggio S, D'Urbano E, et al. Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq. Mol Pharmacol. 2000;57: 826-831.
-
(2000)
Mol Pharmacol.
, vol.57
, pp. 826-831
-
-
Sallese, M.1
Mariggio, S.2
D'Urbano, E.3
-
73
-
-
0034164456
-
RGS domain in the aminoterminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling
-
Usui H, Nishiyama M, Moroi K, et al. RGS domain in the aminoterminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling. Int J Mol Med. 2000;5:335-340.
-
(2000)
Int J Mol Med.
, vol.5
, pp. 335-340
-
-
Usui, H.1
Nishiyama, M.2
Moroi, K.3
-
74
-
-
0030610854
-
Transgenic Galphaq overexpression induces cardiac contractile failure in mice
-
D'Angelo DD, Sakata Y, Lorenz JN, et al. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci USA. 1997;94:8121-8126.
-
(1997)
Proc Natl Acad Sci USA.
, vol.94
, pp. 8121-8126
-
-
D'Angelo, D.D.1
Sakata, Y.2
Lorenz, J.N.3
-
75
-
-
0033033440
-
Low-and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice
-
Dorn GW II, Tepe NM, Lorenz JN, et al. Low-and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proc Natl Acad Sci USA. 1999;96:6400-6405.
-
(1999)
Proc Natl Acad Sci USA.
, vol.96
, pp. 6400-6405
-
-
Dorn, G.W.I.I.1
Tepe, N.M.2
Lorenz, J.N.3
-
76
-
-
0032543959
-
Enhanced Galphaq signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure
-
Adams JW, Sakata Y, Davis MG, et al. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci USA. 1998;95:10140-10145.
-
(1998)
Proc Natl Acad Sci USA.
, vol.95
, pp. 10140-10145
-
-
Adams, J.W.1
Sakata, Y.2
Davis, M.G.3
-
77
-
-
0034967283
-
RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice
-
Rogers JH, Tsirka A, Kovacs A, et al. RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice. J Mol Cell Cardiol. 2001;33:209-218.
-
(2001)
J Mol Cell Cardiol.
, vol.33
, pp. 209-218
-
-
Rogers, J.H.1
Tsirka, A.2
Kovacs, A.3
-
78
-
-
0032562289
-
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy
-
Akhter SA, Luttrell LM, Rockman HA, et al. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science. 1998;280:574-577.
-
(1998)
Science.
, vol.280
, pp. 574-577
-
-
Akhter, S.A.1
Luttrell, L.M.2
Rockman, H.A.3
-
79
-
-
0035853147
-
Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload
-
Esposito G, Prasad SV, Rapacciuolo A, et al. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation. 2001;103:1453-1458.
-
(2001)
Circulation.
, vol.103
, pp. 1453-1458
-
-
Esposito, G.1
Prasad, S.V.2
Rapacciuolo, A.3
-
80
-
-
0036143851
-
Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress
-
Esposito G, Rapacciuolo A, Naga Prasad SV, et al. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation. 2002;105:85-92.
-
(2002)
Circulation.
, vol.105
, pp. 85-92
-
-
Esposito, G.1
Rapacciuolo, A.2
Naga Prasad, S.V.3
-
81
-
-
28844463975
-
Snapshot of activated G proteins at the membrane: The Galphaq-GRK2-Gbetagamma complex
-
Tesmer VM, Kawano T, Shankaranarayanan A, et al. Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex. Science. 2005;310:1686-1690.
-
(2005)
Science.
, vol.310
, pp. 1686-1690
-
-
Tesmer, V.M.1
Kawano, T.2
Shankaranarayanan, A.3
-
82
-
-
11144226355
-
Characterization of the GRK2 binding site of Galphaq
-
Day PW, Tesmer JJ, Sterne-Marr R, et al. Characterization of the GRK2 binding site of Galphaq. J Biol Chem. 2004;279:53643-53652.
-
(2004)
J Biol Chem.
, vol.279
, pp. 53643-53652
-
-
Day, P.W.1
Tesmer, J.J.2
Sterne-Marr, R.3
-
83
-
-
84961839547
-
A peptide of the RGS domain of GRK2 binds and inhibits Galpha(q) to suppress pathological cardiac hypertrophy and dysfunction
-
Schumacher SM, Gao E, Cohen M, et al. A peptide of the RGS domain of GRK2 binds and inhibits Galpha(q) to suppress pathological cardiac hypertrophy and dysfunction. Sci Signal. 2016;9:ra30.
-
(2016)
Sci Signal.
, vol.9
, pp. ra30
-
-
Schumacher, S.M.1
Gao, E.2
Cohen, M.3
-
84
-
-
0037424294
-
The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site
-
Eichmann T, Lorenz K, Hoffmann M, et al. The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site. J Biol Chem. 2003;278:8052-8057.
-
(2003)
J Biol Chem.
, vol.278
, pp. 8052-8057
-
-
Eichmann, T.1
Lorenz, K.2
Hoffmann, M.3
-
85
-
-
83555174502
-
Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis
-
Fusco A, Santulli G, Sorriento D, et al. Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis. Cell Signal. 2012; 24:468-475.
-
(2012)
Cell Signal.
, vol.24
, pp. 468-475
-
-
Fusco, A.1
Santulli, G.2
Sorriento, D.3
-
86
-
-
84855981733
-
The GRK2 overexpression is a primary hallmark of mitochondrial lesions during early Alzheimer disease
-
Obrenovich ME, Palacios HH, Gasimov E, et al. The GRK2 overexpression is a primary hallmark of mitochondrial lesions during early Alzheimer disease. Cardiovasc Psychiatry Neurol. 2009;2009:327360.
-
(2009)
Cardiovasc Psychiatry Neurol.
, vol.2009
, pp. 327360
-
-
Obrenovich, M.E.1
Palacios, H.H.2
Gasimov, E.3
-
87
-
-
78349313123
-
Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via proand anti-apoptotic mechanisms
-
Brinks H, Boucher M, Gao E, et al. Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via proand anti-apoptotic mechanisms. Circ Res. 2010;107:1140-1149.
-
(2010)
Circ Res.
, vol.107
, pp. 1140-1149
-
-
Brinks, H.1
Boucher, M.2
Gao, E.3
-
88
-
-
84879252168
-
Myocardial Ablation of G protein-coupled receptor kinase 2 (GRK2) decreases ischemia/reperfusion injury through an anti-intrinsic apoptotic pathway
-
Fan Q, Chen M, Zuo L, et al. Myocardial Ablation of G protein-coupled receptor kinase 2 (GRK2) decreases ischemia/reperfusion injury through an anti-intrinsic apoptotic pathway. PLoS One. 2013;8:e66234.
-
(2013)
PLoS One.
, vol.8
, pp. e66234
-
-
Fan, Q.1
Chen, M.2
Zuo, L.3
-
89
-
-
84876413668
-
Prodeath signaling of G proteincoupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting
-
Chen M, Sato PY, Chuprun JK, et al. Prodeath signaling of G proteincoupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ Res. 2013;112: 1121-1134.
-
(2013)
Circ Res.
, vol.112
, pp. 1121-1134
-
-
Chen, M.1
Sato, P.Y.2
Chuprun, J.K.3
-
90
-
-
0345803950
-
G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation
-
Luo J, Benovic JL. G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation. J Biol Chem. 2003;278:50908-50914.
-
(2003)
J Biol Chem.
, vol.278
, pp. 50908-50914
-
-
Luo, J.1
Benovic, J.L.2
-
91
-
-
84952670742
-
GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels
-
Sato PY, Chuprun JK, Ibetti J, et al. GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels. J Mol Cell Cardiol. 2015;89 (pt B):360-364.
-
(2015)
J Mol Cell Cardiol.
, vol.89
, pp. 360-364
-
-
Sato, P.Y.1
Chuprun, J.K.2
Ibetti, J.3
-
92
-
-
0035903669
-
Beta-arrestin-and c-Src-dependent degradation of G-protein-coupled receptor kinase 2
-
Penela P, Elorza A, Sarnago S, et al. Beta-arrestin-and c-Src-dependent degradation of G-protein-coupled receptor kinase 2. EMBO J. 2001;20: 5129-5138.
-
(2001)
EMBO J.
, vol.20
, pp. 5129-5138
-
-
Penela, P.1
Elorza, A.2
Sarnago, S.3
-
93
-
-
0033607513
-
Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase
-
Sarnago S, Elorza A, Mayor F Jr. Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase. J Biol Chem. 1999;274:34411-34416.
-
(1999)
J Biol Chem.
, vol.274
, pp. 34411-34416
-
-
Sarnago, S.1
Elorza, A.2
Mayor, F.3
-
94
-
-
33749426526
-
Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-Src modulates its interaction with Galphaq
-
Mariggio S, Garcia-Hoz C, Sarnago S, et al. Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-Src modulates its interaction with Galphaq. Cell Signal. 2006;18:2004-2012.
-
(2006)
Cell Signal.
, vol.18
, pp. 2004-2012
-
-
Mariggio, S.1
Garcia-Hoz, C.2
Sarnago, S.3
-
95
-
-
0034111097
-
Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases
-
Elorza A, Sarnago S, Mayor F Jr. Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases. Mol Pharmacol. 2000;57:778-783.
-
(2000)
Mol Pharmacol.
, vol.57
, pp. 778-783
-
-
Elorza, A.1
Sarnago, S.2
Mayor, F.3
-
96
-
-
34247470682
-
Regulation of betaadrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2
-
Whalen EJ, Foster MW, Matsumoto A, et al. Regulation of betaadrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007;129:511-522.
-
(2007)
Cell.
, vol.129
, pp. 511-522
-
-
Whalen, E.J.1
Foster, M.W.2
Matsumoto, A.3
-
97
-
-
84887252526
-
Convergence of G proteincoupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury
-
Huang ZM, Gao E, Fonseca FV, et al. Convergence of G proteincoupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal. 2013;6:ra95.
-
(2013)
Sci Signal.
, vol.6
, pp. ra95
-
-
Huang, Z.M.1
Gao, E.2
Fonseca, F.V.3
-
98
-
-
84892909749
-
Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension
-
Avendano MS, Lucas E, Jurado-Pueyo M, et al. Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension. Hypertension. 2014;63:369-375.
-
(2014)
Hypertension.
, vol.63
, pp. 369-375
-
-
Avendano, M.S.1
Lucas, E.2
Jurado-Pueyo, M.3
-
99
-
-
84994016210
-
G-protein-coupled receptor kinase 2 (GRK2) inhibitors: Current trends and future perspectives
-
Guccione M, Ettari R, Taliani S, et al. G-protein-coupled receptor kinase 2 (GRK2) inhibitors: current trends and future perspectives. J Med Chem. 2016;59:9277-9294.
-
(2016)
J Med Chem.
, vol.59
, pp. 9277-9294
-
-
Guccione, M.1
Ettari, R.2
Taliani, S.3
-
100
-
-
84869435029
-
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility
-
Thal DM, Homan KT, Chen J, et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol. 2012;7:1830-1839.
-
(2012)
ACS Chem Biol.
, vol.7
, pp. 1830-1839
-
-
Thal, D.M.1
Homan, K.T.2
Chen, J.3
-
101
-
-
84929001066
-
Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction
-
Schumacher SM, Gao E, Zhu W, et al. Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction. Sci Transl Med. 2015;7:277ra31.
-
(2015)
Sci Transl Med.
, vol.7
, pp. 277ra31
-
-
Schumacher, S.M.1
Gao, E.2
Zhu, W.3
-
102
-
-
84891839423
-
Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog
-
Homan KT, Wu E, Wilson MW, et al. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol Pharmacol. 2014;85:237-248.
-
(2014)
Mol Pharmacol.
, vol.85
, pp. 237-248
-
-
Homan, K.T.1
Wu, E.2
Wilson, M.W.3
-
103
-
-
84968735613
-
Structure-based design, synthesis, and biological evaluation of highly selective and potent G protein-coupled receptor kinase 2 inhibitors
-
Waldschmidt HV, Homan KT, Cruz-Rodriguez O, et al. Structure-based design, synthesis, and biological evaluation of highly selective and potent G protein-coupled receptor kinase 2 inhibitors. J Med Chem. 2016;59:3793-3807.
-
(2016)
J Med Chem.
, vol.59
, pp. 3793-3807
-
-
Waldschmidt, H.V.1
Homan, K.T.2
Cruz-Rodriguez, O.3
-
104
-
-
0025779498
-
Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2
-
Benovic JL, Onorato JJ, Arriza JL, et al. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. J Biol Chem. 1991;266:14939-14946.
-
(1991)
A New Member of the Receptor Kinase Family. J Biol Chem.
, vol.266
, pp. 14939-14946
-
-
Benovic, J.L.1
Onorato, J.J.2
Arriza, J.L.3
-
105
-
-
0035653752
-
Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats
-
Vinge LE, Oie E, Andersson Y, et al. Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. Am J Physiol Heart Circ Physiol. 2001;281:H2490-H2499.
-
(2001)
Am J Physiol Heart Circ Physiol.
, vol.281
, pp. H2490-H2499
-
-
Vinge, L.E.1
Oie, E.2
Andersson, Y.3
-
106
-
-
0029061324
-
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor
-
Koch WJ, Rockman HA, Samama P, et al. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 1995;268:1350-1353.
-
(1995)
Science.
, vol.268
, pp. 1350-1353
-
-
Koch, W.J.1
Rockman, H.A.2
Samama, P.3
-
107
-
-
0029844311
-
Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice
-
Rockman HA, Choi DJ, Rahman NU, et al. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc Natl Acad Sci USA. 1996;93:9954-9959.
-
(1996)
Proc Natl Acad Sci USA.
, vol.93
, pp. 9954-9959
-
-
Rockman, H.A.1
Choi, D.J.2
Rahman, N.U.3
-
108
-
-
33750866137
-
Myocardial overexpression of GRK3 in transgenic mice: Evidence for in vivo selectivity of GRKs
-
Iaccarino G, Rockman HA, Shotwell KF, et al. Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. Am J Physiol. 1998;275(4 pt 2):H1298-H1306.
-
(1998)
Am J Physiol.
, vol.275
, Issue.4
, pp. H1298-H1306
-
-
Iaccarino, G.1
Rockman, H.A.2
Shotwell, K.F.3
-
109
-
-
0032938105
-
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3
-
Walker JK, Peppel K, Lefkowitz RJ, et al. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. Am J Physiol. 1999;276(4 pt 2):R1214-R1221.
-
(1999)
Am J Physiol.
, vol.276
, Issue.4
, pp. R1214-R1221
-
-
Walker, J.K.1
Peppel, K.2
Lefkowitz, R.J.3
-
110
-
-
34548316597
-
Substrate specificities of g protein-coupled receptor kinase-2 and-3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
-
Vinge LE, Andressen KW, Attramadal T, et al. Substrate specificities of g protein-coupled receptor kinase-2 and-3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Mol Pharmacol. 2007;72:582-591.
-
(2007)
Mol Pharmacol.
, vol.72
, pp. 582-591
-
-
Vinge, L.E.1
Andressen, K.W.2
Attramadal, T.3
-
112
-
-
0039699863
-
Identification of a short sequence highly divergent between beta-adrenergic-receptor kinases 1 and 2 that determines the affinity of binding to betagamma subunits of heterotrimeric guanine-nucleotide-binding regulatory proteins
-
Chuang TT, Pompili E, Paolucci L, et al. Identification of a short sequence highly divergent between beta-adrenergic-receptor kinases 1 and 2 that determines the affinity of binding to betagamma subunits of heterotrimeric guanine-nucleotide-binding regulatory proteins. Eur J Biochem. 1997;245:533-540.
-
(1997)
Eur J Biochem.
, vol.245
, pp. 533-540
-
-
Chuang, T.T.1
Pompili, E.2
Paolucci, L.3
-
113
-
-
0030615225
-
Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases
-
Daaka Y, Pitcher JA, Richardson M, et al. Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. Proc Natl Acad Sci USA. 1997;94:2180-2185.
-
(1997)
Proc Natl Acad Sci USA.
, vol.94
, pp. 2180-2185
-
-
Daaka, Y.1
Pitcher, J.A.2
Richardson, M.3
-
114
-
-
0026752495
-
Different beta-subunits determine G-protein interaction with transmembrane receptors
-
Kleuss C, Scherubl H, Hescheler J, et al. Different beta-subunits determine G-protein interaction with transmembrane receptors. Nature. 1992;358:424-426.
-
(1992)
Nature.
, vol.358
, pp. 424-426
-
-
Kleuss, C.1
Scherubl, H.2
Hescheler, J.3
-
115
-
-
0027530916
-
Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins
-
Kleuss C, Scherubl H, Hescheler J, et al. Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins. Science. 1993;259:832-834.
-
(1993)
Science.
, vol.259
, pp. 832-834
-
-
Kleuss, C.1
Scherubl, H.2
Hescheler, J.3
-
116
-
-
44849086536
-
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 uncovers distinct functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
-
Vinge LE, von Lueder TG, Aasum E, et al. Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 uncovers distinct functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness. J Biol Chem. 2008;283:10601-10610.
-
(2008)
J Biol Chem.
, vol.283
, pp. 10601-10610
-
-
Vinge, L.E.1
Von Lueder, T.G.2
Aasum, E.3
-
117
-
-
0035903243
-
Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy
-
Lin F, Owens WA, Chen S, et al. Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy. Circ Res. 2001;89:343-350.
-
(2001)
Circ Res.
, vol.89
, pp. 343-350
-
-
Lin, F.1
Owens, W.A.2
Chen, S.3
-
118
-
-
7444256231
-
Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction
-
Du XJ, Fang L, Gao XM, et al. Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction. J Mol Cell Cardiol. 2004;37:979-987.
-
(2004)
J Mol Cell Cardiol.
, vol.37
, pp. 979-987
-
-
Du, X.J.1
Fang, L.2
Gao, X.M.3
-
119
-
-
33845186121
-
Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival
-
Du XJ, Gao XM, Kiriazis H, et al. Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival. Cardiovasc Res. 2006;71:735-743.
-
(2006)
Cardiovasc Res.
, vol.71
, pp. 735-743
-
-
Du, X.J.1
Gao, X.M.2
Kiriazis, H.3
-
120
-
-
84863658667
-
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload
-
von Lueder TG, Gravning J, How OJ, et al. Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. Am J Physiol Heart Circ Physiol. 2012;303:H66-H74.
-
(2012)
Am J Physiol Heart Circ Physiol.
, vol.303
, pp. H66-H74
-
-
Von Lueder, T.G.1
Gravning, J.2
How, O.J.3
-
121
-
-
0025368163
-
Muscarinic receptors in airways: Recent developments
-
Barnes PJ. Muscarinic receptors in airways: recent developments. J Appl Physiol (1985). 1990;68:1777-1785.
-
(1990)
J Appl Physiol (1985).
, vol.68
, pp. 1777-1785
-
-
Barnes, P.J.1
-
122
-
-
0015147806
-
Sympathetic versus parasympathetic nervous regulation of airways in dogs
-
Cabezas GA, Graf PD, Nadel JA. Sympathetic versus parasympathetic nervous regulation of airways in dogs. J Appl Physiol (1985). 1971;31: 651-655.
-
(1971)
J Appl Physiol (1985).
, vol.31
, pp. 651-655
-
-
Cabezas, G.A.1
Graf, P.D.2
Nadel, J.A.3
-
123
-
-
0027511541
-
Functional characterization of muscarinic receptors in murine airways
-
Garssen J, Van Loveren H, Gierveld CM, et al. Functional characterization of muscarinic receptors in murine airways. Br J Pharmacol. 1993;109:53-60.
-
(1993)
Br J Pharmacol.
, vol.109
, pp. 53-60
-
-
Garssen, J.1
Van Loveren, H.2
Gierveld, C.M.3
-
124
-
-
0030971394
-
Cardiovascular indexes in the mouse at rest and with exercise: New tools to study models of cardiac disease
-
Desai KH, Sato R, Schauble E, et al. Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. Am J Physiol. 1997;272(2 pt 2):H1053-H1061.
-
(1997)
Am J Physiol.
, vol.272
, Issue.2
, pp. H1053-H1061
-
-
Desai, K.H.1
Sato, R.2
Schauble, E.3
-
125
-
-
0010007805
-
Central monoamine neurons and cardiovascular control
-
Head GA. Central monoamine neurons and cardiovascular control. Kidney Int Suppl. 1992;37:S8-S13.
-
(1992)
Kidney Int Suppl.
, vol.37
, pp. S8-S13
-
-
Head, G.A.1
-
126
-
-
0035726972
-
Linkage of left ventricular contractility to chromosome 11 in humans: The HyperGEN Study
-
Hypertension Genetic Epidemiology Network Study Group
-
Arnett DK, Devereux RB, Kitzman D, et al; Hypertension Genetic Epidemiology Network Study Group. Linkage of left ventricular contractility to chromosome 11 in humans: the HyperGEN Study. Hypertension. 2001;38:767-772.
-
(2001)
Hypertension.
, vol.38
, pp. 767-772
-
-
Arnett, D.K.1
Devereux, R.B.2
Kitzman, D.3
-
127
-
-
0028300574
-
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases
-
Premont RT, Koch WJ, Inglese J, et al. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J Biol Chem. 1994;269:6832-6841.
-
(1994)
J Biol Chem.
, vol.269
, pp. 6832-6841
-
-
Premont, R.T.1
Koch, W.J.2
Inglese, J.3
-
128
-
-
0027193453
-
Cloning and expression of GRK5: A member of the G protein-coupled receptor kinase family
-
Kunapuli P, Benovic JL. Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. Proc Natl Acad Sci USA. 1993;90:5588-5592.
-
(1993)
Proc Natl Acad Sci USA.
, vol.90
, pp. 5588-5592
-
-
Kunapuli, P.1
Benovic, J.L.2
-
129
-
-
84883288744
-
Grk5l controls heart development by limiting mTOR signaling during symmetry breaking
-
Burkhalter MD, Fralish GB, Premont RT, et al. Grk5l controls heart development by limiting mTOR signaling during symmetry breaking. Cell Rep. 2013;4:625-632.
-
(2013)
Cell Rep.
, vol.4
, pp. 625-632
-
-
Burkhalter, M.D.1
Fralish, G.B.2
Premont, R.T.3
-
130
-
-
84907200682
-
Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development
-
Philipp M, Berger IM, Just S, et al. Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. J Biol Chem. 2014;289:26119-26130.
-
(2014)
J Biol Chem.
, vol.289
, pp. 26119-26130
-
-
Philipp, M.1
Berger, I.M.2
Just, S.3
-
131
-
-
11344250461
-
Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure
-
Yi XP, Zhou J, Baker J, et al. Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure. Anat Rec A Discov Mol Cell Evol Biol. 2005;282:13-23.
-
(2005)
Anat Rec A Discov Mol Cell Evol Biol.
, vol.282
, pp. 13-23
-
-
Yi, X.P.1
Zhou, J.2
Baker, J.3
-
132
-
-
1942453389
-
Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases
-
Dzimiri N, Muiya P, Andres E, et al. Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases. Eur J Pharmacol. 2004;489:167-177.
-
(2004)
Eur J Pharmacol.
, vol.489
, pp. 167-177
-
-
Dzimiri, N.1
Muiya, P.2
Andres, E.3
-
133
-
-
84864542754
-
Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables
-
Monto F, Oliver E, Vicente D, et al. Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables. Am J Physiol Heart Circ Physiol. 2012;303:H368-H376.
-
(2012)
Am J Physiol Heart Circ Physiol.
, vol.303
, pp. H368-H376
-
-
Monto, F.1
Oliver, E.2
Vicente, D.3
-
134
-
-
84855702779
-
Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure
-
Aguero J, Almenar L, Monto F, et al. Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure. J Card Fail. 2012;18:53-61.
-
(2012)
J Card Fail.
, vol.18
, pp. 53-61
-
-
Aguero, J.1
Almenar, L.2
Monto, F.3
-
135
-
-
0031022334
-
Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C
-
Pronin AN, Benovic JL. Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. J Biol Chem. 1997;272:3806-3812.
-
(1997)
J Biol Chem.
, vol.272
, pp. 3806-3812
-
-
Pronin, A.N.1
Benovic, J.L.2
-
137
-
-
50449087071
-
Uncovering G proteincoupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes
-
Martini JS, Raake P, Vinge LE, et al. Uncovering G proteincoupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci USA. 2008;105: 12457-12462.
-
(2008)
Proc Natl Acad Sci USA.
, vol.105
, pp. 12457-12462
-
-
Martini, J.S.1
Raake, P.2
Vinge, L.E.3
-
138
-
-
84877020037
-
Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability
-
Johnson LR, Robinson JD, Lester KN, et al. Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability. PLoS One. 2013;8:e62508.
-
(2013)
PLoS One.
, vol.8
, pp. e62508
-
-
Johnson, L.R.1
Robinson, J.D.2
Lester, K.N.3
-
139
-
-
8644290071
-
G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence
-
Johnson LR, Scott MG, Pitcher JA. G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence. Mol Cell Biol. 2004;24:10169-10179.
-
(2004)
Mol Cell Biol.
, vol.24
, pp. 10169-10179
-
-
Johnson, L.R.1
Scott, M.G.2
Pitcher, J.A.3
-
140
-
-
84874607739
-
Nuclear translocation of cardiac G protein-coupled receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process
-
Gold JI, Martini JS, Hullmann J, et al. Nuclear translocation of cardiac G protein-coupled receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. PLoS One. 2013;8:e57324.
-
(2013)
PLoS One.
, vol.8
, pp. e57324
-
-
Gold, J.I.1
Martini, J.S.2
Hullmann, J.3
-
141
-
-
84863012898
-
Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure
-
Zhang Y, Matkovich SJ, Duan X, et al. Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure. Circ Heart Fail. 2011;4:659-668.
-
(2011)
Circ Heart Fail.
, vol.4
, pp. 659-668
-
-
Zhang, Y.1
Matkovich, S.J.2
Duan, X.3
-
142
-
-
0034714204
-
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
-
Pronin AN, Morris AJ, Surguchov A, et al. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem. 2000; 275:26515-26522.
-
(2000)
J Biol Chem.
, vol.275
, pp. 26515-26522
-
-
Pronin, A.N.1
Morris, A.J.2
Surguchov, A.3
-
143
-
-
84867033583
-
Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: Short communication
-
Gold JI, Gao E, Shang X, et al. Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. Circ Res. 2012;111:1048-1053.
-
(2012)
Circ Res.
, vol.111
, pp. 1048-1053
-
-
Gold, J.I.1
Gao, E.2
Shang, X.3
-
144
-
-
84917732136
-
GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity
-
Hullmann JE, Grisanti LA, Makarewich CA, et al. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circ Res. 2014;115:976-985.
-
(2014)
Circ Res.
, vol.115
, pp. 976-985
-
-
Hullmann, J.E.1
Grisanti, L.A.2
Makarewich, C.A.3
-
145
-
-
70949099222
-
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression
-
Liu P, Wang X, Gao N, et al. G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression. Brain Res. 2010;1307:134-141.
-
(2010)
Brain Res.
, vol.1307
, pp. 134-141
-
-
Liu, P.1
Wang, X.2
Gao, N.3
-
146
-
-
77953423842
-
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling
-
Valanne S, Myllymaki H, Kallio J, et al. Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J Immunol. 2010;184: 6188-6198.
-
(2010)
J Immunol.
, vol.184
, pp. 6188-6198
-
-
Valanne, S.1
Myllymaki, H.2
Kallio, J.3
-
147
-
-
84890397362
-
Regulation of nuclear factor kappaB (NF-kappaB) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5)
-
Islam KN, Bae JW, Gao E, et al. Regulation of nuclear factor kappaB (NF-kappaB) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5). J Biol Chem. 2013; 288:35683-35689.
-
(2013)
J Biol Chem.
, vol.288
, pp. 35683-35689
-
-
Islam, K.N.1
Bae, J.W.2
Gao, E.3
-
148
-
-
79251571503
-
G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFkappaB activation in primary macrophages and modulates inflammation in vivo in mice
-
Patial S, Shahi S, Saini Y, et al. G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFkappaB activation in primary macrophages and modulates inflammation in vivo in mice. J Cell Physiol. 2011;226:1323-1333.
-
(2011)
J Cell Physiol.
, vol.226
, pp. 1323-1333
-
-
Patial, S.1
Shahi, S.2
Saini, Y.3
-
149
-
-
33845960758
-
Arrestin-2 and G proteincoupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages
-
Parameswaran N, Pao CS, Leonhard KS, et al. Arrestin-2 and G proteincoupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages. J Biol Chem. 2006;281:34159-34170.
-
(2006)
J Biol Chem.
, vol.281
, pp. 34159-34170
-
-
Parameswaran, N.1
Pao, C.S.2
Leonhard, K.S.3
-
150
-
-
56649094511
-
The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha
-
Sorriento D, Ciccarelli M, Santulli G, et al. The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha. Proc Natl Acad Sci USA. 2008; 105:17818-17823.
-
(2008)
Proc Natl Acad Sci USA.
, vol.105
, pp. 17818-17823
-
-
Sorriento, D.1
Ciccarelli, M.2
Santulli, G.3
-
151
-
-
80051616441
-
Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin
-
Nobles KN, Xiao K, Ahn S, et al. Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin. Sci Signal. 2011;4:ra51.
-
(2011)
Sci Signal.
, vol.4
, pp. ra51
-
-
Nobles, K.N.1
Xiao, K.2
Ahn, S.3
-
152
-
-
77953819826
-
Beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress
-
Rakesh K, Yoo B, Kim IM, et al. beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Sci Signal. 2010;3: ra46.
-
(2010)
Sci Signal.
, vol.3
, pp. ra46
-
-
Rakesh, K.1
Yoo, B.2
Kim, I.M.3
-
153
-
-
34848820302
-
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection
-
Noma T, Lemaire A, Naga Prasad SV, et al. Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest. 2007;117:2445-2458.
-
(2007)
J Clin Invest.
, vol.117
, pp. 2445-2458
-
-
Noma, T.1
Lemaire, A.2
Naga Prasad, S.V.3
-
154
-
-
84939611234
-
Crystal structure of G protein-coupled receptor kinase 5 in complex with a rationally designed inhibitor
-
Homan KT, Waldschmidt HV, Glukhova A, et al. Crystal structure of G protein-coupled receptor kinase 5 in complex with a rationally designed inhibitor. J Biol Chem. 2015;290:20649-20659.
-
(2015)
J Biol Chem.
, vol.290
, pp. 20649-20659
-
-
Homan, K.T.1
Waldschmidt, H.V.2
Glukhova, A.3
-
155
-
-
42449152447
-
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration
-
Penela P, Ribas C, Aymerich I, et al. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008;27:1206-1218.
-
(2008)
EMBO J.
, vol.27
, pp. 1206-1218
-
-
Penela, P.1
Ribas, C.2
Aymerich, I.3
-
156
-
-
79955782045
-
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia
-
Ciccarelli M, Chuprun JK, Rengo G, et al. G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation. 2011;123:1953-1962.
-
(2011)
Circulation.
, vol.123
, pp. 1953-1962
-
-
Ciccarelli, M.1
Chuprun, J.K.2
Rengo, G.3
-
157
-
-
70450227198
-
The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptorinduced insulin resistance
-
Cipolletta E, Campanile A, Santulli G, et al. The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptorinduced insulin resistance. Cardiovasc Res. 2009;84:407-415.
-
(2009)
Cardiovasc Res.
, vol.84
, pp. 407-415
-
-
Cipolletta, E.1
Campanile, A.2
Santulli, G.3
-
158
-
-
3543038233
-
GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation
-
Usui I, Imamura T, Satoh H, et al. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004;23:2821-2829.
-
(2004)
EMBO J.
, vol.23
, pp. 2821-2829
-
-
Usui, I.1
Imamura, T.2
Satoh, H.3
-
159
-
-
0032573192
-
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade
-
Iaccarino G, Tomhave ED, Lefkowitz RJ, et al. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. 1998;98:1783-1789.
-
(1998)
Circulation.
, vol.98
, pp. 1783-1789
-
-
Iaccarino, G.1
Tomhave, E.D.2
Lefkowitz, R.J.3
-
161
-
-
0034595227
-
Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: Regulation by signal transduction systems in aortic smooth muscle cells
-
Ramos-Ruiz R, Penela P, Penn RB, et al. Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells. Circulation. 2000;101:2083-2089.
-
(2000)
Circulation.
, vol.101
, pp. 2083-2089
-
-
Ramos-Ruiz, R.1
Penela, P.2
Penn, R.B.3
-
162
-
-
77954146850
-
MicroRNAs in heart disease: Putative novel therapeutic targets?
-
Condorelli G, Latronico MV, Dorn GW II. microRNAs in heart disease: putative novel therapeutic targets? Eur Heart J. 2010;31:649-658.
-
(2010)
Eur Heart J.
, vol.31
, pp. 649-658
-
-
Condorelli, G.1
Latronico, M.V.2
Dorn, G.W.I.I.3
-
163
-
-
74049096307
-
MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts
-
Matkovich SJ, Wang W, Tu Y, et al. MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ Res. 2010;106:166-175.
-
(2010)
Circ Res.
, vol.106
, pp. 166-175
-
-
Matkovich, S.J.1
Wang, W.2
Tu, Y.3
-
164
-
-
33845317603
-
A signature pattern of stressresponsive microRNAs that can evoke cardiac hypertrophy and heart failure
-
van Rooij E, Sutherland LB, Liu N, et al. A signature pattern of stressresponsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci USA. 2006;103:18255-18260.
-
(2006)
Proc Natl Acad Sci USA.
, vol.103
, pp. 18255-18260
-
-
Van Rooij, E.1
Sutherland, L.B.2
Liu, N.3
-
165
-
-
48849095818
-
MiRNA expression in the failing human heart: Functional correlates
-
Sucharov C, Bristow MR, Port JD. miRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol. 2008;45:185-192.
-
(2008)
J Mol Cell Cardiol.
, vol.45
, pp. 185-192
-
-
Sucharov, C.1
Bristow, M.R.2
Port, J.D.3
-
166
-
-
84943533620
-
A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling
-
Hu M, Wang C, Li W, et al. A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling. PLoS Pathog. 2015;11:e1005171.
-
(2015)
PLoS Pathog.
, vol.11
, pp. e1005171
-
-
Hu, M.1
Wang, C.2
Li, W.3
-
167
-
-
84960172266
-
Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G proteincoupled receptor kinases
-
Cannavo A, Liccardo D, Eguchi A, et al. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G proteincoupled receptor kinases. Nat Commun. 2016;7:10877.
-
(2016)
Nat Commun.
, vol.7
, pp. 10877
-
-
Cannavo, A.1
Liccardo, D.2
Eguchi, A.3
|