The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 46, 2008, Pages 17818-17823

  Sorriento, Daniela ^a   Ciccarelli, Michele ^a   Santulli, Gaetano ^a   Campanile, Alfonso ^a   Altobelli, Giovanna Giuseppina ^a   Cimini, Vincenzo ^a   Galasso, Gennaro ^a   Astone, Dalila ^b   Piscione, Federico ^a   Pastore, Lucio ^b   Trimarco, Bruno ^a   Iaccarino, Guido ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Centro di Ingegneria Genetica e Biotecnologia Avanzate CEINGE   (Italy)

Author keywords

Angiogenesis; Gene transcription; Inflammation; Signal transduction

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 5; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE CONTROL; GENE INTERACTION; GENE OVEREXPRESSION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; RAT; SIGNAL TRANSDUCTION; TISSUE REGENERATION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CATTLE; CELL LINE; CELL MOVEMENT; CELL NUCLEUS; ENDOTHELIAL CELLS; G-PROTEIN-COUPLED RECEPTOR KINASE 5; HUMANS; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; NEOVASCULARIZATION, PHYSIOLOGIC; NF-KAPPA B; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RATS; REGENERATION; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 56649094511     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804446105     Document Type: Article

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