G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia

Circulation

Volumn 123, Issue 18, 2011, Pages 1953-1962

  Ciccarelli, Michele ^a,b   Chuprun, J Kurt ^a   Rengo, Giuseppe ^a,c   Gao, Erhe ^a   Wei, Zhengyu ^a   Peroutka, Raymond J ^a   Gold, Jessica I ^a   Gumpert, Anna ^a   Chen, Mai ^a   Otis, Nicholas J ^a   Dorn, Gerald W ^d   Trimarco, Bruno ^b   Iaccarino, Guido ^e   Koch, Walter J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c IRCCS   (Italy)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SALERNO   (Italy)

Author keywords

glucose; heart failure; myocardial ischemia; positron emission tomography

Indexed keywords

BETA ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; INSULIN RESISTANCE; INSULIN SYNTHESIS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; BLOOD GLUCOSE; ENERGY METABOLISM; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GENE THERAPY; GLUCOSE TRANSPORTER TYPE 4; HEART FAILURE; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; MICE, TRANSGENIC; MYOCARDIAL ISCHEMIA; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; SIGNAL TRANSDUCTION;

EID: 79955782045     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.988642     Document Type: Article

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