Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Fan, Qian ^a,c   Chen, Mai ^a,d   Zuo, Lin ^a   Shang, Xiying ^a   Huang, Maggie Z ^a   Ciccarelli, Michele ^a   Raake, Philip ^a   Brinks, Henriette ^a   Chuprun, Kurt J ^a   Dorn II, Gerald W ^b   Koch, Walter J ^a   Gao, Erhe ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; G PROTEIN COUPLED RECEPTOR KINASE 2; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; ISOPRENALINE; PROTEIN BCL X;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; CORRELATION ANALYSIS; CYTOSOL; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; GENE DELETION; GENE SILENCING; HEART FUNCTION; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IN VITRO STUDY; KNOCKOUT MOUSE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEART INFARCTION; HEMODYNAMICS; MALE; METABOLISM; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; OXIDATIVE STRESS; PATHOLOGY; RNA INTERFERENCE; UPREGULATION;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CYTOCHROMES C; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEMODYNAMICS; ISOPROTERENOL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; UP-REGULATION;

EID: 84879252168     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066234     Document Type: Article

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