-
1
-
-
0033002089
-
Molecular beta-Adrenergic signaling abnormalities in failing rabbit hearts after infarction
-
Maurice JP, Shah AS, Kypson AP, Hata JA, White DC, Glower DD, Koch WJ. Molecular beta-Adrenergic signaling abnormalities in failing rabbit hearts after infarction. Am J Physiol. 1999;276:H1853-H1860
-
(1999)
Am J Physiol
, vol.276
-
-
Maurice, J.P.1
Shah, A.S.2
Kypson, A.P.3
Hata, J.A.4
White, D.C.5
Glower, D.D.6
Koch, W.J.7
-
2
-
-
79959540189
-
G protein-coupled receptor kinases in normal and failing myocardium
-
Huang ZM, Gold JI, Koch WJ. G protein-coupled receptor kinases in normal and failing myocardium. Front Biosci (Landmark Ed). 2011;16:3047-3060
-
(2011)
Front Biosci (Landmark Ed)
, vol.16
, pp. 3047-3060
-
-
Huang, Z.M.1
Gold, J.I.2
Koch, W.J.3
-
3
-
-
59049097977
-
Myocardial adeno-Associated virus serotype 6-βARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure
-
Rengo G, Lymperopoulos A, Koch WJ. Myocardial adeno-Associated virus serotype 6-βARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation. 2009;119:89-98
-
(2009)
Circulation
, vol.119
, pp. 89-98
-
-
Rengo, G.1
Lymperopoulos, A.2
Koch, W.J.3
-
4
-
-
77952840083
-
The complex G protein- coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets
-
Penela P, Murga C, Ribas C, Lafarga V, Mayor F Jr. The complex G protein- coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol. 2010;160:821-832
-
(2010)
Br J Pharmacol
, vol.160
, pp. 821-832
-
-
Penela, P.1
Murga, C.2
Ribas, C.3
Lafarga, V.4
Mayor Jr., F.5
-
5
-
-
0029057061
-
Phosphorylation and desensitization of the human beta 1-Adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMPdependent protein kinase
-
Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ. Phosphorylation and desensitization of the human beta 1-Adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMPdependent protein kinase. J Biol Chem. 1995;270:17953-17961
-
(1995)
J Biol Chem
, vol.270
, pp. 17953-17961
-
-
Freedman, N.J.1
Liggett, S.B.2
Drachman, D.E.3
Pei, G.4
Caron, M.G.5
Lefkowitz, R.J.6
-
6
-
-
33947375174
-
Physiological roles of G protein-coupled receptor kinases and arrestins
-
Premont RT, Gainetdinov RR. Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol. 2007;69:511-534
-
(2007)
Annu Rev Physiol
, vol.69
, pp. 511-534
-
-
Premont, R.T.1
Gainetdinov, R.R.2
-
9
-
-
0032499733
-
Expression of a beta-Adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-Targeted mice
-
Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J Jr, Lefkowitz RJ, Koch WJ. Expression of a beta-Adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-Targeted mice. Proc Natl Acad Sci U S A. 1998;95:7000-7005
-
(1998)
Proc Natl Acad Sci U S A.
, vol.95
, pp. 7000-7005
-
-
Rockman, H.A.1
Chien, K.R.2
Choi, D.J.3
Iaccarino, G.4
Hunter, J.J.5
Ross Jr., J.6
Lefkowitz, R.J.7
Koch, W.J.8
-
10
-
-
24044543283
-
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure
-
Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J. 2005;26:1752-1758
-
(2005)
Eur Heart J.
, vol.26
, pp. 1752-1758
-
-
Iaccarino, G.1
Barbato, E.2
Cipolletta, E.3
De Amicis, V.4
Margulies, K.B.5
Leosco, D.6
Trimarco, B.7
Koch, W.J.8
-
11
-
-
33744533073
-
Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: Lower GRK2 associated with improved beta-Adrenergic signaling after mechanical unloading
-
Hata JA, Williams ML, Schroder JN, Lima B, Keys JR, Blaxall BC, Petrofski JA, Jakoi A, Milano CA, Koch WJ. Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: Lower GRK2 associated with improved beta-Adrenergic signaling after mechanical unloading. J Card Fail. 2006;12:360-368
-
(2006)
J Card Fail
, vol.12
, pp. 360-368
-
-
Hata, J.A.1
Williams, M.L.2
Schroder, J.N.3
Lima, B.4
Keys, J.R.5
Blaxall, B.C.6
Petrofski, J.A.7
Jakoi, A.8
Milano, C.A.9
Koch, W.J.10
-
12
-
-
77953366234
-
Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: A biomarker for left ventricular function
-
Bonita RE, Raake PW, Otis NJ, Chuprun JK, Spivack T, Dasgupta A, Whellan DJ, Mather PJ, Koch WJ. Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: A biomarker for left ventricular function. Clin Transl Sci. 2010;3:14-18
-
(2010)
Clin Transl Sci
, vol.3
, pp. 14-18
-
-
Bonita, R.E.1
Raake, P.W.2
Otis, N.J.3
Chuprun, J.K.4
Spivack, T.5
Dasgupta, A.6
Whellan, D.J.7
Mather, P.J.8
Koch, W.J.9
-
13
-
-
77952546627
-
Reversal of impaired myocardial beta-Adrenergic receptor signaling by continuous-flow left ventricular assist device support
-
Akhter SA, D'Souza KM, Malhotra R, Staron ML, Valeroso TB, Fedson SE, Anderson AS, Raman J, Jeevanandam V. Reversal of impaired myocardial beta-Adrenergic receptor signaling by continuous-flow left ventricular assist device support. J Heart Lung Transplant. 2010;29:603-609
-
(2010)
J Heart Lung Transplant
, vol.29
, pp. 603-609
-
-
Akhter, S.A.1
D'Souza, K.M.2
Malhotra, R.3
Staron, M.L.4
Valeroso, T.B.5
Fedson, S.E.6
Anderson, A.S.7
Raman, J.8
Jeevanandam, V.9
-
14
-
-
84890454726
-
Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure
-
Rengo G, Galasso G, Femminella GD, et al. Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure. Eur J Prev Cardiol. 2014;21:4-11
-
(2014)
Eur J Prev Cardiol
, vol.21
, pp. 4-11
-
-
Rengo, G.1
Galasso, G.2
Femminella, G.D.3
-
15
-
-
33947198179
-
Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease
-
Leosco D, Fortunato F, Rengo G, Iaccarino G, Sanzari E, Golino L, Zincarelli C, Canonico V, Marchese M, Koch WJ, Rengo F. Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease. Neurosci Lett. 2007;415:279-282
-
(2007)
Neurosci Lett
, vol.415
, pp. 279-282
-
-
Leosco, D.1
Fortunato, F.2
Rengo, G.3
Iaccarino, G.4
Sanzari, E.5
Golino, L.6
Zincarelli, C.7
Canonico, V.8
Marchese, M.9
Koch, W.J.10
Rengo, F.11
-
16
-
-
84992193817
-
Effects of exercise training on cardiovascular adrenergic system
-
Leosco D, Parisi V, Femminella GD, Formisano R, Petraglia L, Allocca E, Bonaduce D. Effects of exercise training on cardiovascular adrenergic system. Front Physiol. 2013;4:348
-
(2013)
Front Physiol
, vol.4
, pp. 348
-
-
Leosco, D.1
Parisi, V.2
Femminella, G.D.3
Formisano, R.4
Petraglia, L.5
Allocca, E.6
Bonaduce, D.7
-
17
-
-
84856504934
-
GRK2 inhibition in heart failure: Something old, something new
-
Lymperopoulos A, Rengo G, Koch WJ. GRK2 inhibition in heart failure: Something old, something new. Curr Pharm Des. 2012;18:186-191
-
(2012)
Curr Pharm Des
, vol.18
, pp. 186-191
-
-
Lymperopoulos, A.1
Rengo, G.2
Koch, W.J.3
-
18
-
-
10544242967
-
Essential role of beta-Adrenergic receptor kinase 1 in cardiac development and function
-
Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, Sulik KK, Ross J Jr, Lefkowitz RJ, Caron MG, Giros B. Essential role of beta-Adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996;93:12974-12979
-
(1996)
Proc Natl Acad Sci U S A.
, vol.93
, pp. 12974-12979
-
-
Jaber, M.1
Koch, W.J.2
Rockman, H.3
Smith, B.4
Bond, R.A.5
Sulik, K.K.6
Ross Jr., J.7
Lefkowitz, R.J.8
Caron, M.G.9
Giros, B.10
-
19
-
-
33750428974
-
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-Adrenergic signaling
-
Matkovich SJ, Diwan A, Klanke JL, Hammer DJ, Marreez Y, Odley AM, Brunskill EW, Koch WJ, Schwartz RJ, Dorn GW 2nd. Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-Adrenergic signaling. Circ Res. 2006;99:996-1003
-
(2006)
Circ Res
, vol.99
, pp. 996-1003
-
-
Matkovich, S.J.1
Diwan, A.2
Klanke, J.L.3
Hammer, D.J.4
Marreez, Y.5
Odley, A.M.6
Brunskill, E.W.7
Koch, W.J.8
Schwartz, R.J.9
Dorn II, G.W.10
-
20
-
-
0032540893
-
Control of myocardial contractile function by the level of beta-Adrenergic receptor kinase 1 in gene-Targeted mice
-
Rockman HA, Choi DJ, Akhter SA, Jaber M, Giros B, Lefkowitz RJ, Caron MG, Koch WJ. Control of myocardial contractile function by the level of beta-Adrenergic receptor kinase 1 in gene-Targeted mice. J Biol Chem. 1998;273:18180-18184
-
(1998)
J Biol Chem
, vol.273
, pp. 18180-18184
-
-
Rockman, H.A.1
Choi, D.J.2
Akhter, S.A.3
Jaber, M.4
Giros, B.5
Lefkowitz, R.J.6
Caron, M.G.7
Koch, W.J.8
-
21
-
-
50949099098
-
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure
-
Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW 2nd, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res. 2008;103:413-422
-
(2008)
Circ Res
, vol.103
, pp. 413-422
-
-
Raake, P.W.1
Vinge, L.E.2
Gao, E.3
Boucher, M.4
Rengo, G.5
Chen, X.6
DeGeorge Jr., B.R.7
Matkovich, S.8
Houser, S.R.9
Most, P.10
Eckhart, A.D.11
Dorn II, G.W.12
Koch, W.J.13
-
22
-
-
84879252168
-
Myocardial ablation of G protein-coupled receptor kinase 2 (GRK2) decreases ischemia/ reperfusion injury through an anti-intrinsic apoptotic pathway
-
Fan Q, Chen M, Zuo L, Shang X, Huang MZ, Ciccarelli M, Raake P, Brinks H, Chuprun KJ, Dorn GW 2nd, Koch WJ, Gao E. Myocardial ablation of G protein-coupled receptor kinase 2 (GRK2) decreases ischemia/ reperfusion injury through an anti-intrinsic apoptotic pathway. PLoS One. 2013;8:e66234
-
(2013)
PLoS One
, vol.8
-
-
Fan, Q.1
Chen, M.2
Zuo, L.3
Shang, X.4
Huang, M.Z.5
Ciccarelli, M.6
Raake, P.7
Brinks, H.8
Chuprun, K.J.9
Dorn II, G.W.10
Koch, W.J.11
Gao, E.12
-
23
-
-
0035048223
-
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy
-
Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J Clin Invest. 2001;107:967-974
-
(2001)
J Clin Invest
, vol.107
, pp. 967-974
-
-
Freeman, K.1
Lerman, I.2
Kranias, E.G.3
Bohlmeyer, T.4
Bristow, M.R.5
Lefkowitz, R.J.6
Iaccarino, G.7
Koch, W.J.8
Leinwand, L.A.9
-
24
-
-
0035826710
-
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure
-
Harding V, Jones L, Lefkowitz RJ, Koch WJ, Rockman HA. Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure. Proc Natl Acad Sci USA. 2001;98:5809-5814
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5809-5814
-
-
Harding, V.1
Jones, L.2
Lefkowitz, R.J.3
Koch, W.J.4
Rockman, H.A.5
-
25
-
-
78349313123
-
Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- And anti-Apoptotic mechanisms
-
Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ. Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- And anti-Apoptotic mechanisms. Circ Res. 2010;107:1140-1149
-
(2010)
Circ Res
, vol.107
, pp. 1140-1149
-
-
Brinks, H.1
Boucher, M.2
Gao, E.3
Chuprun, J.K.4
Pesant, S.5
Raake, P.W.6
Huang, Z.M.7
Wang, X.8
Qiu, G.9
Gumpert, A.10
Harris, D.M.11
Eckhart, A.D.12
Most, P.13
Koch, W.J.14
-
26
-
-
84885034477
-
Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species
-
Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW 2nd, Trimarco B, Iaccarino G. Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species. Arterioscler Thromb Vasc Biol. 2013;33:2415-2424
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 2415-2424
-
-
Ciccarelli, M.1
Sorriento, D.2
Franco, A.3
Fusco, A.4
Del Giudice, C.5
Annunziata, R.6
Cipolletta, E.7
Monti, M.G.8
Dorn II, G.W.9
Trimarco, B.10
Iaccarino, G.11
-
27
-
-
84887448328
-
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2
-
Rivas V, Carmona R, Muñoz-Chápuli R, Mendiola M, Nogués L, Reglero C, Miguel-Martín M, García-Escudero R, Dorn GW 2nd, Hardisson D, Mayor F Jr, Penela P. Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2. J Clin Invest. 2013;123:4714-4730
-
(2013)
J Clin Invest
, vol.123
, pp. 4714-4730
-
-
Rivas, V.1
Carmona, R.2
Muñoz-Chápuli, R.3
Mendiola, M.4
Nogués, L.5
Reglero, C.6
Miguel-Martín, M.7
García-Escudero, R.8
Dorn II, G.W.9
Hardisson, D.10
Mayor Jr., F.11
Penela, P.12
-
28
-
-
84892909749
-
Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension
-
Avendaño MS, Lucas E, Jurado-Pueyo M, Martínez-Revelles S, Vila- Bedmar R, Mayor F Jr, Salaices M, Briones AM, Murga C. Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension. Hypertension. 2014;63:369-375
-
(2014)
Hypertension
, vol.63
, pp. 369-375
-
-
Avendaño, M.S.1
Lucas, E.2
Jurado-Pueyo, M.3
Martínez-Revelles, S.4
Vila- Bedmar, R.5
Mayor Jr., F.6
Salaices, M.7
Briones, A.M.8
Murga, C.9
-
29
-
-
84862745056
-
Inhibitor of G proteincoupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-Arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction
-
Taguchi K, Matsumoto T, Kamata K, Kobayashi T. Inhibitor of G proteincoupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-Arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction. Endocrinology. 2012;153:2985-2996
-
(2012)
Endocrinology
, vol.153
, pp. 2985-2996
-
-
Taguchi, K.1
Matsumoto, T.2
Kamata, K.3
Kobayashi, T.4
-
30
-
-
84864386792
-
G protein-coupled receptor kinase 2, with β-Arrestin 2, impairs insulin-induced Akt/endothelial nitric oxide synthase signaling in ob/ob mouse aorta
-
Taguchi K, Matsumoto T, Kamata K, Kobayashi T. G protein-coupled receptor kinase 2, with β-Arrestin 2, impairs insulin-induced Akt/endothelial nitric oxide synthase signaling in ob/ob mouse aorta. Diabetes. 2012;61:1978-1985
-
(2012)
Diabetes
, vol.61
, pp. 1978-1985
-
-
Taguchi, K.1
Matsumoto, T.2
Kamata, K.3
Kobayashi, T.4
-
31
-
-
33846082671
-
Physiologically tolerable insulin reduces myocardial injury and improves cardiac functional recovery in myocardial ischemic/reperfused dogs
-
Zhang HX, Zang YM, Huo JH, Liang SJ, Zhang HF, Wang YM, Fan Q, Guo WY, Wang HC, Gao F. Physiologically tolerable insulin reduces myocardial injury and improves cardiac functional recovery in myocardial ischemic/reperfused dogs. J Cardiovasc Pharmacol. 2006;48:306-313
-
(2006)
J Cardiovasc Pharmacol
, vol.48
, pp. 306-313
-
-
Zhang, H.X.1
Zang, Y.M.2
Huo, J.H.3
Liang, S.J.4
Zhang, H.F.5
Wang, Y.M.6
Fan, Q.7
Guo, W.Y.8
Wang, H.C.9
Gao, F.10
-
32
-
-
33845711358
-
Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
-
Shiojima I, Walsh K. Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev. 2006;20:3347-3365
-
(2006)
Genes Dev
, vol.20
, pp. 3347-3365
-
-
Shiojima, I.1
Walsh, K.2
-
33
-
-
36549055740
-
Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction
-
Díaz R, Goyal A, Mehta SR, Afzal R, Xavier D, Pais P, Chrolavicius S, Zhu J, Kazmi K, Liu L, Budaj A, Zubaid M, Avezum A, Ruda M, Yusuf S. Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction. JAMA. 2007;298:2399-2405
-
(2007)
JAMA
, vol.298
, pp. 2399-2405
-
-
Díaz, R.1
Goyal, A.2
Mehta, S.R.3
Afzal, R.4
Xavier, D.5
Pais, P.6
Chrolavicius, S.7
Zhu, J.8
Kazmi, K.9
Liu, L.10
Budaj, A.11
Zubaid, M.12
Avezum, A.13
Ruda, M.14
Yusuf, S.15
-
34
-
-
84883425232
-
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes
-
Kolwicz SC Jr, Purohit S, Tian R. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res. 2013;113:603-616
-
(2013)
Circ Res
, vol.113
, pp. 603-616
-
-
Kolwicz Jr., S.C.1
Purohit, S.2
Tian, R.3
-
35
-
-
33947239659
-
The failing heart-An engine out of fuel
-
Neubauer S. The failing heart-An engine out of fuel. N Engl J Med. 2007;356:1140-1151
-
(2007)
N Engl J Med
, vol.356
, pp. 1140-1151
-
-
Neubauer, S.1
-
36
-
-
0035136262
-
An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-Thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure
-
Taylor M, Wallhaus TR, Degrado TR, Russell DC, Stanko P, Nickles RJ, Stone CK. An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-Thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure. J Nucl Med. 2001;42:55-62
-
(2001)
J Nucl Med
, vol.42
, pp. 55-62
-
-
Taylor, M.1
Wallhaus, T.R.2
Degrado, T.R.3
Russell, D.C.4
Stanko, P.5
Nickles, R.J.6
Stone, C.K.7
-
37
-
-
0037020157
-
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status
-
Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem. 2002;277:37670-37677
-
(2002)
J Biol Chem
, vol.277
, pp. 37670-37677
-
-
Shiojima, I.1
Yefremashvili, M.2
Luo, Z.3
Kureishi, Y.4
Takahashi, A.5
Tao, J.6
Rosenzweig, A.7
Kahn, C.R.8
Abel, E.D.9
Walsh, K.10
-
38
-
-
37349085478
-
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy
-
Kemi OJ, Ceci M, Wisloff U, Grimaldi S, Gallo P, Smith GL, Condorelli G, Ellingsen O. Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy. J Cell Physiol. 2008;214:316-321
-
(2008)
J Cell Physiol
, vol.214
, pp. 316-321
-
-
Kemi, O.J.1
Ceci, M.2
Wisloff, U.3
Grimaldi, S.4
Gallo, P.5
Smith, G.L.6
Condorelli, G.7
Ellingsen, O.8
-
39
-
-
0042750799
-
Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival
-
Matsui T, Nagoshi T, Rosenzweig A. Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival. Cell Cycle. 2003;2:220-223
-
(2003)
Cell Cycle
, vol.2
, pp. 220-223
-
-
Matsui, T.1
Nagoshi, T.2
Rosenzweig, A.3
-
40
-
-
84860340270
-
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13
-
Grueter CE, Van Rooij E, Johnson BA, DeLeon SM, Sutherland LB, Qi X, Gautron L, Elmquist JK, Bassel-Duby R, Olson EN. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell. 2012;149:671-683
-
(2012)
Cell
, vol.149
, pp. 671-683
-
-
Grueter, C.E.1
Van Rooij, E.2
Johnson, B.A.3
DeLeon, S.M.4
Sutherland, L.B.5
Qi, X.6
Gautron, L.7
Elmquist, J.K.8
Bassel-Duby, R.9
Olson, E.N.10
-
41
-
-
79955782045
-
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia
-
Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW 2nd, Trimarco B, Iaccarino G, Koch WJ. G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation. 2011;123:1953-1962
-
(2011)
Circulation
, vol.123
, pp. 1953-1962
-
-
Ciccarelli, M.1
Chuprun, J.K.2
Rengo, G.3
Gao, E.4
Wei, Z.5
Peroutka, R.J.6
Gold, J.I.7
Gumpert, A.8
Chen, M.9
Otis, N.J.10
Dorn II, G.W.11
Trimarco, B.12
Iaccarino, G.13
Koch, W.J.14
-
42
-
-
0018629905
-
Adrenaline-induced 'oxygen-wastage' and enzyme release from working rat heart. Effects of calcium antagonism, beta-blockade, nicotinic acid and coronary artery ligation
-
Opie LH, Thandroyen FT, Muller C, Bricknell OL. Adrenaline-induced 'oxygen-wastage' and enzyme release from working rat heart. Effects of calcium antagonism, beta-blockade, nicotinic acid and coronary artery ligation. J Mol Cell Cardiol. 1979;11:1073-1094
-
(1979)
J Mol Cell Cardiol
, vol.11
, pp. 1073-1094
-
-
Opie, L.H.1
Thandroyen, F.T.2
Muller, C.3
Bricknell, O.L.4
-
43
-
-
0025772752
-
Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure
-
Paolisso G, De Riu S, Marrazzo G, Verza M, Varricchio M, D'Onofrio F. Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure. Metabolism. 1991;40:972-977
-
(1991)
Metabolism
, vol.40
, pp. 972-977
-
-
Paolisso, G.1
De Riu, S.2
Marrazzo, G.3
Verza, M.4
Varricchio, M.5
D'Onofrio, F.6
-
44
-
-
18844362383
-
The association of heart failure with insulin resistance and the development of type 2 diabetes
-
Kostis JB, Sanders M. The association of heart failure with insulin resistance and the development of type 2 diabetes. Am J Hypertens. 2005;18:731-737
-
(2005)
Am J Hypertens
, vol.18
, pp. 731-737
-
-
Kostis, J.B.1
Sanders, M.2
-
45
-
-
33749995725
-
Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity
-
Sasaoka T, Wada T, Tsuneki H. Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity. Pharmacol Ther. 2006;112:799-809
-
(2006)
Pharmacol Ther
, vol.112
, pp. 799-809
-
-
Sasaoka, T.1
Wada, T.2
Tsuneki, H.3
-
46
-
-
33751085848
-
Novel mechanisms of sympathetic regulation in chronic heart failure
-
Zucker IH. Novel mechanisms of sympathetic regulation in chronic heart failure. Hypertension. 2006;48:1005-1011
-
(2006)
Hypertension
, vol.48
, pp. 1005-1011
-
-
Zucker, I.H.1
-
47
-
-
34547591337
-
The metabolic syndrome, does it exist?
-
Opie LH, Kasuga M, Yellon DM, eds Cape Town, South Africa: University of Cape Town Press
-
Opie LH. The metabolic syndrome, does it exist? In: Opie LH, Kasuga M, Yellon DM, eds. Diabetes at the Limits. Vol. 2. Cape Town, South Africa: University of Cape Town Press; 2006:95-110
-
(2006)
Diabetes at the Limits
, pp. 95-110
-
-
Opie, L.H.1
-
48
-
-
84864746050
-
GRK2 contribution to the regulation of energy expenditure and brown fat function
-
Vila-Bedmar R, Garcia-Guerra L, Nieto-Vazquez I, Mayor F Jr, Lorenzo M, Murga C, Fernández-Veledo S. GRK2 contribution to the regulation of energy expenditure and brown fat function. FASEB J. 2012;26:3503-3514
-
(2012)
FASEB J.
, vol.26
, pp. 3503-3514
-
-
Vila-Bedmar, R.1
Garcia-Guerra, L.2
Nieto-Vazquez, I.3
Mayor Jr., F.4
Lorenzo, M.5
Murga, C.6
Fernández-Veledo, S.7
-
50
-
-
70450227198
-
The G protein coupled receptor kinase 2 plays an essential role in beta-Adrenergic receptor-induced insulin resistance
-
Cipolletta E, Campanile A, Santulli G, Sanzari E, Leosco D, Campiglia P, Trimarco B, Iaccarino G. The G protein coupled receptor kinase 2 plays an essential role in beta-Adrenergic receptor-induced insulin resistance. Cardiovasc Res. 2009;84:407-415
-
(2009)
Cardiovasc Res
, vol.84
, pp. 407-415
-
-
Cipolletta, E.1
Campanile, A.2
Santulli, G.3
Sanzari, E.4
Leosco, D.5
Campiglia, P.6
Trimarco, B.7
Iaccarino, G.8
-
51
-
-
33750208522
-
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2
-
Salcedo A, Mayor F Jr, Penela P. Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J. 2006;25:4752-4762
-
(2006)
EMBO J.
, vol.25
, pp. 4752-4762
-
-
Salcedo, A.1
Mayor Jr., F.2
Penela, P.3
-
52
-
-
84860789159
-
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor
-
Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, Girnita L. Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor. Proc Natl Acad Sci U S A. 2012;109:7055-7060
-
(2012)
Proc Natl Acad Sci U S A.
, vol.109
, pp. 7055-7060
-
-
Zheng, H.1
Worrall, C.2
Shen, H.3
Issad, T.4
Seregard, S.5
Girnita, A.6
Girnita, L.7
-
53
-
-
0028982925
-
G beta gamma subunits mediate mitogen-Activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor
-
Luttrell LM, Van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma subunits mediate mitogen-Activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem. 1995;270:16495-16498
-
(1995)
J Biol Chem
, vol.270
, pp. 16495-16498
-
-
Luttrell, L.M.1
Van Biesen, T.2
Hawes, B.E.3
Koch, W.J.4
Touhara, K.5
Lefkowitz, R.J.6
-
54
-
-
79959199413
-
G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance
-
Mayor F Jr, Lucas E, Jurado-Pueyo M, Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Fernández-Veledo S, Murga C. G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance. Arch Physiol Biochem. 2011;117:125-130
-
(2011)
Arch Physiol Biochem
, vol.117
, pp. 125-130
-
-
Mayor Jr., F.1
Lucas, E.2
Jurado-Pueyo, M.3
Garcia-Guerra, L.4
Nieto-Vazquez, I.5
Vila-Bedmar, R.6
Fernández-Veledo, S.7
Murga, C.8
-
56
-
-
77957600228
-
G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity
-
Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Jurado-Pueyo M, Zalba G, Díez J, Murga C, Fernández-Veledo S, Mayor F Jr, Lorenzo M. G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. Diabetes. 2010;59:2407-2417
-
(2010)
Diabetes
, vol.59
, pp. 2407-2417
-
-
Garcia-Guerra, L.1
Nieto-Vazquez, I.2
Vila-Bedmar, R.3
Jurado-Pueyo, M.4
Zalba, G.5
Díez, J.6
Murga, C.7
Fernández-Veledo, S.8
Mayor Jr., F.9
Lorenzo, M.10
-
57
-
-
84885575620
-
Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise- induced alleviation of hypertension in spontaneously hypertensive rats
-
Xing W, Li Y, Zhang H, Mi C, Hou Z, Quon MJ, Gao F. Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise- induced alleviation of hypertension in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2013;305:H1111-H1119
-
(2013)
Am J Physiol Heart Circ Physiol
, vol.305
-
-
Xing, W.1
Li, Y.2
Zhang, H.3
Mi, C.4
Hou, Z.5
Quon, M.J.6
Gao, F.7
-
58
-
-
4143138843
-
Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes
-
Anis Y, Leshem O, Reuveni H, Wexler I, Ben Sasson R, Yahalom B, Laster M, Raz I, Ben Sasson S, Shafrir E, Ziv E. Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes. Diabetologia. 2004;47:1232-1244
-
(2004)
Diabetologia
, vol.47
, pp. 1232-1244
-
-
Anis, Y.1
Leshem, O.2
Reuveni, H.3
Wexler, I.4
Ben Sasson, R.5
Yahalom, B.6
Laster, M.7
Raz, I.8
Ben Sasson, S.9
Shafrir, E.10
Ziv, E.11
-
59
-
-
0034164456
-
RGS domain in the amino-Terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling
-
Usui H, Nishiyama M, Moroi K, Shibasaki T, Zhou J, Ishida J, Fukamizu A, Haga T, Sekiya S, Kimura S. RGS domain in the amino-Terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling. Int J Mol Med. 2000;5:335-340
-
(2000)
Int J Mol Med
, vol.5
, pp. 335-340
-
-
Usui, H.1
Nishiyama, M.2
Moroi, K.3
Shibasaki, T.4
Zhou, J.5
Ishida, J.6
Fukamizu, A.7
Haga, T.8
Sekiya, S.9
Kimura, S.10
-
60
-
-
3543038233
-
GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation
-
Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky JM. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 2004;23:2821-2829
-
(2004)
EMBO J.
, vol.23
, pp. 2821-2829
-
-
Usui, I.1
Imamura, T.2
Satoh, H.3
Huang, J.4
Babendure, J.L.5
Hupfeld, C.J.6
Olefsky, J.M.7
-
61
-
-
27644433164
-
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes
-
Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol. 2005;19:2760-2768
-
(2005)
Mol Endocrinol
, vol.19
, pp. 2760-2768
-
-
Usui, I.1
Imamura, T.2
Babendure, J.L.3
Satoh, H.4
Lu, J.C.5
Hupfeld, C.J.6
Olefsky, J.M.7
-
62
-
-
24744444714
-
A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
-
Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med. 2005;11:952-958
-
(2005)
Nat Med
, vol.11
, pp. 952-958
-
-
Liu, S.1
Premont, R.T.2
Kontos, C.D.3
Zhu, S.4
Rockey, D.C.5
-
63
-
-
33750617659
-
Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions
-
Obrenovich ME, Smith MA, Siedlak SL, Chen SG, De la Torre JC, Perry G, Aliev G. Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. Neurotox Res. 2006;10:43-56
-
(2006)
Neurotox Res
, vol.10
, pp. 43-56
-
-
Obrenovich, M.E.1
Smith, M.A.2
Siedlak, S.L.3
Chen, S.G.4
De La Torre, J.C.5
Perry, G.6
Aliev, G.7
-
64
-
-
83555174502
-
Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis
-
Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW 2nd, Trimarco B, Feliciello A, Iaccarino G. Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis. Cell Signal. 2012;24:468-475
-
(2012)
Cell Signal
, vol.24
, pp. 468-475
-
-
Fusco, A.1
Santulli, G.2
Sorriento, D.3
Cipolletta, E.4
Garbi, C.5
Dorn II, G.W.6
Trimarco, B.7
Feliciello, A.8
Iaccarino, G.9
-
65
-
-
84876413668
-
Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting
-
Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ. Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ Res. 2013;112:1121-1134.
-
(2013)
Circ Res
, vol.112
, pp. 1121-1134
-
-
Chen, M.1
Sato, P.Y.2
Chuprun, J.K.3
Peroutka, R.J.4
Otis, N.J.5
Ibetti, J.6
Pan, S.7
Sheu, S.S.8
Gao, E.9
Koch, W.J.10
-
66
-
-
84887252526
-
Convergence of G-protein coupled receptor and nitric oxide pathways determines the outcome to cardiac ischemic injury
-
6:ra95
-
Huang ZM, Gao E, Fonseca F, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ. Convergence of G-protein coupled receptor and nitric oxide pathways determines the outcome to cardiac ischemic injury. Science Signaling. 2013;6:ra95.
-
(2013)
Science Signaling
-
-
Huang, Z.M.1
Gao, E.2
Fonseca, F.3
Hayashi, H.4
Shang, X.5
Hoffman, N.E.6
Chuprun, J.K.7
Tian, X.8
Tilley, D.G.9
Madesh, M.10
Lefer, D.J.11
Stamler, J.S.12
Koch, W.J.13
-
67
-
-
34247470682
-
Regulation of beta-Adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2
-
Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-Adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007;129:511-522.
-
(2007)
Cell
, vol.129
, pp. 511-522
-
-
Whalen, E.J.1
Foster, M.W.2
Matsumoto, A.3
Ozawa, K.4
Violin, J.D.5
Que, L.G.6
Nelson, C.D.7
Benhar, M.8
Keys, J.R.9
Rockman, H.A.10
Koch, W.J.11
Daaka, Y.12
Lefkowitz, R.J.13
Stamler, J.S.14
|