G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits

Molecular Biology of the Cell

Volumn 17, Issue 1, 2006, Pages 25-31

  Jiménez Sainz, M Carmen ^a   Murga, Cristina ^a   Kavelaars, Annemieke ^b   Jurado Pueyo, María ^a   Krakstad, Beate F ^c   Heijnen, Cobi J ^b   Mayor Jr , Federico ^a   Aragay, Anna M ^c  

^a CSIC   (Spain)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MUTANT PROTEIN; PROTEIN CCR2BIX; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CELLS, CULTURED; CHEMOKINE CCL2; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN SUBUNITS; SIGNAL TRANSDUCTION;

EID: 30044434455     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E05-05-0399     Document Type: Article

References (33)

1. Aragay, A. M., Mellado, M., Frade, J. M., Martin, A. M., Jiménez-Sainz, M. C., Martinez, A. C., and Mayor, F., Jr. (1998a). Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proc. Natl. Acad. Sci. USA 95, 2985-2990.
2. Aragay, A. M., Ruiz-Gomez, A., Penela, P., Sarnago, S., Elorza, A., Jiménez-Sainz, M. C., and Mayor, F., Jr. (1998b). G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions. FEBS Lett. 430, 37-40.
3. Ashida, N., Arai, H., Yamasaki, M., and Kita, T. (2001). Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxis. J. Biol. Chem. 276, 16555-16560.
4. Carman, C. V., Barak, L. S., Chen, C., Liu-Chen, L. Y., Onorato, J. J., Kennedy, S. P., Caron, M. G., and Benovic, J. L. (2000). Mutational analysis of Gβγ and phospholipid interaction with G protein-coupled receptor kinase 2. J. Biol. Chem. 275, 10443-10452.
5. Carman, C. V., Parent, J. L., Day, P. W., Pronin, A. N., Sternweis, P. M., Wedegaertner, P. B., Gilman, A. G., Benovic, J. L., and Kozasa, T. (1999). Selective regulation of Gα(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J. Biol. Chem. 274, 34483-34492.
6. De Blasi, A., Parruti, G., and Sallese, M. (1995). Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of β-adrenergic receptor kinase 1 and 2. J. Clin. Investig. 95, 203-210.
7. Franci, C., Gosling, J., Tsou, C. L., Coughlin, S. R., and Charo, I. F. (1996). Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J. Immunol. 157, 5606-5612.
8. Ge, L., Ly, Y., Hollenberg, M., and DeFea, K. (2003). A β-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J. Biol. Chem. 278, 34418-34426.
9. Gerard, C., and Rollins, B. J. (2001). Chemokines and disease. Nat. Immunol. 2, 108-115.
10. Gros, R., Benovic, J. L., Tan, C. M., and Feldman, R. D. (1997). G-protein-coupled receptor kinase activity is increased in hypertension. J. Clin. Investig. 99, 2087-2093.
11. Gros, R., Tan, C. M., Chorazyczewski, J., Kelvin, D. J., Benovic, J. L., and Feldman, R. D. (1999). G-protein-coupled receptor kinase expression in hypertension. Clin. Pharmacol. Ther. 65, 545-551.
12. Harigai, M., Hara, M., Yoshimura, T., Leonard, E. J., Inoue, K., and Kashiwazaki, S. (1993). Monocyte chemoattractant protein-1 (MCP-1) in inflammatory joint diseases and its involvement in the cytokine network of rheumatoid synovium. Clin. Immunol. Immunopathol. 69, 83-91.
13. Jaber, M., Koch, W. J., Rockman, H., Smith, B., Bond, R. A., Sulik, K. K., Ross, J., Jr., Lefkowitz, R. J., Caron, M. G., and Giros, B. (1996). Essential role of β-adrenergic receptor kinase 1 in cardiac development and function. Proc. Natl. Acad. Sci. USA 93, 12974-12979.
14. Jiménez-Sainz, M. C., Fast, B., Mayor, F., Jr., and Aragay, A. M. (2003). Signaling pathways for monocyte chemoattractant protein 1-mediated extracellular signal-regulated kinase activation. Mol. Pharmacol. 64, 773-782.
15. Kim, J., Ahn, S., Ren, X. R., Whalen, E. J., Reiter, E., Wei, H., and Lefkowitz, R. J. (2005). Functional antagonism of different C protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc. Natl. Acad. Sci. USA 102, 1442-1447.
16. Kong, G., Penn, R., and Benovic, J. L. (1994). A β-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the β2-adrenergic receptor. J. Biol. Chem. 269, 13084-13087.
17. Kranenburg, O., Verlaan, I., and Moolenaar, W. H. (1999). Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. J. Biol. Chem. 274, 35301-35304.
18. Kuziel, W. A., Morgan, S. J., Dawson, T. C., Griffin, S., Smithies, O., Ley, K., and Maeda, N. (1997). Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc. Natl. Acad. Sci. USA 94, 12053-12058.
19. Lodowski, D. T., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J., and Tesmer, J. J. (2003). Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gβγ. Science 300, 1256-1262.
20. Lombard!, M. S., Kavelaars, A., Schedlowski, M., Bijlsma, J. W., Okihara, K. L., Van de Pol, M., Ochsmann, S., Pawlak, C., Schmidt, R. E., and Heijnen, C. J. (1999). Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononucluar cells of patients with rheumatoid arthritis. FASEB J. 13, 715-725.
21. Luttrell, L. M., Ostrowski, J., Cotecchia, S., Kendall, H., and Lefkowitz, R. J. (1993). Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. Science 259, 1453-1457.
22. Murga, C., Ruiz-Gomez, A., Garcia-Higuera, I., Kim, C. M., Benovic, J. L., and Mayor, F., Jr. (1996). High affinity binding of β-adrenergic receptor kinase to microsomal membranes. Modulation of the activity of bound kinase by heterotrimeric G protein activation. J. Biol. Chem. 271, 985-994.
23. Oppermann, M., Mack, M., Proudfoot, A. E., and Olbrich, H. (1999). Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J. Biol. Chem. 274, 8875-8885.
24. Orsini, M. J., Parent, J. L., Mundell, S. J., Benovic, J. L., and Marchese, A. (1999). Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274, 31076-31086.
25. Penela, P., Ribas, C., and Mayor, F., Jr. (2003). Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15, 973-981.
26. Ren, X. R., Reiter, E., Ahn, S., Kim, J., Chen, W., and Lefkowitz, R. J. (2005). Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor. Proc. Natl. Acad. Sci. USA 102, 1448-1453.
27. Rossi, D., and Zlotnik, A. (2000). The biology of chemokines and their receptors. Annu. Rev. Immunol. 18, 217-242.
28. Sallese, M., Mariggio, S., D'Urbano, E., Iacovelli, L., and De Blasi, A. (2000). Selective regulation of Gq signaling by G protein-coupled receptor kinase 2, direct interaction of kinase N terminus with activated Gαq. Mol. Pharmacol. 57, 826-831.
29. Sterne-Marr, R., Tesmer, J. J., Day, P. W., Stracquatanio, R. P., Cilente, J. A., O'Connor, K. E., Pronin, A. N., Benovic, J. L., and Wedegaertner, P. B. (2003). G. protein-coupled receptor kinase 2/G αq/11 interaction. A novel surface on a regulator of G. protein signaling homology domain for binding Gα subunits. J. Biol. Chem. 278, 6050-6058.
30. Tilton, B., Ho, L., Oberlin, E., Loetscher, P., Baleux, F., Clark-Lewis, I., and Thelen, M. (2000). Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. J. Exp. Med. 192, 313-324.
31. Vroon, A., Heijnen, C. J., Lombardi, M. S., Cobelens, P. M., Mayor, F., Jr., Caron, M. G., and Kavelaars, A. (2004). Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. J. Leukoc. Biol. 75, 901-909.
32. Vroon, A., Kavelaars, A., Limmroth, V., Lombardi, M. S., Goebe, M. U., Van Dam, A. M., Caron, M. G., Schedlowski, M., and Heijnen, C. J. (2005). G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J. Immunol. 174, 4400-4406.
33. Willets, J. M., Challiss, R. A., and Nahorski, S. R. (2003). Non-visual GRKs: are we seeing the whole picture? Trends Pharmacol. Sci. 24, 626-633.