Paroxetine is a direct inhibitor of G protein-coupled receptor kinase 2 and increases myocardial contractility

ACS Chemical Biology

Volumn 7, Issue 11, 2012, Pages 1830-1839

  Thal, David M ^a   Homan, Kristoff T ^a   Chen, Jun ^b   Wu, Emily K ^a   Hinkle, Patricia M ^c   Huang, Z Maggie ^d   Chuprun, J Kurt ^d   Song, Jianliang ^d   Gao, Erhe ^d   Cheung, Joseph Y ^d   Sklar, Larry A ^b   Koch, Walter J ^d   Tesmer, John J G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; FLUOXETINE; G PROTEIN COUPLED RECEPTOR KINASE 2; ISOPRENALINE; PAROXETINE; PROTEIN SERINE THREONINE KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING SITE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HEART CONTRACTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

ANIMALS; CATALYTIC DOMAIN; CELLS, CULTURED; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEART; HUMANS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PAROXETINE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEROTONIN UPTAKE INHIBITORS; THYROTROPIN-RELEASING HORMONE;

MUS;

EID: 84869435029     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb3003013     Document Type: Article

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