Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 276, Issue 6 45-6, 1999, Pages

  Maurice, John P ^a   Shah, Ashish S ^a   Kypson, Alan P ^a   Hata, Jonathan A ^a   White, David C ^a   Glower, Donald D ^a   Koch, Walter J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

G protein signaling; Heart failure; Myocardial infarction; adrenergic receptor; adrenergic receptor desensitization; adrenergic receptor kinase

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CORONARY ARTERY CIRCUMFLEX BRANCH; ENZYME ACTIVITY; HEART FAILURE; HEART INFARCTION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

EID: 0033002089     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.276.6.h1853     Document Type: Article

References (27)

1. Akhter, S. A., C. A. Skaer, A. P. Kypson, P. H. McDonald, K. C. Peppel, D. D. Glower, R. J. Lefkowitz, and W. J. Koch. Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc. Natl. Acad. Sci. USA 94: 12000-12105, 1997.
2. Bristow, M. R. Changes in myocardial and vascular receptors in heart failure. J. Am. Coll. Cardiol. 22: 61A-71A, 1993.
3. Bristow, M. R., R. Ginsburg, W. Minobe, R. Cubicciotti, W. S. Sageman, K. Lurie, M. E. Billingham, D. C. Harrison, and E. B. Stinson. Decreased catecholamine sensitivity and β-adrenergic receptor density in failing human hearts. N. Engl. J. Med. 307: 205-211, 1982.
4. 2 adrenergic receptor mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol. Pharmacol. 35: 295-303, 1989.
5. 1 receptor messenger RNA abundance in the failing human heart. J. Clin. Invest. 92: 2737-2745, 1993.
6. Brodde, O. E. Beta-adrenoceptors in cardiac disease. Pharmacol. Ther. 60: 405-430, 1993.
7. Choi, D.-J., W. J. Koch, J. J. Hunter, and H. A. Rockman. Mechanism of β-adrenergic receptor desensitization in cardiac hypertrophy is increased β-adrenergic receptor kinase. J. Biol. Chem. 272: 17223-17229, 1997.
8. Drazner, M. H., K. C. Peppel, S. Dyer, A. O. Grant, W. J. Koch, and R. J. Lefkowitz. Potentiation of β-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. J. Clin. Invest. 99: 288-296, 1997.
9. Feldman, A. M., A. E. Cates, W. B. Veazey, R. E. Hershberger, M. R. Bristow, K. L. Baughman, W. A. Baumgartner, and C. Van Dop. Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J. Clin. Invest. 82: 189-197, 1988.
10. Hongo, M., R. Tsutomu, and J. Ross, Jr. Animal models of heart failure: recent developments and perspectives. Trends Cardiovasc. Med. 7: 161-167, 1997.
11. Iaccarino, G., E. D. Tomhave, R. J. Lefkowitz, and W. J. Koch. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade. Circulation 98: 1783-1789, 1998.
12. Inglese, J., N. J. Freedman, W. J. Koch, andR. J. Lefkowitz. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 268: 23735-23738, 1993.
13. Koch, W. J., J. Inglese, W. C. Stone, and R. J. Lefkowitz. The binding site for the βγ subunits of heterotrimeric G proteins on the βγ-adrenergic receptor kinase. J. Biol. Chem. 268: 8256-8260, 1993.
14. Koch, W. J., H. A. Rockman, P. Samama, R. A. Hamilton, R. A. Bond, C. A. Milano, and R. J. Lefkowitz. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a β-ARK inhibitor. Science 268: 1350-1353, 1995.
15. Mahaffey, K. W., T. E. Raya, G. D. Pennock, E. Morkin, and S. Goldman. Left ventricular performance and remodeling after myocardial infarction: effects of a thyroid hormone analogue. Circulation 91: 794-802, 1995.
16. Packer, M., M. R. Bristow, J. N. Cohn, W. S. Colucci, M. B. Fowler, E. M. Gilbert, and N. H. Shusterman. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N. Engl. J. Med. 334: 1349-1355, 1996.
17. Pennock, G. D., D. D. Yun, P. G. Agarwal, P. H. Spooner, and S. Goldman. Echocardiographic changes after myocardial infarction in a model of left ventricular diastolic dysfunction. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2018-H2029, 1997.
18. Peppel, K., W. J. Koch, and R. J. Lefkowitz. Gene transfer strategies for augmenting cardiac function. Trends in Cardiovasc. Med. 1: 145-150, 1997.
19. Ping, P., T. Anzai, M. Gao, and H. K. Hammond. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H707-H717, 1997.
20. Pitcher, J. A., J. Inglese, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. Role of βγ-subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science 257: 1264-1267, 1992.
21. Rockman, H. A., K. R. Chien, D.-J. Choi, G. Iaccarino, J. J. Hunter, J. Ross, Jr., R. J. Lefkowitz, and W. J. Koch. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of heart failure in gene targeted mice. Proc. Natl. Acad. Sci. USA 95: 7000-7005, 1998.
22. Rockman, H. A., D. J. Choi, N. U. Rahman, S. A. Akhter, R. J. Lefkowitz, and W. J. Koch. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc. Natl. Acad. Sci. USA 93: 9954-9959, 1996.
23. Sigurdsson, A., and K. Swedberg. The role of neurohormonal activation in chronic heart failure and postmyocardial infarction. Am. Heart J. 132: 229-234, 1996.
24. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N. Engl. J. Med. 325: 293-302, 1991.
25. 1-adrenergic receptors in the failing heart. Circulation 87: 454-463, 1993.
26. Ungerer, M., K. Kessebohm, K. Kronsbein, M. J. Lohse, and G. Richardt. Activation of β-adrenergic receptor kinase during myocardial ischemia. Circ. Res. 79: 455-460, 1996.
27. Williams, R. S. Boosting cardiac contractility with genes. N. Engl. J. Med. 332: 817-818, 1995.