메뉴 건너뛰기




Volumn 184, Issue 11, 2010, Pages 6188-6198

Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-κB signaling

Author keywords

[No Author keywords available]

Indexed keywords

DROSOMYCIN; G PROTEIN COUPLED RECEPTOR KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REGULATOR PROTEIN; SMALL INTERFERING RNA; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR KINASE 5; GPRK2 PROTEIN, DROSOPHILA;

EID: 77953423842     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000261     Document Type: Article
Times cited : (81)

References (49)
  • 1
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden, M. S., and S. Ghosh. 2004. Signaling to NF-kappaB. Genes Dev. 18: 2195-2224.
    • (2004) Genes Dev. , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 2
    • 34047268684 scopus 로고    scopus 로고
    • The host defense of Drosophila melanogaster
    • Lemaitre, B., and J. Hoffmann. 2007. The host defense of Drosophila melanogaster. Annu. Rev. Immunol. 25: 697-743.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 697-743
    • Lemaitre, B.1    Hoffmann, J.2
  • 3
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre, B., E. Nicolas, L. Michaut, J. M. Reichhart, and J. A. Hoffmann. 1996. The dorsoventral regulatory gene cassette spätzle/Toll/ cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 4
    • 0031446642 scopus 로고    scopus 로고
    • Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
    • Lemaitre, B., J. M. Reichhart, and J. A. Hoffmann. 1997. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc. Natl. Acad. Sci. U.S.A. 94: 14614-14619.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 14614-14619
    • Lemaitre, B.1    Reichhart, J.M.2    Hoffmann, J.A.3
  • 6
    • 0037061482 scopus 로고    scopus 로고
    • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
    • Rämet, M., P. Manfruelli, A. Pearson, B. Mathey-Prevot, and R. A. Ezekowitz. 2002. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 416: 644-648.
    • (2002) Nature , vol.416 , pp. 644-648
    • Rämet, M.1    Manfruelli, P.2    Pearson, A.3    Mathey-Prevot, B.4    Ezekowitz, R.A.5
  • 7
    • 0037066464 scopus 로고    scopus 로고
    • Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    • Choe, K. M., T. Werner, S. Stöven, D. Hultmark, and K. V. Anderson. 2002. Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 296: 359-362.
    • (2002) Science , vol.296 , pp. 359-362
    • Choe, K.M.1    Werner, T.2    Stöven, S.3    Hultmark, D.4    Anderson, K.V.5
  • 8
    • 0037061450 scopus 로고    scopus 로고
    • The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
    • DOI 10.1038/nature734
    • Gottar, M., V. Gobert, T. Michel, M. Belvin, G. Duyk, J. A. Hoffmann, D. Ferrandon, and J. Royet. 2002. The Drosophilaimmune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416: 640-644. (Pubitemid 34406765)
    • (2002) Nature , vol.416 , Issue.6881 , pp. 640-644
    • Gottar, M.1    Gobert, V.2    Michel, T.3    Belvin, M.4    Duyk, G.5    Hoffmann, J.A.6    Ferrandon, D.7    Royet, J.8
  • 10
    • 0035423794 scopus 로고    scopus 로고
    • Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
    • Vidal, S., R. S. Khush, F. Leulier, P. Tzou, M. Nakamura, and B. Lemaitre. 2001. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev. 15: 1900-1912.
    • (2001) Genes Dev. , vol.15 , pp. 1900-1912
    • Vidal, S.1    Khush, R.S.2    Leulier, F.3    Tzou, P.4    Nakamura, M.5    Lemaitre, B.6
  • 11
    • 0037172656 scopus 로고    scopus 로고
    • Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults
    • Leulier, F., S. Vidal, K. Saigo, R. Ueda, and B. Lemaitre. 2002. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Curr. Biol. 12: 996-1000.
    • (2002) Curr. Biol. , vol.12 , pp. 996-1000
    • Leulier, F.1    Vidal, S.2    Saigo, K.3    Ueda, R.4    Lemaitre, B.5
  • 13
    • 0034287444 scopus 로고    scopus 로고
    • A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity
    • Silverman, N., R. Zhou, S. Stöven, N. Pandey, D. Hultmark, and T. A. Maniatis. 2000. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev. 14: 2461-2471.
    • (2000) Genes Dev. , vol.14 , pp. 2461-2471
    • Silverman, N.1    Zhou, R.2    Stöven, S.3    Pandey, N.4    Hultmark, D.5    Maniatis, T.A.6
  • 14
    • 0034303480 scopus 로고    scopus 로고
    • Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage
    • Stöven, S., I. Ando, L. Kadalayil, Y. Engström, and D. Hultmark. 2000. Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage. EMBO Rep. 1: 347-352.
    • (2000) EMBO Rep. , vol.1 , pp. 347-352
    • Stöven, S.1    Ando, I.2    Kadalayil, L.3    Engström, Y.4    Hultmark, D.5
  • 16
    • 0034305744 scopus 로고    scopus 로고
    • The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
    • Leulier, F., A. Rodriguez, R. S. Khush, J. M. Abrams, and B. Lemaitre. 2000. The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep. 1: 353-358.
    • (2000) EMBO Rep. , vol.1 , pp. 353-358
    • Leulier, F.1    Rodriguez, A.2    Khush, R.S.3    Abrams, J.M.4    Lemaitre, B.5
  • 18
    • 27344453240 scopus 로고    scopus 로고
    • An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila
    • DOI 10.1038/sj.embor.7400530, PII 7400530
    • Gesellchen, V., D. Kuttenkeuler, M. Steckel, N. Pelte, and M. Boutros. 2005. An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila. EMBO Rep. 6: 979-984. (Pubitemid 41521955)
    • (2005) EMBO Reports , vol.6 , Issue.10 , pp. 979-984
    • Gesellchen, V.1    Kuttenkeuler, D.2    Steckel, M.3    Pelte, N.4    Boutros, M.5
  • 19
    • 33750330952 scopus 로고    scopus 로고
    • The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection
    • Leulier, F., N. Lhocine, B. Lemaitre, and P. Meier. 2006. The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol. Cell. Biol. 26: 7821-7831.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 7821-7831
    • Leulier, F.1    Lhocine, N.2    Lemaitre, B.3    Meier, P.4
  • 21
    • 0035856990 scopus 로고    scopus 로고
    • Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
    • DOI 10.1038/414756a
    • Michel, T., J. M. Reichhart, J. A. Hoffmann, and J. Royet. 2001. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414: 756-759. (Pubitemid 34000773)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 756-759
    • Michel, T.1    Relchhart, J.2    Hoffmann, J.A.3    Royet, J.4
  • 23
    • 0028922245 scopus 로고
    • Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line
    • Rosetto, M., Y. Engström, C. T. Baldari, J. L. Telford, and D. Hultmark. 1995. Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line. Biochem. Biophys. Res. Commun. 209: 111-116.
    • (1995) Biochem. Biophys. Res. Commun. , vol.209 , pp. 111-116
    • Rosetto, M.1    Engström, Y.2    Baldari, C.T.3    Telford, J.L.4    Hultmark, D.5
  • 24
    • 0035940499 scopus 로고    scopus 로고
    • Drosophila MyD88 is an adapter in the Toll signaling pathway
    • Horng, T., and R. Medzhitov. 2001. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 98: 12654-12658.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 12654-12658
    • Horng, T.1    Medzhitov, R.2
  • 25
    • 20044396975 scopus 로고    scopus 로고
    • Regulators of the Toll and Imd pathways in the Drosophila innate immune response
    • Tanji, T., and Y. T. Ip. 2005. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol. 26: 193-198.
    • (2005) Trends Immunol. , vol.26 , pp. 193-198
    • Tanji, T.1    Ip, Y.T.2
  • 26
    • 1942485935 scopus 로고    scopus 로고
    • Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila
    • Sorrentino, R. P., J. P. Melk, and S. Govind. 2004. Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila. Genetics 166: 1343-1356.
    • (2004) Genetics , vol.166 , pp. 1343-1356
    • Sorrentino, R.P.1    Melk, J.P.2    Govind, S.3
  • 28
    • 20444506693 scopus 로고    scopus 로고
    • Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells
    • DOI 10.1016/j.micinf.2005.03.014, PII S1286457905001024
    • Kallio, J., A. Leinonen, J. Ulvila, S. Valanne, R. A. Ezekowitz, and M. Rämet. 2005. Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells. Microbes Infect. 7: 811-819. (Pubitemid 40826646)
    • (2005) Microbes and Infection , vol.7 , Issue.5-6 , pp. 811-819
    • Kallio, J.1    Leinonen, A.2    Ulvila, J.3    Valanne, S.4    Ezekowitz, R.A.5    Ramet, M.6
  • 29
    • 0034641738 scopus 로고    scopus 로고
    • Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
    • Tauszig, S., E. Jouanguy, J. A. Hoffmann, and J. L. Imler. 2000. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 97: 10520-10525.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 10520-10525
    • Tauszig, S.1    Jouanguy, E.2    Hoffmann, J.A.3    Imler, J.L.4
  • 32
    • 0842307067 scopus 로고    scopus 로고
    • Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning
    • Sun, H., P. Towb, D. N. Chiem, B. A. Foster, and S. A. Wasserman. 2004. Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning. EMBO J. 23: 100-110.
    • (2004) EMBO J. , vol.23 , pp. 100-110
    • Sun, H.1    Towb, P.2    Chiem, D.N.3    Foster, B.A.4    Wasserman, S.A.5
  • 33
    • 10944238599 scopus 로고    scopus 로고
    • Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes
    • Sinenko, S. A., and B. Mathey-Prevot. 2004. Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. Oncogene 23: 9120-9128.
    • (2004) Oncogene , vol.23 , pp. 9120-9128
    • Sinenko, S.A.1    Mathey-Prevot, B.2
  • 35
    • 45549104911 scopus 로고    scopus 로고
    • Drosophila immunity: Methods for monitoring the activity of Toll and Imd signaling pathways
    • Romeo, Y., and B. Lemaitre. 2008. Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways. Methods Mol. Biol. 415: 379-394.
    • (2008) Methods Mol. Biol. , vol.415 , pp. 379-394
    • Romeo, Y.1    Lemaitre, B.2
  • 36
    • 34250221179 scopus 로고    scopus 로고
    • Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster
    • Tanji, T., X. Hu, A. N. Weber, and Y. T. Ip. 2007. Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster. Mol. Cell. Biol. 27: 4578-4588.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4578-4588
    • Tanji, T.1    Hu, X.2    Weber, A.N.3    Ip, Y.T.4
  • 37
    • 33744910636 scopus 로고    scopus 로고
    • Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells
    • Ulvila, J., M. Parikka, A. Kleino, R. Sormunen, R. A. Ezekowitz, C. Kocks, and M. Rämet. 2006. Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J. Biol. Chem. 281: 14370-14375.
    • (2006) J. Biol. Chem. , vol.281 , pp. 14370-14375
    • Ulvila, J.1    Parikka, M.2    Kleino, A.3    Sormunen, R.4    Ezekowitz, R.A.5    Kocks, C.6    Rämet, M.7
  • 39
    • 72449146904 scopus 로고    scopus 로고
    • G-protein-coupled-receptor kinases mediate TNFalpha-induced NF-kappaB signalling via direct interaction with and phosphorylation of IkappaBalpha
    • Patial, S., J. Luo, K. J. Porter, J. L. Benovic, and N. Parameswaran. 2009. G-protein-coupled-receptor kinases mediate TNFalpha-induced NF-kappaB signalling via direct interaction with and phosphorylation of IkappaBalpha. Biochem. J. 425: 169-178.
    • (2009) Biochem. J. , vol.425 , pp. 169-178
    • Patial, S.1    Luo, J.2    Porter, K.J.3    Benovic, J.L.4    Parameswaran, N.5
  • 40
    • 33845960758 scopus 로고    scopus 로고
    • Arrestin-2 and G protein-coupled receptor kinase 5 interactwith NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages
    • Parameswaran, N., C. S. Pao, K. S. Leonhard, D. S. Kang, M. Kratz, S. C. Ley, and J. L. Benovic. 2006. Arrestin-2 and G protein-coupled receptor kinase 5 interactwith NFkappaB1 p105 and negatively regulate lipopolysaccharide- stimulated ERK1/2 activation in macrophages. J. Biol. Chem. 281: 34159-34170.
    • (2006) J. Biol. Chem. , vol.281 , pp. 34159-34170
    • Parameswaran, N.1    Pao, C.S.2    Leonhard, K.S.3    Kang, D.S.4    Kratz, M.5    Ley, S.C.6    Benovic, J.L.7
  • 42
    • 12344333473 scopus 로고    scopus 로고
    • GATA factors in Drosophila heart and blood cell development
    • Sorrentino, R. P., K. M. Gajewski, and R. A. Schulz. 2005. GATA factors in Drosophila heart and blood cell development. Semin. Cell Dev. Biol. 16: 107-116.
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 107-116
    • Sorrentino, R.P.1    Gajewski, K.M.2    Schulz, R.A.3
  • 43
    • 0030668934 scopus 로고    scopus 로고
    • U-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila
    • Cubadda, Y., P. Heitzler, R. P. Ray, M. Bourouis, P. Ramain, W. Gelbart, P. Simpson, and M. Haenlin. 1997. u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. Genes Dev. 11: 3083-3095. (Pubitemid 27508517)
    • (1997) Genes and Development , vol.11 , Issue.22 , pp. 3083-3095
    • Cubadda, Y.1    Heitzler, P.2    Ray, R.P.3    Bourouis, M.4    Ramain, P.5    Gelbart, W.6    Simpson, P.7    Haenlin, M.8
  • 44
    • 0041828953 scopus 로고    scopus 로고
    • Transcription elongation factors repress transcription initiation from cryptic sites
    • Kaplan, C. D., L. Laprade, and F. Winston. 2003. Transcription elongation factors repress transcription initiation from cryptic sites. Science 301: 1096-1099.
    • (2003) Science , vol.301 , pp. 1096-1099
    • Kaplan, C.D.1    Laprade, L.2    Winston, F.3
  • 45
    • 0026093312 scopus 로고
    • Sequence and expression of a metabotropic glutamate receptor
    • Masu, M., Y. Tanabe, K. Tsuchida, R. Shigemoto, and S. Nakanishi. 1991. Sequence and expression of a metabotropic glutamate receptor. Nature 349: 760-765. (Pubitemid 21912156)
    • (1991) Nature , vol.349 , Issue.6312 , pp. 760-765
    • Masu, M.1    Tanabe, Y.2    Tsuchida, K.3    Shigemoto, R.4    Nakanishi, S.5
  • 47
    • 8644290071 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence
    • Johnson, L. R., M. G. Scott, and J. A. Pitcher. 2004. G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence. Mol. Cell. Biol. 24: 10169-10179.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 10169-10179
    • Johnson, L.R.1    Scott, M.G.2    Pitcher, J.A.3
  • 49
    • 34249950014 scopus 로고    scopus 로고
    • The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
    • Molnar, C., H. Holguin, F. Mayor, Jr., A. Ruiz-Gomez, and J. F. deCelis. 2007. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 104: 7963-7968.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 7963-7968
    • Molnar, C.1    Holguin, H.2    Mayor Jr., F.3    Ruiz-Gomez, A.4    DeCelis, J.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.