Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 303, Issue 1, 2012, Pages

  von Lueder, Thomas G ^a,b   Gravning, Jørgen ^a,b   How, Ole Jakob ^c   Vinge, Leif E ^a   Ahmed, Mohammed Shakil ^a   Krobert, Kurt A ^d   Levy, Finn Olav ^d   Larsen, Terje S ^c   Smiseth, Otto A ^b   Aasum, Ellen ^c   Attramadal, Håvard ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF TROMSØ   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Adrenergic receptor; Aortic banding; Heart failure; Hypertrophy

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BRAIN NATRIURETIC PEPTIDE; G PROTEIN COUPLED RECEPTOR KINASE 3; ISOENZYME; ISOPRENALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENZYME INHIBITION; HEART CATHETERIZATION; HEART FAILURE; HEART HYPERTROPHY; HEART LEFT VENTRICLE OVERLOAD; HEART MASSAGE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE ENDDIASTOLIC PRESSURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHAM PROCEDURE; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE; WALL STRESS;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOMEGALY; ENDOMYOCARDIAL FIBROSIS; G-PROTEIN-COUPLED RECEPTOR KINASE 3; HEART DISEASES; HEART FAILURE; HYPERTENSION; IMMUNOHISTOCHEMISTRY; ISOPROTERENOL; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MYOCARDIUM; MYOCYTES, CARDIAC; RNA, MESSENGER; VENTRICULAR FUNCTION, LEFT;

EID: 84863658667     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00724.2011     Document Type: Article

References (40)

1. Ahmed MS, Gravning J, Martinov VN, von Lueder TG, Edvardsen T, Czibik G, Moe IT, Vinge LE, Øie E, Valen G, Attramadal H. Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 300: H1291-H1302, 2011.
2. Anderson KM, Eckhart AD, Willette RN, Koch WJ. The myocardial β-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats. Hypertension 33: 402-407, 1999.
3. Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J 18: 1723-1729, 1999.
4. Brodde OE, Bruck H, Leineweber K. Cardiac adrenoceptors: physiological and pathophysiological relevance. J Pharmacol Sci 100: 323-337, 2006.
5. Byrne JA, Grieve DJ, Bendall JK, Li JM, Gove C, Lambeth JD, Cave AC, Shah AM. Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Circ Res 93: 802-805, 2003.
6. Choi DJ, Koch WJ, Hunter JJ, Rockman HA. Mechanism of β-adrenergic receptor desensitization in cardiac hypertrophy is increased β-adrenergic receptor kinase. J Biol Chem 272: 17223-17229, 1997.
7. Du XJ, Fang L, Gao XM, Kiriazis H, Feng X, Hotchkin E, Finch AM, Chaulet H, Graham RM. Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction. J Mol Cell Cardiol 37: 979-987, 2004.
8. 1A -adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival. Cardiovasc Res 71: 735-743, 2006.
9. Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ. Hybrid transgenic mice reveal in vivo specificity of G proteincoupled receptor kinases in the heart. Circ Res 86: 43-50, 2000.
10. Harding VB, Jones LR, Lefkowitz RJ, Koch WJ, Rockman HA. Cardiac β ARK1 inhibition prolongs survival and augments β-blocker therapy in a mouse model of severe heart failure. Proc Natl Acad Sci USA 98: 5809-5814, 2001.
11. Hata JA, Koch WJ. Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease. Mol Interv 3: 264-272, 2003.
12. How OJ, Aasum E, Kunnathu S, Severson DL, Myhre ES, Larsen TS. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. Am J Physiol Heart Circ Physiol 288: H2979-H2985, 2005.
13. 1A -adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation 115: 763-772, 2007.
14. Iaccarino G, Rockman HA, Shotwell KF, Tomhave ED, Koch WJ. Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. Am J Physiol Heart Circ Physiol 275: H1298-H1306, 1998.
15. Koch WJ, Inglese J, Stone WC, Lefkowitz RJ. The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. J Biol Chem 268: 8256-8260, 1993.
16. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a β ARK inhibitor. Science 268: 1350-1353, 1995.
17. Krobert KA, Bach T, Syversveen T, Kvingedal AM, Levy FO. The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution. Naunyn Schmiedebergs Arch Pharmacol 363: 620-632, 2001.
18. Li Z, Laugwitz KL, Pinkernell K, Pragst I, Baumgartner C, Hoffmann E, Rosport K, Munch G, Moretti A, Humrich J, Lohse MJ, Ungerer M. Effects of two G β γ-binding proteins-N-terminally truncated phosducin and β-adrenergic receptor kinase C terminus (β ARKct)-in heart failure. Gene Ther 10: 1354-1361, 2003.
19. 1A -adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy. Circ Res 89: 343-350, 2001.
20. Manning BS, Shotwell K, Mao L, Rockman HA, Koch WJ. Physiological induction of a β-adrenergic receptor kinase inhibitor transgene preserves β-adrenergic responsiveness in pressure-overload cardiac hypertrophy. Circulation 102: 2751-2757, 2000.
21. Maurice JP, Shah AS, Kypson AP, Hata JA, White DC, Glower DD, Koch WJ. Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction. Am J Physiol Heart Circ Physiol 276: H1853-H1860, 1999.
22. Naga Prasad SV, Barak LS, Rapacciuolo A, Caron MG, Rockman HA. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by β-adrenergic receptor kinase 1. A role in receptor sequestration. J Biol Chem 276: 18953-18959, 2001.
23. Naga Prasad SV, Esposito G, Mao L, Koch WJ, Rockman HA. G β γ-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. J Biol Chem 275: 4693-4698, 2000.
24. Nienaber JJ, Tachibana H, Naga Prasad SV, Esposito G, Wu D, Mao L, Rockman HA. Inhibition of receptor-localized PI3K preserves cardiac β-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest 112: 1067-1079, 2003.
25. Ping P, Anzai T, Gao M, Hammond HK. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol Heart Circ Physiol 273: H707-H717, 1997.
26. Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annu Rev Biochem 67: 653-692, 1998.
27. Pitcher JA, Inglese J, Higgins JB, Arriza JL, Casey PJ, Kim C, Benovic JL, Kwatra MM, Caron MG, Lefkowitz RJ. Role of β γ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science 257: 1264-1267, 1992.
28. Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, De-George BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res 103: 413-422, 2008.
29. Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J Jr, Lefkowitz RJ, Koch WJ. Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci USA 95: 7000-7005, 1998.
30. Rockman HA, Choi DJ, Akhter SA, Jaber M, Giros B, Lefkowitz RJ, Caron MG, Koch WJ. Control of myocardial contractile function by the level of β-adrenergic receptor kinase 1 in gene-targeted mice. J Biol Chem 273: 18180-18184, 1998.
31. Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 415: 206-212, 2002.
32. Shah AS, White DC, Emani S, Kypson AP, Lilly RE, Wilson K, Glower DD, Lefkowitz RJ, Koch WJ. In vivo ventricular gene delivery of a β-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 103: 1311-1316, 2001.
33. Tachibana H, Naga Prasad SV, Lefkowitz RJ, Koch WJ, Rockman HA. Level of β-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation 111: 591-597, 2005.
34. 1 -adrenergic receptors in the failing human heart. Circulation 87: 454-463, 1993.
35. Ungerer M, Parruti G, Bohm M, Puzicha M, DeBlasi A, Erdmann E, Lohse MJ. Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart. Circ Res 74: 206-213, 1994.
36. Vinge LE, Andressen KW, Attramadal T, Andersen GØ, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H. Substrate specificities of g protein-coupled receptor kinase-2 and-3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function. Mol Pharmacol 72: 582-591, 2007.
37. Vinge LE, Øie E, Andersson Y, Grøgaard HK, Andersen G, Attramadal H. Myocardial distribution and regulation of GRK and β-arrestin isoforms in congestive heart failure in rats. Am J Physiol Heart Circ Physiol 281: H2490-H2499, 2001.
38. 1 -adrenergic receptor responsiveness. J Biol Chem 283: 10601-10610, 2008.
39. Volkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, von Wegner F, Peppel K, Muller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P. The inotropic peptide β ARKct improves betaAR responsiveness in normal and failing cardiomyocytes through G β γ-mediated L-type calcium current disinhibition. Circ Res 108: 27-39, 2011.
40. White DC, Hata JA, Shah AS, Glower DD, Lefkowitz RJ, Koch WJ. Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proc Natl Acad Sci USA 97: 5428-5433, 2000.