Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A

Molecular Biology of the Cell

Volumn 18, Issue 8, 2007, Pages 2960-2969

  Jiang, Xiaoshan ^a   Benovic, Jeffrey L ^a   Wedegaertner, Philip B ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMOPALMITIC ACID; ALANINE; AMINO ACID; CYSTEINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 6A; LEPTOMYCIN B; LEUCINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMPHIPATHIC HELIX; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CYTOPLASM; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MEMBRANE BINDING; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; RECEPTOR DOWN REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; FATTY ACIDS, UNSATURATED; HUMANS; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PALMITATES; PALMITIC ACID; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; SUBCELLULAR FRACTIONS;

EID: 34547781132     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-01-0013     Document Type: Article

References (51)

1. Acconcia, F., Ascenzi, P., Bocedi, A., Spisni, E., Tomasi, V., Trentalance, A., Visca, P., and Marino, M. (2005). Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. Mol. Biol. Cell 16, 231-237.
2. Benovic, J. L., and Gomez, J. (1993). Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. J. Biol. Chem. 268, 19521-19527.
3. Bivona, T. G. et al. (2006). PKC regulates a farnesyl- electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol. Cell 21, 481-493.
4. Drenan, R. M., Doupnik, C. A., Boyle, M. P., Muglia, L. J., Huettner, J. E., Linder, M. E., and Blumer, K. J. (2005). Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J. Cell Biol. 169, 623-633.
5. Drenan, R. M., Doupnik, C. A., Jayaraman, M., Buchwalter, A. L., Kaltenbronn, K. M., Huettner, J. E., Linder, M. E., and Blumer, K. J. (2006). R7BP augments the function of RGS7/Gbeta 5 complexes by a plasma-membrane targeting mechanism. J. Biol. Chem. 281, 28222-28231.
6. Evanko, D. S., Thiyagarajan, M. M., and Wedegaertner, P. B. (2000). Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q). J. Biol. Chem. 275, 1327-1336.
7. Firsov, D., and Elalouf, J. M. (1997). Molecular cloning of two rat GRK6 splice variants. Am J. Physiol. 273, C953-C961.
8. Gobeil, F., Fortier, A., Zhu, T., Bossolasco, M., Leduc, M., Grandbois, M., Heveker, N., Bkaily, G., Chemtob, S., and Barbaz, D. (2006). G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm. Can J. Physiol. Pharmacol. 84, 287-297.
9. Grabocka, E., and Wedegaertner, P. B. (2005). Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. Oncogene 24, 2155-2165.
10. Hall, R. A., Spurney, R. F., Premont, R. T., Rahman, N., Blitzer, J. T., Pitcher, J. A., and Lefkowitz, R. J. (1999). G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. J. Biol. Chem. 274, 24328-24334.
11. ras to the plasma membrane. Cell 63, 133-139.
12. Heo, W. D., Inoue, T., Park, W. S., Kim, M. L., Park, B. O., Wandless, T. J., and Meyer, T. (2006). PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314, 1458-1461.
13. Johnson, L. R., Scott, M. G., and Pitcher, J. A. (2004). G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence. Mol. Cell. Biol. 24, 10169-10179.
14. Kang, J. et al. (2005). A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123, 833-847.
15. Kino, T., Tiulpakov, A., Ichijo, T., Chheng, L., Kozasa, T., and Chrousos, G. P. (2005). G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. J. Cell Biol. 169, 885-896.
16. Kunapuli, P., and Benovic, J. L. (1993). Cloning and expression of GRK 5, a member of the G protein-coupled receptor kinase family. Proc. Natl. Acad Sci. USA 90, 5588-5592.
17. Kunapuli, P., Gurevich, V. V., and Benovic, J. L. (1994). Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5. J. Biol. Chem. 269, 10209-10212.
18. Li, L., Haynes, M. P., and Bender, J. R. (2003). Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc. Natl. Acad Sci. USA 100, 4807-4812.
19. Lodowski, D. T., Tesmer, V. M., Benovic, J. L., and Tesmer, J. J. (2006). The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. J. Biol. Chem. 281, 16785-16793.
20. Loudon, R. P., and Benovic, J. L. (1997). Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. J. Biol. Chem. 272, 27422-27427.
21. McLaughlin, S., and Aderem, A. (1995). The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. Trends Biochem. Sci. 20, 272-280.
22. Moepps, B., Vatter, P., Frodl, R., Waechter, F., Dixkens, C., Hameister, H., and Gierschik, P. (1999). Alternative splicing produces transcripts encoding four variants of mouse G-protein-coupled receptor kinase 6. Genomics 60, 199-209.
23. Neuhaus, E. M., Mashukova, A., Barbour, J., Wolters, D., and Halt, H. (2006). Novel function of β-arrestin2 in the nucleus of mature spermatozoa. J. Cell Sci. 119, 3047-3056.
24. Peitzsch, R. M., and McLaughlin, S. (1993). Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteins. Biochemistry 32, 10436-10443.
25. Penela, P., Ribas, C., and Mayor, F., Jr. (2003). Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal. 15, 973-981.
26. Penn, R. B., Pronin, A. N., and Benovic, J. L. (2000). Regulation of G protein-coupled receptor kinases. Trends Cardiovasc. Med. 10, 81-89.
27. Premont, R. T., Macrae, A. D., Aparicio, S. A., Kendall, H. E., Welch, J. E., and Lefkowitz, R. J. (1999). The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. J. Biol. Chem. 274, 29381-29389.
28. Premont, R. T., Macrae, A. D., Stoffel, R. H., Chung, N., Pitcher, J. A., Ambrose, C., Inglese, J., MacDonald, M. E., and Lefkowitz, R. J. (1996). Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. J. Biol. Chem. 271, 6403-6410.
29. Pronin, A. N., Carman, C. V., and Benovic, J. L. (1998). Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation. J. Biol. Chem. 273, 31510-31518.
30. Pronin, A. N., Morris, A. J., Surguchov, A., and Benovic, J. L. (2000). Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 275, 26515-26522.
31. Rai, D., Frolova, A., Frasor, J., Carpenter, A. E., and Katzenellenbogen, B. S. (2005). Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells. Mol. Endocrinol. 19, 1606-1617.
32. Reiter, E., and Lefkowitz, R. J. (2006). GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol. Metab. 17, 159-165.
33. Rotblat, B., Prior, I. A., Muncke, C., Parton, R. G., Kloog, Y., Henis, Y. I., and Hancock, J. F. (2004). Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol. Cell. Biol. 24, 6799-6810.
34. Scott, M. G., Le Rouzic, E., Perianin, A., Pierotti, V., Enslen, H., Benichou, S., Marullo, S., and Benmerah, A. (2002). Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2. J. Biol. Chem. 277, 37693-37701.
35. Silvius, J. R., and l'Heureux, F. (1994). Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers. Biochemistry 33, 3014-3022.
36. Smith, N. J., and Luttrell, L. M. (2006). Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease. Hypertension 48, 173-179.
37. Smotrys, J. E., and Linder, M. E. (2004). Palmitoylation of intracellular signaling proteins: regulation and function. Annu. Rev. Biochem. 73, 559-587.
38. Song, J. H., Waataja, J. J., and Martemyanov, K. A. (2006). Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. J. Biol. Chem. 281, 15361-15369.
39. Stoffel, R. H., Inglese, J., Macrae, A. D., Lefkowitz, R. J., and Premont, R. T. (1998). Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. Biochemistry 37, 16053-16059.
40. Stoffel, R. H., Randall, R. R., Premont, R. T., Lefkowitz, R. J., and Inglese, J. (1994). Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. J. Biol. Chem. 269, 27791-27794.
41. Takida, S., Fischer, C. C., and Wedegaertner, P. B. (2005). Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Mol. Pharmacol. 67, 132-139.
42. Takida, S., and Wedegaertner, P. B. (2003). Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbeta gamma. J. Biol. Chem. 278, 17284-17290.
43. Thiyagarajan, M. M., Stracquatanio, R. P., Pronin, A. N., Evanko, D. S., Benovic, J. L., and Wedegaertner, P. B. (2004). A predicted amphipathic helix mediates plasma membrane localization of GRK5. J. Biol. Chem. 279, 17989-17995.
44. Vatter, P., Stoesser, C., Samel, I., Gierschik, P., and Moepps, B. (2005). The variable C-terminal extension of G-protein-coupled receptor kinase 6 constitutes an accessorial autoregulatory domain. FEBS J. 272, 6039-6051.
45. Wang, P., Wu, Y., Ge, X., Ma, L., and Pei, G. (2003). Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus. J. Biol. Chem. 278, 11648-11653.
46. Webb, Y., Hermida-Matsumoto, L., and Resh, M. D. (2000). Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J. Biol. Chem. 275, 261-270.
47. Wedegaertner, P. B., and Bourne, H. R. (1994). Activation and depalmitoylation of Gs alpha. Cell 77, 1063-1070.
48. Wiedmer, T., Zhao, J., Nanjundan, M., and Sims, P. J. (2003). Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane. Biochemistry 42, 1227-1233.
49. Willard, F. S., and Crouch, M. F. (2000). Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins. Immunol. Cell Biol. 78, 387-394.
50. Yi, X. P., Gerdes, A. M., and Li, F. (2002). Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats. Hypertension 39, 1058-1063.
51. Yi, X. P., Zhou, J., Baker, J., Wang, X., Gerdes, A. M., and Li, F. (2005). Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure. Anat. Rec. A Discov. Mol. Cell Evol. Biol. 282, 13-23.