Structural biology: Snapshot of activated G proteins at the membrane: The Gαq-GRK2-Gβγ complex

Science

Volumn 310, Issue 5754, 2005, Pages 1686-1690

  Tesmer, Valerie M ^a,b   Kawano, Takeharu ^c   Shankaranarayanan, Aruna ^a,b   Kozasa, Tohru ^c   Tesmer, John J G ^a,b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOLOGICAL MEMBRANES; ENZYMES;

ATOMIC STRUCTURES; DESENSITIZATION;

PROTEINS;

G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA GAMMA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; RGS PROTEIN; RGS4 PROTEIN; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR KINASE; G PROTEIN BETA GAMMA; G-PROTEIN BETA GAMMA; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; PROTEIN SUBUNIT;

PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; DISSOCIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CATTLE; CRYSTALLOGRAPHY, X-RAY; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 28844463975     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1118890     Document Type: Article

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56. q. This work was supported by NIH grant HL071818, American Heart Association Scientist Development grant 0235273N and an American Cancer Society Research Scholar grant to J.J.G.T., and NIH grants GM61454 and NS41441 to T. Kozasa. T. Kawano gratefully acknowledges support from Y. Nakajima (NIH AG006093). The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences, and Materials Sciences Division, of the U.S. Department of Energy under contract no. DE-AC03-76SF00098 at Lawrence Berkeley National Laboratory. Coordinates and diffraction data for the structure reported in this paper have been deposited in the Protein Data Bank as the entry 2BCJ.