RGS4 reduces contractile dysfunction and hypertrophic gene induction in Gαq overexpressing mice

Journal of Molecular and Cellular Cardiology

Volumn 33, Issue 2, 2001, Pages 209-218

  Rogers, Jason H ^a   Tsirka, Anna ^a   Kovacs, Attila ^a   Blumer, Kendall J ^a   Dorn II, Gerald W ^b   Muslin, Anthony J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiac hypertrophy; G protein; RGS; Signal transduction; Transgenic mice

Indexed keywords

ATRIAL NATRIURETIC FACTOR; GUANOSINE TRIPHOSPHATASE; PROTEIN KINASE C; RGS PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE INDUCTION; GENE OVEREXPRESSION; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0034967283     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1307     Document Type: Article

References (41)

1. The cellular and molecular response of cardiac myocytes to mechanical stress
2. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
3. Hypertension, left ventricular hypertrophy, ventricular ectopy, and sudden death
4. Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive physiologic response
5. Proto-oncogene induction and reprogramming of cardiac gene expression produced by pressure overload
6. The power athlete
7. The athlete's heart: Is big beautiful?
8. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
9. Functional coupling between endothelin receptors and multiple G-proteins in rat heart myocytes
10. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes
11. Functional coupling between endothelin receptors and multiple G-proteins in rat heart myocytes
12. Myocyte hypertrophy in neonatal rat cultures and its regulation by serum and by catecholamines
13. Acquisition by innervated cardiac myocytes of a pertussis toxin-specific regulatory protein linked to the alpha 1-receptor
14. Prostaglandin F2 alpha stimulates hypertrophic growth of cultured neonatal rat ventricular myocytes
15. Tyrosine kinase and c-Jun NH2-terminal kinase mediate hypertrophic responses to prostaglandin F2alpha in cultured neonatal rat ventricular myocytes
16. Heterotrimeric G proteins
17. αrq overexpression induces cardiac contractile failure in mice
18. Enhanced Galphaq signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure
19. Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction
20. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice
21. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
22. Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse
23. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload
24. Inhibition of a G protein-mediated MAP kinase activation by a new mammalian gene family
25. 1α1: Stabilization of the transition state for GTP hydrolysis
26. Interaction of human retinal RGS with G-protein alpha-subunits
27. GAIP and RGS4 are GTPase-activating proteins for the Gi sub-family of G protein α subunits
28. RGS family members: GTPase activating proteins for α subunits of heterotrimeric G proteins
29. Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells
30. Mouse phospholamban gene expression during development in vivo and in vitro
31. Protein kinase C. Seeing two domains
32. Localization of protein kinases by anchoring proteins: A theme in signal transduction
33. RGS4 inhibits G protein signaling in cardiomyocytes
34. The energy substrate switch during development of heart failure: Gene regulatory mechanisms
35. Signaling pathways for cardiac hypertrophy and failure
36. Gq signaling in cardiac adaptation and maladaptation
37. RGS3 and RGS4 are G protein inhibitors in the heart
38. Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways
39. Crosstalk between Galpha(i)-and Galpha(q)-coupled receptors is mediated by Gbetagamma exchange
40. New roles for G-protein beta gamma-dimers in transmembrane signalling
41. G protein selectivity is a determinant of RGS2 function