A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling

PLoS Pathogens

Volumn 11, Issue 9, 2015, Pages

  Hu, Minmin ^a   Wang, Cong ^b   Li, Wan ^a   Lu, Weiping ^a   Bai, Zhiqiang ^a   Qin, Di ^a   Yan, Qin ^a   Zhu, Jianzhong ^c   Krueger, Brian J ^d   Renne, Rolf ^d   Gao, Shou Jiang ^e   Lu, Chun ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; G PROTEIN COUPLED RECEPTOR KINASE 2; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MICRORNA; MICRORNA K3; PROTEIN KINASE B; STROMELYSIN 2; UNCLASSIFIED DRUG; ADRBK1 PROTEIN, HUMAN; AKT1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; RNA; RNA, RECOMBINANT; VIRUS RNA;

ARTICLE; CELL INVASION; CELL MIGRATION; CELL MIGRATION ASSAY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LUCIFERASE ASSAY; METASTASIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; AGONISTS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL MOTION; CHEMISTRY; ENZYME REPRESSION; GENE DELETION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; KAPOSI SARCOMA; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE; TUMOR INVASION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; VIROLOGY; VIRUS ENTRY;

CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME REPRESSION; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GENE DELETION; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICRORNAS; MUTATION; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-8B; RECOMBINANT PROTEINS; RNA; RNA INTERFERENCE; RNA, VIRAL; SARCOMA, KAPOSI; SIGNAL TRANSDUCTION; VIRUS INTERNALIZATION;

EID: 84943533620     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005171     Document Type: Article

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