Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting

Circulation Research

Volumn 112, Issue 8, 2013, Pages 1121-1134

  Chen, Mai ^a   Sato, Priscila Y ^b   Chuprun, J Kurt ^b   Peroutka, Raymond J ^b   Otis, Nicholas J ^b   Ibetti, Jessica ^b   Pan, Shi ^c   Sheu, Shey Shing ^c   Gao, Erhe ^b   Koch, Walter J ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

G protein coupled receptor kinase 2; heat shock protein 90; mitochondria; myocyte apoptosis; necrosis; oxidative stress

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 2; HEAT SHOCK PROTEIN 90; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART STRESS; HUMAN; HUMAN CELL; IN VIVO CULTURE; MITOCHONDRIAL TARGETING SIGNAL; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; CATTLE; CELLS, CULTURED; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEK293 CELLS; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS; SIGNAL TRANSDUCTION;

EID: 84876413668     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.300754     Document Type: Article

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