Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases

Molecular Pharmacology

Volumn 57, Issue 4, 2000, Pages 778-783

  Elorza, Ana ^a   Sarnago, Susana ^a   Mayor Jr , Federico ^a,b  

^a CSIC   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 0034111097     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.57.4.778     Document Type: Article

References (31)

1. Ahn S, Maudsley S, Luttrell LM, Lefkowitz RJ and Daaka Y (1999) Src-mediated tyrosine phosphorylation of dynamin is required for β2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem 274:1185-1188.
2. Aragay AM, Ruiz-Gómez A, Penela P, Sarnago S, Elorza A, Jimenez-Sainz MC and Mayor F Jr (1998) G protein-coupled receptor kinase 2 (GRK2): Mechanisms of regulation and physiological functions. FEBS Lett 430:37-40
3. Carman CV and Benovic JL (1998) G-protein-coupled receptors: Turn-ons and turn-offs. Curr Opin Cell Biol 8:335-344.
4. Catling AD, Schaeffer HJ, Reuter CWM, Reddy GR and Weber MJ (1995) A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. Mol Cell Biol 15:5214-5225.
5. Choi D-J, Walter JK, Hunter JJ and Rockman HA (1997) Mechanism of β-adrenergic receptor desensitization in cardiac hypertrophy is increased β-adrenergic receptor kinase. J Biol Chem 272:17223-17229.
6. Chuang TT, LeVine H 3rd and De Blasi A (1995) Phosphorylation and activation of beta-adrenergic receptor kinase by protein kinase C. J Biol Chem 270:18660-18665.
7. Cowley S, Paterson H, Kemp P and Marshall CJ (1994) Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
8. Daaka Y, Luttrell LM, Ahn S, Della Rocca GJ, Ferguson SSG, Caron MG and Lefkowitz RJ (1998) Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem 273:685-688
9. Daaka Y, Pitcher JA, Richardson M, Stoffel RH, Robishaw JD and Lefkowitz RJ (1997) Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. Proc Natl Acad Sci USA 94:2180-2185.
10. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyck DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA and Trzaskos JM (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632.
11. Foschi M, Chari S, Duna MJ and Sorokin A (1997) Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J 21:6439-6451.
12. Gutkind JS (1998) The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 273:1839-1842.
13. Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, Sulik KK, Ross J jr, Lefkowitz RJ, Caron MG and Giros B (1996) Essential role of β-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci USA 93:12974-12979.
14. Koch WJ, Inglese J, Stone WC and Lefkowitz RJ (1993) The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. J Biol Chem 268:8256-8260.
15. Krupnick JG and Benovic JL (1998) The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 38:289-319.
16. Lefkowitz RJ (1998) G protein-coupled receptors. J Biol Chem 273:18677-18680.
17. Lin F-T, Miller WE, Luttrell LM and Lefkowitz J (1999) Feedback regulation of β-arrestin1 function by extracellular signal-regulated kinases. J Biol Chem 274: 15971-15974.
18. Luttrell LM, Daaka Y, Della Rocca GJ and Lefkowitz RJ (1997) G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. J Biol Chem 272:31648-31656.
19. Luttrell LM, Daaka Y and Lefkowitz RJ (1999a) Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 11:177-183.
20. Luttrell LM, Ferguson SSG, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F-T, Kawakatsu H, Owada K, Luttrell DK, Caron MG and Lefkowitz RJ (1999b) β-arrestin-dependent formation of 2Adrenergic receptor-src protein kinase complexes. Science 283:655-661.
21. Mayor F Jr, Penela P and Ruiz-Gómez A (1998) Role of G protein-coupled receptor kinase 2 and arrestins in β-adrenergic receptor internalization. Trends Cardiovasc Med 8:234-240.
22. Murga C, Ruiz-Gómez A, García-Higuera I, Kim CM, Benovic JL and Mayor F Jr (1996) High affinity finding of β-adrenergic receptor kinase to microsomal membranes. J Biol Chem 271:985-994.
23. Penela P, Ruiz-Gómez A, Castaño JG and Mayor F Jr (1998) Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway. J Biol Chem 273: 35238-35244
24. Pitcher JA, Freedman NJ and Lefkowitz RJ (1998) G protein-coupled receptor kinases. Annu Rev Biochem 67:653-692.
25. Pitcher JA, Tesmer JJG, Freeman JLR, Capel WD, Stone WC and Lefkowitz RJ (1999) Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem 274:34531-34534.
26. Porfiri E and McCormick F (1996) Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1. J Biol Chem 271:5871-5877.
27. Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J Jr, Lefkowitz RJ and Koch WJ (1998) Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci USA 12:7000-7005.
28. Ruiz-Gómez A and Mayor F Jr (1997) β-adrenergic receptor kinase (GRK2) colocalizes with β-adrenergic receptors during agonist-induced receptor internalization. J Biol Chem 272:9601-9604.
29. Sarnago S, Elorza A and Mayor F Jr (1999) Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by src tyrosine kinase. J Biol Chem 274:34411-34416.
30. Ungerer M, Bohm M, Elce JS, Erdmann E and Lohse MJ (1993) Alttered expression of β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart. Circulation 87:454-463.
31. Winstel R, Freund S, Krasel C, Hoppe E and Lohse MJ (1996) Protein kinase cross-talk: Membrane targeting of the β-adrenergic receptor kinase by protein kinase C. Proc Natl Acad Sci USA 93:2105-2109.