G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance

Archives of Physiology and Biochemistry

Volumn 117, Issue 3, 2011, Pages 125-130

  Mayor Jr , Federico ^a,b   Lucas, Elisa ^a,b   Jurado Pueyo, María ^a,b   Garcia Guerra, Lucia ^c   Nieto Vazquez, Iria ^d,f   Vila Bedmar, Rocio ^a,b   Fernández Veledo, Sonia ^e,f   Murga, Cristina ^a,b  

^a CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^b Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas   (Spain)

^c INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

arrestin; diabetes; G protein coupled receptors; obesity

Indexed keywords

EID: 79959199413     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.3109/13813455.2011.584693     Document Type: Conference Paper

References (47)

1. Anis Y, Leshem O, Reuveni H, Wexler I, Ben Sasson R, Yahalom B, Laster M, Raz I, Ben Sasson S, Shafrir E, Ziv E. (2004). Antidiabetic efect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes. Diabetologia 47:1232-44. (Pubitemid 39093319)
2. Biddinger SB, Kahn CR. (2006). From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 68:123-58.
3. Boura-Halfon S, Zick Y. (2009). Serine kinases of insulin receptor substrate proteins. Vitam Horm 80:313-49.
4. Cipolletta E, Campanile A, Santulli G, Sanzari E, Leosco D, Campiglia P, Trimarco B, Iaccarino G. (2009). Te G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance. Cardiovasc Res 84:407-15.
5. Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM. (2002). Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1. Mol Cell Biol 22:6272-85. (Pubitemid 34857845)
6. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. (2007). Beta-arrestins and cell signaling. Annu Rev Physiol 69:483-510.
7. Dorn 2nd GW. (2009). GRK mythology: G-protein receptor kinases in cardiovascular disease. J Mol Med 87:455-63.
8. Eijkelkamp N, Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, et al. (2010). GRK2: a novel cell-specifc regulator of severity and duration of infammatory pain. J Neurosci 30:2138-49.
9. Fernandez-Veledo S, Nieto-Vazquez I, de Castro J, Ramos MP, Bruderlein S, Moller P, Lorenzo M. (2008). Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: paracrine interaction with myocytes. J Clin Endocrinol Metab 93:2866-76. (Pubitemid 352008563)
10. Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Jurado-Pueyo M, Zalba G, Diez J, Murga C, Fernandez-Veledo S, Mayor Jr F, Lorenzo M. (2010). G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. Diabetes 59:2407-17.
11. Guilherme A, Virbasius JV Puri V, Czech MP. (2008). Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9:367-77. (Pubitemid 351574198)
12. Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y James DE. (2008). IRS1-independent defects defne major nodes of insulin resistance. Cell Metab 7:421-33. (Pubitemid 351598028)
13. Hupfeld CJ, Dalle S, Olefsky JM. (2003). Beta-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 100:161-6. (Pubitemid 36078045)
14. Hupfeld CJ, Olefsky JM. (2007). Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol 69:561-77. (Pubitemid 46457655)
15. Iaccarino G, Barbato E, Cipolletta E, De Amicis V Margulies KB, Leosco D, Trimarco B, Koch WJ. (2005). Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J 26:1752-8. (Pubitemid 41219848)
16. Imamura T, Vollenweider P, Egawa K, Clodi M, Ishibashi K, Nakashima N, Ugi S, Adams JW, Brown JH, Olefsky JM. (1999). G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes. Mol Cell Biol 19:6765-74. (Pubitemid 29441860)
17. Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, Sulik KK, Ross J, Jr., Lefkowitz RJ, Caron MG, Giros B. (1996). Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci USA 93:12974-9. (Pubitemid 26382754)
18. Jimenez-Sainz MC, Murga C, Kavelaars A, Jurado-Pueyo M, Krakstad BF, Heijnen CJ, Mayor F, Jr., Aragay AM. (2006). G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol Biol Cell 17:25-31. (Pubitemid 43049458)
19. Kanzaki M, Watson RT, Artemyev NO, Pessin JE. (2000). Te trimeric GTP-binding protein (G(q)/G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes. J Biol Chem 275:7167-75. (Pubitemid 30146266)
20. Kleibeuker W, Jurado-Pueyo M, Murga C, Eijkelkamp N, Mayor F, Jr., Heijnen CJ, Kavelaars A. (2008). Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium. J Neurochem 104:979-92. (Pubitemid 351143638)
21. Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ. (2009). Arrestin development:emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell 17:443-58.
22. Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC (2005). A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 11:952-8. (Pubitemid 41294440)
23. Luan B, Zhao J, Wu H, Duan B, Shu G, Wang X, Li D, Jia W, Kang J, Pei G. (2009). Defciency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 457:1146-9.
24. Luttrell LM, Gesty-Palmer D. (2010). Beyond desensitization:physiological relevance of arrestin-dependent signaling. Pharmacol Rev 62:305-30.
25. Mariggio S, Garcia-Hoz C, Sarnago S, De Blasi A, Mayor F, Jr., Ribas C. (2006). Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-Src modulates its interaction with Galphaq. Cell Signal 18:2004-12. (Pubitemid 44508723)
26. Molnar C, Holguin H, Mayor F, Jr., Ruiz-Gomez A, de Celis JF. (2007). Te G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci USA 104:7963-8. (Pubitemid 47185859)
27. Nieto-Vazquez I, Fernandez-Veledo S, de Alvaro C, Rondinone CM, Valverde AM, Lorenzo M. (2007). Protein-tyrosine phosphatase 1B-defcient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance. Diabetes 56:404-13.
28. Nieto-Vazquez I, Fernandez-Veledo S, de Alvaro C, Lorenzo M. (2008). Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes 57:3211-21.
29. Penela P, Ribas C, Mayor Jr F. (2003). Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15:973-81. (Pubitemid 37130155)
30. Penela P, Murga C, Ribas C, Tutor AS, Peregrin S, Mayor Jr F. (2006). Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc Res 69:46-56. (Pubitemid 41814810)
31. Penela P, Murga C, Ribas C, Salcedo A, Jurado-Pueyo M, Rivas V Aymerich I, Mayor Jr F. (2008a). G protein-coupled receptor kinase 2 (GRK2) in migration and infammation. Arch Physiol Biochem 114:195-200. (Pubitemid 352009301)
32. Penela P, Ribas C, Aymerich I, Eijkelkamp N, Barreiro O, Heijnen CJ, Kavelaars A, Sanchez-Madrid F, Mayor Jr F. (2008b). G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. Embo J 27:1206-18. (Pubitemid 351574750)
33. Penela P, Murga C, Ribas C, Lafarga V, Mayor Jr F. (2010a). Te complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. Br J Pharmacol 160:821-32.
34. Penela P, Rivas V Salcedo A, Mayor Jr F. (2010b). G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression. Proc Natl Acad Sci USA 107:1118-23.
35. Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V Ruiz-Gomez A, Crespo P, Mayor Jr F, Murga C. (2006). Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol 16:2042-7. (Pubitemid 44604449)
36. Premont RT, Gainetdinov RR. (2007). Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 69:511-34. (Pubitemid 46457653)
37. Ramos-Ruiz R, Penela P, Penn RB, Mayor Jr F. (2000). Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells. Circulation 101:2083-9. (Pubitemid 30233173)
38. Ribas C, Penela P, Murga C, Salcedo A, Garcia-Hoz C, Jurado-Pueyo M, Aymerich I, Mayor Jr F. (2007). Te G protein-coupled receptor kinase (GRK) interactome:role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta 1768:913-22. (Pubitemid 46452540)
39. Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. (2008). A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322:1539-43.
40. Salcedo A, Mayor Jr F, Penela P. (2006). Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. Embo J 25:4752-62. (Pubitemid 44607021)
41. Sarnago S, Elorza A, Mayor Jr F. (1999). Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase. J Biol Chem 274:34411-16. (Pubitemid 129511786)
42. Shahid G, Hussain T. (2007). GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells. J Biol Chem 282:20612-20. (Pubitemid 47100045)
43. Trivedi M, Lokhandwala MF. (2005). Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Am J Physiol Renal Physiol 289:F298-304 (Pubitemid 41003659)
44. Usui I, Imamura T, Huang J, Satoh H, Olefsky JM. (2003). Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes. J Biol Chem 278:13765-74. (Pubitemid 36799913)
45. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, Olefsky JM. (2004). GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. Embo J 23:2821-9. (Pubitemid 39013554)
46. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, Olefsky JM. (2005). G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol Endocrinol 19:2760-68. (Pubitemid 41577248)
47. Vroon A, Heijnen CJ, Kavelaars A. (2006). GRKs and arrestins: regulators of migration and infammation. J Leukoc Biol 80:1214-21. (Pubitemid 44904958)