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Volumn 1307, Issue , 2010, Pages 134-141

G protein-coupled receptor kinase 5, overexpressed in the α-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression

Author keywords

Synuclein; Bcl 2; Gene regulation; GRK5; Histone deacetylase

Indexed keywords

ALPHA SYNUCLEIN; G PROTEIN COUPLED RECEPTOR KINASE 5; HISTONE DEACETYLASE; PROTEIN BCL 2; SERINE; SHORT HAIRPIN RNA;

EID: 70949099222     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.10.036     Document Type: Article
Times cited : (29)

References (37)
  • 3
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba M., Nakajo S., Tu P.H., Tomita T., Nakaya K., Lee V.M., Trojanowski J.Q., and Iwatsubo T. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152 (1998) 879-884
    • (1998) Am. J. Pathol. , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3    Tomita, T.4    Nakaya, K.5    Lee, V.M.6    Trojanowski, J.Q.7    Iwatsubo, T.8
  • 4
    • 38949138075 scopus 로고    scopus 로고
    • Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia
    • Bychkov E.R., Gurevich V.V., Joyce J.N., Benovic J.L., and Gurevich E.V. Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia. Neurobiol. Aging 29 (2008) 379-396
    • (2008) Neurobiol. Aging , vol.29 , pp. 379-396
    • Bychkov, E.R.1    Gurevich, V.V.2    Joyce, J.N.3    Benovic, J.L.4    Gurevich, E.V.5
  • 5
    • 0032493759 scopus 로고    scopus 로고
    • Binding and phosphorylation of tubulin by G protein-coupled receptor kinases
    • Carman C.V., Som T., Kim C.M., and Benovic J.L. Binding and phosphorylation of tubulin by G protein-coupled receptor kinases. J. Biol. Chem. 273 (1998) 20308-20316
    • (1998) J. Biol. Chem. , vol.273 , pp. 20308-20316
    • Carman, C.V.1    Som, T.2    Kim, C.M.3    Benovic, J.L.4
  • 6
    • 17844406856 scopus 로고    scopus 로고
    • Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
    • Chen L., and Feany M.B. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 8 (2005) 657-663
    • (2005) Nat. Neurosci. , vol.8 , pp. 657-663
    • Chen, L.1    Feany, M.B.2
  • 7
    • 0037159189 scopus 로고    scopus 로고
    • beta 2-Adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated phosphorylation of ribosomal protein P2
    • Freeman J.L., Gonzalo P., Pitcher J.A., Claing A., Lavergne J.P., Reboud J.P., and Lefkowitz R.J. beta 2-Adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated phosphorylation of ribosomal protein P2. Biochemistry 41 (2002) 12850-12857
    • (2002) Biochemistry , vol.41 , pp. 12850-12857
    • Freeman, J.L.1    Gonzalo, P.2    Pitcher, J.A.3    Claing, A.4    Lavergne, J.P.5    Reboud, J.P.6    Lefkowitz, R.J.7
  • 10
    • 39149111608 scopus 로고    scopus 로고
    • Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells
    • Guo J.T., Chen A.Q., Kong Q., Zhu H., Ma C.M., and Qin C. Inhibition of vesicular monoamine transporter-2 activity in alpha-synuclein stably transfected SH-SY5Y cells. Cell Mol. Neurobiol. 28 (2008) 35-47
    • (2008) Cell Mol. Neurobiol. , vol.28 , pp. 35-47
    • Guo, J.T.1    Chen, A.Q.2    Kong, Q.3    Zhu, H.4    Ma, C.M.5    Qin, C.6
  • 12
    • 0035313071 scopus 로고    scopus 로고
    • Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis
    • Hartmann A., Troadec J.D., Hunot S., Kikly K., Faucheux B.A., Mouatt-Prigent A., Ruberg M., Agid Y., and Hirsch E.C. Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis. J. Neurosci. 21 (2001) 2247-2255
    • (2001) J. Neurosci. , vol.21 , pp. 2247-2255
    • Hartmann, A.1    Troadec, J.D.2    Hunot, S.3    Kikly, K.4    Faucheux, B.A.5    Mouatt-Prigent, A.6    Ruberg, M.7    Agid, Y.8    Hirsch, E.C.9
  • 13
    • 33748474961 scopus 로고    scopus 로고
    • Challenges in neuronal apoptosis
    • Jellinger K.A. Challenges in neuronal apoptosis. Curr. Alzheimer Res. 3 (2006) 377-391
    • (2006) Curr. Alzheimer Res. , vol.3 , pp. 377-391
    • Jellinger, K.A.1
  • 14
    • 8644290071 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence
    • Johnson L.R., Scott M.G., and Pitcher J.A. G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence. Mol. Cell. Biol. 24 (2004) 10169-10179
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 10169-10179
    • Johnson, L.R.1    Scott, M.G.2    Pitcher, J.A.3
  • 16
    • 0031747997 scopus 로고    scopus 로고
    • The role of receptor kinases and arrestins in G protein-coupled receptor regulation
    • Krupnick J.G., and Benovic J.L. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu. Rev. Pharmacol. Toxicol. 38 (1998) 289-319
    • (1998) Annu. Rev. Pharmacol. Toxicol. , vol.38 , pp. 289-319
    • Krupnick, J.G.1    Benovic, J.L.2
  • 17
    • 0032563291 scopus 로고    scopus 로고
    • G protein-coupled receptors: III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
    • Lefkowitz R.J. G protein-coupled receptors: III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J. Biol. Chem. 273 (1998) 18677-18680
    • (1998) J. Biol. Chem. , vol.273 , pp. 18677-18680
    • Lefkowitz, R.J.1
  • 20
    • 0029942337 scopus 로고    scopus 로고
    • Histochemical detection of apoptosis in Parkinson's disease
    • Mochizuki H., Goto K., Mori H., and Mizuno Y. Histochemical detection of apoptosis in Parkinson's disease. J. Neurol. Sci. 137 (1996) 120-123
    • (1996) J. Neurol. Sci. , vol.137 , pp. 120-123
    • Mochizuki, H.1    Goto, K.2    Mori, H.3    Mizuno, Y.4
  • 22
    • 0030971573 scopus 로고    scopus 로고
    • Dopamine-melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease
    • Offen D., Ziv I., Barzilai A., Gorodin S., Glater E., Hochman A., and Melamed E. Dopamine-melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease. Neurochem. Int. 31 (1997) 207-216
    • (1997) Neurochem. Int. , vol.31 , pp. 207-216
    • Offen, D.1    Ziv, I.2    Barzilai, A.3    Gorodin, S.4    Glater, E.5    Hochman, A.6    Melamed, E.7
  • 24
    • 0029785214 scopus 로고    scopus 로고
    • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies
    • Pitcher J.A., Fredericks Z.L., Stone W.C., Premont R.T., Stoffel R.H., Koch W.J., and Lefkowitz R.J. Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J. Biol. Chem. 271 (1996) 24907-24913
    • (1996) J. Biol. Chem. , vol.271 , pp. 24907-24913
    • Pitcher, J.A.1    Fredericks, Z.L.2    Stone, W.C.3    Premont, R.T.4    Stoffel, R.H.5    Koch, W.J.6    Lefkowitz, R.J.7
  • 26
    • 0032553549 scopus 로고    scopus 로고
    • Structure-function analysis of G protein-coupled receptor kinase-5
    • Pronin A.N., Carman C.V., and Benovic J.L. Structure-function analysis of G protein-coupled receptor kinase-5. J. Biol. Chem. 273 (1998) 31510-31518
    • (1998) J. Biol. Chem. , vol.273 , pp. 31510-31518
    • Pronin, A.N.1    Carman, C.V.2    Benovic, J.L.3
  • 27
    • 0034714204 scopus 로고    scopus 로고
    • Synucleins are a novel class of substrates for G protein-coupled receptor kinases
    • Pronin A.N., Morris A.J., Surguchov A., and Benovic J.L. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 275 (2000) 26515-26522
    • (2000) J. Biol. Chem. , vol.275 , pp. 26515-26522
    • Pronin, A.N.1    Morris, A.J.2    Surguchov, A.3    Benovic, J.L.4
  • 28
    • 0031593727 scopus 로고    scopus 로고
    • 2 receptor is elevated in the striatum of Parkinson's disease
    • 2 receptor is elevated in the striatum of Parkinson's disease. Mov. Disord. 13 (1998) 788-797
    • (1998) Mov. Disord. , vol.13 , pp. 788-797
    • Ryoo, H.L.1    Pierrotti, D.2    Joyce, J.N.3
  • 32
    • 0032568534 scopus 로고    scopus 로고
    • alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., and Goedert M. alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 6469-6473
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 33
    • 0032531980 scopus 로고    scopus 로고
    • Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine
    • Takai N., Nakanishi H., Tanabe K., Nishioku T., Sugiyama T., Fujiwara M., and Yamamoto K. Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine. J. Neurosci. Res. 54 (1998) 214-222
    • (1998) J. Neurosci. Res. , vol.54 , pp. 214-222
    • Takai, N.1    Nakanishi, H.2    Tanabe, K.3    Nishioku, T.4    Sugiyama, T.5    Fujiwara, M.6    Yamamoto, K.7
  • 34
    • 0345561544 scopus 로고    scopus 로고
    • Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons
    • Tamatani M., Che Y.H., Matsuzaki H., Ogawa S., Okado H., Miyake S., Mizuno T., and Tohyama M. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J. Biol. Chem. 274 (1999) 8531-8538
    • (1999) J. Biol. Chem. , vol.274 , pp. 8531-8538
    • Tamatani, M.1    Che, Y.H.2    Matsuzaki, H.3    Ogawa, S.4    Okado, H.5    Miyake, S.6    Mizuno, T.7    Tohyama, M.8
  • 35
    • 0037378897 scopus 로고    scopus 로고
    • Apoptosis in Parkinson's disease: signals for neuronal degradation
    • Tatton W.G., Chalmers-Redman R., Brown D., and Tatton N. Apoptosis in Parkinson's disease: signals for neuronal degradation. Ann. Neurol. 53 Suppl. 3 (2003) S61-S70
    • (2003) Ann. Neurol. , vol.53 , Issue.SUPPL. 3
    • Tatton, W.G.1    Chalmers-Redman, R.2    Brown, D.3    Tatton, N.4
  • 36
    • 0031013141 scopus 로고    scopus 로고
    • Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons
    • Tompkins M.M., Basgall F.J., Zanrini E., and Hill W.D. Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am. J. Pathol. 150 (1997) 119-131
    • (1997) Am. J. Pathol. , vol.150 , pp. 119-131
    • Tompkins, M.M.1    Basgall, F.J.2    Zanrini, E.3    Hill, W.D.4
  • 37
    • 5444249974 scopus 로고    scopus 로고
    • Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease
    • Yamada M., Iwatsubo T., Mizuno Y., and Mochizuki H. Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease. J. Neurochem. 91 (2004) 451-461
    • (2004) J. Neurochem. , vol.91 , pp. 451-461
    • Yamada, M.1    Iwatsubo, T.2    Mizuno, Y.3    Mochizuki, H.4


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