메뉴 건너뛰기




Volumn 31, Issue 6, 2010, Pages 649-658

MicroRNAs in heart disease: Putative novel therapeutic targets?

Author keywords

Heart; microRNA

Indexed keywords

MESSENGER RNA; MICRORNA; RIBONUCLEOPROTEIN;

EID: 77954146850     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp573     Document Type: Review
Times cited : (150)

References (97)
  • 2
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75: 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 3
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993; 75:855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 4
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 6
    • 9344235449 scopus 로고    scopus 로고
    • Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    • Cai X, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 2004;10: 1957-1966.
    • (2004) RNA , vol.10 , pp. 1957-1966
    • Cai, X.1    Hagedorn, C.H.2    Cullen, B.R.3
  • 8
    • 52449116560 scopus 로고    scopus 로고
    • MicroRNAs: Novel regulators in cardiac development and disease
    • Thum T, Catalucci D, Bauersachs J. MicroRNAs: novel regulators in cardiac development and disease. Cardiovasc Res 2008;79:562-570.
    • (2008) Cardiovasc Res , vol.79 , pp. 562-570
    • Thum, T.1    Catalucci, D.2    Bauersachs, J.3
  • 10
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003;17:3011-3016.
    • (2003) Genes Dev , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    MacAra, I.G.3    Cullen, B.R.4
  • 11
    • 29144431656 scopus 로고    scopus 로고
    • A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
    • Maniataki E, Mourelatos Z. A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev 2005;19:2979-2990.
    • (2005) Genes Dev , vol.19 , pp. 2979-2990
    • Maniataki, E.1    Mourelatos, Z.2
  • 12
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T, Zamore PD. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001;293:834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Bálint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 13
    • 37549014207 scopus 로고    scopus 로고
    • Argonaute proteins: Key players in RNA silencing
    • Hutvagner G, Simard MJ. Argonaute proteins: key players in RNA silencing. Nat Rev Mol Cell Biol 2008;9:22-32.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 22-32
    • Hutvagner, G.1    Simard, M.J.2
  • 14
    • 67651000077 scopus 로고    scopus 로고
    • The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing
    • Eulalio A, Tritschler F, Izaurralde E. The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA 2009;15:1433-4142.
    • (2009) RNA , vol.15 , pp. 1433-4142
    • Eulalio, A.1    Tritschler, F.2    Izaurralde, E.3
  • 15
    • 34447097693 scopus 로고    scopus 로고
    • Intronic microRNA precursors that bypass Drosha processing
    • Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing. Nature 2007;448:83-86.
    • (2007) Nature , vol.448 , pp. 83-86
    • Ruby, J.G.1    Jan, C.H.2    Bartel, D.P.3
  • 16
    • 34447107760 scopus 로고    scopus 로고
    • The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila
    • Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 2007;130:89-100.
    • (2007) Cell , vol.130 , pp. 89-100
    • Okamura, K.1    Hagen, J.W.2    Duan, H.3    Tyler, D.M.4    Lai, E.C.5
  • 18
    • 54349104464 scopus 로고    scopus 로고
    • Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
    • Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev 2008;22:2773-2785.
    • (2008) Genes Dev , vol.22 , pp. 2773-2785
    • Babiarz, J.E.1    Ruby, J.G.2    Wang, Y.3    Bartel, D.P.4    Blelloch, R.5
  • 20
    • 4644310115 scopus 로고    scopus 로고
    • Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    • Pillai RS, Artus CG, Filipowicz W. Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA 2004;10: 1518-1525.
    • (2004) RNA , vol.10 , pp. 1518-1525
    • Pillai, R.S.1    Artus, C.G.2    Filipowicz, W.3
  • 21
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 22
    • 58849093262 scopus 로고    scopus 로고
    • Revisiting the principles of microRNA target recognition and mode of action
    • Brodersen P, Voinnet O. Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 2009;10:141-148.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 141-148
    • Brodersen, P.1    Voinnet, O.2
  • 23
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008;9:102-114.
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 24
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell 2009;136:642-655.
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 26
    • 33947262696 scopus 로고    scopus 로고
    • AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
    • Vasudevan S, Steitz JA. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell 2007;128:1105-1118.
    • (2007) Cell , vol.128 , pp. 1105-1118
    • Vasudevan, S.1    Steitz, J.A.2
  • 27
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: Micro-RNAs can up-regulate translation
    • Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: micro-RNAs can up-regulate translation. Science 2007;318:1931-1934.
    • (2007) Science , vol.318 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 28
    • 43449090367 scopus 로고    scopus 로고
    • MicroRNA-10a binds the 5UTR of ribosomal protein mRNAs and enhances their translation
    • Orom UA, Nielsen FC, Lund AH. MicroRNA-10a binds the 5UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell 2008;30:460-471.
    • (2008) Mol Cell , vol.30 , pp. 460-471
    • Orom, U.A.1    Nielsen, F.C.2    Lund, A.H.3
  • 30
    • 33745248430 scopus 로고    scopus 로고
    • MicroRNA target predictions in animals
    • Rajewsky N. microRNA target predictions in animals. Nat Genet 2006;38:S8-S13.
    • (2006) Nat Genet , vol.38
    • Rajewsky, N.1
  • 38
    • 57749121689 scopus 로고    scopus 로고
    • Olson EN. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
    • Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R, Olson EN. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev 2008;22:3242-3254.
    • (2008) Genes Dev , vol.22 , pp. 3242-3254
    • Liu, N.1    Bezprozvannaya, S.2    Williams, A.H.3    Qi, X.4    Richardson, J.A.5    Bassel-Duby, R.6
  • 41
    • 64249165694 scopus 로고    scopus 로고
    • MicroRNA regulation of cardiovascular development
    • Cordes KR, Srivastava D. MicroRNA regulation of cardiovascular development. Circ Res 2009;104:724-732.
    • (2009) Circ Res , vol.104 , pp. 724-732
    • Cordes, K.R.1    Srivastava, D.2
  • 42
    • 33847038668 scopus 로고    scopus 로고
    • MicroRNAs play an essential role in the development of cardiac hypertrophy
    • Sayed D, Hong C, leng-Yi C, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 2007;100:416-424.
    • (2007) Circ Res , vol.100 , pp. 416-424
    • Sayed, D.1    Hong, C.2    Leng-Yi, C.3    Lypowy, J.4    Abdellatif, M.5
  • 48
    • 59149104760 scopus 로고    scopus 로고
    • RNA silencing: Small RNA-mediated posttranscrip-tional regulation of mRNA and the implications for heart electropathophysiology
    • Latronico MV, Condorelli G. RNA silencing: small RNA-mediated posttranscrip-tional regulation of mRNA and the implications for heart electropathophysiology. J Cardiovasc Electrophysiol 2009;20:230-237.
    • (2009) J Cardiovasc Electrophysiol , vol.20 , pp. 230-237
    • Latronico, M.V.1    Condorelli, G.2
  • 51
    • 34948829119 scopus 로고    scopus 로고
    • The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes
    • Xu C, Lu Y, Pan Z, Chu W, Luo X, Lin H, Xiao J, Shan H, Wang Z, Yang B. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J Cell Sci 2007;120:3045-3052.
    • (2007) J Cell Sci , vol.120 , pp. 3045-3052
    • Xu, C.1    Lu, Y.2    Pan, Z.3    Chu, W.4    Luo, X.5    Lin, H.6    Xiao, J.7    Shan, H.8    Wang, Z.9    Yang, B.10
  • 53
    • 66349123063 scopus 로고    scopus 로고
    • MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfu-sion injury by targeting heat-shock protein 20
    • Ren X-P, Wu J, Wang X, Sartor MA, Qian J, Jones K, Nicolaou P, Pritchard TJ, Fan G-C. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfu-sion injury by targeting heat-shock protein 20. Circulation 2009;119:2357-2366.
    • (2009) Circulation , vol.119 , pp. 2357-2366
    • Ren, X.-P.1    Wu, J.2    Wang, X.3    Sartor, M.A.4    Qian, J.5    Jones, K.6    Nicolaou, P.7    Pritchard, T.J.8    Fan, G.-C.9
  • 54
    • 67649908891 scopus 로고    scopus 로고
    • MicroRNA-1 regulates cardiomyo-cyte apoptosis by targeting Bcl-2
    • Tang Y, Zheng J, Sun Y, Wu Z, Liu Z, Huang G. MicroRNA-1 regulates cardiomyo-cyte apoptosis by targeting Bcl-2. Int Heart J 2009;50:377-387.
    • (2009) Int Heart J , vol.50 , pp. 377-387
    • Tang, Y.1    Zheng, J.2    Sun, Y.3    Wu, Z.4    Liu, Z.5    Huang, G.6
  • 59
    • 62349119294 scopus 로고    scopus 로고
    • MiRNA-21: A key to controlling the cardiac fibro-blast compartment?
    • Haghikia A, Hilfiker-Kleiner D. MiRNA-21: a key to controlling the cardiac fibro-blast compartment? Cardiovasc Res 2009;82:1-3.
    • (2009) Cardiovasc Res , vol.82 , pp. 1-3
    • Haghikia, A.1    Hilfiker-Kleiner, D.2
  • 60
    • 34247554263 scopus 로고    scopus 로고
    • Dicer dependent micro-RNAs regulate gene expression and functions in human endothelial cells
    • Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC. Dicer dependent micro-RNAs regulate gene expression and functions in human endothelial cells. Circ Res 2007;100:1164-1173.
    • (2007) Circ Res , vol.100 , pp. 1164-1173
    • Suárez, Y.1    Fernández-Hernando, C.2    Pober, J.S.3    Sessa, W.C.4
  • 64
    • 70349213385 scopus 로고    scopus 로고
    • Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
    • Boettger T, Beetz N, Kostin S, Schneider J, Krüger M, Hein L, Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest 2009;119:2634-2647.
    • (2009) J Clin Invest , vol.119 , pp. 2634-2647
    • Boettger, T.1    Beetz, N.2    Kostin, S.3    Schneider, J.4    Krüger, M.5    Hein, L.6    Braun, T.7
  • 65
    • 68049083397 scopus 로고    scopus 로고
    • MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation
    • Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, Deitch EA, Huo Y, Delphin ES, Zhang C. MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res 2009;105: 158-166.
    • (2009) Circ Res , vol.105 , pp. 158-166
    • Cheng, Y.1    Liu, X.2    Yang, J.3    Lin, Y.4    Xu, D.Z.5    Lu, Q.6    Deitch, E.A.7    Huo, Y.8    Delphin, E.S.9    Zhang, C.10
  • 69
    • 55249123349 scopus 로고    scopus 로고
    • Cardiac dissonance without conductors: How dicer depletion provokes chaos in the heart
    • Thum T. Cardiac dissonance without conductors: how dicer depletion provokes chaos in the heart. Circulation 2008;118:1524-1527.
    • (2008) Circulation , vol.118 , pp. 1524-1527
    • Thum, T.1
  • 76
    • 48849095818 scopus 로고    scopus 로고
    • MiRNA expression in the failing human heart: Functional correlates
    • Sucharov C, Bristow MR, Port JD. miRNA expression in the failing human heart: functional correlates. J Mol Cell Cardiol 2008;45:185-192.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 185-192
    • Sucharov, C.1    Bristow, M.R.2    Port, J.D.3
  • 79
    • 57049092842 scopus 로고    scopus 로고
    • Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support
    • Schipper ME, van Kuik J, de Jonge N, Dullens HF, de Weger RA. Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support. J Heart Lung Transplant 2008;27:1282-1285.
    • (2008) J Heart Lung Transplant , vol.27 , pp. 1282-1285
    • Schipper, M.E.1    Van Kuik, J.2    De Jonge, N.3    Dullens, H.F.4    De Weger, R.A.5
  • 85
    • 0026349336 scopus 로고
    • Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive physiologic response
    • Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J 1991;5:3037-3046.
    • (1991) FASEB J , vol.5 , pp. 3037-3046
    • Chien, K.R.1    Knowlton, K.U.2    Zhu, H.3    Chien, S.4
  • 86
    • 0038380271 scopus 로고    scopus 로고
    • Phenotyping hypertrophy: Eschew obfusca-tion
    • Dorn GW II, Robbins J, Sugden PH. Phenotyping hypertrophy: eschew obfusca-tion. Circ Res 2003;92:1171-1175.
    • (2003) Circ Res , vol.92 , pp. 1171-1175
    • Dorn, G.W.I.I.1    Robbins, J.2    Sugden, P.H.3
  • 87
    • 65349121886 scopus 로고    scopus 로고
    • Genomics, transcriptional profiling, and heart failure
    • Margulies KB, Bednarik DP, Dries DL. Genomics, transcriptional profiling, and heart failure. J Am Coll Cardiol 2009;53:1752-1759.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1752-1759
    • Margulies, K.B.1    Bednarik, D.P.2    Dries, D.L.3
  • 88
    • 49149127971 scopus 로고    scopus 로고
    • Put your chips on transcriptomics
    • Dorn GW II, Matkovich SJ. Put your chips on transcriptomics. Circulation 2008; 118:216-218.
    • (2008) Circulation , vol.118 , pp. 216-218
    • Dorn, G.W.I.I.1    Matkovich, S.J.2
  • 90
    • 41349098339 scopus 로고    scopus 로고
    • MicroRNAs make big impression in disease after disease
    • Couzin J. MicroRNAs make big impression in disease after disease. Science 2008; 319:1782-1784.
    • (2008) Science , vol.319 , pp. 1782-1784
    • Couzin, J.1
  • 91
    • 33847036990 scopus 로고    scopus 로고
    • Strategies for silencing human disease using RNA interference
    • Kim DH, Rossi JJ. Strategies for silencing human disease using RNA interference. Nat Rev Genet 2007;8:173-184.
    • (2007) Nat Rev Genet , vol.8 , pp. 173-184
    • Kim, D.H.1    Rossi, J.J.2
  • 94
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of smallRNAs in mammalian cells
    • Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: Competitive inhibitors of smallRNAs in mammalian cells. Nat Methods 2007;4:721-726.
    • (2007) Nat Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 95
    • 63349085394 scopus 로고    scopus 로고
    • A single anti-microRNA anti-sense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference
    • Lu Y, Xiao J, Lin H, Bai Y, Luo X, Wang Z, Yang B. A single anti-microRNA anti-sense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Res 2009; 37:e24.
    • (2009) Nucleic Acids Res , vol.37
    • Lu, Y.1    Xiao, J.2    Lin, H.3    Bai, Y.4    Luo, X.5    Wang, Z.6    Yang, B.7
  • 96
    • 34347381752 scopus 로고    scopus 로고
    • Novel approaches for gene-specific interference via manipulating actions of microRNAs: Examination on the pacemaker channel genes HCN2 and HCN4
    • Xiao J, Yang B, Lin H, Lu Y, Luo X, Wang Z. Novel approaches for gene-specific interference via manipulating actions of microRNAs: Examination on the pacemaker channel genes HCN2 and HCN4. J Cell Physiol 2007;212:285-292.
    • (2007) J Cell Physiol , vol.212 , pp. 285-292
    • Xiao, J.1    Yang, B.2    Lin, H.3    Lu, Y.4    Luo, X.5    Wang, Z.6
  • 97
    • 55849135596 scopus 로고    scopus 로고
    • MicroRNA-directed transcriptional gene silencing in mammalian cells
    • Kim DH, Saetrom P, Snøve O Jr, Rossi JJ. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci USA 2008;105:16230-16235.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16230-16235
    • Kim, D.H.1    Saetrom, P.2    Snøve Jr., O.3    Rossi, J.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.