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Volumn 160, Issue 4, 2010, Pages 821-832

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

Author keywords

Arrestin; Cardiovascular; Cell cycle; GPCR; GRK2; Migration

Indexed keywords

ACTIN; ADENOVIRUS VECTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR4; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOXORUBICIN; EZRIN; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 4; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PARVOVIRUS VECTOR; PAXILLIN; PHOSDUCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; RANTES; RETINA S ANTIGEN; RHODOPSIN KINASE; STROMAL CELL DERIVED FACTOR 1; SYNUCLEIN; TOLL LIKE RECEPTOR 4; TUBULIN; UNINDEXED DRUG; ENZYME INHIBITOR;

EID: 77952840083     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00727.x     Document Type: Review
Times cited : (182)

References (80)
  • 1
    • 40949095655 scopus 로고    scopus 로고
    • Guide to Receptors and Channels (GRAC), 3rd edition (2008 revision)
    • Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
    • (2008) Br J Pharmacol , vol.153 , Issue.2 SUPPL.
    • Alexander, S.P.H.1    Mathie, A.2    Peters, J.A.3
  • 2
    • 4143138843 scopus 로고    scopus 로고
    • Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes
    • Anis Y, Leshem O, Reuveni H, Wexler I, Ben Sasson R, Yahalom B et al 2004). Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes. Diabetologia 47 : 1232 1244.
    • (2004) Diabetologia , vol.47 , pp. 1232-1244
    • Anis, Y.1    Leshem, O.2    Reuveni, H.3    Wexler, I.4    Ben Sasson, R.5    Yahalom, B.6
  • 3
    • 64849098229 scopus 로고    scopus 로고
    • Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK
    • Aziziyeh AI, Li TT, Pape C, Pampillo M, Chidiac P, Possmayer F et al 2009). Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. Cell Signal 21 : 1207 1217.
    • (2009) Cell Signal , vol.21 , pp. 1207-1217
    • Aziziyeh, A.I.1    Li, T.T.2    Pape, C.3    Pampillo, M.4    Chidiac, P.5    Possmayer, F.6
  • 4
    • 0033838695 scopus 로고    scopus 로고
    • Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function
    • Bliziotes M, Gunness M, Zhang X, Nissenson R, Wiren K (2000). Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function. Bone 27 : 367 373.
    • (2000) Bone , vol.27 , pp. 367-373
    • Bliziotes, M.1    Gunness, M.2    Zhang, X.3    Nissenson, R.4    Wiren, K.5
  • 5
    • 13244275005 scopus 로고    scopus 로고
    • Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo
    • Brockbank EC, Bridges J, Marshall CJ, Sahai E (2005). Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. Br J Cancer 92 : 102 112.
    • (2005) Br J Cancer , vol.92 , pp. 102-112
    • Brockbank, E.C.1    Bridges, J.2    Marshall, C.J.3    Sahai, E.4
  • 6
    • 11144256194 scopus 로고    scopus 로고
    • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
    • Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA et al 2004). Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 306 : 2257 2260.
    • (2004) Science , vol.306 , pp. 2257-2260
    • Chen, W.1    Ren, X.R.2    Nelson, C.D.3    Barak, L.S.4    Chen, J.K.5    Beachy, P.A.6
  • 7
    • 51349094203 scopus 로고    scopus 로고
    • EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation
    • Chen Y, Long H, Wu Z, Jiang X, Ma L (2008). EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation. Mol Biol Cell 19 : 2973 2983.
    • (2008) Mol Biol Cell , vol.19 , pp. 2973-2983
    • Chen, Y.1    Long, H.2    Wu, Z.3    Jiang, X.4    Ma, L.5
  • 8
    • 70450227198 scopus 로고    scopus 로고
    • The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance
    • Cipolletta E, Campanile A, Santulli G, Sanzari E, Leosco D, Campiglia P et al 2009). The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance. Cardiovasc Res 84 : 407 415.
    • (2009) Cardiovasc Res , vol.84 , pp. 407-415
    • Cipolletta, E.1    Campanile, A.2    Santulli, G.3    Sanzari, E.4    Leosco, D.5    Campiglia, P.6
  • 9
    • 57049088645 scopus 로고    scopus 로고
    • Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction
    • Cohn HI, Harris DM, Pesant S, Pfeiffer M, Zhou RH, Koch WJ et al 2008). Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction. Am J Physiol 295 : H1695 H1704.
    • (2008) Am J Physiol , vol.295
    • Cohn, H.I.1    Harris, D.M.2    Pesant, S.3    Pfeiffer, M.4    Zhou, R.H.5    Koch, W.J.6
  • 10
    • 67649842618 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans
    • Cohn HI, Xi Y, Pesant S, Harris DM, Hyslop T, Falkner B et al 2009). G protein-coupled receptor kinase 2 expression and activity are associated with blood pressure in black Americans. Hypertension 54 : 71 76.
    • (2009) Hypertension , vol.54 , pp. 71-76
    • Cohn, H.I.1    Xi, Y.2    Pesant, S.3    Harris, D.M.4    Hyslop, T.5    Falkner, B.6
  • 11
    • 33947424807 scopus 로고    scopus 로고
    • Stop that cell! Beta-arrestin-dependent chemotaxis: A tale of localized actin assembly and receptor desensitization
    • DeFea KA (2007). Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization. Annu Rev Physiol 69 : 535 560.
    • (2007) Annu Rev Physiol , vol.69 , pp. 535-560
    • Defea, K.A.1
  • 14
    • 67349181755 scopus 로고    scopus 로고
    • GRK mythology: G-protein receptor kinases in cardiovascular disease
    • Dorn GW, 2nd. (2009a). GRK mythology: G-protein receptor kinases in cardiovascular disease. J Mol Med 87 : 455 463.
    • (2009) J Mol Med , vol.87 , pp. 455-463
    • Dorn II, G.W.1
  • 15
    • 67649644872 scopus 로고    scopus 로고
    • Novel pharmacotherapies to abrogate postinfarction ventricular remodeling
    • Dorn GW, 2nd. (2009b). Novel pharmacotherapies to abrogate postinfarction ventricular remodeling. Nat Rev Cardiol 6 : 283 291.
    • (2009) Nat Rev Cardiol , vol.6 , pp. 283-291
    • Dorn II, G.W.1
  • 16
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS (2007). G-protein-coupled receptors and cancer. Nat Rev Cancer 7 : 79 94.
    • (2007) Nat Rev Cancer , vol.7 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 17
    • 0036209075 scopus 로고    scopus 로고
    • Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure
    • Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, Koch WJ (2002). Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol 61 : 749 758.
    • (2002) Mol Pharmacol , vol.61 , pp. 749-758
    • Eckhart, A.D.1    Ozaki, T.2    Tevaearai, H.3    Rockman, H.A.4    Koch, W.J.5
  • 18
    • 0042707658 scopus 로고    scopus 로고
    • MAPK-dependent degradation of G protein-coupled receptor kinase 2
    • Elorza A, Penela P, Sarnago S, Mayor F, Jr. (2003). MAPK-dependent degradation of G protein-coupled receptor kinase 2. J Biol Chem 278 : 29164 29173.
    • (2003) J Biol Chem , vol.278 , pp. 29164-29173
    • Elorza, A.1    Penela, P.2    Sarnago, S.3    Mayor Jr., F.4
  • 19
    • 0034111097 scopus 로고    scopus 로고
    • Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases
    • Elorza A, Sarnago S, Mayor F, Jr. (2000). Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases. Mol Pharmacol 57 : 778 783.
    • (2000) Mol Pharmacol , vol.57 , pp. 778-783
    • Elorza, A.1    Sarnago, S.2    Mayor Jr., F.3
  • 20
    • 0346101775 scopus 로고    scopus 로고
    • Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq
    • Fan G, Ballou LM, Lin RZ (2003). Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq. J Biol Chem 278 : 52432 52436.
    • (2003) J Biol Chem , vol.278 , pp. 52432-52436
    • Fan, G.1    Ballou, L.M.2    Lin, R.Z.3
  • 21
    • 33947585981 scopus 로고    scopus 로고
    • Phosphorylation-independent attenuation of GPCR signalling
    • Ferguson SS (2007). Phosphorylation-independent attenuation of GPCR signalling. Trends Pharmacol Sci 28 : 173 179.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 173-179
    • Ferguson, S.S.1
  • 22
    • 0031000256 scopus 로고    scopus 로고
    • G-protein-coupled receptor kinase activity is increased in hypertension
    • Gros R, Benovic JL, Tan CM, Feldman RD (1997). G-protein-coupled receptor kinase activity is increased in hypertension. J Clin Invest 99 : 93.
    • (1997) J Clin Invest , vol.99 , pp. 93
    • Gros, R.1    Benovic, J.L.2    Tan, C.M.3    Feldman, R.D.4
  • 23
    • 0033954751 scopus 로고    scopus 로고
    • G-protein-coupled receptor kinase activity in hypertension: Increased vascular and lymphocyte G-protein receptor kinase-2 protein expression
    • Gros R, Chorazyczewski J, Meek MD, Benovic JL, Ferguson SS, Feldman RD (2000). G-protein-coupled receptor kinase activity in hypertension: increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Hypertension 35 : 38 42.
    • (2000) Hypertension , vol.35 , pp. 38-42
    • Gros, R.1    Chorazyczewski, J.2    Meek, M.D.3    Benovic, J.L.4    Ferguson, S.S.5    Feldman, R.D.6
  • 24
    • 62749127825 scopus 로고    scopus 로고
    • TGFbeta-induced GRK2 expression attenuates AngII-regulated Vascular Smooth Muscle Cell proliferation and migration
    • Guo J, Chen H, Ho J, Mancini J, Sontag T, Laporte SA et al 2009). TGFbeta-induced GRK2 expression attenuates AngII-regulated Vascular Smooth Muscle Cell proliferation and migration. Cell Signal 21 : 899 905.
    • (2009) Cell Signal , vol.21 , pp. 899-905
    • Guo, J.1    Chen, H.2    Ho, J.3    Mancini, J.4    Sontag, T.5    Laporte, S.A.6
  • 25
    • 4744349417 scopus 로고    scopus 로고
    • Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor
    • Hildreth KL, Wu JH, Barak LS, Exum ST, Kim LK, Peppel K et al 2004). Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor. J Biol Chem 279 : 41775 41782.
    • (2004) J Biol Chem , vol.279 , pp. 41775-41782
    • Hildreth, K.L.1    Wu, J.H.2    Barak, L.S.3    Exum, S.T.4    Kim, L.K.5    Peppel, K.6
  • 26
    • 25144432973 scopus 로고    scopus 로고
    • The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction
    • Ho J, Cocolakis E, Dumas VM, Posner BI, Laporte SA, Lebrun JJ (2005). The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction. Embo J 24 : 3247 3258.
    • (2005) Embo J , vol.24 , pp. 3247-3258
    • Ho, J.1    Cocolakis, E.2    Dumas, V.M.3    Posner, B.I.4    Laporte, S.A.5    Lebrun, J.J.6
  • 27
    • 33646705915 scopus 로고    scopus 로고
    • The multifunctional GIT family of proteins
    • Hoefen RJ, Berk BC (2006). The multifunctional GIT family of proteins. J Cell Sci 119 : 1469 1475.
    • (2006) J Cell Sci , vol.119 , pp. 1469-1475
    • Hoefen, R.J.1    Berk, B.C.2
  • 28
    • 33947354585 scopus 로고    scopus 로고
    • Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins
    • Hupfeld CJ, Olefsky JM (2007). Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol 69 : 561 577.
    • (2007) Annu Rev Physiol , vol.69 , pp. 561-577
    • Hupfeld, C.J.1    Olefsky, J.M.2
  • 30
    • 10544242967 scopus 로고    scopus 로고
    • Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function
    • Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, Sulik KK et al 1996). Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A 93 : 12974 12979.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12974-12979
    • Jaber, M.1    Koch, W.J.2    Rockman, H.3    Smith, B.4    Bond, R.A.5    Sulik, K.K.6
  • 31
    • 67649836304 scopus 로고    scopus 로고
    • Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development
    • Jiang X, Yang P, Ma L (2009). Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development. Proc Natl Acad Sci U S A 106 : 10183 10188.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 10183-10188
    • Jiang, X.1    Yang, P.2    Ma, L.3
  • 32
    • 30044434455 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from g protein subunits
    • Jimenez-Sainz MC, Murga C, Kavelaars A, Jurado-Pueyo M, Krakstad BF, Heijnen CJ et al 2006). G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from g protein subunits. Mol Biol Cell 17 : 25 31.
    • (2006) Mol Biol Cell , vol.17 , pp. 25-31
    • Jimenez-Sainz, M.C.1    Murga, C.2    Kavelaars, A.3    Jurado-Pueyo, M.4    Krakstad, B.F.5    Heijnen, C.J.6
  • 34
    • 24744444714 scopus 로고    scopus 로고
    • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
    • Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC (2005). A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 11 : 952 958.
    • (2005) Nat Med , vol.11 , pp. 952-958
    • Liu, S.1    Premont, R.T.2    Kontos, C.D.3    Zhu, S.4    Rockey, D.C.5
  • 35
    • 0038363395 scopus 로고    scopus 로고
    • Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2
    • Lodowski DT, Barnhill JF, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ (2003). Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. Acta Crystallogr D Biol Crystallogr 59 : 936 939.
    • (2003) Acta Crystallogr D Biol Crystallogr , vol.59 , pp. 936-939
    • Lodowski, D.T.1    Barnhill, J.F.2    Pitcher, J.A.3    Capel, W.D.4    Lefkowitz, R.J.5    Tesmer, J.J.6
  • 36
    • 33847728682 scopus 로고    scopus 로고
    • Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure
    • Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ (2007). Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med 13 : 315 323.
    • (2007) Nat Med , vol.13 , pp. 315-323
    • Lymperopoulos, A.1    Rengo, G.2    Funakoshi, H.3    Eckhart, A.D.4    Koch, W.J.5
  • 37
    • 33750428974 scopus 로고    scopus 로고
    • Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling
    • Matkovich SJ, Diwan A, Klanke JL, Hammer DJ, Marreez Y, Odley AM et al 2006). Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res 99 : 996 1003.
    • (2006) Circ Res , vol.99 , pp. 996-1003
    • Matkovich, S.J.1    Diwan, A.2    Klanke, J.L.3    Hammer, D.J.4    Marreez, Y.5    Odley, A.M.6
  • 38
    • 40449089764 scopus 로고    scopus 로고
    • An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro
    • Mayer G, Wulffen B, Huber C, Brockmann J, Flicke B, Neumann L et al 2008). An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro. RNA 14 : 524 534.
    • (2008) RNA , vol.14 , pp. 524-534
    • Mayer, G.1    Wulffen, B.2    Huber, C.3    Brockmann, J.4    Flicke, B.5    Neumann, L.6
  • 40
    • 19344363250 scopus 로고    scopus 로고
    • Pathophysiological roles of G-protein-coupled receptor kinases
    • Metaye T, Gibelin H, Perdrisot R, Kraimps JL (2005). Pathophysiological roles of G-protein-coupled receptor kinases. Cell Signal 17 : 917 928.
    • (2005) Cell Signal , vol.17 , pp. 917-928
    • Metaye, T.1    Gibelin, H.2    Perdrisot, R.3    Kraimps, J.L.4
  • 41
    • 47849125977 scopus 로고    scopus 로고
    • Immunohistochemical detection, regulation and antiproliferative function of G-protein-coupled receptor kinase 2 in thyroid carcinomas
    • Metaye T, Levillain P, Kraimps JL, Perdrisot R (2008). Immunohistochemical detection, regulation and antiproliferative function of G-protein-coupled receptor kinase 2 in thyroid carcinomas. J Endocrinol 198 : 101 110.
    • (2008) J Endocrinol , vol.198 , pp. 101-110
    • Metaye, T.1    Levillain, P.2    Kraimps, J.L.3    Perdrisot, R.4
  • 42
    • 0036324072 scopus 로고    scopus 로고
    • Expression and activity of G protein-coupled receptor kinases in differenciated thyroid carcinoma
    • Metaye T, Menet E, Guilhot J, Kraimps JL (2002). Expression and activity of G protein-coupled receptor kinases in differenciated thyroid carcinoma. J Clin Endocrinol Metab 87 : 3279 3286.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3279-3286
    • Metaye, T.1    Menet, E.2    Guilhot, J.3    Kraimps, J.L.4
  • 43
    • 33644832772 scopus 로고    scopus 로고
    • Targeting sphingosine-1-phosphate: A novel avenue for cancer therapeutics
    • Milstien S, Spiegel S (2006). Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. Cancer Cell 9 : 148 150.
    • (2006) Cancer Cell , vol.9 , pp. 148-150
    • Milstien, S.1    Spiegel, S.2
  • 44
    • 34249950014 scopus 로고    scopus 로고
    • The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
    • Molnar C, Holguin H, Mayor F, Jr., Ruiz-Gomez A, de Celis JF (2007). The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A 104 : 7963 7968.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7963-7968
    • Molnar, C.1    Holguin, H.2    Mayor Jr., F.3    Ruiz-Gomez, A.4    De Celis, J.F.5
  • 45
    • 33947314576 scopus 로고    scopus 로고
    • Regulation of receptor trafficking by GRKs and arrestins
    • Moore CA, Milano SK, Benovic JL (2007). Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69 : 451 482.
    • (2007) Annu Rev Physiol , vol.69 , pp. 451-482
    • Moore, C.A.1    Milano, S.K.2    Benovic, J.L.3
  • 46
    • 0036327388 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex
    • Naga Prasad SV, Laporte SA, Chamberlain D, Caron MG, Barak L, Rockman HA (2002). Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J Cell Biol 158 : 563 575.
    • (2002) J Cell Biol , vol.158 , pp. 563-575
    • Naga Prasad, S.V.1    Laporte, S.A.2    Chamberlain, D.3    Caron, M.G.4    Barak, L.5    Rockman, H.A.6
  • 47
    • 34848820302 scopus 로고    scopus 로고
    • Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection
    • Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J et al 2007). Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest 117 : 2445 2458.
    • (2007) J Clin Invest , vol.117 , pp. 2445-2458
    • Noma, T.1    Lemaire, A.2    Naga Prasad, S.V.3    Barki-Harrington, L.4    Tilley, D.G.5    Chen, J.6
  • 48
    • 72449146904 scopus 로고    scopus 로고
    • G-protein coupled receptor kinases mediate TNFalpha-induced NFkappaB signaling via direct interaction with and phosphorylation of IkappaBalpha
    • Patial S, Luo J, Porter KJ, Benovic JL, Parameswaran N (2009). G-protein coupled receptor kinases mediate TNFalpha-induced NFkappaB signaling via direct interaction with and phosphorylation of IkappaBalpha. Biochem J 425 : 169 178.
    • (2009) Biochem J , vol.425 , pp. 169-178
    • Patial, S.1    Luo, J.2    Porter, K.J.3    Benovic, J.L.4    Parameswaran, N.5
  • 49
    • 0032567351 scopus 로고    scopus 로고
    • Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway
    • DOI 10.1074/jbc.273.52.35238
    • Penela P, Ruiz-Gomez A, Castano JG, Mayor F, Jr. (1998). Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway. J Biol Chem 273 : 35238 35244. (Pubitemid 29028230)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.52 , pp. 35238-35244
    • Penela, P.1    Ruiz-Gomez, A.2    Castano, J.G.3    Mayor Jr., F.4
  • 50
    • 0035903669 scopus 로고    scopus 로고
    • Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2
    • Penela P, Elorza A, Sarnago S, Mayor F, Jr. (2001). Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2. Embo J 20 : 5129 5138.
    • (2001) Embo J , vol.20 , pp. 5129-5138
    • Penela, P.1    Elorza, A.2    Sarnago, S.3    Mayor Jr., F.4
  • 51
    • 0141629679 scopus 로고    scopus 로고
    • Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
    • Penela P, Ribas C, Mayor F, Jr. (2003). Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15 : 973 981.
    • (2003) Cell Signal , vol.15 , pp. 973-981
    • Penela, P.1    Ribas, C.2    Mayor Jr., F.3
  • 52
    • 29144497998 scopus 로고    scopus 로고
    • Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease
    • Penela P, Murga C, Ribas C, Tutor AS, Peregrin S, Mayor F, Jr. (2006). Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc Res 69 : 46 56.
    • (2006) Cardiovasc Res , vol.69 , pp. 46-56
    • Penela, P.1    Murga, C.2    Ribas, C.3    Tutor, A.S.4    Peregrin, S.5    Mayor Jr., F.6
  • 54
    • 67049101075 scopus 로고    scopus 로고
    • New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration
    • Penela P, Ribas C, Aymerich I, Mayor F, Jr. (2009). New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration. Cell Adh Migr 3 : 19 23.
    • (2009) Cell Adh Migr , vol.3 , pp. 19-23
    • Penela, P.1    Ribas, C.2    Aymerich, I.3    Mayor Jr., F.4
  • 55
    • 75749118972 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression
    • Penela P, Rivas V, Salcedo A, Mayor F Jr. (2010). G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression. Proc Natl Acad Sci U S A 107 : 1118 1123.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1118-1123
    • Penela, P.1    Rivas, V.2    Salcedo, A.3    Mayor Jr., F.4
  • 56
    • 0033869812 scopus 로고    scopus 로고
    • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors
    • Peppel K, Jacobson A, Huang X, Murray JP, Oppermann M, Freedman NJ (2000). Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors. Circulation 102 : 793 799.
    • (2000) Circulation , vol.102 , pp. 793-799
    • Peppel, K.1    Jacobson, A.2    Huang, X.3    Murray, J.P.4    Oppermann, M.5    Freedman, N.J.6
  • 57
    • 33750218229 scopus 로고    scopus 로고
    • Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK
    • Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P et al 2006). Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol 16 : 2042 2047.
    • (2006) Curr Biol , vol.16 , pp. 2042-2047
    • Peregrin, S.1    Jurado-Pueyo, M.2    Campos, P.M.3    Sanz-Moreno, V.4    Ruiz-Gomez, A.5    Crespo, P.6
  • 58
    • 0033521109 scopus 로고    scopus 로고
    • Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
    • Pitcher JA, Tesmer JJ, Freeman JL, Capel WD, Stone WC, Lefkowitz RJ (1999). Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem 274 : 34531 34534.
    • (1999) J Biol Chem , vol.274 , pp. 34531-34534
    • Pitcher, J.A.1    Tesmer, J.J.2    Freeman, J.L.3    Capel, W.D.4    Stone, W.C.5    Lefkowitz, R.J.6
  • 59
    • 0032564277 scopus 로고    scopus 로고
    • β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    • Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton W et al 1998). β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A 95 : 14082 14087.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14082-14087
    • Premont, R.T.1    Claing, A.2    Vitale, N.3    Freeman, J.L.4    Pitcher, J.A.5    Patton, W.6
  • 60
    • 33947375174 scopus 로고    scopus 로고
    • Physiological roles of G protein-coupled receptor kinases and arrestins
    • Premont RT, Gainetdinov RR (2007). Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 69 : 511 534.
    • (2007) Annu Rev Physiol , vol.69 , pp. 511-534
    • Premont, R.T.1    Gainetdinov, R.R.2
  • 61
    • 33846230600 scopus 로고    scopus 로고
    • Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays
    • Prowatke I, Devens F, Benner A, Grone EF, Mertens D, Grone HJ et al 2007). Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays. Br J Cancer 96 : 82 88.
    • (2007) Br J Cancer , vol.96 , pp. 82-88
    • Prowatke, I.1    Devens, F.2    Benner, A.3    Grone, E.F.4    Mertens, D.5    Grone, H.J.6
  • 62
    • 50949099098 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure
    • Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X et al 2008). G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res 103 : 413 422.
    • (2008) Circ Res , vol.103 , pp. 413-422
    • Raake, P.W.1    Vinge, L.E.2    Gao, E.3    Boucher, M.4    Rengo, G.5    Chen, X.6
  • 63
    • 0034595227 scopus 로고    scopus 로고
    • Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: Regulation by signal transduction systems in aortic smooth muscle cells
    • Ramos-Ruiz R, Penela P, Penn RB, Mayor F, Jr. (2000). Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells. Circulation 101 : 2083 2089.
    • (2000) Circulation , vol.101 , pp. 2083-2089
    • Ramos-Ruiz, R.1    Penela, P.2    Penn, R.B.3    Mayor Jr., F.4
  • 64
    • 33646162635 scopus 로고    scopus 로고
    • GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling
    • Reiter E, Lefkowitz RJ (2006). GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17 : 159 165.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 65
    • 59049097977 scopus 로고    scopus 로고
    • Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure
    • Rengo G, Lymperopoulos A, Zincarelli C, Donniacuo M, Soltys S, Rabinowitz JE et al 2009). Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation 119 : 89 98.
    • (2009) Circulation , vol.119 , pp. 89-98
    • Rengo, G.1    Lymperopoulos, A.2    Zincarelli, C.3    Donniacuo, M.4    Soltys, S.5    Rabinowitz, J.E.6
  • 66
    • 33947424008 scopus 로고    scopus 로고
    • The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling
    • Ribas C, Penela P, Murga C, Salcedo A, Garcia-Hoz C, Jurado-Pueyo M et al 2007). The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta 1768 : 913 922.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 913-922
    • Ribas, C.1    Penela, P.2    Murga, C.3    Salcedo, A.4    Garcia-Hoz, C.5    Jurado-Pueyo, M.6
  • 68
    • 0032499733 scopus 로고    scopus 로고
    • Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
    • Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J et al 1998). Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci U S A 95 : 7000 7005.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7000-7005
    • Rockman, H.A.1    Chien, K.R.2    Choi, D.J.3    Iaccarino, G.4    Hunter, J.J.5    Ross, J.6
  • 69
    • 33750208522 scopus 로고    scopus 로고
    • Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2
    • Salcedo A, Mayor F, Jr., Penela P (2006). Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. Embo J 25 : 4752 4762.
    • (2006) Embo J , vol.25 , pp. 4752-4762
    • Salcedo, A.1    Mayor Jr., F.2    Penela, P.3
  • 70
    • 0033607513 scopus 로고    scopus 로고
    • Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase
    • Sarnago S, Elorza A, Mayor F, Jr. (1999). Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase. J Biol Chem 274 : 34411 34416.
    • (1999) J Biol Chem , vol.274 , pp. 34411-34416
    • Sarnago, S.1    Elorza, A.2    Mayor Jr., F.3
  • 71
    • 51249099564 scopus 로고    scopus 로고
    • Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)
    • Tarrant TK, Rampersad RR, Esserman D, Rothlein LR, Liu P, Premont RT et al 2008). Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clin Immunol 129 : 115 122.
    • (2008) Clin Immunol , vol.129 , pp. 115-122
    • Tarrant, T.K.1    Rampersad, R.R.2    Esserman, D.3    Rothlein, L.R.4    Liu, P.5    Premont, R.T.6
  • 72
    • 28844463975 scopus 로고    scopus 로고
    • Snapshot of activated G proteins at the membrane: The Galphaq-GRK2-Gbetagamma complex
    • Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ (2005). Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex. Science 310 : 1686 1690.
    • (2005) Science , vol.310 , pp. 1686-1690
    • Tesmer, V.M.1    Kawano, T.2    Shankaranarayanan, A.3    Kozasa, T.4    Tesmer, J.J.5
  • 73
    • 0346034895 scopus 로고    scopus 로고
    • Differential G protein receptor kinase 2 expression in compensated hypertrophy and heart failure after myocardial infarction in the rat
    • Theilade J, Strom C, Christiansen T, Haunso S, Sheikh SP (2003). Differential G protein receptor kinase 2 expression in compensated hypertrophy and heart failure after myocardial infarction in the rat. Basic Res Cardiol 98 : 97 103.
    • (2003) Basic Res Cardiol , vol.98 , pp. 97-103
    • Theilade, J.1    Strom, C.2    Christiansen, T.3    Haunso, S.4    Sheikh, S.P.5
  • 74
    • 33845412884 scopus 로고    scopus 로고
    • GRKs and arrestins: Regulators of migration and inflammation
    • Vroon A, Heijnen CJ, Kavelaars A (2006). GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol 80 : 1214 1221.
    • (2006) J Leukoc Biol , vol.80 , pp. 1214-1221
    • Vroon, A.1    Heijnen, C.J.2    Kavelaars, A.3
  • 76
    • 15444372618 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis
    • Vroon A, Kavelaars A, Limmroth V, Lombardi MS, Goebel MU, Van Dam AM et al 2005). G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Immunol 174 : 4400 4406.
    • (2005) J Immunol , vol.174 , pp. 4400-4406
    • Vroon, A.1    Kavelaars, A.2    Limmroth, V.3    Lombardi, M.S.4    Goebel, M.U.5    Van Dam, A.M.6
  • 77
    • 0038381488 scopus 로고    scopus 로고
    • The inhibitory γ subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor
    • Wan KF, Sambi BS, Tate R, Waters C, Pyne NG (2003). The inhibitory γ subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor. J Biol Chem 278 : 18658 18663.
    • (2003) J Biol Chem , vol.278 , pp. 18658-18663
    • Wan, K.F.1    Sambi, B.S.2    Tate, R.3    Waters, C.4    Pyne, N.G.5
  • 78
    • 69449105718 scopus 로고    scopus 로고
    • Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2)
    • Wang L, Gesty-Palmer D, Fields TA, Spurney RF (2009). Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2). Mol Endocrinol 23 : 1455 1465.
    • (2009) Mol Endocrinol , vol.23 , pp. 1455-1465
    • Wang, L.1    Gesty-Palmer, D.2    Fields, T.A.3    Spurney, R.F.4
  • 79
    • 34247470682 scopus 로고    scopus 로고
    • Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2
    • Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG et al 2007). Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 129 : 511 522.
    • (2007) Cell , vol.129 , pp. 511-522
    • Whalen, E.J.1    Foster, M.W.2    Matsumoto, A.3    Ozawa, K.4    Violin, J.D.5    Que, L.G.6


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