-
1
-
-
84871720518
-
Ceramide-orchestrated signalling in cancer cells
-
Morad SA and Cabot MC. Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer. 2013; 13(1):51-65.
-
(2013)
Nat Rev Cancer.
, vol.13
, Issue.1
, pp. 51-65
-
-
Morad, S.A.1
Cabot, M.C.2
-
2
-
-
84926293921
-
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
-
Proia RL and Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. 2015; 125(4):1379-1387.
-
(2015)
J Clin Invest.
, vol.125
, Issue.4
, pp. 1379-1387
-
-
Proia, R.L.1
Hla, T.2
-
3
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S and Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature. 1996; 381(6585):800-803.
-
(1996)
Nature.
, vol.381
, Issue.6585
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Coso, O.A.5
Gutkind, S.6
Spiegel, S.7
-
4
-
-
38549152194
-
Principles of bioactive lipid signalling: lessons from sphingolipids
-
Hannun YA and Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008; 9(2):139-150.
-
(2008)
Nat Rev Mol Cell Biol.
, vol.9
, Issue.2
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
5
-
-
46949104885
-
"Insideout" signaling of sphingosine-1-phosphate: therapeutic targets
-
Takabe K, Paugh SW, Milstien S and Spiegel S. "Insideout" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev. 2008; 60(2):181-195.
-
(2008)
Pharmacol Rev.
, vol.60
, Issue.2
, pp. 181-195
-
-
Takabe, K.1
Paugh, S.W.2
Milstien, S.3
Spiegel, S.4
-
6
-
-
84927913180
-
Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy
-
Newton J, Lima S, Maceyka M and Spiegel S. Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. Exp Cell Res. 2015; 333(2):195-200.
-
(2015)
Exp Cell Res.
, vol.333
, Issue.2
, pp. 195-200
-
-
Newton, J.1
Lima, S.2
Maceyka, M.3
Spiegel, S.4
-
7
-
-
33645278951
-
Sphingosine kinase: biochemical and cellular regulation and role in disease
-
Taha TA, Hannun YA and Obeid LM. Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006; 39(2):113-131.
-
(2006)
J Biochem Mol Biol.
, vol.39
, Issue.2
, pp. 113-131
-
-
Taha, T.A.1
Hannun, Y.A.2
Obeid, L.M.3
-
8
-
-
79551614173
-
Regulation of sphingosine kinase and sphingolipid signaling
-
Pitson SM. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci. 2011; 36:97-107.
-
(2011)
Trends Biochem Sci.
, vol.36
, pp. 97-107
-
-
Pitson, S.M.1
-
9
-
-
56949095716
-
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
-
Pyne S, Lee SC, Long J and Pyne NJ. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell Signal. 2009; 21(1):14-21.
-
(2009)
Cell Signal.
, vol.21
, Issue.1
, pp. 14-21
-
-
Pyne, S.1
Lee, S.C.2
Long, J.3
Pyne, N.J.4
-
10
-
-
0142091073
-
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
-
Igarashi N, Okada T, Hayashi S, Fujita T, Jahangeer S and Nakamura S. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J Biol Chem. 2003; 278(47):46832-46839.
-
(2003)
J Biol Chem.
, vol.278
, Issue.47
, pp. 46832-46839
-
-
Igarashi, N.1
Okada, T.2
Hayashi, S.3
Fujita, T.4
Jahangeer, S.5
Nakamura, S.6
-
11
-
-
0034721844
-
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation
-
Pitson SM, Moretti PA, Zebol JR, Xia P, Gamble JR, Vadas MA, D'Andrea RJ and Wattenberg BW. Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. J Biol Chem. 2000; 275(43):33945-33950.
-
(2000)
A dominant-negative sphingosine kinase. J Biol Chem.
, vol.275
, Issue.43
, pp. 33945-33950
-
-
Pitson, S.M.1
Moretti, P.A.2
Zebol, J.R.3
Xia, P.4
Gamble, J.R.5
Vadas, M.A.6
D'Andrea, R.J.7
Wattenberg, B.W.8
-
12
-
-
0142105397
-
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
-
Pitson SM, Moretti PA, Zebol JR, Lynn HE, Xia P, Vadas MA and Wattenberg BW. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. Embo J. 2003; 22(20):5491-5500.
-
(2003)
Embo J.
, vol.22
, Issue.20
, pp. 5491-5500
-
-
Pitson, S.M.1
Moretti, P.A.2
Zebol, J.R.3
Lynn, H.E.4
Xia, P.5
Vadas, M.A.6
Wattenberg, B.W.7
-
13
-
-
33845708225
-
Ceramide/sphingosine/ sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space
-
Tani M, Ito M and Igarashi Y. Ceramide/sphingosine/ sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. Cell Signal. 2007; 19(2):229-237.
-
(2007)
Cell Signal.
, vol.19
, Issue.2
, pp. 229-237
-
-
Tani, M.1
Ito, M.2
Igarashi, Y.3
-
14
-
-
28544437478
-
Essential role for sphingosine kinases in neural and vascular development
-
Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S and Proia RL. Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005; 25(24):11113-11121.
-
(2005)
Mol Cell Biol.
, vol.25
, Issue.24
, pp. 11113-11121
-
-
Mizugishi, K.1
Yamashita, T.2
Olivera, A.3
Miller, G.F.4
Spiegel, S.5
Proia, R.L.6
-
15
-
-
12344272084
-
Phosphorylationdependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
-
Pitson SM, Xia P, Leclercq TM, Moretti PA, Zebol JR, Lynn HE, Wattenberg BW and Vadas MA. Phosphorylationdependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. J Exp Med. 2005; 201(1):49-54.
-
(2005)
J Exp Med.
, vol.201
, Issue.1
, pp. 49-54
-
-
Pitson, S.M.1
Xia, P.2
Leclercq, T.M.3
Moretti, P.A.4
Zebol, J.R.5
Lynn, H.E.6
Wattenberg, B.W.7
Vadas, M.A.8
-
16
-
-
84901930134
-
Export of sphingosine-1-phosphate and cancer progression
-
Takabe K and Spiegel S. Export of sphingosine-1-phosphate and cancer progression. J Lipid Res. 2014; 55(9):1839-1846.
-
(2014)
J Lipid Res.
, vol.55
, Issue.9
, pp. 1839-1846
-
-
Takabe, K.1
Spiegel, S.2
-
17
-
-
0037201970
-
Sphingosine-1-phosphate: dual messenger functions
-
Payne SG, Milstien S and Spiegel S. Sphingosine-1-phosphate: dual messenger functions. FEBS Lett. 2002; 531(1):54-57.
-
(2002)
FEBS Lett.
, vol.531
, Issue.1
, pp. 54-57
-
-
Payne, S.G.1
Milstien, S.2
Spiegel, S.3
-
18
-
-
77949425176
-
Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications
-
Verzijl D, Peters SL and Alewijnse AE. Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications. Mol Cells. 2010; 29(2):99-104.
-
(2010)
Mol Cells.
, vol.29
, Issue.2
, pp. 99-104
-
-
Verzijl, D.1
Peters, S.L.2
Alewijnse, A.E.3
-
19
-
-
34247874512
-
Immunosuppressive and antiangiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
-
Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY and Hla T. Immunosuppressive and antiangiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem. 2007; 282(12):9082-9089.
-
(2007)
J Biol Chem.
, vol.282
, Issue.12
, pp. 9082-9089
-
-
Oo, M.L.1
Thangada, S.2
Wu, M.T.3
Liu, C.H.4
Macdonald, T.L.5
Lynch, K.R.6
Lin, C.Y.7
Hla, T.8
-
20
-
-
78049502852
-
Extracellular and intracellular actions of sphingosine-1-phosphate
-
Strub GM, Maceyka M, Hait NC, Milstien S and Spiegel S. Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol. 2010; 688:141-155.
-
(2010)
Adv Exp Med Biol.
, vol.688
, pp. 141-155
-
-
Strub, G.M.1
Maceyka, M.2
Hait, N.C.3
Milstien, S.4
Spiegel, S.5
-
21
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S and Spiegel S. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science. 2009; 325(5945):1254-1257.
-
(2009)
Science.
, vol.325
, Issue.5945
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
Maceyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
Spiegel, S.11
-
22
-
-
77953923379
-
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
-
Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S and Spiegel S. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature. 2010; 465(7301):1084-1088.
-
(2010)
Nature.
, vol.465
, Issue.7301
, pp. 1084-1088
-
-
Alvarez, S.E.1
Harikumar, K.B.2
Hait, N.C.3
Allegood, J.4
Strub, G.M.5
Kim, E.Y.6
Maceyka, M.7
Jiang, H.8
Luo, C.9
Kordula, T.10
Milstien, S.11
Spiegel, S.12
-
23
-
-
84871762787
-
Interdiction of sphingolipid metabolism to improve standard cancer therapies
-
Beckham TH, Cheng JC, Marrison ST, Norris JS and Liu X. Interdiction of sphingolipid metabolism to improve standard cancer therapies. Adv Cancer Res. 2013; 117:1-36.
-
(2013)
Adv Cancer Res.
, vol.117
, pp. 1-36
-
-
Beckham, T.H.1
Cheng, J.C.2
Marrison, S.T.3
Norris, J.S.4
Liu, X.5
-
24
-
-
24344501665
-
Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue
-
Johnson KR, Johnson KY, Crellin HG, Ogretmen B, Boylan AM, Harley RA and Obeid LM. Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J Histochem Cytochem. 2005; 53(9):1159-1166.
-
(2005)
J Histochem Cytochem.
, vol.53
, Issue.9
, pp. 1159-1166
-
-
Johnson, K.R.1
Johnson, K.Y.2
Crellin, H.G.3
Ogretmen, B.4
Boylan, A.M.5
Harley, R.A.6
Obeid, L.M.7
-
25
-
-
23844498431
-
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
-
Van Brocklyn JR, Jackson CA, Pearl DK, Kotur MS, Snyder PJ and Prior TW. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J Neuropathol Exp Neurol. 2005; 64(8):695-705.
-
(2005)
J Neuropathol Exp Neurol.
, vol.64
, Issue.8
, pp. 695-705
-
-
Van Brocklyn, J.R.1
Jackson, C.A.2
Pearl, D.K.3
Kotur, M.S.4
Snyder, P.J.5
Prior, T.W.6
-
26
-
-
46749153415
-
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions
-
Bayerl MG, Bruggeman RD, Conroy EJ, Hengst JA, King TS, Jimenez M, Claxton DF and Yun JK. Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions. Leuk Lymphoma. 2008; 49(5):948-954.
-
(2008)
Leuk Lymphoma.
, vol.49
, Issue.5
, pp. 948-954
-
-
Bayerl, M.G.1
Bruggeman, R.D.2
Conroy, E.J.3
Hengst, J.A.4
King, T.S.5
Jimenez, M.6
Claxton, D.F.7
Yun, J.K.8
-
27
-
-
0141507968
-
Discovery and evaluation of inhibitors of human sphingosine kinase
-
French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JL, Yun JK and Smith CD. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003; 63(18):5962-5969.
-
(2003)
Cancer Res.
, vol.63
, Issue.18
, pp. 5962-5969
-
-
French, K.J.1
Schrecengost, R.S.2
Lee, B.D.3
Zhuang, Y.4
Smith, S.N.5
Eberly, J.L.6
Yun, J.K.7
Smith, C.D.8
-
28
-
-
78149348826
-
High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signalregulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients
-
Watson C, Long JS, Orange C, Tannahill CL, Mallon E, McGlynn LM, Pyne S, Pyne NJ and Edwards J. High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signalregulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. The American journal of pathology. 2010; 177(5):2205-2215.
-
(2010)
The American journal of pathology.
, vol.177
, Issue.5
, pp. 2205-2215
-
-
Watson, C.1
Long, J.S.2
Orange, C.3
Tannahill, C.L.4
Mallon, E.5
McGlynn, L.M.6
Pyne, S.7
Pyne, N.J.8
Edwards, J.9
-
29
-
-
58149231552
-
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival
-
Li J, Guan HY, Gong LY, Song LB, Zhang N, Wu J, Yuan J, Zheng YJ, Huang ZS and Li M. Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival. Clin Cancer Res. 2008; 14(21):6996-7003.
-
(2008)
Clin Cancer Res.
, vol.14
, Issue.21
, pp. 6996-7003
-
-
Li, J.1
Guan, H.Y.2
Gong, L.Y.3
Song, L.B.4
Zhang, N.5
Wu, J.6
Yuan, J.7
Zheng, Y.J.8
Huang, Z.S.9
Li, M.10
-
30
-
-
52949143502
-
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
-
Ruckhaberle E, Rody A, Engels K, Gaetje R, von Minckwitz G, Schiffmann S, Grosch S, Geisslinger G, Holtrich U, Karn T and Kaufmann M. Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat. 2008; 112(1):41-52.
-
(2008)
Breast Cancer Res Treat.
, vol.112
, Issue.1
, pp. 41-52
-
-
Ruckhaberle, E.1
Rody, A.2
Engels, K.3
Gaetje, R.4
von Minckwitz, G.5
Schiffmann, S.6
Grosch, S.7
Geisslinger, G.8
Holtrich, U.9
Karn, T.10
Kaufmann, M.11
-
31
-
-
78649630419
-
Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens.
-
Malavaud B, Pchejetski D, Mazerolles C, de Paiva GR, Calvet C, Doumerc N, Pitson S, Rischmann P and Cuvillier O. Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens. Eur J Cancer. 2010.
-
(2010)
Eur J Cancer.
-
-
Malavaud, B.1
Pchejetski, D.2
Mazerolles, C.3
de Paiva, G.R.4
Calvet, C.5
Doumerc, N.6
Pitson, S.7
Rischmann, P.8
Cuvillier, O.9
-
32
-
-
63149167365
-
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients
-
Li W, Yu CP, Xia JT, Zhang L, Weng GX, Zheng HQ, Kong QL, Hu LJ, Zeng MS, Zeng YX, Li M, Li J and Song LB. Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res. 2009; 15(4):1393-1399.
-
(2009)
Clin Cancer Res.
, vol.15
, Issue.4
, pp. 1393-1399
-
-
Li, W.1
Yu, C.P.2
Xia, J.T.3
Zhang, L.4
Weng, G.X.5
Zheng, H.Q.6
Kong, Q.L.7
Hu, L.J.8
Zeng, M.S.9
Zeng, Y.X.10
Li, M.11
Li, J.12
Song, L.B.13
-
33
-
-
79953324725
-
Sphingosine kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-[kappa]B Pathway in Human Non-small Cell Lung Cancer
-
Song L, Xiong H, Li M, Liao WT, Wang L and Wu J. Sphingosine kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-[kappa]B Pathway in Human Non-small Cell Lung Cancer. Clin Cancer Res. 2011; 17:1839-49.
-
(2011)
Clin Cancer Res.
, vol.17
, pp. 1839-1849
-
-
Song, L.1
Xiong, H.2
Li, M.3
Liao, W.T.4
Wang, L.5
Wu, J.6
-
34
-
-
77956589444
-
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy
-
Liu G, Zheng H, Zhang Z, Wu Z, Xiong H, Li J and Song L. Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy. BMC Cancer. 2010; 10:495.
-
(2010)
BMC Cancer.
, vol.10
, pp. 495
-
-
Liu, G.1
Zheng, H.2
Zhang, Z.3
Wu, Z.4
Xiong, H.5
Li, J.6
Song, L.7
-
35
-
-
77958025091
-
The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma
-
Facchinetti MM, Gandini NA, Fermento ME, Sterin-Speziale NB, Ji Y, Patel V, Gutkind JS, Rivadulla MG and Curino AC. The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma. Cells Tissues Organs. 2010; 192:314-24.
-
(2010)
Cells Tissues Organs.
, vol.192
, pp. 314-324
-
-
Facchinetti, M.M.1
Gandini, N.A.2
Fermento, M.E.3
Sterin-Speziale, N.B.4
Ji, Y.5
Patel, V.6
Gutkind, J.S.7
Rivadulla, M.G.8
Curino, A.C.9
-
36
-
-
78751544538
-
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition
-
Sinha UK, Schorn VJ, Hochstim C, Chinn SB, Zhu S and Masood R. Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head Neck. 2011; 33:178-88.
-
(2011)
Head Neck.
, vol.33
, pp. 178-188
-
-
Sinha, U.K.1
Schorn, V.J.2
Hochstim, C.3
Chinn, S.B.4
Zhu, S.5
Masood, R.6
-
37
-
-
0034735916
-
An oncogenic role of sphingosine kinase
-
Xia P, Gamble JR, Wang L, Pitson SM, Moretti PA, Wattenberg BW, D'Andrea RJ and Vadas MA. An oncogenic role of sphingosine kinase. Curr Biol. 2000; 10(23):1527-1530.
-
(2000)
Curr Biol.
, vol.10
, Issue.23
, pp. 1527-1530
-
-
Xia, P.1
Gamble, J.R.2
Wang, L.3
Pitson, S.M.4
Moretti, P.A.5
Wattenberg, B.W.6
D'Andrea, R.J.7
Vadas, M.A.8
-
38
-
-
78649876185
-
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells
-
Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ and Pyne S. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. The Journal of biological chemistry. 2010; 285(50):38841-38852.
-
(2010)
The Journal of biological chemistry.
, vol.285
, Issue.50
, pp. 38841-38852
-
-
Loveridge, C.1
Tonelli, F.2
Leclercq, T.3
Lim, K.G.4
Long, J.S.5
Berdyshev, E.6
Tate, R.J.7
Natarajan, V.8
Pitson, S.M.9
Pyne, N.J.10
Pyne, S.11
-
39
-
-
72949118378
-
Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival
-
Dayon A, Brizuela L, Martin C, Mazerolles C, Pirot N, Doumerc N, Nogueira L, Golzio M, Teissie J, Serre G, Rischmann P, Malavaud B and Cuvillier O. Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival. PLoS One. 2009; 4(11):e8048.
-
(2009)
PLoS One.
, vol.4
, Issue.11
-
-
Dayon, A.1
Brizuela, L.2
Martin, C.3
Mazerolles, C.4
Pirot, N.5
Doumerc, N.6
Nogueira, L.7
Golzio, M.8
Teissie, J.9
Serre, G.10
Rischmann, P.11
Malavaud, B.12
Cuvillier, O.13
-
40
-
-
29244457577
-
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models
-
Pchejetski D, Golzio M, Bonhoure E, Calvet C, Doumerc N, Garcia V, Mazerolles C, Rischmann P, Teissie J, Malavaud B and Cuvillier O. Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. Cancer Res. 2005; 65(24):11667-11675.
-
(2005)
Cancer Res.
, vol.65
, Issue.24
, pp. 11667-11675
-
-
Pchejetski, D.1
Golzio, M.2
Bonhoure, E.3
Calvet, C.4
Doumerc, N.5
Garcia, V.6
Mazerolles, C.7
Rischmann, P.8
Teissie, J.9
Malavaud, B.10
Cuvillier, O.11
-
41
-
-
33644974376
-
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
-
Bonhoure E, Pchejetski D, Aouali N, Morjani H, Levade T, Kohama T and Cuvillier O. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia. 2006; 20(1):95-102.
-
(2006)
Leukemia.
, vol.20
, Issue.1
, pp. 95-102
-
-
Bonhoure, E.1
Pchejetski, D.2
Aouali, N.3
Morjani, H.4
Levade, T.5
Kohama, T.6
Cuvillier, O.7
-
42
-
-
35648995431
-
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
-
Leroux ME, Auzenne E, Evans R, Hail N, Jr., Spohn W, Ghosh SC, Farquhar D, McDonnell T and Klostergaard J. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. Prostate. 2007; 67(15):1699-1717.
-
(2007)
Prostate.
, vol.67
, Issue.15
, pp. 1699-1717
-
-
Leroux, M.E.1
Auzenne, E.2
Evans, R.3
Hail, N.4
Spohn, W.5
Ghosh, S.C.6
Farquhar, D.7
McDonnell, T.8
Klostergaard, J.9
-
43
-
-
33644886904
-
High expression of sphingosine kinase 1 and S1P receptors in chemotherapyresistant prostate cancer PC3 cells and their camptothecininduced up-regulation
-
Akao Y, Banno Y, Nakagawa Y, Hasegawa N, Kim TJ, Murate T, Igarashi Y and Nozawa Y. High expression of sphingosine kinase 1 and S1P receptors in chemotherapyresistant prostate cancer PC3 cells and their camptothecininduced up-regulation. Biochem Biophys Res Commun. 2006; 342(4):1284-1290.
-
(2006)
Biochem Biophys Res Commun.
, vol.342
, Issue.4
, pp. 1284-1290
-
-
Akao, Y.1
Banno, Y.2
Nakagawa, Y.3
Hasegawa, N.4
Kim, T.J.5
Murate, T.6
Igarashi, Y.7
Nozawa, Y.8
-
44
-
-
78449267550
-
FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1
-
Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissie J, Malavaud B, Waxman J and Cuvillier O. FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1. Cancer research. 2010; 70:8651-61.
-
(2010)
Cancer research.
, vol.70
, pp. 8651-8661
-
-
Pchejetski, D.1
Bohler, T.2
Brizuela, L.3
Sauer, L.4
Doumerc, N.5
Golzio, M.6
Salunkhe, V.7
Teissie, J.8
Malavaud, B.9
Waxman, J.10
Cuvillier, O.11
-
45
-
-
48749121214
-
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal
-
Gude DR, Alvarez SE, Paugh SW, Mitra P, Yu J, Griffiths R, Barbour SE, Milstien S and Spiegel S. Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. Faseb J. 2008; 22(8):2629-2638.
-
(2008)
Faseb J.
, vol.22
, Issue.8
, pp. 2629-2638
-
-
Gude, D.R.1
Alvarez, S.E.2
Paugh, S.W.3
Mitra, P.4
Yu, J.5
Griffiths, R.6
Barbour, S.E.7
Milstien, S.8
Spiegel, S.9
-
46
-
-
12444323123
-
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression
-
Bektas M, Jolly PS, Muller C, Eberle J, Spiegel S and Geilen CC. Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression. Oncogene. 2005; 24(1):178-187.
-
(2005)
Oncogene.
, vol.24
, Issue.1
, pp. 178-187
-
-
Bektas, M.1
Jolly, P.S.2
Muller, C.3
Eberle, J.4
Spiegel, S.5
Geilen, C.C.6
-
47
-
-
0036436697
-
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
-
Nava VE, Hobson JP, Murthy S, Milstien S and Spiegel S. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp Cell Res. 2002; 281(1):115-127.
-
(2002)
Exp Cell Res.
, vol.281
, Issue.1
, pp. 115-127
-
-
Nava, V.E.1
Hobson, J.P.2
Murthy, S.3
Milstien, S.4
Spiegel, S.5
-
48
-
-
0142056955
-
Sphingosine kinase transmits estrogen signaling in human breast cancer cells
-
Sukocheva OA, Wang L, Albanese N, Pitson SM, Vadas MA and Xia P. Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol Endocrinol. 2003; 17(10):2002-2012.
-
(2003)
Mol Endocrinol.
, vol.17
, Issue.10
, pp. 2002-2012
-
-
Sukocheva, O.A.1
Wang, L.2
Albanese, N.3
Pitson, S.M.4
Vadas, M.A.5
Xia, P.6
-
49
-
-
3242791547
-
Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis
-
Melendez AJ and Ibrahim FB. Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. J Immunol. 2004; 173(3):1596-1603.
-
(2004)
J Immunol.
, vol.173
, Issue.3
, pp. 1596-1603
-
-
Melendez, A.J.1
Ibrahim, F.B.2
-
50
-
-
0041703016
-
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha
-
Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM and Hannun YA. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. Faseb J. 2003; 17(11):1411-1421.
-
(2003)
Faseb J.
, vol.17
, Issue.11
, pp. 1411-1421
-
-
Pettus, B.J.1
Bielawski, J.2
Porcelli, A.M.3
Reames, D.L.4
Johnson, K.R.5
Morrow, J.6
Chalfant, C.E.7
Obeid, L.M.8
Hannun, Y.A.9
-
51
-
-
34948853738
-
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate
-
Weigert A, Tzieply N, von Knethen A, Johann AM, Schmidt H, Geisslinger G and Brune B. Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. Mol Biol Cell. 2007; 18(10):3810-3819.
-
(2007)
Mol Biol Cell.
, vol.18
, Issue.10
, pp. 3810-3819
-
-
Weigert, A.1
Tzieply, N.2
von Knethen, A.3
Johann, A.M.4
Schmidt, H.5
Geisslinger, G.6
Brune, B.7
-
52
-
-
58149166482
-
Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization
-
Xie B, Shen J, Dong A, Rashid A, Stoller G and Campochiaro PA. Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization. J Cell Physiol. 2009; 218(1):192-198.
-
(2009)
J Cell Physiol.
, vol.218
, Issue.1
, pp. 192-198
-
-
Xie, B.1
Shen, J.2
Dong, A.3
Rashid, A.4
Stoller, G.5
Campochiaro, P.A.6
-
53
-
-
31044433663
-
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
-
Condeelis J and Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006; 124(2):263-266.
-
(2006)
Cell.
, vol.124
, Issue.2
, pp. 263-266
-
-
Condeelis, J.1
Pollard, J.W.2
-
54
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin M and Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005; 5(10):749-759.
-
(2005)
Nat Rev Immunol.
, vol.5
, Issue.10
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
55
-
-
40449098552
-
Apoptotic cell-derived sphingosine-1-phosphate promotes HuRdependent cyclooxygenase-2 mRNA stabilization and protein expression
-
Johann AM, Weigert A, Eberhardt W, Kuhn AM, Barra V, von Knethen A, Pfeilschifter JM and Brune B. Apoptotic cell-derived sphingosine-1-phosphate promotes HuRdependent cyclooxygenase-2 mRNA stabilization and protein expression. J Immunol. 2008; 180(2):1239-1248.
-
(2008)
J Immunol.
, vol.180
, Issue.2
, pp. 1239-1248
-
-
Johann, A.M.1
Weigert, A.2
Eberhardt, W.3
Kuhn, A.M.4
Barra, V.5
von Knethen, A.6
Pfeilschifter, J.M.7
Brune, B.8
-
56
-
-
13144254221
-
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway
-
Xia P, Gamble JR, Rye KA, Wang L, Hii CS, Cockerill P, Khew-Goodall Y, Bert AG, Barter PJ and Vadas MA. Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. Proc Natl Acad Sci U S A. 1998; 95(24):14196-14201.
-
(1998)
Proc Natl Acad Sci U S A.
, vol.95
, Issue.24
, pp. 14196-14201
-
-
Xia, P.1
Gamble, J.R.2
Rye, K.A.3
Wang, L.4
Hii, C.S.5
Cockerill, P.6
Khew-Goodall, Y.7
Bert, A.G.8
Barter, P.J.9
Vadas, M.A.10
-
57
-
-
33847702961
-
TNF-alpha -stimulated cell proliferation is mediated through sphingosine kinase-dependent AKT activation and cyclin D expression
-
Radeff-Huang J, Seasholtz TM, Chang JW, Smith JM and Walsh CT. TNF-alpha -stimulated cell proliferation is mediated through sphingosine kinase-dependent AKT activation and cyclin D expression. J Biol Chem. 2007; 282:863-70.
-
(2007)
J Biol Chem.
, vol.282
, pp. 863-870
-
-
Radeff-Huang, J.1
Seasholtz, T.M.2
Chang, J.W.3
Smith, J.M.4
Walsh, C.T.5
-
58
-
-
0037040908
-
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling
-
Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR and Vadas MA. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. J Biol Chem. 2002; 277(10):7996-8003.
-
(2002)
J Biol Chem.
, vol.277
, Issue.10
, pp. 7996-8003
-
-
Xia, P.1
Wang, L.2
Moretti, P.A.3
Albanese, N.4
Chai, F.5
Pitson, S.M.6
D'Andrea, R.J.7
Gamble, J.R.8
Vadas, M.A.9
-
59
-
-
84887485366
-
Sphingosine kinases are not required for inflammatory responses in macrophages
-
Xiong Y, Lee HJ, Mariko B, Lu YC, Dannenberg AJ, Haka AS, Maxfield FR, Camerer E, Proia RL and Hla T. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. 2013; 288(45):32563-32573.
-
(2013)
J Biol Chem.
, vol.288
, Issue.45
, pp. 32563-32573
-
-
Xiong, Y.1
Lee, H.J.2
Mariko, B.3
Lu, Y.C.4
Dannenberg, A.J.5
Haka, A.S.6
Maxfield, F.R.7
Camerer, E.8
Proia, R.L.9
Hla, T.10
-
60
-
-
53049096639
-
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
-
Shida D, Fang X, Kordula T, Takabe K, Lepine S, Alvarez SE, Milstien S and Spiegel S. Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res. 2008; 68(16):6569-6577.
-
(2008)
Cancer Res.
, vol.68
, Issue.16
, pp. 6569-6577
-
-
Shida, D.1
Fang, X.2
Kordula, T.3
Takabe, K.4
Lepine, S.5
Alvarez, S.E.6
Milstien, S.7
Spiegel, S.8
-
61
-
-
0035793866
-
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
-
Hobson JP, Rosenfeldt HM, Barak LS, Olivera A, Poulton S, Caron MG, Milstien S and Spiegel S. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science. 2001; 291(5509):1800-1803.
-
(2001)
Science.
, vol.291
, Issue.5509
, pp. 1800-1803
-
-
Hobson, J.P.1
Rosenfeldt, H.M.2
Barak, L.S.3
Olivera, A.4
Poulton, S.5
Caron, M.G.6
Milstien, S.7
Spiegel, S.8
-
62
-
-
0037162064
-
Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors
-
Takuwa Y. Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. Biochim Biophys Acta. 2002; 1582(1-3):112-120.
-
(2002)
Biochim Biophys Acta.
, vol.1582
, Issue.1-3
, pp. 112-120
-
-
Takuwa, Y.1
-
63
-
-
33644830810
-
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
-
Visentin B, Vekich JA, Sibbald BJ, Cavalli AL, Moreno KM, Matteo RG, Garland WA, Lu Y, Yu S, Hall HS, Kundra V, Mills GB and Sabbadini RA. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell. 2006; 9(3):225-238.
-
(2006)
Cancer Cell.
, vol.9
, Issue.3
, pp. 225-238
-
-
Visentin, B.1
Vekich, J.A.2
Sibbald, B.J.3
Cavalli, A.L.4
Moreno, K.M.5
Matteo, R.G.6
Garland, W.A.7
Lu, Y.8
Yu, S.9
Hall, H.S.10
Kundra, V.11
Mills, G.B.12
Sabbadini, R.A.13
-
64
-
-
34547820916
-
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration
-
Doll F, Pfeilschifter J and Huwiler A. Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration. Endocr Relat Cancer. 2007; 14(2):325-335.
-
(2007)
Endocr Relat Cancer.
, vol.14
, Issue.2
, pp. 325-335
-
-
Doll, F.1
Pfeilschifter, J.2
Huwiler, A.3
-
66
-
-
51349102583
-
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration
-
Maceyka M, Alvarez SE, Milstien S and Spiegel S. Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol Cell Biol. 2008; 28(18):5687-5697.
-
(2008)
Mol Cell Biol.
, vol.28
, Issue.18
, pp. 5687-5697
-
-
Maceyka, M.1
Alvarez, S.E.2
Milstien, S.3
Spiegel, S.4
-
67
-
-
40049096040
-
Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells
-
Schwalm S, Doll F, Romer I, Bubnova S, Pfeilschifter J and Huwiler A. Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochem Biophys Res Commun. 2008; 368(4):1020-1025.
-
(2008)
Biochem Biophys Res Commun.
, vol.368
, Issue.4
, pp. 1020-1025
-
-
Schwalm, S.1
Doll, F.2
Romer, I.3
Bubnova, S.4
Pfeilschifter, J.5
Huwiler, A.6
-
68
-
-
66449125409
-
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2
-
Bergelin N, Blom T, Heikkila J, Lof C, Alam C, Balthasar S, Slotte JP, Hinkkanen A and Tornquist K. Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. Endocrinology. 2009; 150(5):2055-2063.
-
(2009)
Endocrinology.
, vol.150
, Issue.5
, pp. 2055-2063
-
-
Bergelin, N.1
Blom, T.2
Heikkila, J.3
Lof, C.4
Alam, C.5
Balthasar, S.6
Slotte, J.P.7
Hinkkanen, A.8
Tornquist, K.9
-
69
-
-
0037401876
-
Signaling and biological actions of sphingosine 1-phosphate
-
Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol Res. 2003; 47(5):401-407.
-
(2003)
Pharmacol Res.
, vol.47
, Issue.5
, pp. 401-407
-
-
Hla, T.1
-
70
-
-
0033783522
-
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
-
Liu Y, Wada R, Yamashita T, Mi Y, Deng CX, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S and Proia RL. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. 2000; 106(8):951-961.
-
(2000)
J Clin Invest.
, vol.106
, Issue.8
, pp. 951-961
-
-
Liu, Y.1
Wada, R.2
Yamashita, T.3
Mi, Y.4
Deng, C.X.5
Hobson, J.P.6
Rosenfeldt, H.M.7
Nava, V.E.8
Chae, S.S.9
Lee, M.J.10
Liu, C.H.11
Hla, T.12
Spiegel, S.13
Proia, R.L.14
-
71
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL and Cyster JG. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004; 427(6972):355-360.
-
(2004)
Nature.
, vol.427
, Issue.6972
, pp. 355-360
-
-
Matloubian, M.1
Lo, C.G.2
Cinamon, G.3
Lesneski, M.J.4
Xu, Y.5
Brinkmann, V.6
Allende, M.L.7
Proia, R.L.8
Cyster, J.G.9
-
72
-
-
0035853689
-
Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3-and beta1-containing integrins
-
Paik JH, Chae S, Lee MJ, Thangada S and Hla T. Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3-and beta1-containing integrins. J Biol Chem. 2001; 276(15):11830-11837.
-
(2001)
J Biol Chem.
, vol.276
, Issue.15
, pp. 11830-11837
-
-
Paik, J.H.1
Chae, S.2
Lee, M.J.3
Thangada, S.4
Hla, T.5
-
73
-
-
51249101373
-
Sphingosine 1-phosphate Potentiates Human Lung Fibroblast Chemotaxis through the S1P2 Receptor
-
Hashimoto M, Wang X, Mao L, Kobayashi T, Kawasaki S, Mori N, Toews ML, Kim HJ, Cerutis R, Liu X and Rennard SI. Sphingosine 1-phosphate Potentiates Human Lung Fibroblast Chemotaxis through the S1P2 Receptor. Am J Respir Cell Mol Biol. 2008; 39:356-63.
-
(2008)
Am J Respir Cell Mol Biol.
, vol.39
, pp. 356-363
-
-
Hashimoto, M.1
Wang, X.2
Mao, L.3
Kobayashi, T.4
Kawasaki, S.5
Mori, N.6
Toews, M.L.7
Kim, H.J.8
Cerutis, R.9
Liu, X.10
Rennard, S.I.11
-
74
-
-
20144363126
-
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation
-
Goparaju SK, Jolly PS, Watterson KR, Bektas M, Alvarez S, Sarkar S, Mel L, Ishii I, Chun J, Milstien S and Spiegel S. The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol. 2005; 25(10):4237-4249.
-
(2005)
Mol Cell Biol.
, vol.25
, Issue.10
, pp. 4237-4249
-
-
Goparaju, S.K.1
Jolly, P.S.2
Watterson, K.R.3
Bektas, M.4
Alvarez, S.5
Sarkar, S.6
Mel, L.7
Ishii, I.8
Chun, J.9
Milstien, S.10
Spiegel, S.11
-
75
-
-
15444373513
-
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
-
Sanchez T, Thangada S, Wu MT, Kontos CD, Wu D, Wu H and Hla T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12):4312-4317.
-
(2005)
Proc Natl Acad Sci U S A.
, vol.102
, Issue.12
, pp. 4312-4317
-
-
Sanchez, T.1
Thangada, S.2
Wu, M.T.3
Kontos, C.D.4
Wu, D.5
Wu, H.6
Hla, T.7
-
76
-
-
0037370012
-
Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
-
Sugimoto N, Takuwa N, Okamoto H, Sakurada S and Takuwa Y. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol. 2003; 23(5):1534-1545.
-
(2003)
Mol Cell Biol.
, vol.23
, Issue.5
, pp. 1534-1545
-
-
Sugimoto, N.1
Takuwa, N.2
Okamoto, H.3
Sakurada, S.4
Takuwa, Y.5
-
77
-
-
53349127597
-
Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinasetype plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness
-
Bryan L, Paugh BS, Kapitonov D, Wilczynska KM, Alvarez SM, Singh SK, Milstien S, Spiegel S and Kordula T. Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinasetype plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. Mol Cancer Res. 2008; 6(9):1469-1477.
-
(2008)
Mol Cancer Res.
, vol.6
, Issue.9
, pp. 1469-1477
-
-
Bryan, L.1
Paugh, B.S.2
Kapitonov, D.3
Wilczynska, K.M.4
Alvarez, S.M.5
Singh, S.K.6
Milstien, S.7
Spiegel, S.8
Kordula, T.9
-
78
-
-
3242720378
-
Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells
-
Duan HF, Wu CT, Lu Y, Wang H, Liu HJ, Zhang QW, Jia XX, Lu ZZ and Wang LS. Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. Exp Cell Res. 2004; 298(2):593-601.
-
(2004)
Exp Cell Res.
, vol.298
, Issue.2
, pp. 593-601
-
-
Duan, H.F.1
Wu, C.T.2
Lu, Y.3
Wang, H.4
Liu, H.J.5
Zhang, Q.W.6
Jia, X.X.7
Lu, Z.Z.8
Wang, L.S.9
-
79
-
-
0141567617
-
Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3)
-
Licht T, Tsirulnikov L, Reuveni H, Yarnitzky T and Ben-Sasson SA. Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3). Blood. 2003; 102(6):2099-2107.
-
(2003)
Blood.
, vol.102
, Issue.6
, pp. 2099-2107
-
-
Licht, T.1
Tsirulnikov, L.2
Reuveni, H.3
Yarnitzky, T.4
Ben-Sasson, S.A.5
-
80
-
-
0034974903
-
Differential regulation of sphingosine-1-phosphate-and VEGF-induced endothelial cell chemotaxis
-
Liu F, Verin AD, Wang P, Day R, Wersto RP, Chrest FJ, English DK and Garcia JG. Differential regulation of sphingosine-1-phosphate-and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. Am J Respir Cell Mol Biol. 2001; 24(6):711-719.
-
(2001)
Involvement of G(ialpha2)-linked Rho kinase activity. Am J Respir Cell Mol Biol.
, vol.24
, Issue.6
, pp. 711-719
-
-
Liu, F.1
Verin, A.D.2
Wang, P.3
Day, R.4
Wersto, R.P.5
Chrest, F.J.6
English, D.K.7
Garcia, J.G.8
-
81
-
-
0038118495
-
VEGF receptor expression and signaling in human bladder tumors
-
Wu W, Shu X, Hovsepyan H, Mosteller RD and Broek D. VEGF receptor expression and signaling in human bladder tumors. Oncogene. 2003; 22(22):3361-3370.
-
(2003)
Oncogene.
, vol.22
, Issue.22
, pp. 3361-3370
-
-
Wu, W.1
Shu, X.2
Hovsepyan, H.3
Mosteller, R.D.4
Broek, D.5
-
82
-
-
9644252866
-
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
-
Chae SS, Paik JH, Furneaux H and Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest. 2004; 114(8):1082-1089.
-
(2004)
J Clin Invest.
, vol.114
, Issue.8
, pp. 1082-1089
-
-
Chae, S.S.1
Paik, J.H.2
Furneaux, H.3
Hla, T.4
-
83
-
-
77955801617
-
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro
-
Anelli V, Gault CR, Snider AJ and Obeid LM. Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J. 2010; 24(8):2727-2738.
-
(2010)
FASEB J.
, vol.24
, Issue.8
, pp. 2727-2738
-
-
Anelli, V.1
Gault, C.R.2
Snider, A.J.3
Obeid, L.M.4
-
84
-
-
77957831195
-
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer
-
Brizuela L, Dayon A, Doumerc N, Ader I, Golzio M, Izard JC, Hara Y, Malavaud B and Cuvillier O. The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer. FASEB J. 2010; 24(10):3882-3894.
-
(2010)
FASEB J.
, vol.24
, Issue.10
, pp. 3882-3894
-
-
Brizuela, L.1
Dayon, A.2
Doumerc, N.3
Ader, I.4
Golzio, M.5
Izard, J.C.6
Hara, Y.7
Malavaud, B.8
Cuvillier, O.9
-
85
-
-
18544390682
-
Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner
-
Min J, Van Veldhoven PP, Zhang L, Hanigan MH, Alexander H and Alexander S. Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner. Mol Cancer Res. 2005; 3(5):287-296.
-
(2005)
Mol Cancer Res.
, vol.3
, Issue.5
, pp. 287-296
-
-
Min, J.1
Van Veldhoven, P.P.2
Zhang, L.3
Hanigan, M.H.4
Alexander, H.5
Alexander, S.6
-
86
-
-
51049121847
-
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models
-
Pchejetski D, Doumerc N, Golzio M, Naymark M, Teissie J, Kohama T, Waxman J, Malavaud B and Cuvillier O. Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. Mol Cancer Ther. 2008; 7(7):1836-1845.
-
(2008)
Mol Cancer Ther.
, vol.7
, Issue.7
, pp. 1836-1845
-
-
Pchejetski, D.1
Doumerc, N.2
Golzio, M.3
Naymark, M.4
Teissie, J.5
Kohama, T.6
Waxman, J.7
Malavaud, B.8
Cuvillier, O.9
-
87
-
-
70350707758
-
Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel
-
Sauer L, Nunes J, Salunkhe V, Skalska L, Kohama T, Cuvillier O, Waxman J and Pchejetski D. Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel. International journal of cancer. 2009; 125:2728-36.
-
(2009)
International journal of cancer.
, vol.125
, pp. 2728-2736
-
-
Sauer, L.1
Nunes, J.2
Salunkhe, V.3
Skalska, L.4
Kohama, T.5
Cuvillier, O.6
Waxman, J.7
Pchejetski, D.8
-
88
-
-
78449267550
-
FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1
-
Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissie J, Malavaud B, Waxman J and Cuvillier O. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1. Cancer Res. 2010; 70(21):8651-8661.
-
(2010)
Cancer Res.
, vol.70
, Issue.21
, pp. 8651-8661
-
-
Pchejetski, D.1
Bohler, T.2
Brizuela, L.3
Sauer, L.4
Doumerc, N.5
Golzio, M.6
Salunkhe, V.7
Teissie, J.8
Malavaud, B.9
Waxman, J.10
Cuvillier, O.11
-
89
-
-
70349333252
-
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
-
Sukocheva O, Wang L, Verrier E, Vadas MA and Xia P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology. 2009; 150(10):4484-4492.
-
(2009)
Endocrinology.
, vol.150
, Issue.10
, pp. 4484-4492
-
-
Sukocheva, O.1
Wang, L.2
Verrier, E.3
Vadas, M.A.4
Xia, P.5
-
90
-
-
78650407629
-
Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage
-
Huwiler A, Kotelevets N, Xin C, Pastukhov O, Pfeilschifter J and Zangemeister-Wittke U. Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. Br J Pharmacol. 2011; 162(2):532-543.
-
(2011)
Br J Pharmacol.
, vol.162
, Issue.2
, pp. 532-543
-
-
Huwiler, A.1
Kotelevets, N.2
Xin, C.3
Pastukhov, O.4
Pfeilschifter, J.5
Zangemeister-Wittke, U.6
-
91
-
-
34047114465
-
Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells
-
Jung ID, Lee JS, Kim YJ, Jeong YI, Lee CM, Baumruker T, Billlich A, Banno Y, Lee MG, Ahn SC, Park WS, Han J and Park YM. Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. Int Immunol. 2007; 19(4):411-426.
-
(2007)
Int Immunol.
, vol.19
, Issue.4
, pp. 411-426
-
-
Jung, I.D.1
Lee, J.S.2
Kim, Y.J.3
Jeong, Y.I.4
Lee, C.M.5
Baumruker, T.6
Billlich, A.7
Banno, Y.8
Lee, M.G.9
Ahn, S.C.10
Park, W.S.11
Han, J.12
Park, Y.M.13
-
92
-
-
0031851003
-
Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation
-
Bruno AP, Laurent G, Averbeck D, Demur C, Bonnet J, Bettaieb A, Levade T and Jaffrezou JP. Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death Differ. 1998; 5(2):172-182.
-
(1998)
Cell Death Differ.
, vol.5
, Issue.2
, pp. 172-182
-
-
Bruno, A.P.1
Laurent, G.2
Averbeck, D.3
Demur, C.4
Bonnet, J.5
Bettaieb, A.6
Levade, T.7
Jaffrezou, J.P.8
-
93
-
-
0030945257
-
Loss of ceramide production confers resistance to radiation-induced apoptosis
-
Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J and Weichselbaum RR. Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res. 1997; 57(7):1270-1275.
-
(1997)
Cancer Res.
, vol.57
, Issue.7
, pp. 1270-1275
-
-
Chmura, S.J.1
Nodzenski, E.2
Beckett, M.A.3
Kufe, D.W.4
Quintans, J.5
Weichselbaum, R.R.6
-
94
-
-
0032530864
-
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide
-
Edsall LC, Van Brocklyn JR, Cuvillier O, Kleuser B and Spiegel S. N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry. 1998; 37(37):12892-12898.
-
(1998)
Biochemistry.
, vol.37
, Issue.37
, pp. 12892-12898
-
-
Edsall, L.C.1
Van Brocklyn, J.R.2
Cuvillier, O.3
Kleuser, B.4
Spiegel, S.5
-
95
-
-
0030004270
-
Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
-
Sweeney EA, Sakakura C, Shirahama T, Masamune A, Ohta H, Hakomori S and Igarashi Y. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int J Cancer. 1996; 66(3):358-366.
-
(1996)
Int J Cancer.
, vol.66
, Issue.3
, pp. 358-366
-
-
Sweeney, E.A.1
Sakakura, C.2
Shirahama, T.3
Masamune, A.4
Ohta, H.5
Hakomori, S.6
Igarashi, Y.7
-
96
-
-
48449100702
-
Downregulating sphingosine kinase-1 for cancer therapy
-
Cuvillier O. Downregulating sphingosine kinase-1 for cancer therapy. Expert Opin Ther Targets. 2008; 12(8):1009-1020.
-
(2008)
Expert Opin Ther Targets.
, vol.12
, Issue.8
, pp. 1009-1020
-
-
Cuvillier, O.1
-
97
-
-
0025756765
-
Cell membrane signaling as target in cancer therapy: inhibitory effect of N, N-dimethyl and N, N, N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice
-
Endo K, Igarashi Y, Nisar M, Zhou Q and Hakomori S. Cell membrane signaling as target in cancer therapy: inhibitory effect of N, N-dimethyl and N, N, N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer research. 1991; 51(6):1613.
-
(1991)
Cancer research.
, vol.51
, Issue.6
, pp. 1613
-
-
Endo, K.1
Igarashi, Y.2
Nisar, M.3
Zhou, Q.4
Hakomori, S.5
-
98
-
-
0026319890
-
Cell membrane signaling as target in cancer therapy II: Inhibitory effect of N, N, N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor celldependent platelet aggregation
-
Okoshi H, Hakomori S, Nisar M, Zhou Q, Kimura S, Tashiro K and Igarashi Y. Cell membrane signaling as target in cancer therapy II: Inhibitory effect of N, N, N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor celldependent platelet aggregation. Cancer research. 1991; 51(22):6019.
-
(1991)
Cancer research.
, vol.51
, Issue.22
, pp. 6019
-
-
Okoshi, H.1
Hakomori, S.2
Nisar, M.3
Zhou, Q.4
Kimura, S.5
Tashiro, K.6
Igarashi, Y.7
-
99
-
-
0034662612
-
Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells
-
Nava VE, Cuvillier O, Edsall LC, Kimura K, Milstien S, Gelmann EP and Spiegel S. Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. Cancer Res. 2000; 60(16):4468-4474.
-
(2000)
Cancer Res.
, vol.60
, Issue.16
, pp. 4468-4474
-
-
Nava, V.E.1
Cuvillier, O.2
Edsall, L.C.3
Kimura, K.4
Milstien, S.5
Gelmann, E.P.6
Spiegel, S.7
-
100
-
-
0031031859
-
Sphingolipids-the enigmatic lipid class: biochemistry, physiology, and pathophysiology
-
Merrill AH, Jr., Schmelz EM, Dillehay DL, Spiegel S, Shayman JA, Schroeder JJ, Riley RT, Voss KA and Wang E. Sphingolipids-the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol Appl Pharmacol. 1997; 142(1):208-225.
-
(1997)
Toxicol Appl Pharmacol.
, vol.142
, Issue.1
, pp. 208-225
-
-
Merrill, A.H.1
Schmelz, E.M.2
Dillehay, D.L.3
Spiegel, S.4
Shayman, J.A.5
Schroeder, J.J.6
Riley, R.T.7
Voss, K.A.8
Wang, E.9
-
101
-
-
0036173656
-
Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c
-
Kono K, Sugiura M and Kohama T. Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c. J Antibiot (Tokyo). 2002; 55(1):99-103.
-
(2002)
J Antibiot (Tokyo).
, vol.55
, Issue.1
, pp. 99-103
-
-
Kono, K.1
Sugiura, M.2
Kohama, T.3
-
102
-
-
43749123266
-
Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells
-
Bonhoure E, Lauret A, Barnes D, Martin C, Malavaud B, Kohama T, Melo J and Cuvillier O. Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells. Leukemia. 2008; 22(5):971-979.
-
(2008)
Leukemia.
, vol.22
, Issue.5
, pp. 971-979
-
-
Bonhoure, E.1
Lauret, A.2
Barnes, D.3
Martin, C.4
Malavaud, B.5
Kohama, T.6
Melo, J.7
Cuvillier, O.8
-
103
-
-
33745964562
-
Antitumor activity of sphingosine kinase inhibitors
-
French K, Upson J, Keller S, Zhuang Y, Yun J and Smith C. Antitumor activity of sphingosine kinase inhibitors. Journal of Pharmacology and Experimental Therapeutics. 2006; 318(2):596.
-
(2006)
Journal of Pharmacology and Experimental Therapeutics.
, vol.318
, Issue.2
, pp. 596
-
-
French, K.1
Upson, J.2
Keller, S.3
Zhuang, Y.4
Yun, J.5
Smith, C.6
-
104
-
-
84874425286
-
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism
-
Tonelli F, Alossaimi M, Williamson L, Tate RJ, Watson DG, Chan E, Bittman R, Pyne NJ and Pyne S. The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. Br J Pharmacol. 2013; 168(6):1497-1505.
-
(2013)
Br J Pharmacol.
, vol.168
, Issue.6
, pp. 1497-1505
-
-
Tonelli, F.1
Alossaimi, M.2
Williamson, L.3
Tate, R.J.4
Watson, D.G.5
Chan, E.6
Bittman, R.7
Pyne, N.J.8
Pyne, S.9
-
105
-
-
51649122574
-
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
-
Paugh SW, Paugh BS, Rahmani M, Kapitonov D, Almenara JA, Kordula T, Milstien S, Adams JK, Zipkin RE, Grant S and Spiegel S. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood. 2008; 112:1382-91.
-
(2008)
Blood.
, vol.112
, pp. 1382-1391
-
-
Paugh, S.W.1
Paugh, B.S.2
Rahmani, M.3
Kapitonov, D.4
Almenara, J.A.5
Kordula, T.6
Milstien, S.7
Adams, J.K.8
Zipkin, R.E.9
Grant, S.10
Spiegel, S.11
-
106
-
-
71749100899
-
Discovery of novel sphingosine kinase 1 inhibitors
-
Xiang Y, Asmussen G, Booker M, Hirth B, Kane JL, Jr., Liao J, Noson KD and Yee C. Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett. 2009; 19(21):6119-6121.
-
(2009)
Bioorg Med Chem Lett.
, vol.19
, Issue.21
, pp. 6119-6121
-
-
Xiang, Y.1
Asmussen, G.2
Booker, M.3
Hirth, B.4
Kane, J.L.5
Liao, J.6
Noson, K.D.7
Yee, C.8
-
107
-
-
79957775905
-
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells
-
Kennedy AJ, Mathews TP, Kharel Y, Field SD, Moyer ML, East JE, Houck JD, Lynch KR and Macdonald TL. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem. 2011; 54(10):3524-3548.
-
(2011)
J Med Chem.
, vol.54
, Issue.10
, pp. 3524-3548
-
-
Kennedy, A.J.1
Mathews, T.P.2
Kharel, Y.3
Field, S.D.4
Moyer, M.L.5
East, J.E.6
Houck, J.D.7
Lynch, K.R.8
Macdonald, T.L.9
-
108
-
-
77954535502
-
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
-
Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S and Pyne NJ. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal. 2010; 22(10):1536-1542.
-
(2010)
Cell Signal.
, vol.22
, Issue.10
, pp. 1536-1542
-
-
Tonelli, F.1
Lim, K.G.2
Loveridge, C.3
Long, J.4
Pitson, S.M.5
Tigyi, G.6
Bittman, R.7
Pyne, S.8
Pyne, N.J.9
-
109
-
-
79955112221
-
Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247)
-
Sharma AK. Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247). Expert Opin Ther Pat. 2011; 21(5):807-812.
-
(2011)
Expert Opin Ther Pat.
, vol.21
, Issue.5
, pp. 807-812
-
-
Sharma, A.K.1
-
110
-
-
78449295649
-
Development of a Sphingosine Kinase 1 Specific Small-Molecule Inhibitor
-
Hengst J, Wang X, Sk U, Sharma A, Amin S and Yun J. Development of a Sphingosine Kinase 1 Specific Small-Molecule Inhibitor. Bioorganic & Medicinal Chemistry Letters. 2010; 20:7498-502.
-
(2010)
Bioorganic & Medicinal Chemistry Letters.
, vol.20
, pp. 7498-7502
-
-
Hengst, J.1
Wang, X.2
Sk, U.3
Sharma, A.4
Amin, S.5
Yun, J.6
-
111
-
-
0032532629
-
Evidence for the presence of multiple forms of Sph kinase in human platelets
-
Banno Y, Kato M, Hara A and Nozawa Y. Evidence for the presence of multiple forms of Sph kinase in human platelets. Biochemical Journal. 1998; 335(Pt 2):301.
-
(1998)
Biochemical Journal.
, vol.335
, pp. 301
-
-
Banno, Y.1
Kato, M.2
Hara, A.3
Nozawa, Y.4
-
112
-
-
79954625512
-
A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors
-
Dickson MA, Carvajal RD, Merrill AH, Jr., Gonen M, Cane LM and Schwartz GK. A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clin Cancer Res. 2011; 17(8):2484-2492.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.8
, pp. 2484-2492
-
-
Dickson, M.A.1
Carvajal, R.D.2
Merrill, A.H.3
Gonen, M.4
Cane, L.M.5
Schwartz, G.K.6
-
113
-
-
84860812174
-
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1
-
Schnute ME, McReynolds MD, Kasten T, Yates M, Jerome G, Rains JW, Hall T, Chrencik J, Kraus M, Cronin CN, Saabye M, Highkin MK, Broadus R, Ogawa S, Cukyne K, Zawadzke LE, et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012; 444(1):79-88.
-
(2012)
Biochem J.
, vol.444
, Issue.1
, pp. 79-88
-
-
Schnute, M.E.1
McReynolds, M.D.2
Kasten, T.3
Yates, M.4
Jerome, G.5
Rains, J.W.6
Hall, T.7
Chrencik, J.8
Kraus, M.9
Cronin, C.N.10
Saabye, M.11
Highkin, M.K.12
Broadus, R.13
Ogawa, S.14
Cukyne, K.15
Zawadzke, L.E.16
-
114
-
-
82455192466
-
Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate
-
Kharel Y, Mathews TP, Gellett AM, Tomsig JL, Kennedy PC, Moyer ML, Macdonald TL and Lynch KR. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. Biochem J. 2011; 440(3):345-353.
-
(2011)
Biochem J.
, vol.440
, Issue.3
, pp. 345-353
-
-
Kharel, Y.1
Mathews, T.P.2
Gellett, A.M.3
Tomsig, J.L.4
Kennedy, P.C.5
Moyer, M.L.6
Macdonald, T.L.7
Lynch, K.R.8
-
115
-
-
84879825795
-
Sphingosine kinase activity is not required for tumor cell viability
-
Rex K, Jeffries S, Brown ML, Carlson T, Coxon A, Fajardo F, Frank B, Gustin D, Kamb A, Kassner PD, Li S, Li Y, Morgenstern K, Plant M, Quon K, Ruefli-Brasse A, et al. Sphingosine kinase activity is not required for tumor cell viability. PLoS One. 2013; 8(7):e68328.
-
(2013)
PLoS One.
, vol.8
, Issue.7
-
-
Rex, K.1
Jeffries, S.2
Brown, M.L.3
Carlson, T.4
Coxon, A.5
Fajardo, F.6
Frank, B.7
Gustin, D.8
Kamb, A.9
Kassner, P.D.10
Li, S.11
Li, Y.12
Morgenstern, K.13
Plant, M.14
Quon, K.15
Ruefli-Brasse, A.16
-
116
-
-
84930416533
-
Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer
-
Lee JW, Ryu JY, Yoon G, Jeon HK, Cho YJ, Choi JJ, Song SY, Do IG, Lee YY, Kim TJ, Choi CH, Kim BG and Bae DS. Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer. Int J Cancer. 2015; 137(1):221-229.
-
(2015)
Int J Cancer.
, vol.137
, Issue.1
, pp. 221-229
-
-
Lee, J.W.1
Ryu, J.Y.2
Yoon, G.3
Jeon, H.K.4
Cho, Y.J.5
Choi, J.J.6
Song, S.Y.7
Do, I.G.8
Lee, Y.Y.9
Kim, T.J.10
Choi, C.H.11
Kim, B.G.12
Bae, D.S.13
-
117
-
-
84906274282
-
SPHK1 regulates proliferation and survival responses in triple-negative breast cancer
-
Datta A, Loo SY, Huang B, Wong L, Tan SS, Tan TZ, Lee SC, Thiery JP, Lim YC, Yong WP, Lam Y, Kumar AP and Yap CT. SPHK1 regulates proliferation and survival responses in triple-negative breast cancer. Oncotarget. 2014; 5(15):5920-5933. doi 10.18632/oncotarget.1874.
-
(2014)
Oncotarget.
, vol.5
, Issue.15
, pp. 5920-5933
-
-
Datta, A.1
Loo, S.Y.2
Huang, B.3
Wong, L.4
Tan, S.S.5
Tan, T.Z.6
Lee, S.C.7
Thiery, J.P.8
Lim, Y.C.9
Yong, W.P.10
Lam, Y.11
Kumar, A.P.12
Yap, C.T.13
-
118
-
-
84894114392
-
Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triplenegative breast cancer cells to EGF receptor blockade
-
Martin JL, de Silva HC, Lin MZ, Scott CD and Baxter RC. Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triplenegative breast cancer cells to EGF receptor blockade. Molecular cancer therapeutics. 2014; 13(2):316-328.
-
(2014)
Molecular cancer therapeutics.
, vol.13
, Issue.2
, pp. 316-328
-
-
Martin, J.L.1
de Silva, H.C.2
Lin, M.Z.3
Scott, C.D.4
Baxter, R.C.5
-
119
-
-
29244457577
-
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models
-
Pchejetski D, Golzio M, Bonhoure E, Calvet C, Doumerc N, Garcia V, Mazerolles C, Rischmann P, Teissie J, Malavaud B and Cuvillier O. Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. Cancer research. 2005; 65(24):11667-11675.
-
(2005)
Cancer research.
, vol.65
, Issue.24
, pp. 11667-11675
-
-
Pchejetski, D.1
Golzio, M.2
Bonhoure, E.3
Calvet, C.4
Doumerc, N.5
Garcia, V.6
Mazerolles, C.7
Rischmann, P.8
Teissie, J.9
Malavaud, B.10
Cuvillier, O.11
-
120
-
-
0028372227
-
Fungal metabolite
-
Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, Chiba K, Hoshino Y and Okumoto T. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. The Journal of antibiotics. 1994; 47(2):208-215.
-
(1994)
Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. The Journal of antibiotics.
, vol.47
, Issue.2
, pp. 208-215
-
-
Fujita, T.1
Inoue, K.2
Yamamoto, S.3
Ikumoto, T.4
Sasaki, S.5
Toyama, R.6
Chiba, K.7
Hoshino, Y.8
Okumoto, T.9
-
121
-
-
0032525049
-
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats
-
Chiba K, Yanagawa Y, Masubuchi Y, Kataoka H, Kawaguchi T, Ohtsuki M and Hoshino Y. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. Journal of immunology. 1998; 160(10):5037-5044.
-
(1998)
I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. Journal of immunology.
, vol.160
, Issue.10
, pp. 5037-5044
-
-
Chiba, K.1
Yanagawa, Y.2
Masubuchi, Y.3
Kataoka, H.4
Kawaguchi, T.5
Ohtsuki, M.6
Hoshino, Y.7
-
122
-
-
79956301884
-
FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells
-
Lim KG, Tonelli F, Li Z, Lu X, Bittman R, Pyne S and Pyne NJ. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. J Biol Chem. 2011; 286(21):18633-18640.
-
(2011)
J Biol Chem.
, vol.286
, Issue.21
, pp. 18633-18640
-
-
Lim, K.G.1
Tonelli, F.2
Li, Z.3
Lu, X.4
Bittman, R.5
Pyne, S.6
Pyne, N.J.7
-
123
-
-
35548994468
-
Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart
-
Vessey DA, Kelley M, Zhang J, Li L, Tao R and Karliner JS. Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. J Biochem Mol Toxicol. 2007; 21(5):273-279.
-
(2007)
J Biochem Mol Toxicol.
, vol.21
, Issue.5
, pp. 273-279
-
-
Vessey, D.A.1
Kelley, M.2
Zhang, J.3
Li, L.4
Tao, R.5
Karliner, J.S.6
-
124
-
-
27744552046
-
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720
-
Kharel Y, Lee S, Snyder AH, Sheasley-O'Neill SL, Morris MA, Setiady Y, Zhu R, Zigler MA, Burcin TL, Ley K, Tung KS, Engelhard VH, Macdonald TL, Pearson-White S and Lynch KR. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of biological chemistry. 2005; 280(44):36865-36872.
-
(2005)
The Journal of biological chemistry.
, vol.280
, Issue.44
, pp. 36865-36872
-
-
Kharel, Y.1
Lee, S.2
Snyder, A.H.3
Sheasley-O'Neill, S.L.4
Morris, M.A.5
Setiady, Y.6
Zhu, R.7
Zigler, M.A.8
Burcin, T.L.9
Ley, K.10
Tung, K.S.11
Engelhard, V.H.12
Macdonald, T.L.13
Pearson-White, S.14
Lynch, K.R.15
-
125
-
-
0142215631
-
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
-
Paugh SW, Payne SG, Barbour SE, Milstien S and Spiegel S. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS letters. 2003; 554(1-2):189-193.
-
(2003)
FEBS letters.
, vol.554
, Issue.1-2
, pp. 189-193
-
-
Paugh, S.W.1
Payne, S.G.2
Barbour, S.E.3
Milstien, S.4
Spiegel, S.5
-
126
-
-
0347481389
-
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases
-
Billich A, Bornancin F, Devay P, Mechtcheriakova D, Urtz N and Baumruker T. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. The Journal of biological chemistry. 2003; 278(48):47408-47415.
-
(2003)
The Journal of biological chemistry.
, vol.278
, Issue.48
, pp. 47408-47415
-
-
Billich, A.1
Bornancin, F.2
Devay, P.3
Mechtcheriakova, D.4
Urtz, N.5
Baumruker, T.6
-
127
-
-
0344443651
-
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factorinduced vascular permeability
-
Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K and Hla T. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factorinduced vascular permeability. J Biol Chem. 2003; 278(47):47281-47290.
-
(2003)
J Biol Chem.
, vol.278
, Issue.47
, pp. 47281-47290
-
-
Sanchez, T.1
Estrada-Hernandez, T.2
Paik, J.H.3
Wu, M.T.4
Venkataraman, K.5
Brinkmann, V.6
Claffey, K.7
Hla, T.8
-
128
-
-
54849204200
-
Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues
-
Hogenauer K, Billich A, Pally C, Streiff M, Wagner T, Welzenbach K and Nussbaumer P. Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues. ChemMedChem. 2008; 3(7):1027-1029.
-
(2008)
ChemMedChem.
, vol.3
, Issue.7
, pp. 1027-1029
-
-
Hogenauer, K.1
Billich, A.2
Pally, C.3
Streiff, M.4
Wagner, T.5
Welzenbach, K.6
Nussbaumer, P.7
-
129
-
-
33746365908
-
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo
-
Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH and Rosen H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006; 2(8):434-441.
-
(2006)
Nat Chem Biol.
, vol.2
, Issue.8
, pp. 434-441
-
-
Sanna, M.G.1
Wang, S.K.2
Gonzalez-Cabrera, P.J.3
Don, A.4
Marsolais, D.5
Matheu, M.P.6
Wei, S.H.7
Parker, I.8
Jo, E.9
Cheng, W.C.10
Cahalan, M.D.11
Wong, C.H.12
Rosen, H.13
-
130
-
-
33750736991
-
FTY720 (fingolimod) in renal transplantation
-
Budde K, Schutz M, Glander P, Peters H, Waiser J, Liefeldt L, Neumayer HH and Bohler T. FTY720 (fingolimod) in renal transplantation. Clin Transplant. 2006; 20 Suppl 17:17-24.
-
(2006)
Clin Transplant.
, vol.20
, pp. 17-24
-
-
Budde, K.1
Schutz, M.2
Glander, P.3
Peters, H.4
Waiser, J.5
Liefeldt, L.6
Neumayer, H.H.7
Bohler, T.8
-
131
-
-
28044462458
-
FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors
-
Chiba K. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacol Ther. 2005; 108(3):308-319.
-
(2005)
Pharmacol Ther.
, vol.108
, Issue.3
, pp. 308-319
-
-
Chiba, K.1
-
132
-
-
24944535833
-
S1P1-selective in vivo-active agonists from highthroughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate
-
Jo E, Sanna MG, Gonzalez-Cabrera PJ, Thangada S, Tigyi G, Osborne DA, Hla T, Parrill AL and Rosen H. S1P1-selective in vivo-active agonists from highthroughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol. 2005; 12(6):703-715.
-
(2005)
Chem Biol.
, vol.12
, Issue.6
, pp. 703-715
-
-
Jo, E.1
Sanna, M.G.2
Gonzalez-Cabrera, P.J.3
Thangada, S.4
Tigyi, G.5
Osborne, D.A.6
Hla, T.7
Parrill, A.L.8
Rosen, H.9
-
133
-
-
13244270031
-
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit
-
Lo CG, Xu Y, Proia RL and Cyster JG. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med. 2005; 201(2):291-301.
-
(2005)
J Exp Med.
, vol.201
, Issue.2
, pp. 291-301
-
-
Lo, C.G.1
Xu, Y.2
Proia, R.L.3
Cyster, J.G.4
-
134
-
-
79952027563
-
Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
-
Hla T and Brinkmann V. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology. 2011; 76(8 Suppl 3):S3-8.
-
(2011)
Neurology.
, vol.76
, Issue.8
, pp. S3-S8
-
-
Hla, T.1
Brinkmann, V.2
-
135
-
-
54449099880
-
FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
-
Mehling M, Brinkmann V, Antel J, Bar-Or A, Goebels N, Vedrine C, Kristofic C, Kuhle J, Lindberg RL and Kappos L. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology. 2008; 71(16):1261-1267.
-
(2008)
Neurology.
, vol.71
, Issue.16
, pp. 1261-1267
-
-
Mehling, M.1
Brinkmann, V.2
Antel, J.3
Bar-Or, A.4
Goebels, N.5
Vedrine, C.6
Kristofic, C.7
Kuhle, J.8
Lindberg, R.L.9
Kappos, L.10
-
136
-
-
79955408396
-
Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite
-
Strader CR, Pearce CJ and Oberlies NH. Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. Journal of natural products. 2011; 74(4):900-907.
-
(2011)
Journal of natural products.
, vol.74
, Issue.4
, pp. 900-907
-
-
Strader, C.R.1
Pearce, C.J.2
Oberlies, N.H.3
-
137
-
-
74149086892
-
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling
-
Egom EE, Ke Y, Musa H, Mohamed TM, Wang T, Cartwright E, Solaro RJ and Lei M. FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. Journal of molecular and cellular cardiology. 2010; 48(2):406-414.
-
(2010)
Journal of molecular and cellular cardiology.
, vol.48
, Issue.2
, pp. 406-414
-
-
Egom, E.E.1
Ke, Y.2
Musa, H.3
Mohamed, T.M.4
Wang, T.5
Cartwright, E.6
Solaro, R.J.7
Lei, M.8
-
138
-
-
80053266443
-
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury
-
Egom EE, Mohamed TM, Mamas MA, Shi Y, Liu W, Chirico D, Stringer SE, Ke Y, Shaheen M, Wang T, Chacko S, Wang X, Solaro RJ, Fath-Ordoubadi F, Cartwright EJ and Lei M. Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. American journal of physiology Heart and circulatory physiology. 2011; 301(4):H1487-1495.
-
(2011)
American journal of physiology Heart and circulatory physiology.
, vol.301
, Issue.4
, pp. H1487-1495
-
-
Egom, E.E.1
Mohamed, T.M.2
Mamas, M.A.3
Shi, Y.4
Liu, W.5
Chirico, D.6
Stringer, S.E.7
Ke, Y.8
Shaheen, M.9
Wang, T.10
Chacko, S.11
Wang, X.12
Solaro, R.J.13
Fath-Ordoubadi, F.14
Cartwright, E.J.15
Lei, M.16
-
139
-
-
4944246652
-
Sphingosine kinase activation mediates ischemic preconditioning in murine heart
-
Jin ZQ, Goetzl EJ and Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation. 2004; 110(14):1980-1989.
-
(2004)
Circulation.
, vol.110
, Issue.14
, pp. 1980-1989
-
-
Jin, Z.Q.1
Goetzl, E.J.2
Karliner, J.S.3
-
140
-
-
33846047834
-
Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis
-
Pchejetski D, Kunduzova O, Dayon A, Calise D, Seguelas MH, Leducq N, Seif I, Parini A and Cuvillier O. Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. Circ Res. 2007; 100(1):41-49.
-
(2007)
Circ Res.
, vol.100
, Issue.1
, pp. 41-49
-
-
Pchejetski, D.1
Kunduzova, O.2
Dayon, A.3
Calise, D.4
Seguelas, M.H.5
Leducq, N.6
Seif, I.7
Parini, A.8
Cuvillier, O.9
-
141
-
-
27244457788
-
FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship
-
Skerjanec A, Tedesco H, Neumayer HH, Cole E, Budde K, Hsu CH and Schmouder R. FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship. J Clin Pharmacol. 2005; 45(11):1268-1278.
-
(2005)
J Clin Pharmacol.
, vol.45
, Issue.11
, pp. 1268-1278
-
-
Skerjanec, A.1
Tedesco, H.2
Neumayer, H.H.3
Cole, E.4
Budde, K.5
Hsu, C.H.6
Schmouder, R.7
-
142
-
-
0142040190
-
Renal transplantation: basic concepts and evolution of therapy
-
Braun WE. Renal transplantation: basic concepts and evolution of therapy. Journal of clinical apheresis. 2003; 18(3):141-152.
-
(2003)
Journal of clinical apheresis.
, vol.18
, Issue.3
, pp. 141-152
-
-
Braun, W.E.1
-
143
-
-
0029857032
-
A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes
-
Suzuki S, Li XK, Enosawa S and Shinomiya T. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology. 1996; 89(4):518-523.
-
(1996)
Immunology.
, vol.89
, Issue.4
, pp. 518-523
-
-
Suzuki, S.1
Li, X.K.2
Enosawa, S.3
Shinomiya, T.4
-
144
-
-
0034061094
-
Evidence that FTY720 induces T cell apoptosis in vivo
-
Nagahara Y, Enosawa S, Ikekita M, Suzuki S and Shinomiya T. Evidence that FTY720 induces T cell apoptosis in vivo. Immunopharmacology. 2000; 48(1):75-85.
-
(2000)
Immunopharmacology.
, vol.48
, Issue.1
, pp. 75-85
-
-
Nagahara, Y.1
Enosawa, S.2
Ikekita, M.3
Suzuki, S.4
Shinomiya, T.5
-
145
-
-
84859720894
-
Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
-
Yoshino T, Tabunoki H, Sugiyama S, Ishii K, Kim SU and Satoh J. Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2. Cellular and molecular neurobiology. 2011; 31(7):1009-1020.
-
(2011)
Cellular and molecular neurobiology.
, vol.31
, Issue.7
, pp. 1009-1020
-
-
Yoshino, T.1
Tabunoki, H.2
Sugiyama, S.3
Ishii, K.4
Kim, S.U.5
Satoh, J.6
-
146
-
-
28044460091
-
FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer
-
Chua CW, Lee DT, Ling MT, Zhou C, Man K, Ho J, Chan FL, Wang X and Wong YC. FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. Int J Cancer. 2005; 117(6):1039-1048.
-
(2005)
Int J Cancer.
, vol.117
, Issue.6
, pp. 1039-1048
-
-
Chua, C.W.1
Lee, D.T.2
Ling, M.T.3
Zhou, C.4
Man, K.5
Ho, J.6
Chan, F.L.7
Wang, X.8
Wong, Y.C.9
-
147
-
-
0037051102
-
Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis
-
Permpongkosol S, Wang JD, Takahara S, Matsumiya K, Nonomura N, Nishimura K, Tsujimura A, Kongkanand A and Okuyama A. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. Int J Cancer. 2002; 98(2):167-172.
-
(2002)
Int J Cancer.
, vol.98
, Issue.2
, pp. 167-172
-
-
Permpongkosol, S.1
Wang, J.D.2
Takahara, S.3
Matsumiya, K.4
Nonomura, N.5
Nishimura, K.6
Tsujimura, A.7
Kongkanand, A.8
Okuyama, A.9
-
148
-
-
0033564177
-
Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
-
Wang JD, Takahara S, Nonomura N, Ichimaru N, Toki K, Azuma H, Matsumiya K, Okuyama A and Suzuki S. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. Prostate. 1999; 40(1):50-55.
-
(1999)
Prostate.
, vol.40
, Issue.1
, pp. 50-55
-
-
Wang, J.D.1
Takahara, S.2
Nonomura, N.3
Ichimaru, N.4
Toki, K.5
Azuma, H.6
Matsumiya, K.7
Okuyama, A.8
Suzuki, S.9
-
149
-
-
32244448999
-
FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase
-
Zhou C, Ling MT, Kin-Wah Lee T, Man K, Wang X and Wong YC. FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett. 2006; 233(1):36-47.
-
(2006)
Cancer Lett.
, vol.233
, Issue.1
, pp. 36-47
-
-
Zhou, C.1
Ling, M.T.2
Kin-Wah Lee, T.3
Man, K.4
Wang, X.5
Wong, Y.C.6
-
150
-
-
0036494268
-
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
-
Azuma H, Takahara S, Ichimaru N, Wang JD, Itoh Y, Otsuki Y, Morimoto J, Fukui R, Hoshiga M, Ishihara T, Nonomura N, Suzuki S, Okuyama A and Katsuoka Y. Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res. 2002; 62(5):1410-1419.
-
(2002)
Cancer Res.
, vol.62
, Issue.5
, pp. 1410-1419
-
-
Azuma, H.1
Takahara, S.2
Ichimaru, N.3
Wang, J.D.4
Itoh, Y.5
Otsuki, Y.6
Morimoto, J.7
Fukui, R.8
Hoshiga, M.9
Ishihara, T.10
Nonomura, N.11
Suzuki, S.12
Okuyama, A.13
Katsuoka, Y.14
-
151
-
-
45749139274
-
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells
-
Nagaoka Y, Otsuki K, Fujita T and Uesato S. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biol Pharm Bull. 2008; 31(6):1177-1181.
-
(2008)
Biol Pharm Bull.
, vol.31
, Issue.6
, pp. 1177-1181
-
-
Nagaoka, Y.1
Otsuki, K.2
Fujita, T.3
Uesato, S.4
-
152
-
-
16544371726
-
Role of extracelluar regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937
-
Li D, Zhang Y, Hu X, Cao W and Huang W. Role of extracelluar regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937. Journal of Huazhong University of Science and Technology Medical sciences. 2004; 24(1):45-47.
-
(2004)
Journal of Huazhong University of Science and Technology Medical sciences.
, vol.24
, Issue.1
, pp. 45-47
-
-
Li, D.1
Zhang, Y.2
Hu, X.3
Cao, W.4
Huang, W.5
-
153
-
-
38049166147
-
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma
-
Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, Lehman A, Perrotti D, Chen CS, Dalton JT, Muthusamy N and Byrd JC. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood. 2008; 111(1):275-284.
-
(2008)
Blood.
, vol.111
, Issue.1
, pp. 275-284
-
-
Liu, Q.1
Zhao, X.2
Frissora, F.3
Ma, Y.4
Santhanam, R.5
Jarjoura, D.6
Lehman, A.7
Perrotti, D.8
Chen, C.S.9
Dalton, J.T.10
Muthusamy, N.11
Byrd, J.C.12
-
154
-
-
77953694847
-
FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma
-
Liu Q, Alinari L, Chen CS, Yan F, Dalton JT, Lapalombella R, Zhang X, Mani R, Lin T, Byrd JC, Baiocchi RA and Muthusamy N. FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma. Clin Cancer Res. 2010; 16(12):3182-3192.
-
(2010)
Clin Cancer Res.
, vol.16
, Issue.12
, pp. 3182-3192
-
-
Liu, Q.1
Alinari, L.2
Chen, C.S.3
Yan, F.4
Dalton, J.T.5
Lapalombella, R.6
Zhang, X.7
Mani, R.8
Lin, T.9
Byrd, J.C.10
Baiocchi, R.A.11
Muthusamy, N.12
-
155
-
-
34648832173
-
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
-
Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, Blaser BW, Liu S, Trotta R, Muthusamy N, Gambacorti-Passerini C, Druker BJ, Cortes J, Marcucci G, Chen CS, Verrills NM, Roy DC, et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. The Journal of clinical investigation. 2007; 117(9):2408-2421.
-
(2007)
The Journal of clinical investigation.
, vol.117
, Issue.9
, pp. 2408-2421
-
-
Neviani, P.1
Santhanam, R.2
Oaks, J.J.3
Eiring, A.M.4
Notari, M.5
Blaser, B.W.6
Liu, S.7
Trotta, R.8
Muthusamy, N.9
Gambacorti-Passerini, C.10
Druker, B.J.11
Cortes, J.12
Marcucci, G.13
Chen, C.S.14
Verrills, N.M.15
Roy, D.C.16
-
156
-
-
77954376747
-
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers
-
Roberts KG, Smith AM, McDougall F, Carpenter H, Horan M, Neviani P, Powell JA, Thomas D, Guthridge MA, Perrotti D, Sim AT, Ashman LK and Verrills NM. Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Res. 2010; 70(13):5438-5447.
-
(2010)
Cancer Res.
, vol.70
, Issue.13
, pp. 5438-5447
-
-
Roberts, K.G.1
Smith, A.M.2
McDougall, F.3
Carpenter, H.4
Horan, M.5
Neviani, P.6
Powell, J.A.7
Thomas, D.8
Guthridge, M.A.9
Perrotti, D.10
Sim, A.T.11
Ashman, L.K.12
Verrills, N.M.13
-
157
-
-
23844515685
-
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
-
Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, Catley L, Mitsiades CS, Richardson PG, Albert R, Brinkmann V, Chauhan D, et al. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res. 2005; 65(16):7478-7484.
-
(2005)
Cancer Res.
, vol.65
, Issue.16
, pp. 7478-7484
-
-
Yasui, H.1
Hideshima, T.2
Raje, N.3
Roccaro, A.M.4
Shiraishi, N.5
Kumar, S.6
Hamasaki, M.7
Ishitsuka, K.8
Tai, Y.T.9
Podar, K.10
Catley, L.11
Mitsiades, C.S.12
Richardson, P.G.13
Albert, R.14
Brinkmann, V.15
Chauhan, D.16
-
158
-
-
0036181066
-
Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells)
-
Fujino M, Li XK, Kitazawa Y, Guo L, Kawasaki M, Funeshima N, Amano T and Suzuki S. Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells). The Journal of pharmacology and experimental therapeutics. 2002; 300(3):939-945.
-
(2002)
The Journal of pharmacology and experimental therapeutics.
, vol.300
, Issue.3
, pp. 939-945
-
-
Fujino, M.1
Li, X.K.2
Kitazawa, Y.3
Guo, L.4
Kawasaki, M.5
Funeshima, N.6
Amano, T.7
Suzuki, S.8
-
159
-
-
0034665512
-
Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria
-
Nagahara Y, Ikekita M and Shinomiya T. Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria. J Immunol. 2000; 165(6):3250-3259.
-
(2000)
J Immunol.
, vol.165
, Issue.6
, pp. 3250-3259
-
-
Nagahara, Y.1
Ikekita, M.2
Shinomiya, T.3
-
160
-
-
42049107813
-
FTY720 treatment in experimentally urethaneinduced lung tumors
-
Lucas da Silva LB, Ribeiro DA, Cury PM, Cordeiro JA and Bueno V. FTY720 treatment in experimentally urethaneinduced lung tumors. J Exp Ther Oncol. 2008; 7(1):9-15.
-
(2008)
J Exp Ther Oncol.
, vol.7
, Issue.1
, pp. 9-15
-
-
Lucas da Silva, L.B.1
Ribeiro, D.A.2
Cury, P.M.3
Cordeiro, J.A.4
Bueno, V.5
-
161
-
-
74949144693
-
Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720
-
Salinas NR, Lopes CT, Palma PV, Oshima CT and Bueno V. Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720. Pathol Oncol Res. 2009; 15(4):549-554.
-
(2009)
Pathol Oncol Res.
, vol.15
, Issue.4
, pp. 549-554
-
-
Salinas, N.R.1
Lopes, C.T.2
Palma, P.V.3
Oshima, C.T.4
Bueno, V.5
-
162
-
-
65349153065
-
FTY720 and lung tumor development
-
Salinas NR, Oshima CT, Cury PM, Cordeiro JA and Bueno V. FTY720 and lung tumor development. International immunopharmacology. 2009; 9(6):689-693.
-
(2009)
International immunopharmacology.
, vol.9
, Issue.6
, pp. 689-693
-
-
Salinas, N.R.1
Oshima, C.T.2
Cury, P.M.3
Cordeiro, J.A.4
Bueno, V.5
-
163
-
-
34047255599
-
Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway
-
Ng KT, Man K, Ho JW, Sun CK, Lee TK, Zhao Y, Lo CM, Poon RT and Fan ST. Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. Int J Oncol. 2007; 30(2):375-380.
-
(2007)
Int J Oncol.
, vol.30
, Issue.2
, pp. 375-380
-
-
Ng, K.T.1
Man, K.2
Ho, J.W.3
Sun, C.K.4
Lee, T.K.5
Zhao, Y.6
Lo, C.M.7
Poon, R.T.8
Fan, S.T.9
-
164
-
-
33644697587
-
Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma
-
Ho JW, Man K, Sun CK, Lee TK, Poon RT and Fan ST. Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Mol Cancer Ther. 2005; 4(9):1430-1438.
-
(2005)
Mol Cancer Ther.
, vol.4
, Issue.9
, pp. 1430-1438
-
-
Ho, J.W.1
Man, K.2
Sun, C.K.3
Lee, T.K.4
Poon, R.T.5
Fan, S.T.6
-
165
-
-
10344231428
-
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation
-
Lee TK, Man K, Ho JW, Sun CK, Ng KT, Wang XH, Wong YC, Ng IO, Xu R and Fan ST. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis. 2004; 25(12):2397-2405.
-
(2004)
Carcinogenesis.
, vol.25
, Issue.12
, pp. 2397-2405
-
-
Lee, T.K.1
Man, K.2
Ho, J.W.3
Sun, C.K.4
Ng, K.T.5
Wang, X.H.6
Wong, Y.C.7
Ng, I.O.8
Xu, R.9
Fan, S.T.10
-
166
-
-
28544451354
-
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma
-
Lee TK, Man K, Ho JW, Wang XH, Poon RT, Xu Y, Ng KT, Chu AC, Sun CK, Ng IO, Sun HC, Tang ZY, Xu R and Fan ST. FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma. Clin Cancer Res. 2005; 11(23):8458-8466.
-
(2005)
Clin Cancer Res.
, vol.11
, Issue.23
, pp. 8458-8466
-
-
Lee, T.K.1
Man, K.2
Ho, J.W.3
Wang, X.H.4
Poon, R.T.5
Xu, Y.6
Ng, K.T.7
Chu, A.C.8
Sun, C.K.9
Ng, I.O.10
Sun, H.C.11
Tang, Z.Y.12
Xu, R.13
Fan, S.T.14
-
167
-
-
34547408777
-
FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells
-
Shen Y, Cai M, Xia W, Liu J, Zhang Q, Xie H, Wang C, Wang X and Zheng S. FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. Cancer Lett. 2007; 254(2):288-297.
-
(2007)
Cancer Lett.
, vol.254
, Issue.2
, pp. 288-297
-
-
Shen, Y.1
Cai, M.2
Xia, W.3
Liu, J.4
Zhang, Q.5
Xie, H.6
Wang, C.7
Wang, X.8
Zheng, S.9
-
168
-
-
45749146180
-
Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro
-
Shen Y, Wang X, Xia W, Wang C, Cai M, Xie H, Zhou L and Zheng S. Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro. Transplant Proc. 2008; 40(5):1727-1733.
-
(2008)
Transplant Proc.
, vol.40
, Issue.5
, pp. 1727-1733
-
-
Shen, Y.1
Wang, X.2
Xia, W.3
Wang, C.4
Cai, M.5
Xie, H.6
Zhou, L.7
Zheng, S.8
-
169
-
-
0038286415
-
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment
-
Azuma H, Takahara S, Horie S, Muto S, Otsuki Y and Katsuoka Y. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. J Urol. 2003; 169(6):2372-2377.
-
(2003)
J Urol.
, vol.169
, Issue.6
, pp. 2372-2377
-
-
Azuma, H.1
Takahara, S.2
Horie, S.3
Muto, S.4
Otsuki, Y.5
Katsuoka, Y.6
-
170
-
-
33847644587
-
FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft
-
Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y and Katsuoka Y. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft. Anticancer Res. 2007; 27(1A):75-88.
-
(2007)
Anticancer Res.
, vol.27
, Issue.1
, pp. 75-88
-
-
Ubai, T.1
Azuma, H.2
Kotake, Y.3
Inamoto, T.4
Takahara, K.5
Ito, Y.6
Kiyama, S.7
Sakamoto, T.8
Horie, S.9
Muto, S.10
Takahara, S.11
Otsuki, Y.12
Katsuoka, Y.13
-
171
-
-
9344268261
-
Sphingosine mediates FTY720-induced apoptosis in LLCPK1 cells
-
Lee WJ, Yoo HS, Suh PG, Oh S, Lim JS and Lee YM. Sphingosine mediates FTY720-induced apoptosis in LLCPK1 cells. Experimental & molecular medicine. 2004; 36(5):420-427.
-
(2004)
Experimental & molecular medicine.
, vol.36
, Issue.5
, pp. 420-427
-
-
Lee, W.J.1
Yoo, H.S.2
Suh, P.G.3
Oh, S.4
Lim, J.S.5
Lee, Y.M.6
-
172
-
-
0034813958
-
FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells
-
Sonoda Y, Yamamoto D, Sakurai S, Hasegawa M, Aizu-Yokota E, Momoi T and Kasahara T. FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells. Biochemical and biophysical research communications. 2001; 281(2):282-288.
-
(2001)
Biochemical and biophysical research communications.
, vol.281
, Issue.2
, pp. 282-288
-
-
Sonoda, Y.1
Yamamoto, D.2
Sakurai, S.3
Hasegawa, M.4
Aizu-Yokota, E.5
Momoi, T.6
Kasahara, T.7
-
173
-
-
77956791246
-
PTEN-and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice
-
Zheng T, Meng X, Wang J, Chen X, Yin D, Liang Y, Song X, Pan S, Jiang H and Liu L. PTEN-and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. Journal of cellular biochemistry. 2010; 111(1):218-228.
-
(2010)
Journal of cellular biochemistry.
, vol.111
, Issue.1
, pp. 218-228
-
-
Zheng, T.1
Meng, X.2
Wang, J.3
Chen, X.4
Yin, D.5
Liang, Y.6
Song, X.7
Pan, S.8
Jiang, H.9
Liu, L.10
-
174
-
-
84898926856
-
FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1
-
Xing Y, Wang ZH, Ma DH and Han Y. FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1. Journal of digestive diseases. 2014; 15(5):246-259.
-
(2014)
Journal of digestive diseases.
, vol.15
, Issue.5
, pp. 246-259
-
-
Xing, Y.1
Wang, Z.H.2
Ma, D.H.3
Han, Y.4
-
175
-
-
78649305851
-
FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy
-
Zhang N, Qi Y, Wadham C, Wang L, Warren A, Di W and Xia P. FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. Autophagy. 2010; 6(8):1157-1167.
-
(2010)
Autophagy.
, vol.6
, Issue.8
, pp. 1157-1167
-
-
Zhang, N.1
Qi, Y.2
Wadham, C.3
Wang, L.4
Warren, A.5
Di, W.6
Xia, P.7
-
176
-
-
84904003955
-
PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential
-
Cristobal I, Manso R, Rincon R, Carames C, Senin C, Borrero A, Martinez-Useros J, Rodriguez M, Zazo S, Aguilera O, Madoz-Gurpide J, Rojo F and Garcia-Foncillas J. PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. Molecular cancer therapeutics. 2014; 13(4):938-947.
-
(2014)
Molecular cancer therapeutics.
, vol.13
, Issue.4
, pp. 938-947
-
-
Cristobal, I.1
Manso, R.2
Rincon, R.3
Carames, C.4
Senin, C.5
Borrero, A.6
Martinez-Useros, J.7
Rodriguez, M.8
Zazo, S.9
Aguilera, O.10
Madoz-Gurpide, J.11
Rojo, F.12
Garcia-Foncillas, J.13
-
177
-
-
84871982124
-
Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models
-
Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marfe G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, et al. Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models. Clinical cancer research. 2013; 19(1):138-147.
-
(2013)
Clinical cancer research.
, vol.19
, Issue.1
, pp. 138-147
-
-
Rosa, R.1
Marciano, R.2
Malapelle, U.3
Formisano, L.4
Nappi, L.5
D'Amato, C.6
D'Amato, V.7
Damiano, V.8
Marfe, G.9
Del Vecchio, S.10
Zannetti, A.11
Greco, A.12
De Stefano, A.13
Carlomagno, C.14
Veneziani, B.M.15
Troncone, G.16
-
178
-
-
84902140053
-
Allogeneic chimeric antigen receptor-modified cells for adoptive cell therapy of cancer
-
Marcus A and Eshhar Z. Allogeneic chimeric antigen receptor-modified cells for adoptive cell therapy of cancer. Expert opinion on biological therapy. 2014; 14(7):947-954.
-
(2014)
Expert opinion on biological therapy.
, vol.14
, Issue.7
, pp. 947-954
-
-
Marcus, A.1
Eshhar, Z.2
-
179
-
-
31544447428
-
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization
-
LaMontagne K, Littlewood-Evans A, Schnell C, O'Reilly T, Wyder L, Sanchez T, Probst B, Butler J, Wood A, Liau G, Billy E, Theuer A, Hla T and Wood J. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. 2006; 66(1):221-231.
-
(2006)
Cancer Res.
, vol.66
, Issue.1
, pp. 221-231
-
-
LaMontagne, K.1
Littlewood-Evans, A.2
Schnell, C.3
O'Reilly, T.4
Wyder, L.5
Sanchez, T.6
Probst, B.7
Butler, J.8
Wood, A.9
Liau, G.10
Billy, E.11
Theuer, A.12
Hla, T.13
Wood, J.14
-
180
-
-
84928589926
-
FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway
-
Zhang L, Wang H, Zhu J, Ding K and Xu J. FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. Tumour biology. 2014; 35:10707-14.
-
(2014)
Tumour biology.
, vol.35
, pp. 10707-10714
-
-
Zhang, L.1
Wang, H.2
Zhu, J.3
Ding, K.4
Xu, J.5
-
181
-
-
70349333237
-
The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo
-
Wolf AM, Eller K, Zeiser R, Durr C, Gerlach UV, Sixt M, Markut L, Gastl G, Rosenkranz AR and Wolf D. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol. 2009; 183(6):3751-3760.
-
(2009)
J Immunol.
, vol.183
, Issue.6
, pp. 3751-3760
-
-
Wolf, A.M.1
Eller, K.2
Zeiser, R.3
Durr, C.4
Gerlach, U.V.5
Sixt, M.6
Markut, L.7
Gastl, G.8
Rosenkranz, A.R.9
Wolf, D.10
-
182
-
-
77954721060
-
Regulatory T cells in tumor immunity
-
Nishikawa H and Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer. 2010; 127(4):759-767.
-
(2010)
Int J Cancer.
, vol.127
, Issue.4
, pp. 759-767
-
-
Nishikawa, H.1
Sakaguchi, S.2
-
183
-
-
65349143361
-
Immunosuppressive therapy and post-transplant malignancy
-
Domhan S, Zeier M and Abdollahi A. Immunosuppressive therapy and post-transplant malignancy. Nephrol Dial Transplant. 2009; 24(4):1097-1103.
-
(2009)
Nephrol Dial Transplant.
, vol.24
, Issue.4
, pp. 1097-1103
-
-
Domhan, S.1
Zeier, M.2
Abdollahi, A.3
-
184
-
-
84872406787
-
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitisassociated cancer
-
Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S and Spiegel S. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitisassociated cancer. Cancer cell. 2013; 23(1):107-120.
-
(2013)
Cancer cell.
, vol.23
, Issue.1
, pp. 107-120
-
-
Liang, J.1
Nagahashi, M.2
Kim, E.Y.3
Harikumar, K.B.4
Yamada, A.5
Huang, W.C.6
Hait, N.C.7
Allegood, J.C.8
Price, M.M.9
Avni, D.10
Takabe, K.11
Kordula, T.12
Milstien, S.13
Spiegel, S.14
-
185
-
-
84893359343
-
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer
-
Nagahashi M, Hait NC, Maceyka M, Avni D, Takabe K, Milstien S and Spiegel S. Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. Advances in biological regulation. 2014; 54:112-120.
-
(2014)
Advances in biological regulation.
, vol.54
, pp. 112-120
-
-
Nagahashi, M.1
Hait, N.C.2
Maceyka, M.3
Avni, D.4
Takabe, K.5
Milstien, S.6
Spiegel, S.7
-
186
-
-
78649876185
-
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells
-
Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ and Pyne S. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J Biol Chem. 2010; 285(50):38841-38852.
-
(2010)
J Biol Chem.
, vol.285
, Issue.50
, pp. 38841-38852
-
-
Loveridge, C.1
Tonelli, F.2
Leclercq, T.3
Lim, K.G.4
Long, J.S.5
Berdyshev, E.6
Tate, R.J.7
Natarajan, V.8
Pitson, S.M.9
Pyne, N.J.10
Pyne, S.11
-
187
-
-
77952907876
-
A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation
-
Ren S, Xin C, Pfeilschifter J and Huwiler A. A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cell Physiol Biochem. 2010; 26(1):97-104.
-
(2010)
Cell Physiol Biochem.
, vol.26
, Issue.1
, pp. 97-104
-
-
Ren, S.1
Xin, C.2
Pfeilschifter, J.3
Huwiler, A.4
-
188
-
-
84907468386
-
FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression
-
Ishitsuka A, Fujine E, Mizutani Y, Tawada C, Kanoh H, Banno Y and Seishima M. FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression. Int J Mol Med. 2014; 34(4):1169-1174.
-
(2014)
Int J Mol Med.
, vol.34
, Issue.4
, pp. 1169-1174
-
-
Ishitsuka, A.1
Fujine, E.2
Mizutani, Y.3
Tawada, C.4
Kanoh, H.5
Banno, Y.6
Seishima, M.7
-
189
-
-
43049112747
-
Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias
-
Perrotti D and Neviani P. Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. Cancer metastasis reviews. 2008; 27(2):159-168.
-
(2008)
Cancer metastasis reviews.
, vol.27
, Issue.2
, pp. 159-168
-
-
Perrotti, D.1
Neviani, P.2
-
190
-
-
27644569730
-
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
-
Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S, Mao H, Chang JS, Galietta A, Uttam A, Roy DC, Valtieri M, Bruner-Klisovic R, Caligiuri MA, Bloomfield CD, Marcucci G, et al. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer cell. 2005; 8(5):355-368.
-
(2005)
Cancer cell.
, vol.8
, Issue.5
, pp. 355-368
-
-
Neviani, P.1
Santhanam, R.2
Trotta, R.3
Notari, M.4
Blaser, B.W.5
Liu, S.6
Mao, H.7
Chang, J.S.8
Galietta, A.9
Uttam, A.10
Roy, D.C.11
Valtieri, M.12
Bruner-Klisovic, R.13
Caligiuri, M.A.14
Bloomfield, C.D.15
Marcucci, G.16
-
191
-
-
41549090369
-
Multiple pathways regulated by the tumor suppressor PP2A in transformation
-
Westermarck J and Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends in molecular medicine. 2008; 14(4):152-160.
-
(2008)
Trends in molecular medicine.
, vol.14
, Issue.4
, pp. 152-160
-
-
Westermarck, J.1
Hahn, W.C.2
-
192
-
-
79954449794
-
PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect
-
Cristobal I, Garcia-Orti L, Cirauqui C, Alonso MM, Calasanz MJ and Odero MD. PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia. 2011; 25(4):606-614.
-
(2011)
Leukemia.
, vol.25
, Issue.4
, pp. 606-614
-
-
Cristobal, I.1
Garcia-Orti, L.2
Cirauqui, C.3
Alonso, M.M.4
Calasanz, M.J.5
Odero, M.D.6
-
193
-
-
84905035215
-
Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720
-
Baldacchino S, Saliba C, Petroni V, Fenech AG, Borg N and Grech G. Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720. The EPMA journal. 2014; 5(1):3.
-
(2014)
The EPMA journal.
, vol.5
, Issue.1
, pp. 3
-
-
Baldacchino, S.1
Saliba, C.2
Petroni, V.3
Fenech, A.G.4
Borg, N.5
Grech, G.6
-
194
-
-
84876990097
-
Protein phosphatase 2A: a target for anticancer therapy
-
Perrotti D and Neviani P. Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol. 2013; 14(6):e229-238.
-
(2013)
Lancet Oncol.
, vol.14
, Issue.6
, pp. e229-238
-
-
Perrotti, D.1
Neviani, P.2
-
195
-
-
34248193812
-
Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B
-
Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Dohner H, Stilgenbauer S and Lichter P. Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B. Eur J Cancer. 2007; 43(8):1328-1335.
-
(2007)
Eur J Cancer.
, vol.43
, Issue.8
, pp. 1328-1335
-
-
Kalla, C.1
Scheuermann, M.O.2
Kube, I.3
Schlotter, M.4
Mertens, D.5
Dohner, H.6
Stilgenbauer, S.7
Lichter, P.8
-
196
-
-
0037739755
-
A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells
-
Matsuoka Y, Nagahara Y, Ikekita M and Shinomiya T. A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. British journal of pharmacology. 2003; 138(7):1303-1312.
-
(2003)
British journal of pharmacology.
, vol.138
, Issue.7
, pp. 1303-1312
-
-
Matsuoka, Y.1
Nagahara, Y.2
Ikekita, M.3
Shinomiya, T.4
-
199
-
-
0037151038
-
A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function
-
Ruvolo PP, Clark W, Mumby M, Gao F and May WS. A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function. The Journal of biological chemistry. 2002; 277(25):22847-22852.
-
(2002)
The Journal of biological chemistry.
, vol.277
, Issue.25
, pp. 22847-22852
-
-
Ruvolo, P.P.1
Clark, W.2
Mumby, M.3
Gao, F.4
May, W.S.5
-
200
-
-
0033575320
-
Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
-
Ruvolo PP, Deng X, Ito T, Carr BK and May WS. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. The Journal of biological chemistry. 1999; 274(29):20296-20300.
-
(1999)
The Journal of biological chemistry.
, vol.274
, Issue.29
, pp. 20296-20300
-
-
Ruvolo, P.P.1
Deng, X.2
Ito, T.3
Carr, B.K.4
May, W.S.5
-
201
-
-
61549109860
-
Direct interaction between the inhibitor 2 and ceramide via sphingolipidprotein binding is involved in the regulation of protein phosphatase 2A activity and signaling
-
Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA and Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipidprotein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009; 23(3):751-763.
-
(2009)
FASEB J.
, vol.23
, Issue.3
, pp. 751-763
-
-
Mukhopadhyay, A.1
Saddoughi, S.A.2
Song, P.3
Sultan, I.4
Ponnusamy, S.5
Senkal, C.E.6
Snook, C.F.7
Arnold, H.K.8
Sears, R.C.9
Hannun, Y.A.10
Ogretmen, B.11
-
202
-
-
77956259768
-
Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells
-
Habrukowich C, Han DK, Le A, Rezaul K, Pan W, Ghosh M, Li Z, Dodge-Kafka K, Jiang X, Bittman R and Hla T. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. The Journal of biological chemistry. 2010; 285(35):26825-26831.
-
(2010)
The Journal of biological chemistry.
, vol.285
, Issue.35
, pp. 26825-26831
-
-
Habrukowich, C.1
Han, D.K.2
Le, A.3
Rezaul, K.4
Pan, W.5
Ghosh, M.6
Li, Z.7
Dodge-Kafka, K.8
Jiang, X.9
Bittman, R.10
Hla, T.11
-
203
-
-
84907609978
-
SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell
-
Liu H, Gu Y, Yin J, Zheng G, Wang C, Zhang Z, Deng M, Liu J, Jia X and He Z. SET-mediated NDRG1 inhibition is involved in acquisition of epithelial-to-mesenchymal transition phenotype and cisplatin resistance in human lung cancer cell. Cellular signalling. 2014; 26(12):2710-2720.
-
(2014)
Cellular signalling.
, vol.26
, Issue.12
, pp. 2710-2720
-
-
Liu, H.1
Gu, Y.2
Yin, J.3
Zheng, G.4
Wang, C.5
Zhang, Z.6
Deng, M.7
Liu, J.8
Jia, X.9
He, Z.10
-
204
-
-
84902477545
-
The protein phosphatase 2A regulatory subunit B55alpha is a modulator of signaling and microRNA expression in acute myeloid leukemia cells
-
Ruvolo PP, Ruvolo VR, Jacamo R, Burks JK, Zeng Z, Duvvuri SR, Zhou L, Qiu Y, Coombes KR, Zhang N, Yoo SY, Pan R, Hail N, Jr., Konopleva M, Calin G, Kornblau SM, et al. The protein phosphatase 2A regulatory subunit B55alpha is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. Biochimica et biophysica acta. 2014; 1843(9):1969-1977.
-
(2014)
Biochimica et biophysica acta.
, vol.1843
, Issue.9
, pp. 1969-1977
-
-
Ruvolo, P.P.1
Ruvolo, V.R.2
Jacamo, R.3
Burks, J.K.4
Zeng, Z.5
Duvvuri, S.R.6
Zhou, L.7
Qiu, Y.8
Coombes, K.R.9
Zhang, N.10
Yoo, S.Y.11
Pan, R.12
Hail, N.13
Konopleva, M.14
Calin, G.15
Kornblau, S.M.16
-
205
-
-
84885085996
-
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
-
Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. The Journal of clinical investigation. 2013; 123(10):4144-4157.
-
(2013)
The Journal of clinical investigation.
, vol.123
, Issue.10
, pp. 4144-4157
-
-
Neviani, P.1
Harb, J.G.2
Oaks, J.J.3
Santhanam, R.4
Walker, C.J.5
Ellis, J.J.6
Ferenchak, G.7
Dorrance, A.M.8
Paisie, C.A.9
Eiring, A.M.10
Ma, Y.11
Mao, H.C.12
Zhang, B.13
Wunderlich, M.14
May, P.C.15
Sun, C.16
-
206
-
-
84926485450
-
Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia.
-
Mani R, Mao Y, Frissora FW, Chiang CL, Wang J, Zhao Y, Wu Y, Yu B, Yan R, Mo X, Yu L, Flynn J, Jones J, Andritsos L, Baskar S, Rader C, et al. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia. Leukemia. 2014.
-
(2014)
Leukemia.
-
-
Mani, R.1
Mao, Y.2
Frissora, F.W.3
Chiang, C.L.4
Wang, J.5
Zhao, Y.6
Wu, Y.7
Yu, B.8
Yan, R.9
Mo, X.10
Yu, L.11
Flynn, J.12
Jones, J.13
Andritsos, L.14
Baskar, S.15
Rader, C.16
-
207
-
-
84887391984
-
Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies
-
Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, Arlinghaus RB, et al. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 2013; 122(11):1923-1934.
-
(2013)
Blood.
, vol.122
, Issue.11
, pp. 1923-1934
-
-
Oaks, J.J.1
Santhanam, R.2
Walker, C.J.3
Roof, S.4
Harb, J.G.5
Ferenchak, G.6
Eisfeld, A.K.7
Van Brocklyn, J.R.8
Briesewitz, R.9
Saddoughi, S.A.10
Nagata, K.11
Bittman, R.12
Caligiuri, M.A.13
Abdel-Wahab, O.14
Levine, R.15
Arlinghaus, R.B.16
-
208
-
-
84871968824
-
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
-
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, et al. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO molecular medicine. 2013; 5(1):105-121.
-
(2013)
EMBO molecular medicine.
, vol.5
, Issue.1
, pp. 105-121
-
-
Saddoughi, S.A.1
Gencer, S.2
Peterson, Y.K.3
Ward, K.E.4
Mukhopadhyay, A.5
Oaks, J.6
Bielawski, J.7
Szulc, Z.M.8
Thomas, R.J.9
Selvam, S.P.10
Senkal, C.E.11
Garrett-Mayer, E.12
De Palma, R.M.13
Fedarovich, D.14
Liu, A.15
Habib, A.A.16
-
209
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M and Lynch KR. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of biological chemistry. 2002; 277(24):21453-21457.
-
(2002)
The Journal of biological chemistry.
, vol.277
, Issue.24
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
Zollinger, M.12
Lynch, K.R.13
-
210
-
-
70350444557
-
Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog
-
Ushitora Y, Tashiro H, Ogawa T, Tanimoto Y, Kuroda S, Kobayashi T, Miyata Y, Itamoto T, Asahara T and Ohdan H. Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog. Transplantation. 2009; 88(8):980-986.
-
(2009)
Transplantation.
, vol.88
, Issue.8
, pp. 980-986
-
-
Ushitora, Y.1
Tashiro, H.2
Ogawa, T.3
Tanimoto, Y.4
Kuroda, S.5
Kobayashi, T.6
Miyata, Y.7
Itamoto, T.8
Asahara, T.9
Ohdan, H.10
-
211
-
-
84875723927
-
Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration
-
Kluk MJ, Ryan KP, Wang B, Zhang G, Rodig SJ and Sanchez T. Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration. Laboratory investigation. 2013; 93(4):462-471.
-
(2013)
Laboratory investigation.
, vol.93
, Issue.4
, pp. 462-471
-
-
Kluk, M.J.1
Ryan, K.P.2
Wang, B.3
Zhang, G.4
Rodig, S.J.5
Sanchez, T.6
-
212
-
-
0034642507
-
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of rastransformed cells
-
Nam SW, Clair T, Campo CK, Lee HY, Liotta LA and Stracke ML. Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of rastransformed cells. Oncogene. 2000; 19(2):241-247.
-
(2000)
Oncogene.
, vol.19
, Issue.2
, pp. 241-247
-
-
Nam, S.W.1
Clair, T.2
Campo, C.K.3
Lee, H.Y.4
Liotta, L.A.5
Stracke, M.L.6
-
213
-
-
0035884290
-
Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor
-
Nam SW, Clair T, Kim YS, McMarlin A, Schiffmann E, Liotta LA and Stracke ML. Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. Cancer research. 2001; 61(18):6938-6944.
-
(2001)
Cancer research.
, vol.61
, Issue.18
, pp. 6938-6944
-
-
Nam, S.W.1
Clair, T.2
Kim, Y.S.3
McMarlin, A.4
Schiffmann, E.5
Liotta, L.A.6
Stracke, M.L.7
-
214
-
-
18344370242
-
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells
-
Lee HY, Bae GU, Jung ID, Lee JS, Kim YK, Noh SH, Stracke ML, Park CG, Lee HW and Han JW. Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells. FEBS letters. 2002; 515(1-3):137-140.
-
(2002)
FEBS letters.
, vol.515
, Issue.1-3
, pp. 137-140
-
-
Lee, H.Y.1
Bae, G.U.2
Jung, I.D.3
Lee, J.S.4
Kim, Y.K.5
Noh, S.H.6
Stracke, M.L.7
Park, C.G.8
Lee, H.W.9
Han, J.W.10
-
215
-
-
1542359873
-
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
-
Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, Yamori T, Mills GB, Inoue K, Aoki J and Arai H. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of cell biology. 2002; 158(2):227-233.
-
(2002)
The Journal of cell biology.
, vol.158
, Issue.2
, pp. 227-233
-
-
Umezu-Goto, M.1
Kishi, Y.2
Taira, A.3
Hama, K.4
Dohmae, N.5
Takio, K.6
Yamori, T.7
Mills, G.B.8
Inoue, K.9
Aoki, J.10
Arai, H.11
-
216
-
-
0036456916
-
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells
-
Yang SY, Lee J, Park CG, Kim S, Hong S, Chung HC, Min SK, Han JW, Lee HW and Lee HY. Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clinical & experimental metastasis. 2002; 19(7):603-608.
-
(2002)
Clinical & experimental metastasis.
, vol.19
, Issue.7
, pp. 603-608
-
-
Yang, S.Y.1
Lee, J.2
Park, C.G.3
Kim, S.4
Hong, S.5
Chung, H.C.6
Min, S.K.7
Han, J.W.8
Lee, H.W.9
Lee, H.Y.10
-
217
-
-
0037434917
-
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site
-
Gijsbers R, Aoki J, Arai H and Bollen M. The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site. FEBS letters. 2003; 538(1-3):60-64.
-
(2003)
FEBS letters.
, vol.538
, Issue.1-3
, pp. 60-64
-
-
Gijsbers, R.1
Aoki, J.2
Arai, H.3
Bollen, M.4
-
218
-
-
0038405048
-
Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities
-
Koh E, Clair T, Woodhouse EC, Schiffmann E, Liotta L and Stracke M. Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities. Cancer research. 2003; 63(9):2042-2045.
-
(2003)
Cancer research.
, vol.63
, Issue.9
, pp. 2042-2045
-
-
Koh, E.1
Clair, T.2
Woodhouse, E.C.3
Schiffmann, E.4
Liotta, L.5
Stracke, M.6
-
219
-
-
45049086146
-
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasisenhancing and angiogenic lysophospholipase D
-
van Meeteren LA, Brinkmann V, Saulnier-Blache JS, Lynch KR and Moolenaar WH. Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasisenhancing and angiogenic lysophospholipase D. Cancer letters. 2008; 266(2):203-208.
-
(2008)
Cancer letters.
, vol.266
, Issue.2
, pp. 203-208
-
-
van Meeteren, L.A.1
Brinkmann, V.2
Saulnier-Blache, J.S.3
Lynch, K.R.4
Moolenaar, W.H.5
-
220
-
-
77956063681
-
FTY720 mediates cytochrome c release from mitochondria during rat thymocyte apoptosis
-
Matsumura M, Tsuchida M, Isoyama N, Takai K and Matsuyama H. FTY720 mediates cytochrome c release from mitochondria during rat thymocyte apoptosis. Transplant immunology. 2010; 23(4):174-179.
-
(2010)
Transplant immunology.
, vol.23
, Issue.4
, pp. 174-179
-
-
Matsumura, M.1
Tsuchida, M.2
Isoyama, N.3
Takai, K.4
Matsuyama, H.5
-
221
-
-
84886432489
-
FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors
-
Kiyota M, Kuroda J, Yamamoto-Sugitani M, Shimura Y, Nakayama R, Nagoshi H, Mizutani S, Chinen Y, Sasaki N, Sakamoto N, Kobayashi T, Matsumoto Y, Horiike S and Taniwaki M. FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors. Apoptosis. 2013; 18(11):1437-1446.
-
(2013)
Apoptosis.
, vol.18
, Issue.11
, pp. 1437-1446
-
-
Kiyota, M.1
Kuroda, J.2
Yamamoto-Sugitani, M.3
Shimura, Y.4
Nakayama, R.5
Nagoshi, H.6
Mizutani, S.7
Chinen, Y.8
Sasaki, N.9
Sakamoto, N.10
Kobayashi, T.11
Matsumoto, Y.12
Horiike, S.13
Taniwaki, M.14
-
222
-
-
0036899017
-
T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2
-
Nagahara Y, Ikekita M and Shinomiya T. T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2. British journal of pharmacology. 2002; 137(7):953-962.
-
(2002)
British journal of pharmacology.
, vol.137
, Issue.7
, pp. 953-962
-
-
Nagahara, Y.1
Ikekita, M.2
Shinomiya, T.3
-
223
-
-
0042029408
-
Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity
-
Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y and Takahara S. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Res. 2003; 23(4):3183-3193.
-
(2003)
Anticancer Res.
, vol.23
, Issue.4
, pp. 3183-3193
-
-
Azuma, H.1
Horie, S.2
Muto, S.3
Otsuki, Y.4
Matsumoto, K.5
Morimoto, J.6
Gotoh, R.7
Okuyama, A.8
Suzuki, S.9
Katsuoka, Y.10
Takahara, S.11
-
224
-
-
84901717453
-
Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro
-
Marvaso G, Barone A, Amodio N, Raimondi L, Agosti V, Altomare E, Scotti V, Lombardi A, Bianco R, Bianco C, Caraglia M, Tassone P and Tagliaferri P. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro. Cancer Biol Ther. 2014; 15(6):797-805.
-
(2014)
Cancer Biol Ther.
, vol.15
, Issue.6
, pp. 797-805
-
-
Marvaso, G.1
Barone, A.2
Amodio, N.3
Raimondi, L.4
Agosti, V.5
Altomare, E.6
Scotti, V.7
Lombardi, A.8
Bianco, R.9
Bianco, C.10
Caraglia, M.11
Tassone, P.12
Tagliaferri, P.13
-
225
-
-
84880328774
-
FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway
-
Li MH, Hla T and Ferrer F. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatric blood & cancer. 2013; 60(9):1418-1423.
-
(2013)
Pediatric blood & cancer.
, vol.60
, Issue.9
, pp. 1418-1423
-
-
Li, M.H.1
Hla, T.2
Ferrer, F.3
-
226
-
-
77953694599
-
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function
-
Woodcock JM, Ma Y, Coolen C, Pham D, Jones C, Lopez AF and Pitson SM. Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. Cellular signalling. 2010; 22(9):1291-1299.
-
(2010)
Cellular signalling.
, vol.22
, Issue.9
, pp. 1291-1299
-
-
Woodcock, J.M.1
Ma, Y.2
Coolen, C.3
Pham, D.4
Jones, C.5
Lopez, A.F.6
Pitson, S.M.7
-
227
-
-
22544461952
-
Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism
-
Ma Y, Pitson S, Hercus T, Murphy J, Lopez A and Woodcock J. Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. The Journal of biological chemistry. 2005; 280(28):26011-26017.
-
(2005)
The Journal of biological chemistry.
, vol.280
, Issue.28
, pp. 26011-26017
-
-
Ma, Y.1
Pitson, S.2
Hercus, T.3
Murphy, J.4
Lopez, A.5
Woodcock, J.6
-
228
-
-
16744365194
-
Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta
-
Hamaguchi A, Suzuki E, Murayama K, Fujimura T, Hikita T, Iwabuchi K, Handa K, Withers DA, Masters SC, Fu H and Hakomori S. Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta. The Journal of biological chemistry. 2003; 278(42):41557-41565.
-
(2003)
The Journal of biological chemistry.
, vol.278
, Issue.42
, pp. 41557-41565
-
-
Hamaguchi, A.1
Suzuki, E.2
Murayama, K.3
Fujimura, T.4
Hikita, T.5
Iwabuchi, K.6
Handa, K.7
Withers, D.A.8
Masters, S.C.9
Fu, H.10
Hakomori, S.11
-
229
-
-
84936084869
-
Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer
-
Cristobal I, Gonzalez-Alonso P, Daoud L, Solano E, Torrejon B, Manso R, Madoz-Gurpide J, Rojo F and Garcia-Foncillas J. Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer. Mar Drugs. 2015; 13(6):3276-3286.
-
(2015)
Mar Drugs.
, vol.13
, Issue.6
, pp. 3276-3286
-
-
Cristobal, I.1
Gonzalez-Alonso, P.2
Daoud, L.3
Solano, E.4
Torrejon, B.5
Manso, R.6
Madoz-Gurpide, J.7
Rojo, F.8
Garcia-Foncillas, J.9
-
230
-
-
58849167699
-
The isolation and characterization of murine macrophages
-
Chapter 14, Unit 14 11
-
Zhang X, Goncalves R and Mosser DM. The isolation and characterization of murine macrophages. Curr Protoc Immunol. 2008; Chapter 14:Unit 14 11.
-
(2008)
Curr Protoc Immunol.
-
-
Zhang, X.1
Goncalves, R.2
Mosser, D.M.3
-
231
-
-
84885461398
-
Design, Synthesis, and Antileukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).
-
Fransson R, McCracken AN, Chen B, McMonigle RJ, Edinger AL and Hanessian S. Design, Synthesis, and Antileukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya). ACS medicinal chemistry letters. 2013; 4(10).
-
(2013)
ACS medicinal chemistry letters.
, vol.4
, Issue.10
-
-
Fransson, R.1
McCracken, A.N.2
Chen, B.3
McMonigle, R.J.4
Edinger, A.L.5
Hanessian, S.6
-
232
-
-
84899665043
-
[Mechanisms of ROS in U266 cell death induced by FTY720]
-
Li YC, Liu ZG, Yao K, Wang HH, Hu R, Yang W and Liao AJ. [Mechanisms of ROS in U266 cell death induced by FTY720]. Chinese Association of Pathophysiology. 2013; 21(3):643-646.
-
(2013)
Chinese Association of Pathophysiology.
, vol.21
, Issue.3
, pp. 643-646
-
-
Li, Y.C.1
Liu, Z.G.2
Yao, K.3
Wang, H.H.4
Hu, R.5
Yang, W.6
Liao, A.J.7
-
233
-
-
84876567112
-
Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: role of autophagy
-
Zhang N, Dai L, Qi Y, Di W and Xia P. Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: role of autophagy. International journal of oncology. 2013; 42(6):2053-2059.
-
(2013)
International journal of oncology.
, vol.42
, Issue.6
, pp. 2053-2059
-
-
Zhang, N.1
Dai, L.2
Qi, Y.3
Di, W.4
Xia, P.5
-
234
-
-
84881256674
-
FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system
-
Pereira FV, Arruda DC, Figueiredo CR, Massaoka MH, Matsuo AL, Bueno V and Rodrigues EG. FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system. Clinics. 2013; 68(7):1018-1027.
-
(2013)
Clinics.
, vol.68
, Issue.7
, pp. 1018-1027
-
-
Pereira, F.V.1
Arruda, D.C.2
Figueiredo, C.R.3
Massaoka, M.H.4
Matsuo, A.L.5
Bueno, V.6
Rodrigues, E.G.7
-
235
-
-
84929940184
-
FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling
-
Lu Z, Wang J, Zheng T, Liang Y, Yin D, Song R, Pei T, Pan S, Jiang H and Liu L. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling. BMC Cancer. 2014; 14:783.
-
(2014)
BMC Cancer.
, vol.14
, pp. 783
-
-
Lu, Z.1
Wang, J.2
Zheng, T.3
Liang, Y.4
Yin, D.5
Song, R.6
Pei, T.7
Pan, S.8
Jiang, H.9
Liu, L.10
-
236
-
-
84928589926
-
FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway
-
Zhang L, Wang H, Zhu J, Ding K and Xu J. FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway. Tumour Biol. 2014; 35(11):10707-10714.
-
(2014)
Tumour Biol.
, vol.35
, Issue.11
, pp. 10707-10714
-
-
Zhang, L.1
Wang, H.2
Zhu, J.3
Ding, K.4
Xu, J.5
-
237
-
-
84901717453
-
Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro
-
Marvaso G, Barone A, Amodio N, Raimondi L, Agosti V, Altomare E, Scotti V, Lombardi A, Bianco R, Bianco C, Caraglia M, Tassone P and Tagliaferri P. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro. Cancer biology & therapy. 2014; 15(6):797-805.
-
(2014)
Cancer biology & therapy.
, vol.15
, Issue.6
, pp. 797-805
-
-
Marvaso, G.1
Barone, A.2
Amodio, N.3
Raimondi, L.4
Agosti, V.5
Altomare, E.6
Scotti, V.7
Lombardi, A.8
Bianco, R.9
Bianco, C.10
Caraglia, M.11
Tassone, P.12
Tagliaferri, P.13
-
238
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, Hartung HP, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G, Tiel-Wilck K, de Vera A, Jin J, Stites T, Wu S, Aradhye S, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010; 362(5):402-415.
-
(2010)
N Engl J Med.
, vol.362
, Issue.5
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
Hartung, H.P.4
Khatri, B.O.5
Montalban, X.6
Pelletier, J.7
Capra, R.8
Gallo, P.9
Izquierdo, G.10
Tiel-Wilck, K.11
de Vera, A.12
Jin, J.13
Stites, T.14
Wu, S.15
Aradhye, S.16
-
239
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, Calabresi P, Selmaj K, Agoropoulou C, Leyk M, Zhang-Auberson L and Burtin P. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010; 362(5):387-401.
-
(2010)
N Engl J Med.
, vol.362
, Issue.5
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
Polman, C.4
Hohlfeld, R.5
Calabresi, P.6
Selmaj, K.7
Agoropoulou, C.8
Leyk, M.9
Zhang-Auberson, L.10
Burtin, P.11
-
240
-
-
84908698925
-
Random migration contributes to cytotoxicity of activated CD8+ T-lymphocytes but not NK cells
-
Onishi H, Kiyota A, Koya N, Tanaka H, Umebayashi M, Katano M and Morisaki T. Random migration contributes to cytotoxicity of activated CD8+ T-lymphocytes but not NK cells. Anticancer research. 2014; 34(8):3947-3956.
-
(2014)
Anticancer research.
, vol.34
, Issue.8
, pp. 3947-3956
-
-
Onishi, H.1
Kiyota, A.2
Koya, N.3
Tanaka, H.4
Umebayashi, M.5
Katano, M.6
Morisaki, T.7
-
241
-
-
79957525337
-
Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma
-
Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK and Chen CS. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011; 53(6):1943-1958.
-
(2011)
Hepatology.
, vol.53
, Issue.6
, pp. 1943-1958
-
-
Omar, H.A.1
Chou, C.C.2
Berman-Booty, L.D.3
Ma, Y.4
Hung, J.H.5
Wang, D.6
Kogure, T.7
Patel, T.8
Terracciano, L.9
Muthusamy, N.10
Byrd, J.C.11
Kulp, S.K.12
Chen, C.S.13
-
242
-
-
84902135614
-
Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry
-
Mao Y, Wang J, Zhao Y, Yan R, Li H, Chen CS, Lee RJ, Byrd JC, Lee LJ, Muthusamy N and Phelps MA. Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2014; 98:160-165.
-
(2014)
Journal of pharmaceutical and biomedical analysis.
, vol.98
, pp. 160-165
-
-
Mao, Y.1
Wang, J.2
Zhao, Y.3
Yan, R.4
Li, H.5
Chen, C.S.6
Lee, R.J.7
Byrd, J.C.8
Lee, L.J.9
Muthusamy, N.10
Phelps, M.A.11
-
243
-
-
84895071225
-
A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery
-
Mao Y, Wang J, Zhao Y, Wu Y, Kwak KJ, Chen CS, Byrd JC, Lee RJ, Phelps MA, Lee LJ and Muthusamy N. A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery. Nanomedicine. 2014; 10(2):393-400.
-
(2014)
Nanomedicine.
, vol.10
, Issue.2
, pp. 393-400
-
-
Mao, Y.1
Wang, J.2
Zhao, Y.3
Wu, Y.4
Kwak, K.J.5
Chen, C.S.6
Byrd, J.C.7
Lee, R.J.8
Phelps, M.A.9
Lee, L.J.10
Muthusamy, N.11
-
244
-
-
84878654009
-
Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells
-
Yu B, Mao Y, Yuan Y, Yue C, Wang X, Mo X, Jarjoura D, Paulaitis ME, Lee RJ, Byrd JC, Lee LJ and Muthusamy N. Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells. Biomaterials. 2013; 34(26):6185-6193.
-
(2013)
Biomaterials.
, vol.34
, Issue.26
, pp. 6185-6193
-
-
Yu, B.1
Mao, Y.2
Yuan, Y.3
Yue, C.4
Wang, X.5
Mo, X.6
Jarjoura, D.7
Paulaitis, M.E.8
Lee, R.J.9
Byrd, J.C.10
Lee, L.J.11
Muthusamy, N.12
-
245
-
-
84977161108
-
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
-
Spranger S, Koblish HK, Horton B, Scherle PA, Newton R and Gajewski TF. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. Journal for immunotherapy of cancer. 2014; 2:3.
-
(2014)
Journal for immunotherapy of cancer.
, vol.2
, pp. 3
-
-
Spranger, S.1
Koblish, H.K.2
Horton, B.3
Scherle, P.A.4
Newton, R.5
Gajewski, T.F.6
-
246
-
-
77955799815
-
Oral fingolimod (FTY720) for relapsing multiple sclerosis
-
Kappos L, Antel J, Comi G, Montalban X, O'Connor P, Polman CH, Haas T, Korn AA, Karlsson G and Radue EW. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med. 2006; 355(11):1124-1140.
-
(2006)
N Engl J Med.
, vol.355
, Issue.11
, pp. 1124-1140
-
-
Kappos, L.1
Antel, J.2
Comi, G.3
Montalban, X.4
O'Connor, P.5
Polman, C.H.6
Haas, T.7
Korn, A.A.8
Karlsson, G.9
Radue, E.W.10
-
247
-
-
84896528301
-
Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod)
-
Buddaseth S, Gottmann W, Blasczyk R and Huyton T. Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod). Cancer Biol Ther. 2014; 15(3):289-296.
-
(2014)
Cancer Biol Ther.
, vol.15
, Issue.3
, pp. 289-296
-
-
Buddaseth, S.1
Gottmann, W.2
Blasczyk, R.3
Huyton, T.4
-
248
-
-
80054037863
-
Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer
-
Pchejetski D, Bohler T, Stebbing J and Waxman J. Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer. Nat Rev Urol. 2011; 8(10):569-678.
-
(2011)
Nat Rev Urol.
, vol.8
, Issue.10
, pp. 569-678
-
-
Pchejetski, D.1
Bohler, T.2
Stebbing, J.3
Waxman, J.4
-
249
-
-
84871784198
-
Therapeutic potential of targeting SK1 in human cancers
-
Alshaker H, Sauer L, Monteil D, Ottaviani S, Srivats S, Bohler T and Pchejetski D. Therapeutic potential of targeting SK1 in human cancers. Adv Cancer Res. 2013; 117:143-200.
-
(2013)
Adv Cancer Res.
, vol.117
, pp. 143-200
-
-
Alshaker, H.1
Sauer, L.2
Monteil, D.3
Ottaviani, S.4
Srivats, S.5
Bohler, T.6
Pchejetski, D.7
-
250
-
-
79551614173
-
Regulation of sphingosine kinase and sphingolipid signaling
-
Pitson SM. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci. 2011; 36(2):97-107.
-
(2011)
Trends Biochem Sci.
, vol.36
, Issue.2
, pp. 97-107
-
-
Pitson, S.M.1
|