메뉴 건너뛰기




Volumn 93, Issue 4, 2013, Pages 462-471

Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: Assessment of expression and role in cell migration

Author keywords

classical Hodgkin lymphoma; dissemination; fingolimod; migration; S1PR1; sphingosine 1 phosphate

Indexed keywords

BENDAMUSTINE; BLEOMYCIN; BRENTUXIMAB VEDOTIN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DEXAMETHASONE; DOXORUBICIN; ENZYME INHIBITOR; ETOPOSIDE; FINGOLIMOD; GEMCITABINE; GUANINE NUCLEOTIDE BINDING PROTEIN; IFOSFAMIDE; MESSENGER RNA; NAVELBINE; PHOSPHATIDYLINOSITOL 3 KINASE; PREDNISONE; PROCARBAZINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE SULFATE; VPC 44116;

EID: 84875723927     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.7     Document Type: Article
Times cited : (39)

References (46)
  • 1
    • 0025311299 scopus 로고
    • An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors
    • Hla T, Maciag T. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J Biol Chem 1990; 265:9308-9313.
    • (1990) J Biol Chem , vol.265 , pp. 9308-9313
    • Hla, T.1    MacIag, T.2
  • 2
    • 0032489574 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1
    • Lee MJ, Van Brocklyn JR, Thangada S, et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 1998;279:1552-1555.
    • (1998) Science , vol.279 , pp. 1552-1555
    • Lee, M.J.1    Van Brocklyn, J.R.2    Thangada, S.3
  • 3
    • 0033615537 scopus 로고    scopus 로고
    • Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
    • Lee MJ, Thangada S, Claffey KP, et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 1999;99:301-312.
    • (1999) Cell , vol.99 , pp. 301-312
    • Lee, M.J.1    Thangada, S.2    Claffey, K.P.3
  • 4
    • 0032938741 scopus 로고    scopus 로고
    • Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1
    • Liu CH, Thangada S, Lee MJ, et al. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol Biol Cell 1999;10:1179-1190.
    • (1999) Mol Biol Cell , vol.10 , pp. 1179-1190
    • Liu, C.H.1    Thangada, S.2    Lee, M.J.3
  • 5
    • 0033783522 scopus 로고    scopus 로고
    • Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    • Liu Y, Wada R, Yamashita T, et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 2000;106:951-961.
    • (2000) J Clin Invest , vol.106 , pp. 951-961
    • Liu, Y.1    Wada, R.2    Yamashita, T.3
  • 6
    • 0035853689 scopus 로고
    • Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3-and beta1-containing integrins
    • Paik JH, Chae S, Lee MJ, et al. Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3-and beta1-containing integrins. J Biol Chem 2001;276:11830-11837.
    • (1837) J Biol Chem , vol.2001 , Issue.276 , pp. 11830-11831
    • Paik, J.H.1    Chae, S.2    Lee, M.J.3
  • 7
    • 0033544870 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis
    • Wang F, Van Brocklyn JR, Hobson JP, et al. Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. J Biol Chem 1999;274: 35343-35350.
    • (1999) J Biol Chem , vol.274 , pp. 35343-35350
    • Wang, F.1    Van Brocklyn, J.R.2    Hobson, J.P.3
  • 8
    • 0033516586 scopus 로고    scopus 로고
    • Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5
    • Ancellin N, Hla T. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J Biol Chem 1999;274:18997-19002.
    • (1999) J Biol Chem , vol.274 , pp. 18997-19002
    • Ancellin, N.1    Hla, T.2
  • 9
    • 12544253058 scopus 로고    scopus 로고
    • Structural and functional characteristics of S1P receptors
    • Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. J Cell Biochem 2004;92:913-922.
    • (2004) J Cell Biochem , vol.92 , pp. 913-922
    • Sanchez, T.1    Hla, T.2
  • 10
    • 0344443651 scopus 로고    scopus 로고
    • Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    • Sanchez T, Estrada-Hernandez T, Paik JH, et al. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem 2003;278:47281-47290.
    • (2003) J Biol Chem , vol.278 , pp. 47281-47290
    • Sanchez, T.1    Estrada-Hernandez, T.2    Paik, J.H.3
  • 11
    • 0033588370 scopus 로고    scopus 로고
    • Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells
    • Kon J, Sato K, Watanabe T, et al. Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. J Biol Chem 1999;274:23940-23947.
    • (1999) J Biol Chem , vol.274 , pp. 23940-23947
    • Kon, J.1    Sato, K.2    Watanabe, T.3
  • 12
    • 0036434445 scopus 로고    scopus 로고
    • Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist
    • Osada M, Yatomi Y, Ohmori T, et al. Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem Biophys Res Commun 2002;299:483-487.
    • (2002) Biochem Biophys Res Commun , vol.299 , pp. 483-487
    • Osada, M.1    Yatomi, Y.2    Ohmori, T.3
  • 13
    • 0042858413 scopus 로고    scopus 로고
    • Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity
    • Arikawa K, Takuwa N, Yamaguchi H, et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. J Biol Chem 2003;278:32841-32851.
    • (2003) J Biol Chem , vol.278 , pp. 32841-32851
    • Arikawa, K.1    Takuwa, N.2    Yamaguchi, H.3
  • 14
    • 15444373513 scopus 로고    scopus 로고
    • PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
    • Sanchez T, Thangada S, Wu MT, et al. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci USA 2005;102:4312-4317.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4312-4317
    • Sanchez, T.1    Thangada, S.2    Wu, M.T.3
  • 15
    • 34249280944 scopus 로고    scopus 로고
    • Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN
    • Sanchez T, Skoura A, Wu MT, et al. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol 2007;27:1312-1318.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1312-1318
    • Sanchez, T.1    Skoura, A.2    Wu, M.T.3
  • 16
    • 0029977136 scopus 로고    scopus 로고
    • The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway
    • Lee MJ, Evans M, Hla T. The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. J Biol Chem 1996;271:11272-11279.
    • (1996) J Biol Chem , vol.271 , pp. 11272-11279
    • Lee, M.J.1    Evans, M.2    Hla, T.3
  • 17
    • 0035965242 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways
    • Igarashi J, Michel T. Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. J Biol Chem 2001;276: 36281-36288.
    • (2001) J Biol Chem , vol.276 , pp. 36281-36288
    • Igarashi, J.1    Michel, T.2
  • 18
    • 0037067769 scopus 로고    scopus 로고
    • Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3
    • Ishii I, Ye X, Friedman B, et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem 2002;277:25152-25159.
    • (2002) J Biol Chem , vol.277 , pp. 25152-25159
    • Ishii, I.1    Ye, X.2    Friedman, B.3
  • 19
    • 0037370012 scopus 로고    scopus 로고
    • Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform
    • Sugimoto N, Takuwa N, Okamoto H, et al. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol 2003;23:1534-1545.
    • (2003) Mol Cell Biol , vol.23 , pp. 1534-1545
    • Sugimoto, N.1    Takuwa, N.2    Okamoto, H.3
  • 20
    • 0037066466 scopus 로고    scopus 로고
    • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    • Mandala S, Hajdu R, Bergstrom J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002;296:346-349.
    • (2002) Science , vol.296 , pp. 346-349
    • Mandala, S.1    Hajdu, R.2    Bergstrom, J.3
  • 21
    • 0036905055 scopus 로고    scopus 로고
    • Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells
    • Graeler M, Goetzl EJ. Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J 2002;16:1874-1878.
    • (2002) FASEB J , vol.16 , pp. 1874-1878
    • Graeler, M.1    Goetzl, E.J.2
  • 22
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002;277:21453-21457.
    • (2002) J Biol Chem , vol.277 , pp. 21453-21457
    • Brinkmann, V.1    Davis, M.D.2    Heise, C.E.3
  • 23
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004;427:355-360.
    • (2004) Nature , vol.427 , pp. 355-360
    • Matloubian, M.1    Lo, C.G.2    Cinamon, G.3
  • 24
    • 2442561611 scopus 로고    scopus 로고
    • Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration
    • Allende ML, Dreier JL, Mandala S, et al. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem 2004;279:15396-15401.
    • (2004) J Biol Chem , vol.279 , pp. 15396-15401
    • Allende, M.L.1    Dreier, J.L.2    Mandala, S.3
  • 25
    • 77952309720 scopus 로고    scopus 로고
    • S1P1 receptor directs the release of immature B cells from bone marrow into blood
    • Allende ML, Tuymetova G, Lee BG, et al. S1P1 receptor directs the release of immature B cells from bone marrow into blood. J Exp Med 2010;207:1113-1124.
    • (2010) J Exp Med , vol.207 , pp. 1113-1124
    • Allende, M.L.1    Tuymetova, G.2    Lee, B.G.3
  • 26
    • 77949521813 scopus 로고    scopus 로고
    • A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow
    • Pereira JP, Xu Y, Cyster JG. A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS One 2010;5:e9277.
    • (2010) PLoS One , vol.5
    • Pereira, J.P.1    Xu, Y.2    Cyster, J.G.3
  • 27
    • 77954421069 scopus 로고    scopus 로고
    • Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
    • Thangada S, Khanna KM, Blaho VA, et al. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med 2010;207:1475-1483.
    • (2010) J Exp Med , vol.207 , pp. 1475-1483
    • Thangada, S.1    Khanna, K.M.2    Blaho, V.A.3
  • 28
    • 80053345544 scopus 로고    scopus 로고
    • GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood
    • Arnon TI, Xu Y, Lo C, et al. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 2011;333:1898-1903.
    • (2011) Science , vol.333 , pp. 1898-1903
    • Arnon, T.I.1    Xu, Y.2    Lo, C.3
  • 29
    • 24644469502 scopus 로고    scopus 로고
    • Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    • Schwab SR, Pereira JP, Matloubian M, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005;309:1735-1739.
    • (2005) Science , vol.309 , pp. 1735-1739
    • Schwab, S.R.1    Pereira, J.P.2    Matloubian, M.3
  • 30
    • 36248956701 scopus 로고    scopus 로고
    • Finding a way out: Lymphocyte egress from lymphoid organs
    • Schwab SR, Cyster JG. Finding a way out: lymphocyte egress from lymphoid organs. Nat Immunol 2007;8:1295-1301.
    • (2007) Nat Immunol , vol.8 , pp. 1295-1301
    • Schwab, S.R.1    Cyster, J.G.2
  • 31
    • 21844476102 scopus 로고    scopus 로고
    • The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches
    • Halin C, Scimone ML, Bonasio R, et al. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood 2005;106:1314-1322.
    • (2005) Blood , vol.106 , pp. 1314-1322
    • Halin, C.1    Scimone, M.L.2    Bonasio, R.3
  • 32
    • 27744552046 scopus 로고    scopus 로고
    • Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720
    • Kharel Y, Lee S, Snyder AH, et al. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem 2005;280:36865-36872.
    • (2005) J Biol Chem , vol.280 , pp. 36865-36872
    • Kharel, Y.1    Lee, S.2    Snyder, A.H.3
  • 33
    • 32644444604 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
    • Zemann B, Kinzel B, Muller M, et al. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood 2006;107:1454-1458.
    • (2006) Blood , vol.107 , pp. 1454-1458
    • Zemann, B.1    Kinzel, B.2    Muller, M.3
  • 34
    • 31544447428 scopus 로고    scopus 로고
    • Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization
    • LaMontagne K, Littlewood-Evans A, Schnell C, et al. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res 2006;66:221-231.
    • (2006) Cancer Res , vol.66 , pp. 221-231
    • Lamontagne, K.1    Littlewood-Evans, A.2    Schnell, C.3
  • 35
    • 34247874512 scopus 로고    scopus 로고
    • Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
    • Oo ML, Thangada S, Wu MT, et al. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem 2007;282:9082-9089.
    • (2007) J Biol Chem , vol.282 , pp. 9082-9089
    • Oo, M.L.1    Thangada, S.2    Wu, M.T.3
  • 36
    • 78049480679 scopus 로고    scopus 로고
    • Fingolimod (FTY720): Discovery and development of an oral drug to treat multiple sclerosis
    • Brinkmann V, Billich A, Baumruker T, et al. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 2010;9:883-897.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 883-897
    • Brinkmann, V.1    Billich, A.2    Baumruker, T.3
  • 37
    • 79952026310 scopus 로고    scopus 로고
    • Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
    • Mehling M, Johnson TA, Antel J, et al. Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. Neurology 2011;76(Suppl 3):S20-S27.
    • (2011) Neurology , vol.76 , Issue.SUPPL. 3
    • Mehling, M.1    Johnson, T.A.2    Antel, J.3
  • 38
    • 79960855026 scopus 로고    scopus 로고
    • Fingolimod: A review of its use in the management of relapsing-emitting multiple sclerosis
    • Scott LJ. Fingolimod: a review of its use in the management of relapsing-emitting multiple sclerosis. CNS Drugs 2011;25: 673-698.
    • (2011) CNS Drugs , vol.25 , pp. 673-698
    • Scott, L.J.1
  • 39
    • 33845296479 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists
    • Foss Jr FW, Snyder AH, Davis MD, et al. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem 2007;15:663-677.
    • (2007) Bioorg Med Chem , vol.15 , pp. 663-677
    • Foss Jr., F.W.1    Snyder, A.H.2    Davis, M.D.3
  • 40
    • 0013922363 scopus 로고
    • Evidence for an orderly progression in the spread of Hodgkin's disease
    • Rosenberg SA, Kaplan HS. Evidence for an orderly progression in the spread of Hodgkin's disease. Cancer Res 1966;26:1225-1231.
    • (1966) Cancer Res , vol.26 , pp. 1225-1231
    • Rosenberg, S.A.1    Kaplan, H.S.2
  • 41
    • 0031980045 scopus 로고    scopus 로고
    • Contiguous pattern spreading in patients with Hodgkin's disease
    • Roth SL, Sack H, Havemann K, et al. Contiguous pattern spreading in patients with Hodgkin's disease. Radiother Oncol 1998;47:7-16.
    • (1998) Radiother Oncol , vol.47 , pp. 7-16
    • Roth, S.L.1    Sack, H.2    Havemann, K.3
  • 42
    • 22144493746 scopus 로고    scopus 로고
    • Quantitative multi-gene transcriptional profiling using real-time PCR with a master template
    • Shih SC, Smith LE. Quantitative multi-gene transcriptional profiling using real-time PCR with a master template. Exp Mol Pathol 2005;79:14-22.
    • (2005) Exp Mol Pathol , vol.79 , pp. 14-22
    • Shih, S.C.1    Smith, L.E.2
  • 43
    • 0035860831 scopus 로고    scopus 로고
    • Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration
    • Kluk MJ, Hla T. Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res 2001;89:496-502.
    • (2001) Circ Res , vol.89 , pp. 496-502
    • Kluk, M.J.1    Hla, T.2
  • 44
    • 77649275845 scopus 로고    scopus 로고
    • Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma
    • Nishimura H, Akiyama T, Monobe Y, et al. Expression of sphingosine-1-phosphate receptor 1 in mantle cell lymphoma. Mod Pathol 2010;23:439-449.
    • (2010) Mod Pathol , vol.23 , pp. 439-449
    • Nishimura, H.1    Akiyama, T.2    Monobe, Y.3
  • 45
    • 0034462185 scopus 로고    scopus 로고
    • Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G proteincoupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3
    • Okamoto H, Takuwa N, Yokomizo T, et al. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G proteincoupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol Cell Biol 2000;20:9247-9261.
    • (2000) Mol Cell Biol , vol.20 , pp. 9247-9261
    • Okamoto, H.1    Takuwa, N.2    Yokomizo, T.3
  • 46
    • 84865159639 scopus 로고    scopus 로고
    • S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma
    • Liu Y, Deng J, Wang L, et al. S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma. Blood 2012;120:1458-1465.
    • (2012) Blood , vol.120 , pp. 1458-1465
    • Liu, Y.1    Deng, J.2    Wang, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.