Role of extracelluar regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 24, Issue 1, 2004, Pages 45-47

  Li, Dengju ^a   Zhang, Yaozhen ^a   Hu, Xiangrong ^a   Cao, Wenjing ^a   Huang, Wei ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Extracelluar regulated protein kinase; FTY720; Leukemia; Proliferation inhibition

Indexed keywords

APOPTOSIS; EXTRACELLULAR REGULATED PROTEIN KINASE; FTY720; LEUKEMIA; PROLIFERATION INHIBITION;

CELL CULTURE; DISEASES; DNA; ENZYME INHIBITION; IMMUNOLOGY; PROTEINS;

ENZYMES;

DRUG DERIVATIVE; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

APOPTOSIS; ARTICLE; CELL DIVISION; CELL STRAIN HL 60; CELL STRAIN U937; DRUG EFFECT; HUMAN; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL DIVISION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HL-60 CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROPYLENE GLYCOLS; SIGNAL TRANSDUCTION; SPHINGOSINE; U937 CELLS;

EID: 16544371726     PISSN: 0257716X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. 2+-sensing receptor in normal human gastric mucous epithelial cells. Am J Physiol, 1999, 277(3 Pt 1):G662
2. Fujia T R, Hirose M, Yoneta S et al. Potent immunosuppressants. 2-alkyl-2aminopropane-l, 3-diols. J Med Chem, 1996, 39:4451
3. Yamasaki T K, Inoue H, Hayashi Y et al. Effect of a new immunosuppressive agent, FTY720, on survival of islet allografts. 1998, 7:403
4. Li X K, Tamura A, Fujino M et al. Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720. Clin Exp Immunol, 2001, 123(2):331
5. Shinomiya T, Li X K, Amemiya H et al. An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60. Immunology, 1997, 91(4): 594
6. Nagahara Y, Ikekita M, Shinomiya T. Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria. J Immunol, 2000, 165(6):3250
7. Matsuda S, Minowa A, Suzuki S et al. Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway. J Immunol, 1999, 162(6):3321
8. Tsai E Y, Falvo J V, Tsytsykova A V et al. A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Spl, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo. Mol Cell Biol, 2000, 20(16):6084
9. Bonni A, Brunei A, West A E et al. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science, 1999, 286:1358