Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

Biochemical Journal

Volumn 440, Issue 3, 2011, Pages 345-353

  Kharel, Yugesh ^a   Mathews, Thomas P ^a,b   Gellett, Amanda M ^a   Tomsig, Jose L ^a   Kennedy, Perry C ^a   Moyer, Morgan L ^b   Macdonald, Timothy L ^a,b   Lynch, Kevin R ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Sphingosine 1 phosphate (S1P); Sphingosine kinase (SphK); Sphingosine kinase inhibitor

Indexed keywords

AMIDINE; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; TURNOVER TIME; WILD TYPE;

AMIDINES; ANIMALS; CASPASE 3; CELL LINE; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LYSOPHOSPHOLIPIDS; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINES; RATS; SPHINGOLIPIDS; SPHINGOSINE; STEREOISOMERISM;

EID: 82455192466     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110817     Document Type: Article

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