Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 6, 2008, Pages 1177-1181

  Nagaoka, Yasuo ^a   Otsuki, Kota ^a   Fujita, Tetsuro ^b   Uesato, Shinichi ^a  

^a KANSAI UNIVERSITY   (Japan)

^b RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT   (Japan)

Author keywords

Antiproliferation; Breast cancer; Colon cancer; Fingolimod; FTY720; MCF 7

Indexed keywords

CFTY 720 P; DIMETHYLSPHINGOSINE; FINGOLIMOD; FTY 720 P; IMMUNOSUPPRESSIVE AGENT; ISP I 55; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE 1;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRAIN MCF 7; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROPYLENE GLYCOLS; SPECTROPHOTOMETRY, INFRARED; SPHINGOSINE;

EID: 45749139274     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1177     Document Type: Article

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