A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes

Immunology

Volumn 89, Issue 4, 1996, Pages 518-523

  Suzuki, S ^a   Li, X K ^a   Enosawa, S ^a   Shinomiya, T ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTO ONCOGENE; T LYMPHOCYTE;

EID: 0029857032     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.d01-777.x     Document Type: Article

References (31)

1. WYLLIE A.H. (1980) Glucocorticod-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555.
2. FOWLKES B.J., SCHWARTZ R.H. & PARDOLL D.M. (1988) Deletion of self-reactive thymocytes occurs at a CD4+ 8+ precursor stage. Nature 334, 620.
3. WESSELBORG S., JANSSEN O. & KABELITZ D. (1993) Induction of activation-driven death (apoptosis) in activated but resting peripheral blood T cells. J Immunol 150, 4338.
4. UCKER D.S., MEYERS J., OBERMILLER P.S. (1992) Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J Immunol 149, 1583.
5. WYLLIE A.H. & MORRIS R.G. (1982) Hormon-induced cell death. Purification and properties of thymocytes undergoing apoptosis after glucocorticoid treatment. Am J Pathol 109, 78.
6. SMITH C.A., WILLIAMS G.T., KINGSTON R., JENKINSON E.J. & OWEN J.J.T. (1989) Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T. cells in thymic cultures. Nature 337, 181.
7. JANSSEN O., WESSELBORG S., HECKL-OSTEREICHER B. et al. (1991) T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor γδ+ T cells. J Immunol 146, 35.
8. MACDONALD H.R., BASCHIERI S. & LEES R.K. (1991) Clonal expansion precedes anergy and death of Vβ8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur J Immunol 21 (1963).
9. FUJITA T., INOUE K., YAMAMOTO S. et al. (1994) Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiotics (Tokyo) 47, 208.
10. FUJITA T., YONETA M., HIROSE R. et al. (1995) Simple compounds, 2-alkyl-2-amino-1, 3-propanediols have potent immunosuppressive activity. Bioorg Med Chem 5, 847.
11. ADACHI K., KOHARA T., NAKANO N. et al. (1995) Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant, FTY720. Bioorg Med Chem 5, 853.
12. SUZUKI S., ENOSAWA S., KAKEFUDA T. et al. (1996) A novel immunosuppressant, FTY720, with an unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61, 200.
13. ENOSAWA S., SUZUKI S., KAKEFUDA T., LI X.-L. & AMEMIYA H. (1996) Induction of selective cell death targeting on mature T. lymphocytes in rats by a novel immunosuppressant, FTY720. Immunopharmacology 34, 171.
14. YONEHARA S., ISHII A. & YONEHARA M. (1989) A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med 169, 1747.
15. MIYAWAKI T., UEHARA T., NIBU R. et al (1992) Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol 149, 3753.
16. SUZUKI S., LI X.-K., SHINOMIYA T. et al. (1996) The in vitro induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720. Clin Exp Immunol (in press).
17. GRATIOT-DEANS J., DING L., TURKA L.A. & NUNEZ G. (1993) bcl-2 protooncogene expression during human T cell development. Evidence for biphasic regulation. J Immunol 151, 83.
18. VEIS D., SENTMAN C.L., BACH E.A. & KORSMEYER S.J. (1993) Expression of the Bcl-2 protein in murine and human thymocytes and peripheral T lymphocytes. J Immunol 151, 2546.
19. REED J.C. (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124, 1.
20. SATO T., HANADA M., BODRUG S. et al (1994) Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci USA 91, 9238.
21. YANG E., ZHA J., JOCKEL J., BOISE L.H., THOMPSON C.B. & KORSMEYER S.J. (1995) Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces Bax and promotes cell death. Cell 80, 285.
22. OLTVAI Z.N., MILLIMAN C.L. & KORSMEYER S.J. (1993) bcl-2 heterodimerizes in vivo with a conserved homolog Bax, that accelerates programmed cell death. Cell 74, 609.
23. TORIGOE T., MILLAN J.A., TAKAYAMA S., TAICHMAN R., MIYASHITA T. & REED J.C. (1994) Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line. Cancer Res 54, 4851.
24. ALLEY M.C., SCUDIERO D.A., MONKS A. et al. (1988) Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48, 589.
25. MOSMANN T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55.
26. TAKAYAMA S., SATO T., KRAJEWSKI S. et al (1995) Cloning and functional analysis of Bag-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80, 279.
27. HOCKENBERY D., NUNEZ G., MILLIMAN C., SCHREIBER R.D. & KORSMEYER S.J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334.
28. JACOBSON M.D., BURNE J.F., KING M.P., MIYASHITA T., REED J.C. & RAFF M.C. (1993) Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361, 365.
29. DENG G. & PODACK E.R. (1993) Suppression of apoptosis in acytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. Proc Natl Acad Sci USA 90, 2189.
30. SELVAKUMARAN M., LIN H.K., MIYASHITA T. et al (1994) Immediate early upregulation of box expression by p. 53 but not TGF β1: a paradigm for distinct apoptotic pathways. Oncogene 9, 1791.
31. SUZUKI S., ENOSAWA S., KAKEFUDA T. et al. (1996) Immunosuppressive effect of new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. Transplant Immunol 4, 252.