-
1
-
-
84862263011
-
-
American Cancer Society How many men get prostate cancer? [online] 2011
-
American Cancer Society. How many men get prostate cancer? [online] http://www.cancer.org/cancer/prostatecancer/overviewguide/prostate-cancer- overview-key-statistics (2011).
-
-
-
-
2
-
-
84862240862
-
-
Cancer Research UK Prostate cancer statistics-Key Facts
-
Cancer Research UK. Prostate cancer statistics-Key Facts http://info.cancerresearchuk.org/cancerstats/keyfacts/prostate-cancer/ (2011).
-
(2011)
-
-
-
3
-
-
53049107356
-
Molecular alterations in prostate cancer
-
Reynolds, M. A. Molecular alterations in prostate cancer. Cancer Lett. 271, 13-24 (2008).
-
(2008)
Cancer Lett.
, vol.271
, pp. 13-24
-
-
Reynolds, M.A.1
-
4
-
-
21344445903
-
Adenocarcinoma of the prostate: Epidemiological trends, screening, diagnosis, and surgical management of localized disease
-
Routh, J. C. & Leibovich, B. C. Adenocarcinoma of the prostate: Epidemiological trends, screening, diagnosis, and surgical management of localized disease. Mayo Clin. Proc. 80, 899-907 (2005).
-
(2005)
Mayo Clin. Proc.
, vol.80
, pp. 899-907
-
-
Routh, J.C.1
Leibovich, B.C.2
-
5
-
-
0038455688
-
Prostate cancer
-
Nelson, W. G., De Marzo, A. M. & Isaacs, W. B. Prostate cancer. N. Engl. J. Med. 349, 366-381 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 366-381
-
-
Nelson, W.G.1
De Marzo, A.M.2
Isaacs, W.B.3
-
6
-
-
0347296250
-
Cytotoxic treatment of aggressive prostate tumors with or without neuroendocrine elements
-
Steineck, G. et al. Cytotoxic treatment of aggressive prostate tumors with or without neuroendocrine elements. Acta Oncol. 41, 668-674 (2002).
-
(2002)
Acta Oncol.
, vol.41
, pp. 668-674
-
-
Steineck, G.1
-
7
-
-
4744337716
-
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
-
Petrylak, D. P. et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N. Engl. J. Med. 351, 1513-1520 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 1513-1520
-
-
Petrylak, D.P.1
-
8
-
-
4744366279
-
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
-
Tannock, I. F. et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N. Engl. J. Med. 351, 1502-1512 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 1502-1512
-
-
Tannock, I.F.1
-
9
-
-
78649630419
-
Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens
-
Malavaud, B. et al. Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens. Eur. J. Cancer 46, 3417-3424 (2010).
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 3417-3424
-
-
Malavaud, B.1
-
10
-
-
78449267550
-
FTY720 (Fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1
-
Pchejetski, D. et al. FTY720 (Fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1. Cancer Res. 70, 8651-8661 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 8651-8661
-
-
Pchejetski, D.1
-
11
-
-
33645278951
-
Sphingosine kinase: Biochemical and cellular regulation and role in disease
-
Taha, T. A., Hannun, Y. A. & Obeid, L. M. Sphingosine kinase: Biochemical and cellular regulation and role in disease. J. Biochem. Mol. Biol. 39, 113-131 (2006).
-
(2006)
J. Biochem. Mol. Biol.
, vol.39
, pp. 113-131
-
-
Taha, T.A.1
Hannun, Y.A.2
Obeid, L.M.3
-
12
-
-
80054017514
-
Regulation of sphingosine kinase and sphingolipid signaling
-
Pitson, S. M. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem. Sci. (2010).
-
(2010)
Trends Biochem. Sci.
-
-
Pitson, S.M.1
-
13
-
-
33750832270
-
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
-
Mitra, P. et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc. Natl Acad. Sci. USA 103, 16394-16399 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 16394-16399
-
-
Mitra, P.1
-
14
-
-
77951214876
-
Estradiol induces export of sphingosine-1-phosphate from breast cancer cells via ABCC1 and ABCG2
-
Takabe, K. et al. Estradiol induces export of sphingosine-1-phosphate from breast cancer cells via ABCC1 and ABCG2. J. Biol. Chem. 285, 10477-10486 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 10477-10486
-
-
Takabe, K.1
-
15
-
-
78751525273
-
The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720
-
Hisano, Y., Kobayashi, N., Kawahara, A., Yamaguchi, A. & Nishi, T. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J. Biol. Chem. 286, 1758-1766 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 1758-1766
-
-
Hisano, Y.1
Kobayashi, N.2
Kawahara, A.3
Yamaguchi, A.4
Nishi, T.5
-
16
-
-
33747433675
-
Signal transduction of sphingosine-1-phosphate G protein-coupled receptors
-
Young, N. & Van Brocklyn, J. R. Signal transduction of sphingosine-1-phosphate G protein-coupled receptors. Scientific World Journal 6, 946-966 (2006).
-
(2006)
Scientific World Journal
, vol.6
, pp. 946-966
-
-
Young, N.1
Van Brocklyn, J.R.2
-
17
-
-
46949104885
-
Inside-out" signaling of sphingosine-1-phosphate: Therapeutic targets
-
Takabe, K., Paugh, S. W., Milstien, S. & Spiegel, S. "Inside-out" signaling of sphingosine-1-phosphate: Therapeutic targets. Pharmacol. Rev. 60, 181-195 (2008).
-
(2008)
Pharmacol. Rev.
, vol.60
, pp. 181-195
-
-
Takabe, K.1
Paugh, S.W.2
Milstien, S.3
Spiegel, S.4
-
18
-
-
78049502852
-
Extracellular and intracellular actions of sphingosine-1-phosphate
-
Strub, G. M., Maceyka, M., Hait, N. C., Milstien, S. & Spiegel, S. Extracellular and intracellular actions of sphingosine-1-phosphate. Adv. Exp. Med. Biol. 688, 141-155 (2010).
-
(2010)
Adv. Exp. Med. Biol.
, vol.688
, pp. 141-155
-
-
Strub, G.M.1
Maceyka, M.2
Hait, N.C.3
Milstien, S.4
Spiegel, S.5
-
19
-
-
3242720378
-
Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells
-
Duan, H. F. et al. Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. Exp. Cell Res. 298, 593-601 (2004).
-
(2004)
Exp. Cell Res.
, vol.298
, pp. 593-601
-
-
Duan, H.F.1
-
20
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1- phosphate
-
Hait, N. C. et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325, 1254-1257 (2009).
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
-
21
-
-
77953923379
-
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
-
Alvarez, S. E. et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 465, 1084-1088 (2010).
-
(2010)
Nature
, vol.465
, pp. 1084-1088
-
-
Alvarez, S.E.1
-
22
-
-
12344272084
-
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
-
Pitson, S. M. et al. Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. J. Exp. Med. 201, 49-54 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 49-54
-
-
Pitson, S.M.1
-
23
-
-
0034735916
-
An oncogenic role of sphingosine kinase
-
Xia, P. et al. An oncogenic role of sphingosine kinase. Curr. Biol. 10, 1527-1530 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 1527-1530
-
-
Xia, P.1
-
24
-
-
0033230364
-
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
-
Olivera, A. et al. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J. Cell Biol. 147, 545-558 (1999).
-
(1999)
J. Cell Biol.
, vol.147
, pp. 545-558
-
-
Olivera, A.1
-
25
-
-
0033607517
-
Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells
-
Xia, P., Wang, L., Gamble, J. R. & Vadas, M. A. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J. Biol. Chem. 274, 34499-34505 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34499-34505
-
-
Xia, P.1
Wang, L.2
Gamble, J.R.3
Vadas, M.A.4
-
26
-
-
23944509761
-
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression
-
Le Scolan, E. et al. Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood 106, 1808-1816 (2005).
-
(2005)
Blood
, vol.106
, pp. 1808-1816
-
-
Le Scolan, E.1
-
27
-
-
33644974376
-
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
-
Bonhoure, E. et al. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia 20, 95-102 (2006).
-
(2006)
Leukemia
, vol.20
, pp. 95-102
-
-
Bonhoure, E.1
-
28
-
-
79953324725
-
Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-{kappa}B pathway in human non-small cell lung cancer
-
Song, L. et al. Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-{kappa}B pathway in human non-small cell lung cancer. Clin. Cancer Res. 17, 1839-1849 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1839-1849
-
-
Song, L.1
-
29
-
-
0142056955
-
Sphingosine kinase transmits estrogen signaling in human breast cancer cells
-
Sukocheva, O. A. et al. Sphingosine kinase transmits estrogen signaling in human breast cancer cells. Mol. Endocrinol. 17, 2002-2012 (2003).
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 2002-2012
-
-
Sukocheva, O.A.1
-
30
-
-
22144486976
-
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators
-
Billich, A. et al. Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: Function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. Cell Signal. 17, 1203-1217 (2005).
-
(2005)
Cell Signal.
, vol.17
, pp. 1203-1217
-
-
Billich, A.1
-
31
-
-
46749153415
-
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions
-
Bayerl, M. G. et al. Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions. Leuk. Lymphoma 49, 948-954 (2008).
-
(2008)
Leuk. Lymphoma
, vol.49
, pp. 948-954
-
-
Bayerl, M.G.1
-
32
-
-
0141507968
-
Discovery and evaluation of inhibitors of human sphingosine kinase
-
French, K. J. et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63, 5962-5969 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 5962-5969
-
-
French, K.J.1
-
33
-
-
0141567617
-
Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3
-
Licht, T., Tsirulnikov, L., Reuveni, H., Yarnitzky, T. & Ben-Sasson, S. A. Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3). Blood 102, 2099-2107 (2003).
-
(2003)
Blood
, vol.102
, pp. 2099-2107
-
-
Licht, T.1
Tsirulnikov, L.2
Reuveni, H.3
Yarnitzky, T.4
Ben-Sasson, S.A.5
-
34
-
-
33644830810
-
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
-
Visentin, B. et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 9, 225-238 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 225-238
-
-
Visentin, B.1
-
35
-
-
33644886904
-
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation
-
Akao, Y. et al. High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation. Biochem. Biophys. Res. Commun. 342, 1284-1290 (2006).
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.342
, pp. 1284-1290
-
-
Akao, Y.1
-
36
-
-
29244457577
-
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models
-
Pchejetski, D. et al. Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. Cancer Res. 65, 11667-11675 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 11667-11675
-
-
Pchejetski, D.1
-
37
-
-
48749121214
-
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal
-
Gude, D. R. et al. Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. FASEB J. 22, 2629-2638 (2008).
-
(2008)
FASEB J.
, vol.22
, pp. 2629-2638
-
-
Gude, D.R.1
-
38
-
-
34948853738
-
Tumor cell apoptosis polarizes macrophages role of sphingosine-1- phosphate
-
Weigert, A. et al. Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. Mol. Biol. Cell 18, 3810-3819 (2007).
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 3810-3819
-
-
Weigert, A.1
-
39
-
-
40449098552
-
Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression
-
Johann, A. M. et al. Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. J. Immunol. 180, 1239-1248 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 1239-1248
-
-
Johann, A.M.1
-
40
-
-
58149166482
-
Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization
-
Xie, B. et al. Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization. J. Cell Physiol. 218, 192-198 (2009).
-
(2009)
J. Cell Physiol.
, vol.218
, pp. 192-198
-
-
Xie, B.1
-
41
-
-
34547820916
-
Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration
-
Doll, F., Pfeilschifter, J. & Huwiler, A. Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration. Endocr. Relat. Cancer 14, 325-335 (2007).
-
(2007)
Endocr. Relat. Cancer
, vol.14
, pp. 325-335
-
-
Doll, F.1
Pfeilschifter, J.2
Huwiler, A.3
-
42
-
-
0036033179
-
Sphingosine kinase-dependent directional migration of leukocytes in response to phorbol ester
-
Kaneider, N. C., Djanani, A., Fischer-Colbrie, R. & Wiedermann, C. J. Sphingosine kinase-dependent directional migration of leukocytes in response to phorbol ester. Biochem. Biophys. Res. Commun. 297, 806-810 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.297
, pp. 806-810
-
-
Kaneider, N.C.1
Djanani, A.2
Fischer-Colbrie, R.3
Wiedermann, C.J.4
-
43
-
-
51349102583
-
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration
-
Maceyka, M., Alvarez, S. E., Milstien, S. & Spiegel, S. Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol. Cell Biol. 28, 5687-5697 (2008).
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 5687-5697
-
-
Maceyka, M.1
Alvarez, S.E.2
Milstien, S.3
Spiegel, S.4
-
44
-
-
53049096639
-
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion
-
Shida, D. et al. Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res. 68, 6569-6577 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 6569-6577
-
-
Shida, D.1
-
45
-
-
0035793866
-
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
-
Hobson, J. P. et al. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 291, 1800-1803 (2001).
-
(2001)
Science
, vol.291
, pp. 1800-1803
-
-
Hobson, J.P.1
-
46
-
-
0037401876
-
Signaling and biological actions of sphingosine 1-phosphate
-
Hla, T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol. Res. 47, 401-407 (2003).
-
(2003)
Pharmacol. Res.
, vol.47
, pp. 401-407
-
-
Hla, T.1
-
47
-
-
0037684739
-
The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13
-
Graler, M. H. et al. The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13. J. Cell Biochem. 89, 507-519 (2003).
-
(2003)
J. Cell Biochem.
, vol.89
, pp. 507-519
-
-
Graler, M.H.1
-
48
-
-
33947236062
-
Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3
-
Maeda, Y. et al. Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. J. Immunol. 178, 3437-3446 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 3437-3446
-
-
Maeda, Y.1
-
49
-
-
0041378169
-
Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells
-
Van Brocklyn, J. R., Young, N. & Roof, R. Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. Cancer Lett. 199, 53-60 (2003).
-
(2003)
Cancer Lett.
, vol.199
, pp. 53-60
-
-
Van Brocklyn, J.R.1
Young, N.2
Roof, R.3
-
50
-
-
79551628419
-
Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: Role of sphingosine kinase 1 and S1P lyase
-
Berdyshev, E. V. et al. Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: Role of sphingosine kinase 1 and S1P lyase. PLoS ONE 6, e16571 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Berdyshev, E.V.1
-
51
-
-
0042858413
-
Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity
-
Arikawa, K. et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. J. Biol. Chem. 278, 32841-32851 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32841-32851
-
-
Arikawa, K.1
-
52
-
-
34247554847
-
Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
-
Novgorodov, A. S., El-Alwani, M., Bielawski, J., Obeid, L. M. & Gudz, T. I. Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. FASEB J. 21, 1503-1514 (2007).
-
(2007)
FASEB J.
, vol.21
, pp. 1503-1514
-
-
Novgorodov, A.S.1
El-Alwani, M.2
Bielawski, J.3
Obeid, L.M.4
Gudz, T.I.5
-
53
-
-
51249101373
-
Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor
-
Hashimoto, M. et al. Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor. Am. J. Respir. Cell. Mol. Biol. 39, 356-363 (2008).
-
(2008)
Am. J. Respir. Cell. Mol. Biol.
, vol.39
, pp. 356-363
-
-
Hashimoto, M.1
-
54
-
-
53349127597
-
Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: Implications for invasiveness
-
Bryan, L. et al. Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: Implications for invasiveness. Mol. Cancer Res. 6, 1469-1477 (2008).
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 1469-1477
-
-
Bryan, L.1
-
55
-
-
77955295887
-
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine-1-phosphate in estrogen receptor positive breast cancer cells
-
Long, J. S. et al. Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine-1-phosphate in estrogen receptor positive breast cancer cells. Mol. Cell Biol. 30, 3827-3841 (2010).
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 3827-3841
-
-
Long, J.S.1
-
56
-
-
0034974903
-
Differential regulation of sphingosine-1-phosphate-and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity
-
Liu, F. et al. Differential regulation of sphingosine-1-phosphate-and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. Am. J. Respir. Cell. Mol. Biol. 24, 711-719 (2001).
-
(2001)
Am. J. Respir. Cell. Mol. Biol.
, vol.24
, pp. 711-719
-
-
Liu, F.1
-
57
-
-
0038118495
-
VEGF receptor expression and signaling in human bladder tumors
-
Wu, W., Shu, X., Hovsepyan, H., Mosteller, R. D. & Broek, D. VEGF receptor expression and signaling in human bladder tumors. Oncogene 22, 3361-3370 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 3361-3370
-
-
Wu, W.1
Shu, X.2
Hovsepyan, H.3
Mosteller, R.D.4
Broek, D.5
-
58
-
-
77955801617
-
Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro
-
Anelli, V., Gault, C. R., Snider, A. J. & Obeid, L. M. Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J. 24, 2727-2738 (2010).
-
(2010)
FASEB J.
, vol.24
, pp. 2727-2738
-
-
Anelli, V.1
Gault, C.R.2
Snider, A.J.3
Obeid, L.M.4
-
59
-
-
0033564177
-
Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
-
Wang, J. D. et al. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation. Prostate 40, 50-55 (1999).
-
(1999)
Prostate
, vol.40
, pp. 50-55
-
-
Wang, J.D.1
-
60
-
-
0034662612
-
Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells
-
Nava, V. E. et al. Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. Cancer Res. 60, 4468-4474 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 4468-4474
-
-
Nava, V.E.1
-
61
-
-
72949118378
-
Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival
-
Dayon, A. et al. Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival. PLoS ONE 4, e8048 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Dayon, A.1
-
62
-
-
54249088951
-
Sphingosine kinase 1: A new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells
-
Ader, I., Brizuela, L., Bouquerel, P., Malavaud, B. & Cuvillier, O. Sphingosine kinase 1: A new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells. Cancer Res. 68, 8635-8642 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 8635-8642
-
-
Ader, I.1
Brizuela, L.2
Bouquerel, P.3
Malavaud, B.4
Cuvillier, O.5
-
63
-
-
0031028264
-
Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples
-
Sun, Y., Lin, J., Katz, A. E. & Fisher, P. B. Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples. Cancer Res. 57, 18-23 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 18-23
-
-
Sun, Y.1
Lin, J.2
Katz, A.E.3
Fisher, P.B.4
-
64
-
-
0032539665
-
Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes
-
Su, Z., Goldstein, N. I. & Fisher, P. B. Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes. Proc. Natl Acad. Sci. USA 95, 1764-1769 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 1764-1769
-
-
Su, Z.1
Goldstein, N.I.2
Fisher, P.B.3
-
65
-
-
78751649728
-
Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis
-
Leclercq, T. M., Moretti, P. A. & Pitson, S. M. Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. Oncogene 30, 372-378 (2011).
-
(2011)
Oncogene
, vol.30
, pp. 372-378
-
-
Leclercq, T.M.1
Moretti, P.A.2
Pitson, S.M.3
-
66
-
-
0032530864
-
N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide
-
Edsall, L. C., Van Brocklyn, J. R., Cuvillier, O., Kleuser, B. & Spiegel, S. N. N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37, 12892-12898 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 12892-12898
-
-
Edsall, L.C.1
Van Brocklyn, J.R.2
Cuvillier, O.3
Kleuser, B.4
Spiegel, S.N.5
-
67
-
-
0030004270
-
Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
-
Sweeney, E. A. et al. Sphingosine and its methylated derivative N, N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int. J. Cancer 66, 358-366 (1996).
-
(1996)
Int. J. Cancer
, vol.66
, pp. 358-366
-
-
Sweeney, E.A.1
-
68
-
-
0031031859
-
Sphingolipids-the enigmatic lipid class: Biochemistry, physiology, and pathophysiology
-
Merrill, A. H. Jr et al. Sphingolipids-the enigmatic lipid class: Biochemistry, physiology, and pathophysiology. Toxicol. Appl. Pharmacol. 142, 208-225 (1997).
-
(1997)
Toxicol. Appl. Pharmacol.
, vol.142
, pp. 208-225
-
-
Merrill Jr., A.H.1
-
69
-
-
0036173656
-
Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c
-
Kono, K., Sugiura, M. & Kohama, T. Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c. J. Antibiot. (Tokyo) 55, 99-103 (2002).
-
(2002)
J. Antibiot. (Tokyo)
, vol.55
, pp. 99-103
-
-
Kono, K.1
Sugiura, M.2
Kohama, T.3
-
70
-
-
51049121847
-
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models
-
Pchejetski, D. et al. Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. Mol. Cancer Ther. 7, 1836-1845 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 1836-1845
-
-
Pchejetski, D.1
-
71
-
-
35548994468
-
Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart
-
Vessey, D. A. et al. Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. J. Biochem. Mol. Toxicol. 21, 273-279 (2007).
-
(2007)
J. Biochem. Mol. Toxicol.
, vol.21
, pp. 273-279
-
-
Vessey, D.A.1
-
72
-
-
0037051102
-
Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis
-
Permpongkosol, S. et al. Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis. Int. J. Cancer 98, 167-172 (2002).
-
(2002)
Int. J. Cancer
, vol.98
, pp. 167-172
-
-
Permpongkosol, S.1
-
73
-
-
51649122574
-
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
-
Paugh, S. W. et al. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood 112, 1382-1391 (2008).
-
(2008)
Blood
, vol.112
, pp. 1382-1391
-
-
Paugh, S.W.1
-
74
-
-
70349333252
-
Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
-
Sukocheva, O., Wang, L., Verrier, E., Vadas, M. A. & Xia, P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology 150, 4484-4492 (2009).
-
(2009)
Endocrinology
, vol.150
, pp. 4484-4492
-
-
Sukocheva, O.1
Wang, L.2
Verrier, E.3
Vadas, M.A.4
Xia, P.5
-
75
-
-
78650407629
-
Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage
-
Huwiler, A. et al. Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage. Br. J. Pharmacol. 162, 532-543 (2011).
-
(2011)
Br. J. Pharmacol.
, vol.162
, pp. 532-543
-
-
Huwiler, A.1
-
76
-
-
25844457390
-
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
-
Sarkar, S. et al. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett. 579, 5313-5317 (2005).
-
(2005)
FEBS Lett.
, vol.579
, pp. 5313-5317
-
-
Sarkar, S.1
-
77
-
-
77957831195
-
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer
-
Brizuela, L. et al. The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer. FASEB J. 24, 3882-3894 (2010).
-
(2010)
FASEB J.
, vol.24
, pp. 3882-3894
-
-
Brizuela, L.1
-
78
-
-
70350707758
-
Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel
-
Sauer, L. et al. Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel. Int. J. Cancer 125, 2728-2736 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2728-2736
-
-
Sauer, L.1
-
79
-
-
77954535502
-
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
-
Tonelli, F. et al. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal 22, 1536-1542 (2010).
-
(2010)
Cell Signal
, vol.22
, pp. 1536-1542
-
-
Tonelli, F.1
-
80
-
-
79955112221
-
Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247
-
Sharma, A. K. Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247). Expert Opin. Ther. Pat. 21, 807-812 (2011).
-
(2011)
Expert Opin. Ther. Pat.
, vol.21
, pp. 807-812
-
-
Sharma, A.K.1
-
81
-
-
28044462458
-
FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors
-
Chiba, K. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacol. Ther. 108, 308-319 (2005).
-
(2005)
Pharmacol. Ther.
, vol.108
, pp. 308-319
-
-
Chiba, K.1
-
82
-
-
33750736991
-
FTY720 (fingolimod) in renal transplantation
-
Budde, K. et al. FTY720 (fingolimod) in renal transplantation. Clin. Transplant. 20 (Suppl. 17), 17-24 (2006).
-
(2006)
Clin. Transplant.
, vol.20
, Issue.SUPPL. 17
, pp. 17-24
-
-
Budde, K.1
-
83
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen, J. A. et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N. Engl. J. Med. 362, 402-415 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
-
84
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos, L. et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N. Engl. J. Med. 362, 387-401 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 387-401
-
-
Kappos, L.1
-
85
-
-
35648995431
-
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
-
Leroux, M. E. et al. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. Prostate 67, 1699-1717 (2007).
-
(2007)
Prostate
, vol.67
, pp. 1699-1717
-
-
Leroux, M.E.1
-
86
-
-
32244448999
-
FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase
-
Zhou, C. et al. FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett. 233, 36-47 (2006).
-
(2006)
Cancer Lett.
, vol.233
, pp. 36-47
-
-
Zhou, C.1
-
87
-
-
28044460091
-
FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer
-
Chua, C. W. et al. FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. Int. J. Cancer 117, 1039-1048 (2005).
-
(2005)
Int. J. Cancer
, vol.117
, pp. 1039-1048
-
-
Chua, C.W.1
-
88
-
-
0034665512
-
Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria
-
Nagahara, Y., Ikekita, M. & Shinomiya, T. Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria. J. Immunol. 165, 3250-3259 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 3250-3259
-
-
Nagahara, Y.1
Ikekita, M.2
Shinomiya, T.3
-
89
-
-
0042029408
-
Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity
-
Azuma, H. et al. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity. Anticancer Res. 23, 3183-3193 (2003).
-
(2003)
Anticancer Res.
, vol.23
, pp. 3183-3193
-
-
Azuma, H.1
-
90
-
-
31544447428
-
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization
-
LaMontagne, K. et al. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. 66, 221-231 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 221-231
-
-
LaMontagne, K.1
-
91
-
-
33846864904
-
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
-
Payne, S. G. et al. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 109, 1077-1085 (2007).
-
(2007)
Blood
, vol.109
, pp. 1077-1085
-
-
Payne, S.G.1
-
92
-
-
70350444557
-
Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog
-
Ushitora, Y. et al. Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog. Transplantation 88, 980-986 (2009).
-
(2009)
Transplantation
, vol.88
, pp. 980-986
-
-
Ushitora, Y.1
-
93
-
-
45749139274
-
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells
-
Nagaoka, Y., Otsuki, K., Fujita, T. & Uesato, S. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biol. Pharm. Bull. 31, 1177-1181 (2008).
-
(2008)
Biol. Pharm. Bull.
, vol.31
, pp. 1177-1181
-
-
Nagaoka, Y.1
Otsuki, K.2
Fujita, T.3
Uesato, S.4
-
94
-
-
70349333237
-
The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo
-
Wolf, A. M. et al. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J. Immunol. 183, 3751-3760 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 3751-3760
-
-
Wolf, A.M.1
-
95
-
-
77954721060
-
Regulatory T cells in tumor immunity
-
Nishikawa, H. & Sakaguchi, S. Regulatory T cells in tumor immunity. Int. J. Cancer 127, 759-767 (2010).
-
(2010)
Int. J. Cancer
, vol.127
, Issue.759-767
-
-
Nishikawa, H.1
Sakaguchi, S.2
-
96
-
-
65349143361
-
Immunosuppressive therapy and post-transplant malignancy
-
Domhan, S., Zeier, M. & Abdollahi, A. Immunosuppressive therapy and post-transplant malignancy. Nephrol. Dial. Transplant 24, 1097-1103 (2009).
-
(2009)
Nephrol. Dial. Transplant
, vol.24
, pp. 1097-1103
-
-
Domhan, S.1
Zeier, M.2
Abdollahi, A.3
-
97
-
-
38449101346
-
FTY720 versus mycophenolate mofetil in de novo renal transplantation: Six-month results of a double-blind study
-
Tedesco-Silva, H. et al. FTY720 versus mycophenolate mofetil in de novo renal transplantation: Six-month results of a double-blind study. Transplantation 84, 885-892 (2007).
-
(2007)
Transplantation
, vol.84
, pp. 885-892
-
-
Tedesco-Silva, H.1
-
98
-
-
77952918047
-
Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions
-
Graler, M. H. Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions. Cell. Physiol. Biochem. 26, 79-86 (2010).
-
(2010)
Cell. Physiol. Biochem.
, vol.26
, pp. 79-86
-
-
Graler, M.H.1
-
99
-
-
27244457788
-
FTY720 a novel immunomodulator in de novo kidney transplant patients: Pharmacokinetics and exposure-response relationship
-
Skerjanec, A. et al. FTY720, a novel immunomodulator in de novo kidney transplant patients: Pharmacokinetics and exposure-response relationship. J. Clin. Pharmacol. 45, 1268-1278 (2005).
-
(2005)
J. Clin. Pharmacol.
, vol.45
, pp. 1268-1278
-
-
Skerjanec, A.1
-
100
-
-
33847421937
-
Ethnic sensitivity study of fingolimod in white and Asian subjects
-
Kovarik, J. M. et al. Ethnic sensitivity study of fingolimod in white and Asian subjects. Int. J. Clin. Pharmacol. Ther. 45, 98-109 (2007).
-
(2007)
Int. J. Clin. Pharmacol. Ther.
, vol.45
, pp. 98-109
-
-
Kovarik, J.M.1
-
101
-
-
2342634478
-
Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects
-
Kovarik, J. M., Schmouder, R., Barilla, D., Wang, Y. & Kraus, G. Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects. Br. J. Clin. Pharmacol. 57, 586-591 (2004).
-
(2004)
Br. J. Clin. Pharmacol.
, vol.57
, pp. 586-591
-
-
Kovarik, J.M.1
Schmouder, R.2
Barilla, D.3
Wang, Y.4
Kraus, G.5
-
102
-
-
62449300643
-
Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy
-
Sensken, S. C., Bode, C. & Graler, M. H. Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy. J. Pharmacol. Exp. Ther. 328, 963-969 (2009).
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.328
, pp. 963-969
-
-
Sensken, S.C.1
Bode, C.2
Graler, M.H.3
-
103
-
-
0036205659
-
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
-
Budde, K. et al. First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J. Am. Soc. Nephrol. 13, 1073-1083 (2002).
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 1073-1083
-
-
Budde, K.1
-
104
-
-
14644408845
-
The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I
-
Koyrakh, L., Roman, M. I., Brinkmann, V. & Wickman, K. The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I. Am. J. Transplant. 5, 529-536 (2005).
-
(2005)
Am. J. Transplant.
, vol.5
, pp. 529-536
-
-
Koyrakh, L.1
Roman, M.I.2
Brinkmann, V.3
Wickman, K.4
-
105
-
-
1942508223
-
Multiple-dose FTY720: Tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects
-
Kovarik, J. M. et al. Multiple-dose FTY720: Tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J. Clin. Pharmacol. 44, 532-537 (2004).
-
(2004)
J. Clin. Pharmacol.
, vol.44
, pp. 532-537
-
-
Kovarik, J.M.1
-
106
-
-
47249147546
-
The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects
-
Kovarik, J. M. et al. The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects. Br. J. Clin. Pharmacol. 66, 199-206 (2008).
-
(2008)
Br. J. Clin. Pharmacol.
, vol.66
, pp. 199-206
-
-
Kovarik, J.M.1
-
107
-
-
36248956701
-
Finding a way out: Lymphocyte egress from lymphoid organs
-
Schwab, S. R. & Cyster, J. G. Finding a way out: Lymphocyte egress from lymphoid organs. Nat. Immunol. 8, 1295-1301 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1295-1301
-
-
Schwab, S.R.1
Cyster, J.G.2
-
108
-
-
78649876185
-
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p- chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells
-
Loveridge, C. et al. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J. Biol. Chem. 285, 38841-38852 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 38841-38852
-
-
Loveridge, C.1
-
109
-
-
78049490720
-
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640
-
Antoon, J. W. et al. Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. Endocrinology 151, 5124-5135 (2010).
-
(2010)
Endocrinology
, vol.151
, pp. 5124-5135
-
-
Antoon, J.W.1
-
110
-
-
28544437478
-
Essential role for sphingosine kinases in neural and vascular development
-
Mizugishi, K. et al. Essential role for sphingosine kinases in neural and vascular development. Mol. Cell. Biol. 25, 11113-11121 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 11113-11121
-
-
Mizugishi, K.1
-
111
-
-
33847609611
-
Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice
-
Zemann, B. et al. Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice. Immunol. Lett. 109, 56-63 (2007).
-
(2007)
Immunol. Lett.
, vol.109
, pp. 56-63
-
-
Zemann, B.1
-
112
-
-
77957682309
-
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial
-
de Bono, J. S. et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial. Lancet 376, 1147-1154 (2010).
-
(2010)
Lancet
, vol.376
, pp. 1147-1154
-
-
De Bono, J.S.1
-
113
-
-
0034721844
-
Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase
-
Pitson, S. M. et al. Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. J. Biol. Chem. 275, 33945-33950 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 33945-33950
-
-
Pitson, S.M.1
-
114
-
-
0036841720
-
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
-
Shu, X., Wu, W., Mosteller, R. D. & Broek, D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell Biol. 22, 7758-7768 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 7758-7768
-
-
Shu, X.1
Wu, W.2
Mosteller, R.D.3
Broek, D.4
-
115
-
-
4544277807
-
Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1
-
Fujita, T. et al. Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. Biochem. J. 382, 717-723 (2004).
-
(2004)
Biochem.J.
, vol.382
, pp. 717-723
-
-
Fujita, T.1
-
116
-
-
0037040908
-
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling
-
Xia, P. et al. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. J. Biol. Chem. 277, 7996-8003 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7996-8003
-
-
Xia, P.1
-
117
-
-
30044452349
-
The mechanism of membrane targeting of human sphingosine kinase 1
-
Stahelin, R. V. et al. The mechanism of membrane targeting of human sphingosine kinase 1. J. Biol. Chem. 280, 43030-43038 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 43030-43038
-
-
Stahelin, R.V.1
-
118
-
-
33749380038
-
Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts
-
Duan, H. F. et al. Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts. Cell Signal. 18, 2049-2055 (2006).
-
(2006)
Cell Signal.
, vol.18
, pp. 2049-2055
-
-
Duan, H.F.1
-
119
-
-
65649151763
-
Coordinate regulation of sphingosine kinase and actin dynamics
-
Iyer, S. S. & Kusner, D. J. Coordinate regulation of sphingosine kinase and actin dynamics. Methods Mol. Biol. 531, 347-361 (2009).
-
(2009)
Methods Mol. Biol.
, vol.531
, pp. 347-361
-
-
Iyer, S.S.1
Kusner, D.J.2
-
120
-
-
34548189251
-
The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages
-
Kusner, D. J. et al. The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. J. Biol. Chem. 282, 23147-23162 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23147-23162
-
-
Kusner, D.J.1
-
121
-
-
0037031948
-
Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein
-
Hayashi, S. et al. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. J. Biol. Chem. 277, 33319-33324 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 33319-33324
-
-
Hayashi, S.1
-
122
-
-
1242292257
-
Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation
-
Fukuda, Y., Aoyama, Y., Wada, A. & Igarashi, Y. Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation. Biochim. Biophys. Acta 1636, 12-21 (2004).
-
(2004)
Biochim. Biophys. Acta
, vol.1636
, pp. 12-21
-
-
Fukuda, Y.1
Aoyama, Y.2
Wada, A.3
Igarashi, Y.4
-
123
-
-
2942527522
-
Aminoacylase 1 is a sphingosine kinase 1-interacting protein
-
Maceyka, M., Nava, V. E., Milstien, S. & Spiegel, S. Aminoacylase 1 is a sphingosine kinase 1-interacting protein. FEBS Lett. 568, 30-34 (2004).
-
(2004)
FEBS Lett.
, vol.568
, pp. 30-34
-
-
Maceyka, M.1
Nava, V.E.2
Milstien, S.3
Spiegel, S.4
-
124
-
-
58049199390
-
Deactivation of sphingosine kinase 1 by protein phosphatase 2A
-
Barr, R. K., Lynn, H. E., Moretti, P. A., Khew-Goodall, Y. & Pitson, S. M. Deactivation of sphingosine kinase 1 by protein phosphatase 2A. J. Biol. Chem. 283, 34994-35002 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 34994-35002
-
-
Barr, R.K.1
Lynn, H.E.2
Moretti, P.A.3
Khew-Goodall, Y.4
Pitson, S.M.5
-
125
-
-
0037031922
-
Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity
-
Lacana, E., Maceyka, M., Milstien, S. & Spiegel, S. Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. J. Biol. Chem. 277, 32947-32953 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32947-32953
-
-
Lacana, E.1
Maceyka, M.2
Milstien, S.3
Spiegel, S.4
-
126
-
-
77951745863
-
Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase
-
Kovanich, D. et al. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. Chembiochem. 11, 963-971 (2010).
-
(2010)
Chembiochem.
, vol.11
, pp. 963-971
-
-
Kovanich, D.1
-
127
-
-
52949143502
-
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer
-
Ruckhäberle, E. et al. Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res. Treat. 112, 41-52 (2007).
-
(2007)
Breast Cancer Res. Treat.
, vol.112
, pp. 41-52
-
-
Ruckhäberle, E.1
-
128
-
-
78149348826
-
High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients
-
Watson, C. et al. High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. Am. J. Pathol. 177, 2205-2215 (2010).
-
(2010)
Am. J. Pathol.
, vol.177
, pp. 2205-2215
-
-
Watson, C.1
-
129
-
-
58149231552
-
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival
-
Li, J. et al. Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival. Clin. Cancer Res. 14, 6996-7003 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6996-7003
-
-
Li, J.1
-
130
-
-
23844498431
-
Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines
-
Van Brocklyn, J. R. et al. Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: Roles of sphingosine kinase isoforms in growth of glioblastoma cell lines. J. Neuropathol. Exp. Neurol. 64, 695-705 (2005).
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 695-705
-
-
Van Brocklyn, J.R.1
-
131
-
-
63149167365
-
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients
-
Li, W. et al. Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin. Cancer Res. 15, 1393-1399 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1393-1399
-
-
Li, W.1
-
132
-
-
77958025091
-
The expression of sphingosine kinase-1 in head and neck carcinoma
-
Facchinetti, M. M. et al. The expression of sphingosine kinase-1 in head and neck carcinoma. Cells Tissues Organs 192, 314-324 (2010).
-
(2010)
Cells Tissues Organs
, vol.192
, pp. 314-324
-
-
Facchinetti, M.M.1
-
133
-
-
78751544538
-
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition
-
Sinha, U. K. et al. Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head Neck 33, 178-188 (2010).
-
(2010)
Head Neck
, vol.33
, pp. 178-188
-
-
Sinha, U.K.1
-
134
-
-
77956589444
-
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy
-
Liu, G. et al. Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy. BMC Cancer 10, 495 (2010).
-
(2010)
BMC Cancer
, vol.10
, Issue.495
-
-
Liu, G.1
-
135
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
Ogretmen, B. & Hannun, Y. A. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev. Cancer 4, 604-616 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
136
-
-
77953790503
-
An update on sphingosine-1-phosphate and other sphingolipid mediators
-
Fyrst, H. & Saba, J. D. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat. Chem. Biol. 6, 489-497 (2010).
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 489-497
-
-
Fyrst, H.1
Saba, J.D.2
-
137
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Hannun, Y. A. & Obeid, L. M. Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat. Rev. Mol. Cell. Biol. 9, 139-150 (2008).
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
138
-
-
0037203305
-
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
-
Maceyka, M., Payne, S. G., Milstien, S. & Spiegel, S. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim. Biophys. Acta 1585, 193-201 (2002).
-
(2002)
Biochim. Biophys. Acta
, vol.1585
, pp. 193-201
-
-
Maceyka, M.1
Payne, S.G.2
Milstien, S.3
Spiegel, S.4
-
139
-
-
0041703016
-
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha
-
Pettus, B. J. et al. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 17, 1411-1421 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 1411-1421
-
-
Pettus, B.J.1
-
140
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier, O. et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381, 800-803 (1996).
-
(1996)
Nature
, vol.381
, pp. 800-803
-
-
Cuvillier, O.1
-
141
-
-
4944246652
-
Sphingosine kinase activation mediates ischemic preconditioning in murine heart
-
Jin, Z. Q., Goetzl, E. J. & Karliner, J. S. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation 110, 1980-1989 (2004).
-
(2004)
Circulation
, vol.110
, pp. 1980-1989
-
-
Jin, Z.Q.1
Goetzl, E.J.2
Karliner, J.S.3
-
142
-
-
33846047834
-
Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis
-
Pchejetski, D. et al. Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. Circ. Res. 100, 41-49 (2007).
-
(2007)
Circ. Res.
, vol.100
, pp. 41-49
-
-
Pchejetski, D.1
-
143
-
-
34547182992
-
Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide
-
Gomez-Brouchet, A. et al. Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide. Mol. Pharmacol. 72, 341-349 (2007).
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 341-349
-
-
Gomez-Brouchet, A.1
-
144
-
-
23044486229
-
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha
-
Osawa, Y. et al. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J. Biol. Chem. 280, 27879-27887 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 27879-27887
-
-
Osawa, Y.1
-
145
-
-
56949095716
-
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
-
Pyne, S., Lee, S. C., Long, J. & Pyne, N. J. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell Signal. 21, 14-21 (2009).
-
(2009)
Cell Signal.
, vol.21
, pp. 14-21
-
-
Pyne, S.1
Lee, S.C.2
Long, J.3
Pyne, N.J.4
-
146
-
-
13144254221
-
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway
-
Xia, P. et al. Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. Proc. Natl Acad. Sci. USA 95, 14196-14201 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 14196-14201
-
-
Xia, P.1
-
147
-
-
33847702961
-
TNF-alpha -stimulated cell proliferation is mediated through sphingosine kinase-dependent AKT activation and cyclin D expression
-
Radeff-Huang, J., Seasholtz, T. M., Chang, J. W., Smith, J. M. & Walsh, C. T. TNF-alpha -stimulated cell proliferation is mediated through sphingosine kinase-dependent AKT activation and cyclin D expression. J. Biol. Chem. 282, 863-870 (2006).
-
(2006)
J. Biol. Chem.
, vol.282
, pp. 863-870
-
-
Radeff-Huang, J.1
Seasholtz, T.M.2
Chang, J.W.3
Smith, J.M.4
Walsh, C.T.5
-
148
-
-
3242791547
-
Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis
-
Melendez, A. J. & Ibrahim, F. B. Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. J. Immunol. 173, 1596-1603 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 1596-1603
-
-
Melendez, A.J.1
Ibrahim, F.B.2
-
149
-
-
79951942207
-
The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1alpha protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6
-
Pchejetski, D. et al. The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1alpha protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6. Immunol. Cell Biol. 89, 268-274 (2010).
-
(2010)
Immunol. Cell Biol.
, vol.89
, pp. 268-274
-
-
Pchejetski, D.1
-
150
-
-
77953255522
-
SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis
-
Puneet, P. et al. SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis. Science 328, 1290-1294 (2010).
-
(2010)
Science
, vol.328
, pp. 1290-1294
-
-
Puneet, P.1
-
151
-
-
19944427463
-
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation
-
Yamanaka, M. et al. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J. Biol. Chem. 279, 53994-54001 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 53994-54001
-
-
Yamanaka, M.1
-
152
-
-
77949470760
-
Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis
-
Cencetti, F., Bernacchioni, C., Nincheri, P., Donati, C. & Bruni, P. Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis. Mol. Biol. Cell 21, 1111-1124 (2010).
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 1111-1124
-
-
Cencetti, F.1
Bernacchioni, C.2
Nincheri, P.3
Donati, C.4
Bruni, P.5
-
153
-
-
67449124297
-
Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts
-
Gellings Lowe, N., Swaney, J. S., Moreno, K. M. & Sabbadini, R. A. Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. Cardiovasc. Res. 82, 303-312 (2009).
-
(2009)
Cardiovasc. Res.
, vol.82
, pp. 303-312
-
-
Gellings Lowe, N.1
Swaney, J.S.2
Moreno, K.M.3
Sabbadini, R.A.4
-
154
-
-
34347384206
-
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing
-
Serriere-Lanneau, V. et al. The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J. 21, 2005-2013 (2007).
-
(2007)
FASEB J.
, vol.21
, pp. 2005-2013
-
-
Serriere-Lanneau, V.1
-
155
-
-
79952027563
-
Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
-
Hla, T. & Brinkmann, V. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology 76, S3-S8 (2011).
-
(2011)
Neurology
, vol.76
-
-
Hla, T.1
Brinkmann, V.2
-
156
-
-
56949105142
-
Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system
-
Okada, T., Kajimoto, T., Jahangeer, S. & Nakamura, S. Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system. Cell Signal. 21, 7-13 (2009).
-
(2009)
Cell Signal.
, vol.21
, pp. 7-13
-
-
Okada, T.1
Kajimoto, T.2
Jahangeer, S.3
Nakamura, S.4
-
157
-
-
34247552132
-
Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons
-
Kajimoto, T. et al. Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. Mol. Cell. Biol. 27, 3429-3440 (2007).
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3429-3440
-
-
Kajimoto, T.1
-
158
-
-
0036687577
-
Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction
-
Brailoiu, E., Cooper, R. L. & Dun, N. J. Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction. Br. J. Pharmacol. 136, 1093-1097 (2002).
-
(2002)
Br. J. Pharmacol.
, vol.136
, pp. 1093-1097
-
-
Brailoiu, E.1
Cooper, R.L.2
Dun, N.J.3
-
159
-
-
0142105397
-
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
-
Pitson, S. M. et al. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J. 22, 5491-5500 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 5491-5500
-
-
Pitson, S.M.1
-
160
-
-
0142091073
-
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis
-
Igarashi, N. et al. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J. Biol. Chem. 278, 46832-46839 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46832-46839
-
-
Igarashi, N.1
-
161
-
-
35948936347
-
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin
-
Sankala, H. M. et al. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res. 67, 10466-10474 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 10466-10474
-
-
Sankala, H.M.1
-
162
-
-
23844519961
-
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor
-
Hait, N. C. et al. Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J. Biol. Chem. 280, 29462-29469 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29462-29469
-
-
Hait, N.C.1
-
163
-
-
70249125866
-
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype
-
Weigert, A. et al. Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. Int. J. Cancer 125, 2114-2121 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2114-2121
-
-
Weigert, A.1
-
164
-
-
62549143484
-
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells
-
Schnitzer, S. E., Weigert, A., Zhou, J. & Brune, B. Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Mol. Cancer Res. 7, 393-401 (2009).
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 393-401
-
-
Schnitzer, S.E.1
Weigert, A.2
Zhou, J.3
Brune, B.4
-
165
-
-
79952343738
-
Antitumor activity of Sphingosine Kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts
-
Beljanski, V., Lewis, C. S. & Smith, C. D. Antitumor activity of Sphingosine Kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biol. Ther. 11, 524-534 (2011).
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 524-534
-
-
Beljanski, V.1
Lewis, C.S.2
Smith, C.D.3
-
166
-
-
79953314461
-
Targeting NF-kB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2
-
Antoon, J. W. et al. Targeting NF-kB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer Biol. Ther. 11, 678-689 (2011).
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 678-689
-
-
Antoon, J.W.1
|