Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 98, Issue , 2014, Pages 160-165

  Mao, Yicheng ^a,b   Wang, Jiang ^a   Zhao, Yuan ^a   Yan, Ribai ^a   Li, Hao ^a   Chen, Ching Shih ^a   Lee, Robert J ^a,b   Byrd, John C ^c   Lee, L James ^b   Muthusamy, Natarajan ^c   Phelps, Mitch A ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Ohio State University   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

FTY720; Liquid chromatography tandem mass spectrometry; Mouse; OSU 2S; Pharmacokinetics

Indexed keywords

ANTINEOPLASTIC AGENT; FINGOLIMOD; OSU 2S; UNCLASSIFIED DRUG; OSU-2S; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PERITONEAL CAVITY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; FEMALE; HALF LIFE TIME; INSTITUTE FOR CANCER RESEARCH MOUSE; PLASMA; PROCEDURES;

ANIMALS; CHROMATOGRAPHY, LIQUID; FEMALE; HALF-LIFE; MICE; MICE, INBRED ICR; PLASMA; PROPYLENE GLYCOLS; SPHINGOSINE; TANDEM MASS SPECTROMETRY;

EID: 84902135614     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.05.022     Document Type: Article

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