N,N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide

Biochemistry

Volumn 37, Issue 37, 1998, Pages 12892-12898

  Edsall, Lisa C ^a   Van Brocklyn, James R ^a   Cuvillier, Olivier ^a   Kleuser, Burkhard ^a   Spiegel, Sarah ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; N,N DIMETHYLSPHINGOSINE; PROTEIN KINASE; PROTEIN KINASE C; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; COMPETITIVE INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; CERAMIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; LYSOPHOSPHOLIPIDS; MICE; PC12 CELLS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE C; RATS; SPHINGOSINE; TUMOR CELLS, CULTURED;

EID: 0032530864     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980744d     Document Type: Article

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