A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

British Journal of Pharmacology

Volumn 138, Issue 7, 2003, Pages 1303-1312

  Matsuoka, Yumiko ^a,b   Nagahara, Yukitoshi ^a,b   Ikekita, Masahiko ^b   Shinomiya, Takahisa ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Akt; Apoptosis; Bad; FTY720; Leukemia cells; P70 S6k; PKB; PP2A

Indexed keywords

CASPASE 3; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; OKADAIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BAD; PROTEIN KINASE B; PROTEIN P70;

APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTRACELLULAR SPACE; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION;

BLOOD CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKEMIA; PHOSPHORYLATION; PROPYLENE GLYCOLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SPHINGOSINE; U937 CELLS;

EID: 0037739755     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705182     Document Type: Article

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