Design, synthesis, and antileukemic activity of stereochemically defined constrained analogues of FTY720 (Gilenya)

ACS Medicinal Chemistry Letters

Volumn 4, Issue 10, 2013, Pages 969-973

  Fransson, Rebecca ^a   McCracken, Alison N ^b   Chen, Bin ^a   McMonigle, Ryan J ^b   Edinger, Aimee L ^b   Hanessian, Stephen ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

arylmethyl ether; FTY720; leukemia; pyrrolidine

Indexed keywords

AMINO ACID TRANSPORTER; ANTILEUKEMIC AGENT; FINGOLIMOD; PYRROLIDINE DERIVATIVE; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HUMAN; LEUKEMIA CELL LINE; PRIORITY JOURNAL; STEREOCHEMISTRY;

EID: 84885461398     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml4002425     Document Type: Article

References (21)

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