Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization

Cancer Research

Volumn 66, Issue 1, 2006, Pages 221-231

  LaMontagne, Kenneth ^a,d   Littiewood Evans, Amanda ^b   Schnell, Christian ^b   O'Reilly, Terence ^b   Wyder, Lorenza ^b   Sanchez, Teresa ^c   Probst, Beatrice ^b   Butler, Jeannene ^a,d   Wood, Alexander ^a   Liau, Gene ^a   Billy, Eric ^b   Theuer, Andreas ^b   Hla, Timothy ^c   Wood, Jeanette ^b  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; FINGOLIMOD; IMMUNOMODULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE; NVP AAL149; NVP AAL151; NVP AAL993; PROTEIN TYROSINE KINASE INHIBITOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; VATALANIB;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; DRUG POTENCY; FEMALE; GROWTH INHIBITION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; STATISTICAL SIGNIFICANCE; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM;

ANIMALS; CALCIUM; CELL GROWTH PROCESSES; CELL MOVEMENT; CORNEA; ENDOTHELIAL CELLS; FEMALE; HUMANS; MELANOMA, EXPERIMENTAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PHTHALAZINES; PROPYLENE GLYCOLS; PYRIDINES; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 31544447428     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2001     Document Type: Article

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