Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis

Journal of Immunology

Volumn 173, Issue 3, 2004, Pages 1596-1603

  Melendez, Alirio J ^a   Ibrahim, Farazeela Bte Mohd ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CALCIUM; COMPLEMENT COMPONENT C5A RECEPTOR; SPHINGOSINE KINASE;

ARTICLE; AUTOIMMUNITY; CELL MOTILITY; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGRANULATION; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 3242791547     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.3.1596     Document Type: Article

References (57)

1. Smedegard, G., L. X. Cui and T. E. Hugli. 1989. Endotoxin-induced shock in the rat: a role for C5a. Am. J. Pathol. 135:489.
2. Stevens, J. H., P. O'Hanley, J. M. Shapiro, F. G. Mihm, P. S. Satoh, J. A. Collins, and T. A. Raffin. 1986. Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J. Clin. Invest. 77:1812.
3. Wang, Y., S. A. Rollins, J. A. Madri, and L. A. Matis. 1995. Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease. Proc. Natl. Acad. Sci. USA 92:8955.
4. Cooper, N. R. 1999. Biology of the complement system. In Inflammation: Basic principles and clinical correlates. J.I. Gallin and R. Snyderman, eds. Lippincott Williams & Wilkins, Philadelphia, p. 281.
5. Gerard, N. P., and C. Gerard. 1991. The chemotactic receptor for human C5a anaphylatoxin. Nature 349:614.
6. Boulay, F., L. Mery, M. Tardif, L. Brouchon, and P. Vignais. 1991. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. Biochemistry 30:2993.
7. Martin, U., D. Bock, L. Arseniev, M. A. Tornetta, R. S. Ames, W. Bautsch, J. Köhl, A. Ganser, and A. Klos. 1997. The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes. J. Exp. Med. 186:199.
8. Zwirner, J., O. Götze, G. Begemann, A. Kapp, K. Kirchhoff, and T. Werfel. 1999. Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies. Immunology 97:166.
9. Nataf, S., N. Davoust, R. S. Ames, and S. R. Baraum. 1999. Human T cells express the C5a receptor and are chemoattracted to C5a. J. Immunol. 162:4018.
10. Werfel, T., K. Kirchhoff, M. Wittmann, G. Begemann, A. Kapp, F. Heidenreich, O. Gotze, and J. Zwirner. 2000. Activated human T lymphocytes express a functional C3a receptor. J. Immunol. 165:6599.
11. + dendritic cells derived from human skin. Immunology 103:210.
12. Yang, D., Q. Chen, S. Stoll, X. Chen, O. M. Z. Howard, and J. J. Oppenheim. 2000. Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: correlation with receptor expression. J. Immunol. 165:2694.
13. Hartmann, K., B. M. Henz, S. Krüger-Krasagakes, J. Köhl, R. Burger, S. Guhl, I. Haase, U. Lippert, and T. Zuberbier. 1997. C3a and C5a stimulate chemotaxis of human mast cells. Blood 89:2863.
14. Marder, S. R., D. E. Chenoweth, I. M. Goldstein, and H. D. Ferez. 1985. Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg. J. Immunol. 134:3325.
15. Chenoweth, D. E., M. G. Goodman, and W. O. Weigle. 1982. Demonstration of a specific receptor for human C5a anaphylatoxin on murine macrophages. J. Exp. Med. 156:68.
16. Hannun, Y. A. 1994. The sphingomyelin cycle and the second messenger functions of ceramide. J. Biol. Chem. 269:3125.
17. Heller, R. A., and M. Krönke. 1994. Tumor necrosis factor receptor-mediated signaling pathways. J. Cell Biol. 126:5.
18. Kolesnik, R., and D. W. Golde. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77:325.
19. Spiegel, S., and S. Milstien. 1995. Sphingolipid metabolites: members of a new class of lipid second messengers. J. Membr. Biol. 146:225.
20. Meyer zu Heringdorf, D., C. J. van Koppen, and K. H. Jakobs. 1997. Molecular diversity of sphingolipid signaling. FEBS Lett. 410:34.
21. Olivera, A., and S. Spiegel. 1993. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365:557.
22. Bornfeldt, K. E., L. M. Graves, E. W. Raines, Y. Igarashi, G. Wayman, S. Yamamura, Y. Yatomi, J. S. Sidhu, E. G. Krebs, S. Hakomori, and R. Ross. 1995. Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. J. Cell Biol. 130:193.
23. Choi, O. H., J. H. Kim, and J. P. Kinet. 1996. Calcium mobilization via SPHK in signalling by the FcεRI antigen receptor. Nature 18:634.
24. 2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem. 277:17255.
25. Melendez, A., R. A. Floto, D. J. Gillooly, M. M. Harnett, and J. M. Allen. 1998. FcγRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. J. Biol. Chem. 273:9393.
26. Alemany, R., D. M. zu Henringdorf, C. J. van Koppen, and K. H. Jacobs. 1999. Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. J. Biol. Chem. 274:3994.
27. Devaraj, S., I. Hugou, and I. Jialal. 2001. α-Tocopherol decreases CD36 expression in human monocyte-derived macrophages. J. Lipid Res. 42:521.
28. Olivera, A., J. Rosenthal, and S. Spiegel. 1994. Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases. Anal. Biochem. 223:306.
29. Melendez, A., R. A. Floto, A. J. Cameron, D. J. Gillooly, M. M. Harnett, and J. M. Allen. 1998. A molecular switch changes the signalling pathway used by the FCγRI antibody receptor to mobilize calcium. Curr. Biol. 8:210.
30. Melendez, A. J., M. M. Harnett, and J. M. Allen. 1999. Differentiation-dependent switch in protein kinase C isoenzyme activation by FcγRI, the human high-affinity receptor for immunoglobulin G. Immunology 96:457.
31. Melendez, A. J., M. M. Harnett, and J. M. Allen. 2001. Crosstalk between ARF6 and protein kinase Cα in FcγRI-mediated activation of phospholipase D1. Curr. Biol. 5:869.
32. Melendez, A. J., E. Carlos-Dias, M. Gosink, J. M. Allen, and L. Takacs. 2000. Human SPHK: molecular cloning, functional characterization and tissue distribution. Gene 13:19.
33. Liu, H., M. Sugiura, V. E. Nava, L. C. Edsall, K. Kono, S. Poulton, S. Milstien, T. Kohama, and S. Spiegel. 2000. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem. 275:19513.
34. Bless, N. M., S. J. Tojo, H. Kawarai, Y. Natsume, A. B. Lentsch, V. A. Padgaonkar, B. J. Czermak, H. Schmal, H. P. Friedl, and P. A. Ward. 1998. Differing patterns of P-selectin expression in lung injury. Am. J. Pathol 153:1113.
35. DiScipio, R. G., P. J. Daffern, M. A. Jagels, D. H. Broide, and P. Sriramarao. 1999. A comparison of C3a and C5a-mediated stable adhesion of rolling eosinophils in postcapillary venules and transendothelial migration in vitro and in vivo. J. Immunol. 162:1127.
36. Okusawa, S., K. B. Yancey, J. W. van der Meer, S. Endres, G. Lonnemann, K. Hefter, M. M. Frank, J. F. Burke, C. A. Dinarello, and J. A. Gelfand. 1988. C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro: comparison with secretion of interleukin 1β and interleukin 1α. J. Exp. Med. 168:443.
37. Arend, W. P., R. J. Massoni, M. A. Niemann, and P. C. Giclas. 1989. Absence of induction of IL-1 production in human monocytes by complement fragments. J. Immunol. 142:173.
38. Okusawa, S., C. A. Dinarello, K. B. Yancey, S. Endres, T. J. Lawley, M. M. Frank, J. F. Burke, and J. A. Gelfand. 1987. C5a induction of human interleukin 1. J. Immunol. 139:2635.
39. Cavaillon, J.-M., C. Fitting, and N. Haeffner-Cavaillon. 1990. Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophages. Eur. J. Immunol. 20:253.
40. Pellas, T. C., W. Boyar, J. van Oostrum, J. Wasvary, L. R. Fryer, G. Pastor, M. Sills, A. Braunwalder, D. R. Yarwood, R. Kramer, et al. 1998. Novel C5a antagonists regulate neutrophil functions in vitro and in vivo. J. Immunol. 160:5616.
41. Mohr, M., U. Hopken, M. Oppermann, C. Mathes, K. Goldmann, S. Siever, O. Gotze, and H. Burchardi. 1998. Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis. Eur. J. Clin. Invest. 28:227.
42. Short, A., A. K. Wong, A. M. Finch, G. Haaima, I. A. Shiels, D. P. Fairlie, and S. M. Taylor. 1999. Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. Br. J. Pharmacol 126:551.
43. Czermak, B. J., V. Sarma, C. L. Pierson, R. L. Warner, M. Huber-Lang, N. M. Bless, H. Schmal, H. P. Friedl, and P. A. Ward. 1999. Protective effects of C5a blockade in sepsis. Nat. Med. 5:788.
44. Heller, T., M. Hennecke, U. Baumann, J. E. Gessner, A. M. zu Vilsendorf, M. Baensch, F. Boulay, F. Kola, A. Klos, W. Bautsch, and J. Köhl. 1999. Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. J. Immunol. 163:985.
45. Wong, A. K., A. M. Finch, G. K. Pierens, D. J. Craik, S. M. Taylor, and P. Fairlie. 1998. Small molecular probes for the G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a. J. Med. Chem. 41:3417.
46. Finch, A. M., A. K. Wong, N. J. Paczkowski, S. K. Wadi, D. J. Craik, D. P. Fairlie, and S. M. Taylor. 1999. Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J. Med. Chem. 42:1965.
47. Okusawa, S., J. A. Gelfand, T. Ikejima, R. A. Connolly, and C. A. Dinarello. 1988. Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effects of cyclooxygenase inhibition. J. Clin. Invest. 81:1162.
48. Harkin, D. G., and L. P. Bignold. 1994. Neutrophil polarisation in plasma differs to that induced by endogenous chemoattractants with regard to frequency of uropod formation and requirement for divalent cations. Cell Biol. Int. 18:177.
49. Keller, H. U. 1983. Motility, cell shape, and locomotion of neutrophil granulocytes. Cell Motil. 3:47.
50. Zhang, X., Y. Kluger, Y. Nakayama, R. Poddar, C. Whitney, A. DeTora, S. M. Weissman, and P. E. Newburger. 2004. Gene expression in mature neutrophils: early responses to inflammatory stimuli. J. Leukocyte Biol. 75:358.
51. MacKinnon, A. C., A. Buckley, E. R. Chilvers, A. G. Rossi, C. Haslett, and T. Sethi. 2002. Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. J. Immunol. 169:6394.
52. Xia, P., J. R. Gamble, K. A. Rye, L. Wang, C. S. Hii, P. Cockerill, Y. Khew-Goodaall, A. G. Bert, P. J. Barter, and M. A. Vadas. 1998. Tumor necrosis factor-α induces adhesion molecule expression through the SPHK pathway. Proc. Natl. Acad. Sci. USA 95:14196.
53. Niwa, M., O. Kozawa, H. Matsuno, Y. Kanamori, A. Kara, and T. Uematsu. 2000. Tumor necrosis factor-α-mediated signal transduction in human neutrophils: involvement of sphingomyelin metabolites in the priming effect of TNF-α on the fMLP-stimulated superoxide production. Life Sci. 66:245.
54. Prieschl, E. E., R. Csonga, V. Novotny, G. E. Kikuchi, and T. Baumruker. 1999. The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fcε receptor I triggering. J. Exp. Med. 190:1.
55. Matsumoto, K., and K. Kanmatsuse. 1999. Increased IL-12 release by monocytes in nephrotic patients. Clin. Exp. Immunol. 117:361.
56. DeVries, M. E., L. Ran, and D. J. Kelvin. 1999. On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responses. Semin. Immunol. 11:95.
57. Hill, G. R., T. Teshima, A. Gerbitz, L. Pan, K. R. Cooke, Y. S. Brinson, J. M. Crawford, and J. L. Ferrara. 1999. Differential roles of IL-1 and TNF-α on graft-versus-host disease and graft versus leukemia. J. Clin. Invest. 104:459.