Blockade of Sphingosine-1- Phosphate Reduces Macrophage Influx and Retinal and Choroidal Neovascularization

Journal of Cellular Physiology

Volumn 218, Issue 1, 2009, Pages 192-198

  Bing, X I E ^a,b   Shen, Jikui ^b   Dong, Aling ^b   Rashid, Aymen ^b   Stoller, Glenn ^c   Campochiaro, Peter A ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OPHTHALMIC CONSULTANTS OF LONG ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; SONEPCIZUMAB; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; EYE TOXICITY; FEMALE; MALE; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA NEOVASCULARIZATION; RETINOPATHY; SUBRETINAL NEOVASCULARIZATION; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; HUMAN; IMMUNOLOGY; ISCHEMIA; MACACA; MACROPHAGE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA BLOOD VESSEL;

MUS; PRIMATES;

ANIMALS; ANTIBODIES, MONOCLONAL; CHOROIDAL NEOVASCULARIZATION; FEMALE; HUMANS; ISCHEMIA; LYSOPHOSPHOLIPIDS; MACACA FASCICULARIS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; RETINAL NEOVASCULARIZATION; RETINAL VESSELS; SPHINGOSINE;

EID: 58149166482     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21588     Document Type: Article

References (26)

1. Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L, Ferrara N, King GL, Smith LEH. 1995. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF)usingsoluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 92:10457-10461.
2. Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, Sy JP, Schneider S, Anchor Study Group. 2006. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N EngJ Med 355:1432-1444.
3. Chae S-S, Paik JH, Furneaux H, Hla T. 2004. Requirement for sphingosine 1 -phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest 114:1082-1089.
4. Endo A, Nagashima K-1, Kurose H, Mochizuki S, Matsuda M, Mochizuki N. 2002. Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelilal growth factor receptor and CrkII. J Biol Chem 277:23747-23754.
5. Hla T, Maciag T. 1990. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J Biol Chem 265:9308-9317.
6. 1 receptors in endothelial cells: Implication for cross-talk between sphingolipid and growth factor receptors. Proc Natl Acad Sci USA 100:10664-10669.
7. Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL. 2003. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93:1074-1081.
8. Killingsworth MC, Sarks JP, Sarks SH. 1990. Macrophages related to Bruch's membrane in age-related macular degeneration. Eye 4:613-621.
9. Klein R, Klein B. 1995. Vision disorders in diabetes, in: Group NDD , editor. Diabetes in America. Washington, DC: National Institutes of Health. pp 293-330.
10. Klein R,Klein BE,Linton KL.1992. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 99:933-943.
11. Kwon YG, Min JK, Kim KM, Lee DJ, Billiar TR, Kim YM. 2001. Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum deprived apoptosis by nitric oxide production. J Biol Chem 276:10627-10633.
12. Lee MJ, authors ao. 1998. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279:I552-I555.
13. Lee OH, Kim YM, Lee YM, Moon EJ, Lee DJ, Kim JH, Kwon YG. I999. Sphingosine 1- phosphate induces angiogenesis: Its angiogenic action and signaling mechanism in human umbilical bein endothelial cells. Biochem Biophys Res Commun 264:743-750.
14. Lima e Silva R,Shen J, Hackett SF,Kachi S,AkiyamaH, Kiuchi K,Yokoi K, HataraC,McLauer T, Aslam S, Gong YY, Xiao WH, Khu NH, Thut C, Campochiaro P. 2007. The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization. FASEBJ 21:3219-3230.
15. Liu Y,authorsao.2000.Edg-1,theG protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 106:951-961.
16. Mori K, Duh E, Gehlbach P, Ando A, Takahashi K, Pearlman J, Mori K, Yang HS, Zack DJ, Ettyreddy D, Brough DE, Wei LL, Campochiaro PA. 2001. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol 188:253-263.
17. Ozaki H, Seo M-S, Ozaki K, Yamada H, Yamada E, Hofmann F, Wood J, Campochiaro PA. 2000. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol 156:679-707.
18. 1 containing integrins. J Biol Chem 276:11830-11837.
19. Pitson SM,XiaP, LeclercqTM,Moretti PAB,Zebol JR,Lynn HE,WattenbergBW, Vadas MA. 2005. Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. J Exp Med 201:49-54.
20. Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY, Marina Study Group.2006.Ranibizumab for neovascular age-related macular degeneration .N EngJ Med 355:14I9-1431.
21. Shen J, XieB,DongA,Swaim M,Hackett SF,Campochiaro PA. 2007.In vivo immunostaining demonstrates macrophages associate with growing and regressing vessels. Invest Ophthalmol Vis Sci 48:4335-4341.
22. Skoura A, Sanchez T, Claffey KP, Mandala SM, Proia RL, Hla T. 2007. Essential role of sphingosine 1-phosphatereceptor2in pathological angiogenesis of the mouse retina. J Clin Invest 117:2506-2517.
23. Tanimoto T, Zheng-Gen J, Berk BC. 2002. Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-I/KDR is involved in sphingosine I-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthatse (eNOS). J Biol Chem 277:42997-43001.
24. Tobe T, Ortega S, Luna JD, Ozaki H, Okamoto N, Derevjanik NL, Vinores SA, Basilico C, Campochiaro PA. 1998. Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model. Am J Pathol 153:1641-1646.
25. Tsutsumi C, Sonoda KH, Egashira K, Qiao H, Hisatomi T, Nakao S, Ishibashi M, Charo IF, Sakamoto T, Murata T, Ishibashi T. 2003. The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J Leukoc Biol 74:25-32.
26. VisentinB,Vekich JA,SibbaldBJ,Cavalli AL,MorenoKM,MatteoRG,GarlandWA,Lu Y,YuS, Kundra V, Mills GB, Sabbadini RA. 2006. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cells 9:225-238.