Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells

Biochemical and Biophysical Research Communications

Volumn 368, Issue 4, 2008, Pages 1020-1025

  Schwalm, Stephanie ^a,b   Döll, Frauke ^a,b   Römer, Isolde ^a   Bubnova, Svetlana ^a   Pfeilschifter, Josef ^a   Huwiler, Andrea ^a,b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Endothelial cells; HIF 1; Hypoxia; Migration; Sphingosine kinase 1; Sphingosine 1 phosphate

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2;

ANGIOGENESIS; ARTICLE; CANCER GROWTH; CELL HYPOXIA; CELL LINE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE CONTROL; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION;

ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; CELL MOVEMENT; ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 40049096040     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.01.132     Document Type: Article

References (27)

1. 2 homeostasis by hypoxia-inducible factor. Annu. Rev. Cell Dev. Biol. 15 (1999) 551-578
2. Semenza G.L. HIF-1 and human disease: one highly involved factor. Genes Dev. 14 (2006) 1983-1991
3. Huwiler A., Kolter T., Pfeilschifter J., and Sandhoff K. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta 1485 (2000) 63-99
4. Spiegel S., and Milstien S. Sphingosine 1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell. Biol. 4 (2003) 397-407
5. Lee M.J., Van Brocklyn J.R., Thangada S., Liu C.H., Hand A.R., Menzeleev R., Spiegel S., and Hla T. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279 (1998) 1552-1555
6. Liu H., Chakravarty D., Maceyka M., Milstien S., and Spiegel S. Sphingosine kinases: a novel family of lipid kinases. Prog. Nucleic Acid Res. Mol. Biol. 71 (2002) 493-511
7. Alemany R., Koppen C.J., Danneberg K., ter Braak M., and Meyer zu Heringdorf D. Regulation and functional roles of sphingosine kinases. Naunyn Schmiedeb. Arch. Pharmacol. 374 (2007) 413-428
8. Hait N.C., Sarkar S., Le Stunff H., Mikami A., Maceyka M., Milstien S., and Spiegel S. Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J. Biol. Chem. 280 (2005) 29462-29469
9. Huwiler A., Döll F., Ren S., Klawitter S., Greening A., Römer I., Bubnova S., Reinsberg L., and Pfeilschifter J. Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-α-dependent mechanism. Biochim. Biophys. Acta 1761 (2006) 367-376
10. Edgell C.J., McDonald C.C., and Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridisation. Proc. Natl. Acad. Sci. USA 80 (1983) 3734-3737
11. Liu H., Sugiura M., Nava V.E., Edsall L.C., Kono K., Poulton S., Milstien S., Kohama T., and Spiegel S. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem. 275 (2000) 19513-19520
12. Minchenko A., and Caro J. Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: role of hypoxia responsive element. Mol. Cell. Biochem. 208 (2000) 53-62
13. Nakade Y., Banno Y., T-Koizumi K., Hagiwara K., Sobue S., Koda M., Suzuki M., Kojima T., Takagi A., Asano H., Nozawa Y., and Murate T. Regulation of sphingosine kinase 1 gene expression by protein kinase C in a human leukemia cell line MEG-O1. Biochim. Biophys. Acta 1635 (2003) 104-116
14. Calvani M., Rapisarda A., Uranchimeg B., Shoemaker R.H., and Melillo G. Hypoxic induction of an HIF-1α-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 107 (2006) 2705-2712
15. Yun J.K., and Kester M. Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. Arch. Biochem. Biophys. 408 (2002) 78-86
16. Ahmad M., Long J.S., Pyne N.J., and Pyne S. The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. Prostaglandins Other Lipid Mediat. 79 (2006) 278-286
17. Döll F., Pfeilschifter J., and Huwiler A. The epidermal growth factor stimulates sphingosine kinase-1 in the human mammary carcinoma cell line MCF7. Biochim. Biophys. Acta 1738 (2005) 72-81
18. Duan H.F., Wu C.T., Lu Y., Wang H., Liu H.J., Zhang Q.W., Jia X.X., Lu Z.Z., and Wang L.S. Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. Exp. Cell. Res. 298 (2004) 593-601
19. Kimura T., Watanabe T., Sato K., Kon J., Tomura H., Taamama K., Kuwabara A., Kanda T., Kobayashi I., Ohta H., Ui M., and Okajima F. Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. Biochem. J. 348 (2000) 71-76
20. 1-containing integrins. J. Biol. Chem. 276 (2001) 11830-11837
21. Osada M., Yatomi Y., Ohmori T., Ikeda H., and Ozaki Y. Enhancement of sphingosine 1- phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem. Biophys. Res. Commun. 299 (2002) 483-487
22. Allende M.L., Yamashita T., and Proia R.L. G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood 102 (2003) 3665-3667
23. Kono M., Mi Y., Liu Y., Sasaki T., Allende M.L., Wu Y.P., Yamashita T., and Proia R.L. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J. Biol. Chem. 279 (2004) 29367-29373
24. Van Brocklyn J.R., Lee M.J., Menzeleev R., Olivera A., Edsall L., Cuvillier O., Thomas D.M., Coopman P.J., Thangada S., Liu C.H., Hla T., and Spiegel S. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J. Cell. Biol. 142 (1998) 229-240
25. Munoz-Chapuli R., Quesada A.R., and Angel Medina M. Angiogenesis and signal transduction in endothelial cells. Cell. Mol. Life Sci. 61 (2004) 2224-2243
26. Okamoto H., Takuwa N., Yokomizo T., Sugimoto N., Sakurada S., Shigematsu H., and Takuwa Y. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol. Cell. Biol. 20 (2000) 9247-9261
27. Burridge K., and Wennerberg K. Rho and Rac take center stage. Cell 116 (2004) 167-179