Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

Journal of Clinical Investigation

Volumn 114, Issue 8, 2004, Pages 1082-1089

  Chae, Sung Suk ^a   Paik, Ji Hye ^a   Furneaux, Henry ^a   Hla, Timothy ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIGEL; POLYPEPTIDE; RECEPTOR; RNA; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE SILENCING; GENETIC TRANSCRIPTION; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; INJECTION; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; RNA INTERFERENCE; TECHNIQUE; TUMOR VASCULARIZATION;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; LAMININ; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEOGLYCANS; RECEPTORS, LYSOSPHINGOLIPID; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 9644252866     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200422716     Document Type: Article

References (40)

1. Saba, J.D., and Hla, T. 2004. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ. Res. 94:724-734.
2. Spiegel, S., and Milstien, S. 2003. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 4:397-407.
3. Paik, J.H., Chae, S., Lee, M.J., Thangada, S., and Hla, T. 2001. Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. J. Biol. Chem. 276:11830-11837.
4. Lee, M.J., et al. 1999. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. 99:301-312.
5. Hla, T., and Maciag, T. 1990. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein- coupled receptors. J. Biol. Chem. 265:9308-9313.
6. Sanchez, T., et al. 2003. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J. Biol. Chem. 278:47281-47290.
7. Garcia, J.G., et al. 2001. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edgdependent cytoskeletal rearrangement. J. Clin. Invest. 108:689-701. doi:10.1172/JCI200112450.
8. Liu, Y., et al. 2000. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106:951-961.
9. Ferrara, N., Gerber, H.P., and LeCouter, J. 2003. The biology of VEGF and its receptors. Nat. Med. 9:669-676.
10. Ferrara, N., Hillan, K.J., Gerber, H.P., and Novotny, W. 2004. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3:391-400.
11. Hurwitz, H., et al. 2004. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350:2335-2342.
12. Chae, S.S., Praia, R.L., and Hla, T. 2004. Constitutive expression of S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat. 73:141-150.
13. Fire, A., et al. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:806-811.
14. Elbashir, S.M., Lendeckel, W., and Tuschl, T. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:188-200.
15. Milhavet O., Gary, D.S., and Mattson, M.P. 2003. RNA interference in biology and medicine. Pharmacol. Rev. 55:629-648.
16. Hannon, G.J. 2002. RNA interference. Nature. 418:244-251.
17. McCaffrey, A.P., et al. 2002. RNA interference in adult mice. Nature. 418:38-39.
18. Sorensen, D.R., Leirdal, M., and Sioud, M. 2003. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J. Mol. Biol. 327:761-766.
19. Dave, R.S., and Pomerannz, R.J. 2003. RNA interference: on the road to an alternate therapeutic strategy! Rev. Med. Virol. 13:373-385.
20. Yang, D., et al. 2002. Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc. Natl Acad. Sci. U. S. A. 99:9942-9947.
21. Zhang, H., Kolb, P.A., Brondani, V., Billy, E., and Filipowicz, W. 2002. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21:5875-5885.
22. Kuersten, S., and Goodwin, E.B. 2003. The power of the 3′ UTR: translational control and development. Nat. Rev. Genet. 4:626-637.
23. Forrest, M., et al. 2004. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J. Pharmacol. Exp. Ther. 309:758-768.
24. Allende, M.L., Dreier, J.L., Mandala, S., and Proia, R.L. 2004. Expression of the sphingosine-1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem. 279:15396-15401.
25. Liu, C.H., and Hla, T. 1997. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 43:15-24.
26. Ancellin, N., et al. 2002. Extracellular export of sphingosinekinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J. Biol. Chem. 277:6667-6675.
27. Jain, R.K. 2003. Molecular regulation of vessel maturation. Nat. Med. 9:685-693.
28. Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E., and Hanahan, D. 2003. Benefits of targeting both pericytes and endothelial cells in the tumor vasculatute with kinase inhibitors. J. Clin. Invest. 111:1287-1295. doi:10.1172/JCI200317929.
29. English, D., Garcia, J.G., and Brindley, D.N. 2001. Platelet-released phospholipids link haemostasis and angiogenesis. Cardiovasc. Res. 49:588-599.
30. Wang, F., et al. 1999. Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. J. Biol. Chem. 274:35343-35350.
31. Hla, T. 2001. Sphingosine 1-phosphare receptors. Prostaglandins. 64:135-142.
32. Igarashi, J., Erwin, P.A., Dantas, A.P., Chen, H., and Michel, T. 2003. VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Proc. Natl. Acad. Sci. U. S. A. 100:10664-10669.
33. Risau, W. 1997. Mechanisms of angiogenesis. Nature. 386:671-674.
34. Allende, M.L., Yamashita, T., and Proia, R.L. 2003. G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 102:3665-3667.
35. Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., and Muramatsu, T. 2004. A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res. 64:3365-3370.
36. Amarasinghe, A.K., Calin-Jageman, I., Harmouch, A., Sun, W., and Nicholson, A.W. 2001. Escherichia coli ribonuclease III: affinity purification of hexahistidine-tagged enzyme and assays for substrate binding and cleavage. Methods Enzymol. 342:143-158.
37. Ochiya, T., et al. 1999. New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet. Nat. Med. 5:707-710.
38. Morikawa, S., et al. 2002. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am. J. Pathol. 160:985-1000.
39. Bussolino, F., et al. 1991. M urine endochelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines. J. Immunol. 147:2122-2129.
40. Chae, S.S., Paik, J.H., Allende, M.L., Proia, R.L., and Hla, T. 2004. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev. Biol. 268:441-447.