FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

Cellular Signalling

Volumn 22, Issue 10, 2010, Pages 1536-1542

  Tonelli, Francesca ^a   Lim, Keng Gat ^a   Loveridge, Carolyn ^a   Long, Jaclyn ^a   Pitson, Stuart M ^d,e   Tigyi, Gabor ^b   Bittman, Robert ^c   Pyne, Susan ^a   Pyne, Nigel J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

^d University of Adelaide   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Apoptosis; Cancer; Fingolimod; Proteasome; Sphingosine 1 phosphate signalling; Sphingosine kinase 1

Indexed keywords

ANDROGEN RECEPTOR; FINGOLIMOD; FINGOLIMOD PHOSPHATE; FINGOLIMOD PHOSPHONATE; FINGOLIMOD VINYLPHOSPHONATE; IMMUNOSUPPRESSIVE AGENT; PROTEASOME; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL PROTECTION; CELL STRAIN LNCAP; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; DRUG STRUCTURE; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PULMONARY ARTERY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANDROGENS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; FEMALE; HUMANS; MALE; MUSCLE, SMOOTH, VASCULAR; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROPYLENE GLYCOLS; PROSTATIC NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX; PULMONARY ARTERY; SPHINGOSINE; STEREOISOMERISM; VINYL COMPOUNDS;

EID: 77954535502     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2010.05.022     Document Type: Article

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