Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3250-3259

  Nagahara, Y ^a   Ikekita, M ^a   Shinomiya, T ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; CYTOCHROME C OXIDASE; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LYMPHOMA; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0034665512     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3250     Document Type: Article

References (61)

1. Protease activation during apoptosis: Death by a thousand cuts?
2. ICE family proteases: Mediators of all apoptotic cell death?
3. Cytochrome c: Can't live with it - Can't live without it
4. Apoptosis by death factor
5. Caspases: The executioners of apoptosis
6. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/ APO-1) death-inducing signaling complex
7. A cytofluorometric assay of nuclear apoptosis induced in a cell-free system: Application to ceramide-induced apoptosis
8. Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: The impact of irreversible permeability transition
9. Molecular characterization of mitochondrial apoptosis-inducing factor
10. The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
11. The mitochondrial permeability transition
12. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
13. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
14. Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system
15. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
16. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
17. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
18. Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade
19. The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition
20. The release of cytochrome c from mitochondda: A primary site for Bcl-2 regulation of apoptosis
21. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
22. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
23. Bax directly induces release of cytochrome c from isolated mitochondria
24. 2+ ions
25. Caspases disrupt mitochondrial membrane barrier function
26. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
27. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
28. Fungal metabolites. Part II. A potent immunosuppressive activity found in lsaria sinclairii metabolite
29. Simple compounds, 2-alkyl-2-amino-1,3-propanediols have potent immunosuppressive activity
30. Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols
31. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720
32. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation
33. A new immunosuppressant, FTY720, prolongs limb allograft survival in rats
34. Effect of a new immunosuppressive agent, FTY720, on survival of islet allografts
35. Prevention of graft rejection and graft-versus-host reaction by a novel immunosuppressant, FTY720, in rat small bowel transplantation
36. Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720
37. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
38. Analysis of the mode of action of a novel immunosuppressant FTY720 in mice
39. Evidence that FTY720 induces T cell apoptosis in vivo
40. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes
41. The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720
42. Granzyme release and caspase activation in activated human T-lymphocytes
43. Trimetazidine counteracts the hepatic injury associated with ischemia-reperfusion by preserving mitochondrial function
44. Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II
45. Nuclear events of apoptosis in vitro in cell-free mitotic extracts: A model system for analysis of the active phase of apoptosis
46. Mitochondrial control of nuclear apoptosis
47. The permeability transition pore complex: A target for apoptosis regulation by caspases and Bcl-2-related proteins
48. 1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells
49. An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60
50. Cyclosporin A, a peptide metabolite from Trichoderma polysporum (Link ex pers.) Rifai, with a remarkable immunosuppressive activity
51. Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis
52. The effect of azathioprine (Imuran) on the cell cycle of promonocytes and the production of monocytes in the bone marrow
53. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
54. The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal
55. Bcl-2 prevents apoptotic mitochondtial dysfunction by regulating proton flux
56. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity
57. Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP
58. Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
59. Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: A link between the apoptosome and the proteasome pathway
60. 2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway
61. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway