Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells

Cancer Research

Volumn 60, Issue 16, 2000, Pages 4468-4474

  Nava, Victor E ^a   Cuvillier, Olivier ^a   Edsall, Lisa C ^c   Kimura, Kotohiko ^b   Milstien, Sheldon ^c   Gelmann, Edward P ^b   Spiegel, Sarah ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; N,N DIMETHYLSPHINGOSINE; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GAMMA IRRADIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; RADIOSENSITIVITY;

APOPTOSIS; CASPASES; CERAMIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MALE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROSTATIC NEOPLASMS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TUMOR CELLS, CULTURED;

EID: 0034662612     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Dedifferentiation of locally recurrent prostate cancer after radiation therapy. Evidence for tumor progression
2. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
3. Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation
4. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiationinduced apoptosis
5. Loss of ceramide production confers resistance to radiation-induced apoptosis
6. Functions of ceramide in coordinating cellular responses to stress
7. Regulation of ceramide production and apoptosis
8. Ceramide: A signal for apoptosis or mitogenesis?
9. Signalling sphingomyelinases: Which, where, how and why?
10. Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation
11. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death
12. Role of glutathione in the radiation response of mammalian cells in vitro and in vivo
13. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols
14. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
15. 12-O-tetradecanoylphorbol-13-acetateinduced apoptosis in LNCaP cells is mediated through ceramide synthase
16. Tumor necrosis factor-α sensitizes prostate cancer cells to γ-irradiation-induced apoptosis
17. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-α in human neutrophils
18. Tumor necrosis factor α-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death
19. Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells
20. L gene expression
21. Molecular cloning and functional characterization of murine sphingosine kinase
22. Suppression of ceramide-mediated programmed cell death by sphingosine-I-phosphate
23. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation
24. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide- mediated apoptosis in Jurkat T lymphocytes
25. 3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase
26. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
27. Radiation-induced apoptosis mediated by retinoblastoma protein
28. Inorganic and organic phosphate measurements in the nanomolar range
29. Enzymatic measurement of sphingosine 1-phosphate
30. Lysosphingolipids inhibit protein kinase C: Implications for the sphingolipidoses
31. Sphingolipid metabolism and cell growth regulation
32. L inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis
33. N, N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide
34. 2+ mobilization in human platelets: Evaluation with sphingosine kinase inhibitors
35. Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide
36. Signal transduction through lipid second messengers
37. Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy
38. Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase
39. Activation of sphingosine kinase by tumor necrosis factor-α inhibits apoptosis in human endothelial cells
40. Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase
41. Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase
42. An essential role for NF-ΚB in preventing TNF-α-induced cell death
43. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway
44. Ceramide generation by the reaper protein is not blocked by the caspase inhibitor, p35
45. Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells
46. CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition
47. prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
48. Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis
49. Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP
50. L and Bax-α control points: Modulation of apoptosis induced by cancer chemotherapy and relation to TPCK-sensitive protease and caspase activation
51. Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: Overexpression of caspase-7 as a new gene therapy strategy for prostate cancer
52. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
53. Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
54. Regulation of lipid signaling pathways for cell survival and apoptosis by bc1-2 in prostate carcinoma cells