Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells)

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 939-945

  Fujino, Masayuki ^a,b   Xiao Kang, L I ^a,b   Kitazawa, Yusuke ^a,b   Guo, L E I ^a,b   Kawasaki, Mikiko ^a,b   Funeshima, Naoko ^a,b   Amano, Takashi ^a,b   Suzuki, Seiichi ^a,b  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE INHIBITOR; DNA; ETOPOSIDE; FAS ANTIBODY; FINGOLIMOD; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOMA CELL; LYMPHOMA CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIBODIES; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CASPASES; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVATORS; ETOPOSIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; JURKAT CELLS; PROPYLENE GLYCOLS; SPHINGOSINE;

EID: 0036181066     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.939     Document Type: Article

References (38)

1. Design, synthesis, and structure-activity relationship of 2-substituted-2-amino-1,2-propanediols: Discovery of a novel immunosuppressant, FTY720
2. FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing
3. Caspases: The executioners of apoptosis
4. Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720
5. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
6. In vitro prevention of cell-mediated xeno-graft rejection via the Fas/FasL-pathway in CrmA-transducted porcine kidney cells
7. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
8. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
9. Protealytic activities that mediate apoptosis
10. Mitochondrial control of apoptosis
11. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
12. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
13. Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway
14. Caspase requirement for the apoptotic death of WR19L-induced by FTY720
15. Overexpression of the Bcl-2 protein increases the half-life of p21Bax
16. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
17. Evidence that FTY720 induces T cell apoptosis in vivo
18. Apoptosis by death factor
19. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
20. The role of proteases during apoptosis
21. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
22. An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60
23. Serial killers: Ordering caspase activation events in apoptosis
24. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release
25. The clinical pharmacology of etoposide
26. FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells
27. Autoactivation of procaspase-9 by Apaf-l-mediated oligomerization
28. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine pro-teases
29. Mechanisms and genes of cellular suicide
30. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
31. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
32. FTY720: Mechanisms of action and its effect on organ transplantation
33. The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720
34. Apoptosis in the pathogenesis and treatment of disease
35. Identification of a new caspase homologue: Caspase-14
36. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
37. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
38. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3