Development of a sphingosine kinase 1 specific small-molecule inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7498-7502

  Hengst, Jeremy A ^a   Wang, Xujun ^a   Sk, Ugir H ^a   Sharma, Arun K ^a   Amin, Shantu ^a   Yun, Jong K ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Hyperproliferative disease; Inflammatory disease; Small molecule inhibitor; Sphingosine; Sphingosine kinase; Sphingosine 1 phosphate

Indexed keywords

ENZYME INHIBITOR; N' [(2HYDROXY 1 NAPHTHYL)METHYLENE] 3 (2 NAPHTHYL) 1H PYRAZOLE 5 CARBOHYDRAZIDE; SKI 178; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; SPHINGOSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CYTOTOXICITY; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; HYDRAZINES; KINETICS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78449295649     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.005     Document Type: Article

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