Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

Nature

Volumn 465, Issue 7301, 2010, Pages 1084-1088

  Alvarez, Sergio E ^a,c   Harikumar, Kuzhuvelil B ^a   Hait, Nitai C ^a   Allegood, Jeremy ^a   Strub, Graham M ^a   Kim, Eugene Y ^a   MacEyka, Michael ^a   Jiang, Hualiang ^b   Luo, Cheng ^b   Kordula, Tomasz ^a   Milstien, Sheldon ^a   Spiegel, Sarah ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSINE; POLYUBIQUITINATION OF RECEPTOR INTERACTING PROTEIN 1; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO ACID; BIOCHEMISTRY; CATALYSIS; ENZYME ACTIVITY; IMMUNE SYSTEM; LIPID; PHOSPHATE; PROTEIN;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; UBIQUITINATION;

ANIMALS; BIOCATALYSIS; CELL LINE; ENZYME ACTIVATION; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LYSINE; LYSOPHOSPHOLIPIDS; MICE; MODELS, MOLECULAR; NF-KAPPA B; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SPHINGOSINE; SUBSTRATE SPECIFICITY; TNF RECEPTOR-ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77953923379     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09128     Document Type: Article

References (30)

1. Karin, M. & Gallagher, E. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol. Rev. 228, 225-240 (2009).
2. Hayden, M. S. & Ghosh, S. Shared principles in NF-kB signaling. Cell 132, 344-362 (2008).
3. Lee, T. H., Shank, J., Cusson, N. & Kelliher, M. A. The kinase activity of Rip1 is not required for tumor necrosis factor-a-induced IkB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. J. Biol. Chem. 279, 33185-33191 (2004).
4. Xia, P. et al. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-a signaling. J. Biol. Chem. 277, 7996-8003 (2002).
5. Bhoj, V. G. & Chen, Z. J. Ubiquitylation in innate and adaptive immunity. Nature 458, 430-437 (2009).
6. Paugh, S. W. et al. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood 112, 1382-1391 (2008).
7. Spiegel, S. & Milstien, S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nature Rev. Mol. Cell Biol. 4, 397-407 (2003).
8. Kimura, T. et al. Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high-density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells. J. Biol. Chem. 281, 37457-37467 (2006).
9. 12 specifically regulates COX-2 induction by sphingosine 1-phosphate: Role for JNK-dependent ubiquitination and degradation of IkBa. J. Biol. Chem. 282, 1938-1947 (2007).
10. Pitson, S. M. et al. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J. 22, 5491-5500 (2003).
11. Zhao, Y. et al. Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: Role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J. Biol. Chem. 282, 14165-14177 (2007).
12. i-coupled orphan receptor edg-1 and intracellular to regulate proliferation and survival. J. Cell Biol. 142, 229-240 (1998).
13. Giussani, P. et al. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-Golgi trafficking of ceramide. Mol. Cell. Biol. 26, 5055-5069 (2006).
14. Ea, C. K., Deng, L., Xia, Z. P., Pineda, G. & Chen, Z. J. Activation of IKK by TNFa requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22, 245-257 (2006).
15. Wu, C. J., Conze, D. B., Li, T., Srinivasula, S. M. & Ashwell, J. D. Sensing of Lys-63-linked polyubiquitination by NEMO is a key event in NF-kB activation. Nature Cell Biol. 8, 398-406 (2006).
16. Wang, H. et al. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc. Natl Acad. Sci. USA 105, 20197-20202 (2008).
17. Newton, K. et al. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 134, 668-678 (2008).
18. Shi, C. S. & Kehrl, J. H. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J. Biol. Chem. 278, 15429-15434 (2003).
19. Habelhah, H. et al. Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kB. EMBO J. 23, 322-332 (2004).
20. Li, S., Wang, L. & Dorf, M. E. PKC phosphorylation of TRAF2 mediates IKKa/b recruitment and K63-linked polyubiquitination. Mol. Cell 33, 30-42 (2009).
21. Bertrand, M. J. et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30, 689-700 (2008).
22. Varfolomeev, E. et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor a (TNFa)-induced NF-kB activation. J. Biol. Chem. 283, 24295-24299 (2008).
23. Xu, M., Skaug, B., Zeng, W. & Chen, Z. J. A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFa and IL-1b. Mol. Cell 36, 302-314 (2009).
24. Yin, Q., Lamothe, B., Darnay, B. G. & Wu, H. Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry 48, 10558-10567 (2009).
25. Morris, G. M. et al. Automated docking using a Lamarckian genetic algorithm and empirical binding free energy function. J. Comput. Chem. 19, 1639-1662 (1998).
26. Hait, N. C. et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325, 1254-1257 (2009).
27. Maceyka, M., Alvarez, S. E., Milstien, S. & Spiegel, S. Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol. Cell. Biol. 28, 5687-5697 (2008).
28. Allende, M. L. et al. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J. Biol. Chem. 279, 52487-52492 (2004).
29. Paugh, B. S. et al. EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCd, and sphingosine kinase 1 in glioblastoma cells. FASEB J. 22, 455-465 (2008).
30. Theiss, A. L. et al. Prohibitin inhibits tumor necrosis factor a-induced nuclear factor-kB nuclear translocation via the novel mechanism of decreasing importin a3 expression. Mol. Biol. Cell 20, 4412-4423 (2009).