Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3524-3548

  Kennedy, Andrew J ^a   Mathews, Thomas P ^a,b   Kharel, Yugesh ^b   Field, Saundra D ^a   Moyer, Morgan L ^a   East, James E ^a   Houck, Joseph D ^a   Lynch, Kevin R ^b   MacDonald, Timothy L ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE;

AMIDINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; KINETICS; LEUKEMIA; LYSOPHOSPHOLIPIDS; MODELS, CHEMICAL; MODELS, MOLECULAR; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOSINE; U937 CELLS;

EID: 79957775905     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2001053     Document Type: Article

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