Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis

Circulation Research

Volumn 100, Issue 1, 2007, Pages 41-49

  Pchejetski, Dimitri ^a,c,f   Kunduzova, Oxana ^a,c   Dayon, Audrey ^a,c,f   Calise, Denis ^b,c   Seguelas, Marie Hélène ^a,c   Leducq, Nathalie ^d   Seif, Isabelle ^e   Parini, Angelo ^a,c   Cuvillier, Olivier ^a,c,f  

^a INSERM   (France)

^b IFR 31   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d SANOFI   (France)

^e UNIVERSITÉ PARIS SACLAY   (France)

^f INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Ischemia reperfusion; Monoamine oxidases; ROS; Serotonin; Sphingosine kinase 1

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BLOCKING AGENT; CERAMIDE; HYDROGEN PEROXIDE; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; KNOCKOUT MOUSE; LIPID METABOLISM; MALE; MOUSE; MYOBLAST; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION; WILD TYPE;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CERAMIDES; DOWN-REGULATION; DRUG RESISTANCE; HYDROGEN PEROXIDE; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MONOAMINE OXIDASE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; OXIDANTS; OXIDATIVE STRESS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SEROTONIN; SPHINGOLIPIDS; SPHINGOSINE; UP-REGULATION;

EID: 33846047834     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000253900.66640.34     Document Type: Article

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